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Search Results: 1 - 10 of 1199 matches for " Sacha Satram-Hoang "
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The Unmet Need in Chronic Lymphocytic Leukemia: Impact of Comorbidity Burden on Treatment Patterns and Outcomes in Elderly Patients  [PDF]
Sacha Satram-Hoang, Carolina Reyes, Khang Q. Hoang, Faiyaz Momin, Sandra Skettino
Journal of Cancer Therapy (JCT) , 2013, DOI: 10.4236/jct.2013.48156

Introduction: Chronic lymphocytic leukemia (CLL) is a disease of the elderly. Elderly patients often have increased comorbidity burden and loss of organ reserve that may impact their ability to tolerate cancer therapy. We described realworld characteristics of typical CLL patients and identified factors predictive of receiving treatment. Methods: A retrospective cohort analysis of 8343 first primary CLL patients was performed using the linked Surveillance, Epidemiology, and End Results-Medicare database. Patients were diagnosed from 1/1/1998 to 12/31/2007, >66 years, and continuously enrolled in Medicare Parts A and B in the year prior to diagnosis. Comorbidity was examined using the National Cancer Institute comorbidity index and the Cumulative Illness Rating Scale. Cox and Logistic regression modeling assessed patient characteristics predictive of receiving treatment within the first year after diagnosis. Results: Median follow-up time from diagnosis was 782 days. During the study time period, there were 3366 (40%) treated patients and 4977 (60%) untreated. Even among those diagnosed with advanced stage (n = 4213), 57% were not treated. Treated patients were younger at diagnosis compared to untreated (76 vs. 79; p < 0.0001). In general, as age increased, the incidence and severity of comorbidities increased. In multivariate regression analyses, the treatment rate was significantly lower among patients >80 years, females, and with early stage disease; and significantly decreased with increasing comorbidity burden. Conclusions: Age, gender, comorbidity and stage were predictive of receiving treatment. Among patients with advanced stage, 57% were not being treated possibly due to older age and/or higher comorbidity burden.

Increased Mortality Risk among Early Stage Hormone Receptor Positive Breast Cancer Patients Who Did Not Receive Adjuvant or Neoadjuvant Therapy  [PDF]
Sacha Satram-Hoang, Alisha Stein, Patricia Cortazar, Faiyaz Momin, Carolina Reyes
Journal of Cancer Therapy (JCT) , 2019, DOI: 10.4236/jct.2019.101001
Abstract: Background: Hormone receptor positive (HR+), human epidermal growth factor receptor 2 negative (HER2-) is the most common biologic subtype of breast cancer. Although adjuvant therapy has demonstrated a survival benefit in clinical trials, its use is poorly understood in the real-world among elderly breast cancer patients since age is a barrier to receiving adjuvant therapy. An examination of treatment patterns and outcomes associated with receipt of adjuvant/neoadjuvant therapy among elderly HR + HER2-breast cancer patients was undertaken. Methods: There were 18,470 HR + HER2-breast cancer patients from the linked SEER-Medicare database. Patients were diagnosed with stage I-III disease between 1/1/2007-12/31/2011, ≥66 years, enrolled in Medicare Parts A, B and D, and underwent breast cancer surgery after diagnosis. Time-varying Cox proportional hazards regression assessed overall survival. Results: There were 13,670 (74%) patients treated with adjuvant/neoadjuvant therapy and 4800 (26%) untreated. Compared to treated patients, untreated patients were older, had earlier stage, lower grade, smaller tumors, poorer performance, higher comorbidity score, and less use of a 21-gene recurrence score (RS) assay (p < 0.0001). In the survival model, increasing age, stage, tumor size, tumor grade, comorbidity score and poor performance were significantly associated with higher mortality risks, while use of a
Treatment Patterns and Mortality Risk among Elderly Patients with Metastatic Triple Negative Breast Cancer in the United States: An Observational Cohort Study Using SEER-Medicare Data  [PDF]
Sacha Satram-Hoang, Preeti Bajaj, Alisha Stein, Patricia Cortazar, Faiyaz Momin, Carolina Reyes
Journal of Cancer Therapy (JCT) , 2019, DOI: 10.4236/jct.2019.102009
Abstract: Purpose: Triple negative breast cancer is more aggressive than other breast cancer subtypes and accounts for up to 20% of all breast cancers. Despite the poorer prognosis, there are no approved targeted treatments available and chemotherapy remains the only choice. We examined treatment patterns and outcomes among elderly metastatic triple-negative breast cancer (mTNBC) patients in routine clinical practice. Methods: Patients were identified from the linked SEER-Medicare database between 1/1/2001 and 12/31/2013 and included de novo Stage IV (n = 776) and patients with distant metastasis followed an initial diagnosis of Stage I - III disease (n = 1851). Kaplan-Meier analyses and time-varying Cox proportional hazards regression were used to assess overall survival (OS). Results: The mean age at metastatic diagnosis was 77.6 years and 1259 (48%) patients received chemotherapy. Compared to <70 year olds, ≥70 year olds had worse
Risk of second primary cancer in men with breast cancer
Sacha Satram-Hoang, Argyrios Ziogas, Hoda Anton-Culver
Breast Cancer Research , 2007, DOI: 10.1186/bcr1643
Abstract: Data obtained from the California Cancer Registry in the period 1988 to 2003 included 1,926 men aged 85 years and younger diagnosed with a first primary breast cancer. Person-year analysis was applied to determine the risk of second primary cancers after the occurrence of a first primary breast cancer. The effects of age, race, and time since the first breast cancer diagnosis were assessed.Of the 1,926 male breast cancer cases, 221 (11.5%) developed a second primary cancer. Men with first incidence of breast cancer have a significantly higher risk of second cancer (standardized incidence ratio (SIR) = 1.16, 95% confidence interval (CI) = 1.01–1.32). The risk of a second site-specific cancer is elevated for breast cancer (SIR = 52.12, 95% CI = 31.83–80.49), cutaneous melanoma (SIR = 2.98, 95% CI = 1.63–5.00) and stomach cancer (SIR = 2.11, 95% CI = 1.01–3.88). There is a general tendency towards higher risks of second malignancies among younger men compared to older men and the risk increased with the passage of time.Male breast cancer patients should be monitored carefully for the occurrence of second primary cancers, especially a second primary breast cancer.Studying the occurrence of second primary cancers holds important implications for cancer etiology and preventive interventions. An association between a first and second cancer could indicate common host factors (genetic abnormalities, immune function and hormonal imbalances), shared environmental and/or occupational exposures, shared lifestyle factors, the effects of treatment for the first cancer [1,2], hereditary cancer syndromes [3], or even gene-environment interactions. Early age of onset of cancer, family history of disease, bilateral disease, and multiple primary cancers are hallmarks of hereditary cancer [3]. In some cases, the diagnosis of a rare cancer or cancer in the less usually affected sex, for example, male breast cancer (MBC), may also indicate hereditary cancer risk [3]. An awareness of mult
Prevalence of Fracture Risk Factors in Postmenopausal Women Enrolled in the POSSIBLE US Treatment Cohort
Nicole Yurgin,Sally Wade,Sacha Satram-Hoang,David Macarios
International Journal of Endocrinology , 2013, DOI: 10.1155/2013/715025
Comparative Effectiveness of Adjuvant Chemotherapy in Elderly Colon Cancer Patients
Sacha Satram-Hoang,Luen Lee,Shui Yu,Faiyaz Momin
Cancer and Clinical Oncology , 2012, DOI: 10.5539/cco.v2n1p115
Abstract: Introduction: We assessed whether older patients experience the same treatment benefits from adjuvant chemotherapy in a real-world setting as younger patients in clinical trials. Methods: This retrospective cohort analysis used the linked Surveillance, Epidemiology, and End Results (SEER)-Medicare database. The analysis included 3,390 patients, >65 years, diagnosed with stage II or III colon cancer between January 1, 2004, and December 31, 2007. Patients were enrolled in Medicare Parts A and B, and had undergone adjuvant treatment with fluorouracil plus leucovorin (5-FU/LV; n=1,368), 5-FU/LV plus oxaliplatin (FOLFOX; n=1,398), capecitabine (CAP; n=507), or CAP plus oxaliplatin (CAPOX; n=117) within 3 months of surgery. Differences in patient demographics and disease characteristics by treatment were assessed by chi-square test and ANOVA or t-test. Cox proportional hazards regression and propensity score-weighted analyses were used to measure the relative risk of death associated with each treatment. Results: Median time from surgical resection to initiation of treatment was similar across cohorts (44-48 days). Mean treatment duration was longer for 5-FU/LV (149 days) and FOLFOX (144 days) than CAP (121 days) and CAPOX (111 days); p<.0001. In the propensity score-adjusted survival models, patients treated with FOLFOX (HR=0.70; 95%CI=0.55-0.90) and CAPOX (HR=0.44; 95%CI=0.20-0.98) had a significantly lower risk of death than 5FU/LV, while risk of death was similar between CAP and 5-FU/LV. Conclusions: Elderly patients with colon cancer have similar benefits from adjuvant chemotherapies in real-world settings as demonstrated in younger patients in clinical trial settings.
Research on Applying Nano Cutting Oils in Spur Gear Hobbing Process  [PDF]
Tuan Ngo, Vi Hoang, Sinh Hoang
World Journal of Engineering and Technology (WJET) , 2017, DOI: 10.4236/wjet.2017.52023
Abstract: Nanolubricant mixing the normal lubricant with nanoparticles, gradually becomes a new trend study for metal cutting enhancement. An addition of the nanoparticles improves lubricating properties and convective heat transfer coefficient (cooling properties) of nanolubricants. In the present work, nanolubricant is formulated by using dispersions of 0.3% Al2O3 nanoparticles in normal industrial oil VG46 for enhancement of gear machining performance of SCM420 steel. Comparative study of flank wear, crater wear and gear profile error in gear hobbing with normal oils in the existing production line as well as nanolubricant is studied. This study clearly reveals that tool wear, and gear profile error are reduced by the use of nanolubricant compared to that of normal oils. The paper results not only contribute the deeper understanding of the novel performance of nanoparticles in conventional cutting fluids, but also show a very promising solution to achieve the engineering economy effectiveness in gear machining.
The struggle to detect circulating DNA
Sacha Zeerleder
Critical Care , 2006, DOI: 10.1186/cc4932
Abstract: In the previous issue of Critical Care, Rhodes and colleagues [1] report on significantly increased levels of circulating DNA in patients admitted to the intensive care unit (ICU) in comparison with healthy controls. They show plasma DNA levels to be an independent predictor of mortality and the development of sepsis in these patients. In sepsis and trauma, circulating nucleosomal DNA is positively correlated with disease severity and adverse outcome [2,3]. In cancer, changes in circulating DNA levels have a prognostic value [4]. Interestingly, in systemic lupus erythematosus, an autoimmune disease in which nucleosomal DNA functions as autoantigenic target, no correlation of circulating nucleosomal DNA with disease severity can be found; instead there is a correlation with anti-nucleosomal DNA antibodies [5]. It is very likely that these antibodies take care of enhanced clearance of nucleosomes.DNA in plasma most probably circulates bound to proteins in the form of mononucleosomes and/or oligonucleosomes and is released after the cleavage of easily accessible linkage sites of cellular DNA by endonucleases after cell death [6]. A mononucleosome consists of a core particle composed of an octamer of two copies each of histones H2A, H2B, H3 and H4, around which a stretch of helical DNA 146 base pairs in length is wrapped. Oligonucleosomes are composed of variable amounts of mononucleosomes connected by intact linker DNA with a variable length of 15 to 100 base pairs containing a 'linker' histone H1. Once released into the circulation, nucleosomes seem to be protected by their structure from further degradation by endonucleases [7].In healthy individuals, the concentration of circulating DNA is low, because dead cells are removed efficiently from circulation by phagocytes. Circulating DNA has a short half-life (10 to 15 minutes) and is removed mainly by the liver [8,9]. Accumulation of DNA in the circulation can result from an excessive release of DNA caused by massive c
Flavoured Leptogenesis
Davidson, Sacha
High Energy Physics - Phenomenology , 2007,
Abstract: Thermal leptogenesis, in the seesaw model, is a popular mechanism for generating the Baryon Asymmetry of the Universe. It was noticed recently, that including lepton flavour can modify significantly the results. These proceedings aim to discuss why and when flavour matters, in the thermal leptogenesis scenario for hierarchical right-handed neutrinos. No Boltzmann Equations are introduced.
About a Definition of Nano: How to Articulate Nano and Technology?
Sacha Loeve
Hyle : International Journal for Philosophy of Chemistry , 2010,
Abstract: It is often assumed that 'nano' is merely a communication and marketing token. Our inquiry in a number of French laboratories in the field of artificial molecular machines resulted in a quite different picture: a number of researchers are concerned with the definition of nanotechnology. This paper starts from the attempts made by one of the leading figure in the field of molecular machines, Christian Joachim, to draw a clear demarcation between what is 'really nano' and what is not. Probing the epistemological basis of his strategy, we also underline its limits. As this definition is only focused on the prefix 'nano', it would benefit from being completed and enlarged by a definition of 'technology'. We argue that molecular machines belong to the realm of technology in Gilbert Simondon's meaning of this term: a genesis of individualized objects coordinating natural processes and human projects. Finally, this emphasis on the technological dimension of nanotechnology leads to ethical reflections based on the practices of nanotechnology rather than on their potential applications.
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