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Search Results: 1 - 10 of 2304 matches for " Sachin Patil "
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Mitocans as Novel Agents for Anticancer Therapy: An Overview  [PDF]
Vandana Panda, Prashant Khambat, Sachin Patil
International Journal of Clinical Medicine (IJCM) , 2011, DOI: 10.4236/ijcm.2011.24086
Abstract: Many conventional anticancer drugs have an associated lack of safety by their toxicity. Relatively faster mutations in tumor cells pose a significant obstacle in treatment of cancer. Recently, “Mitocans” have emerged as a novel class of anticancer agents selectively targeting tumor cells and thus, are much less toxic than conventional anticancer chemotherapeutic agents. Mitocans are drugs that act directly on mitochondria within the cell, thus causing changes in energy metabolism of the cell. Amongst these mitocans, α-Tocopheryl succinate or vitamin E analogs are studied very well by researchers. This review discusses mitochondrial drug targeting strategies and a variety of novel mitochondrial drug targets of mitocans, such as electron transport chain, mitochondrial permeability transition, Bcl-2 family proteins and mitochondrial DNA. The purpose of this review is to focus on the various classes of mitocans, the mechanisms by which these drugs specifically act on tumor cells and their applications in cancer chemotherapeutics.
A Population-Based Outcomes Analysis of the Impact of Age on Morbidity and Mortality Following Gastrectomy: An Analysis of 13,799 Patients from the Nationwide Inpatient Sample Database  [PDF]
Ami Karkar, Sachin Patil, Ronald S. Chamberlain
Journal of Cancer Therapy (JCT) , 2013, DOI: 10.4236/jct.2013.41A012

Introduction: Gastric cancer is the 4th most common malignancy and second leading cause of cancer-related death worldwide, both its incidence and mortality have decreased over the past 70 years. Advancing life expectancy, as well as subtle change in the type and location of gastric cancer in the US, has resulted in an increased number of elderly patients requiring gastric surgery. By 2050, the population older than 85 years is projected to reach 20.9 million, and as a result, the need to assess the operative outcomes and mortality following gastrectomy in this group is imperative. This study sought to assess age-related clinical outcomes following gastric cancer surgery across all age groups to provide more precise data for pre-operative surgical risk stratification. Methods: Discharge data on 40,276,240 patients was collected from Nationwide Inpatient Sample Database (NIS) (2004-2008). Data on patients undergoing gastrectomy as the primary procedure was analyzed including age, gender, elective/non-elective admission, pre-operative length of stay (LOS), total LOS, and mortality. Eight age groups were compared for two procedures: total gastrectomy (TG) and partial gastrectomy (PG). Categorical data was compared using the Chi square test and continuous data using the Student’s t test. Univariate analysis and multivariate regression analysis were performed to assess independent variables. Results: 13,799 patients underwent gastrectomy surgery with 23.7% having TG and 76.3% PG. Gastric carcinoma was the most common indication for TG, while benign gastric disease was more common for PG, especially in years 51 - 70 (p < 0.001).The mean age for TG and PG groups were 63 ± 12.8 and 64 ± 15 years respectively. Males underwent twice the number of TGs (p < 0.001), whereas equal number of males and females underwent PG (p < 0.001). The number of TGs increased over the 5-year study period, with the highest % change noted in those 41 - 50 years (1500%). PGs performed decreased overall, especially in patients <60 years, however PGs increased in patients >81 years with the greatest % change in the oldest patients >91

Anaesthetic Management of a Patient with Hypertropich Obstructive Cardiomyopathy with Automated Implantable Cardioverter Defibrillator for Septal Myectomy with Mitral Valve Replacement and Coronary Artery Bypass Graft
Patil Sachin,Ninan Benjamin
Annals of Cardiac Anaesthesia , 2005,
Sensitive and selective method for the analysis of menthol from pharmaceutical products by RP-HPLC with refractive index detector
Shaikh K,Patil Sachin
Journal of Pharmacy and Bioallied Sciences , 2010,
Abstract: Objective : Liquid chromatography with refractive index (RI) detection has been found to be very useful for the determination of menthol from pharmaceutical products. A simple and rapid HPLC method has been developed for this purpose compared to conventional GC methods, requiring no special sample pretreatment for the determination of menthol from pharmaceutical products. Materials and Methods : A chromatographic separation was achieved on a Inertsil ODS 3V (4.6mm×250mm, 5μm) column using water : methanol (30:70 v/v) as a mobile phase, at a flow rate of 1.0 ml/min. Results : Method was validated as per ICH guidelines for various parameters such as precision, linearity, accuracy, solution stability, robustness, limit of detection and quantification. Results were found to be within acceptable limits. Conclusion : The method has been successfully applied for the quantification of menthol from syrup formulations. The developed method can be conveniently used by the quality control department to determine assay of menthol from pharmaceutical preparations.
Surgical Outcome Following Hip Fracture in Patients > 100 Years Old: Will They Ever Walk Again?  [PDF]
Sachin Patil, Bertrand Parcells, Alexis Balsted, Ronald S. Chamberlain
Surgical Science (SS) , 2012, DOI: 10.4236/ss.2012.311109
Abstract: Introduction: Advances in medicine have led to a growth in the centenarian population (>100 years old). Centenarians are a largely unstudied population but as longevity increases, so will the cost of providing care for this group. Methods: One hundred and ten patients were admitted to SBMC 195 times between 2000 and 2009. Thirteen patients were treated for hip fracture. Data abstracted from the charts of these patients including age, gender, ethnicity, co-morbidities, advance directives (ADRs), functional status, length of stay (LOS), pre-operative and post-operative residential status and ambulatory status, ASA grade, type of anesthesia, duration of surgery and for complications of surgery or anesthesia. Results: The mean age was 101.2 years (100 to 104 years) with an M:F ratio of 2:11. The most common co-morbidities were hypertension, anemia, congestive heart failure (CHF) and coronary artery disease. Among the 13 patients with hip fractures, 12 had operative intervention while one was treated conservatively. The mean ASA grade was 2.75 (1 - 4). Five patients had surgery under general anesthesia and seven received spinal anesthesia. Five patients received a bi-polar hip replacement and seven patients underwent internal fixation. The mean operative time was 47.6 min (27 - 90 min). Five (41.7%) patients required a peri-operative blood transfusion. The mean post-anesthesia recovery score was 9.42 (9 - 10). All patients, except two, were returned to their pre-operative ambulatory status. Advanced directives were held by only 30.8% of patients on admission. There were 2 post-operative morbidities and 1 mortality. Conclusions: Centenarians represent a high-risk-surgical population due to their age and associated comorbidities. Hip fracture is the cause of >10% of all admissions and accounts for 29% of all surgical procedures in this age group. Despite their age and comorbidities, surgery for hip fracture is well tolerated and nearly all patients were returned to their pre-hospital ambulatory status. Education on advanced directives is lacking.
A United States Population-Based Study on Clinical Outcomes Following Primary Carotid Endarterectomy: Who and When?  [PDF]
Shirali T. Patel, Sachin V. Patil, Ronald S. Chamberlain
Surgical Science (SS) , 2012, DOI: 10.4236/ss.2012.312117
Abstract: Introduction: Carotid Endarterectomy (CEA) is widely recognized as effective in significantly reducing the risk of recurrent stroke emanating from extracranial carotid atherosclerosis and approximately 140,000 carotid endarterectomies are performed annually in the United States (US). As such, data are scarce on the prevalence and clinical outcomes of CEA across different age groups. This study aimed to determine and analyze the prevalence, demographic and clinical outcomes of CEA across six decades of life. Methods: Data on 40,276,240 patients were abstracted from discharge data obtained from the Nationwide Inpatient Sample (NIS) database, a part of the Healthcare Cost and Utilization Project (HCUP) of the Agency for Healthcare Research and Quality (2004-2008). Demographic and clinical characteristics of patients undergoing CEA as the primary procedure were abstracted including age, gender, elective or non-elective admission, comorbidities, Length of Stay (LOS), secondary procedures, NIS severity of illness and risk of mortality class, complications and mortality. CEA outcomes were compared across six decades of life starting at age 41. Categorical variables were compared using the Chi-square test, and the Student’s t-test was used to compare continuous variables. Results: 118,947 patients who underwent CEA as their primary procedure were identified. Caucasians accounted for 67.1% of the population. The overall mean age was 71.2 ± 9.5 years, with a Male: Female ratio of 1.3:1. Nineteen percent of patients had non-elective admission, with the highest percentage (29.5%) in those >91 years old. Over three percent of patients had a prior stroke. The overall number of CEA performed peaked in the 8th decade of life (38.4%). The most common co-morbidities were hypertension, diabetes mellitus, and chronic pulmonary disease. Mean LOS was 3.3 days. Forty-two percent of all cases were performed in a teaching hospital, with the percentage increasing with advancing age. The overall mortality and stroke rates were 0.4% and 0.9%, respectively, and these rates were highest in the oldest patients (>91 years). The overall myocardial infarction rate was 0.8% which was highest incidence in the 7th and 9th decades (1.1%). On multivariate analysis, age >80 years (Odds Ratio (OR), 2.9; 95% Confidence Interval (CI), 1.1 - 8.0), Non-white race (OR, 1.7; CI, 1.1 - 2.7), Charlson co-morbidity index score of 1 - 5 (OR, 1.7; CI, 1.3 - 2.4), carotid artery stenosis with stroke at presentation (OR, 1.7; CI, 1.1 - 2.5), Congestive Heart Failure (CHF) (OR, 3.7; CI, 2.8 - 4.8)
Implementation of Multiple Heterogeneous Interface Mobile Node in NS2
Sachin Dattatraya Patil,Varshapriya Jyotinagar
International Journal of Engineering Innovations and Research , 2012,
Abstract: In the next generation of the mobile network there will be the future of the heterogeneous interface. As it provides the multiple interface at the same time hence will connect to the many interfaces at the same time but will connect to the best one at the time so it will provide the better connectivity at all time. The 4G’s main feature is always providing best connectivity to speedy network. As 4G is providing the mobile-ip connectivity hence will support the voice over ip. This project will provide multiple interfaces to the NS hence will helpful for the research and educational purpose. This paper will provide the idea of creating heterogeneous interface to mobile node architecture in NS. The NS2 is open source so this will provide good environment for the research work. In this paper we are going to explain the architecture of the adding multiple interface to NS2 model.
Crosslinking Of Polysaccharides: Methods And Applications
Sachin Patil,D. R. Jadge
Pharmaceutical Reviews , 2008,
Abstract: Polysaccharides are polymers of simple sugar building blocks. Crosslinked polysaccharides are having many applications in pharmaceuticals.Different methods are available for crosslinking of polysaccharides. Different chemical and physical methods are summarized and discussed. Chemical crosslinking of polysaccharide is highly versatile method with good mechanical stability. However, the crosslinking agents used are not only affects the integrity of substances but are often toxic compounds, which have been extracted from gel before they can be applied. Such adverse effects are avoided with the use of physically crosslinked gels.
PCA Based Image Enhancement in Wavelet Domain
Vikas D Patil, Sachin D. Ruikar
International Journal of Engineering Trends and Technology , 2012,
Abstract: —This paper demonstrates a methodology of image enhancement that uses principle component analysis (PCA) inwavelet domain. PCA fully de-correlates the original data set so that the energy of the signal will concentrate on the small subset of PCA transformed dataset. The energy of random noise evenly spreads over the whole data set, we can easily distinguish signal from random noise over PCA domain. It consists of two stages: image enhancement by removing the random noise and further refinement of the first stage. The random noise is significantly reduced in the first stage; the Local Pixel Grouping (LPG) accuracy will be much improved in the second stage so that the final enhancement result is visually much better. The LPG-PCA enhance procedure is used to improve the image quality from first stage to second stage with edge preservation.The wavelet thresholding methods used for removing random noise has been researched extensively due to its effectiveness and simplicity. However, not much has been done to make the threshold values adaptive to the spatially changing statistics of images. Such adaptivity can improve the wavelet thresholding performance because it allows additional local information of the image (such as the identification of smooth or edge regions) to be incorporated into the algorithm. We compare this two-stage process with traditional principal component analysis and find that the results of the new structure are closer to the structure of traditional quality of image, its purity and descriptors than traditional principal component analysis.
Congenital Absence of the Cystic Duct: A Rare but Significant Anomaly  [PDF]
Sachin Patil, Sudhir Jain, Ramachandra C. M. Kaza, Ronald S. Chamberlain
Surgical Science (SS) , 2013, DOI: 10.4236/ss.2013.44046

Cholecystectomy is the most common digestive tract surgery performed worldwide and injury to the bile duct leads to both acute and chronic sequelae. The incidence of bile duct injury is increased in the presence of severe inflammation and is compounded by congenital abnormalities of the biliary tract. Congenitally absent cystic duct is one such rare anomaly with significant surgical implications. So far only nine clear cases of congenitally absent cystic duct have been reported. In this report we describe two additional cases of a congenitally absent cystic duct and provide a comprehensive discussion of the clinical significance, and appropriate surgical management of this anomaly.

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