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Search Results: 1 - 10 of 139467 matches for " Sabita K Murthy "
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Analphoid supernumerary marker chromosome characterized by aCGH and FISH as inv dup(3)(q25.33qter) de novo in a child with dysmorphic features and streaky pigmentation: case report
Sabita K Murthy, Ashok K Malhotra, Preenu S Jacob, Sehba Naveed, Eman EM Al-Rowaished, Sara Mani, Shabeer Padariyakam, R Pramathan, Ravi Nath, Mahmoud Al-Ali, Lihadh Al-Gazali
Molecular Cytogenetics , 2008, DOI: 10.1186/1755-8166-1-19
Abstract: We describe here a one month old female child with several dysmorphic features and with a de novo analphoid supernumerary marker chromosome only in cultured skin fibroblast cells and not in lymphocytes. The marker was characterized as analphoid inversion-duplication 3q25.33-qter by oligo array comparative genomic hybridization (aCGH) and fluorescence in situ hybridization (FISH) studies. The final skin fibroblast karyotype was interpreted as 47,XX,+der(3).ish inv dup(3)(qter-q25.33::q25.33-qter)(subtel 3q+,subtel 3q+) de novo.In addition to the eight reported cases of analphoid inversion-duplication 3q supernumerary marker in the literature, this is yet another case of 3q sSMC with a new breakpoint at 3q25.33 and with varying phenotype as described in the case report. Identification of more and more similar cases of analphoid inversion-duplication 3q marker will help in establishing a better genotype-phenotype correlation. The study further demonstrates that aCGH in conjunction with routine cytogenetics and FISH is very useful in precisely identifying and characterizing a marker chromosome, and more importantly help in providing with an accurate genetic diagnosis and better counseling to the family.Small supernumerary marker chromosomes occur in 0.075% of unselected prenatal cases and in 0.044% of consecutively studied postnatal cases, and majority of them are de novo in origin [1-4]. Phenotype of individuals with de novo sSMC vary from normal to extremely mild or severe, depending on the chromosomal region involved and the euchromatic content present [5-7]. Although a number of reports describe the occurrence of a variety of sSMC for nearly all the chromosomes, the number for each type is not large enough to suggest a good genotype-phenotype correlation for a given sSMC, except for inv dup(15) and inv dup(22) where the phenotypic consequences are well described [6,8-10]. We describe here the phenotype and corresponding molecular cytogenetic results of a child with
Cardiac Sarcolemmal Defects in Acute Myocarditis Due to Scorpion Envenoming Syndrome  [PDF]
K. Radha Krishna Murthy
World Journal of Cardiovascular Diseases (WJCD) , 2014, DOI: 10.4236/wjcd.2014.49054

Death due to scorpion envenoming syndrome is a common event in tropical and subtropical countries. Severe scorpion envenoming causes autonomic storm, massive release of catecholamines, counter-regulatory hormones, suppressed insulin/hyperinsulinemia, acute myocarditis, hyperglycemia, increased free fatty Acid levels, acute pancreatitis, disseminated intra-vascular coagulation, acute pulmonary oedema and death. Severe scorpion envenoming causes cardiac sarcolemmal defects displayed by alterations in Na+ - K+ ATPase, Mg++ ATPase and Ca2+ ATPase activities, inhibition of erythrocyte Na+ - K+ ATPase activities, hyperkalemia and may result in death. Based on our animal experiments in which insulin administration reversed the metabolic and ECG changes induced by scorpion envenoming and treating the poisonous scorpion sting victims with insulin, we consider that insulin has a primary metabolic role in preventing and reversing acute myocarditis, the cardiovascular, haemodynamic, and neurological manifestations and pulmonary oedema induced by scorpion envenoming. Administration of insulin-glucose infusion to scorpion sting victims appears to be the physiological basis for the control of the metabolic response when that has become a determinant to survival. Continuous infusion of regular crystalline insulin should be given at the rate of 0.3 U/g glucose and glucose at the rate of 0.1 g/kg body weight/hour, for 48 - 72 hours, with supplementation of potassium as needed and maintenance of fluid, electrolytes and acid-base balance. The observation of cardiac sarcolemmal defects and physiological basis of various patho-physiological mechanisms involved in the genesis of scorpion envenoming syndrome and its reversal (in the experimental animals and scorpion sting victims) by administration of insulin are reviewed.

Trabeculectomy in congenital glaucoma
Murthy K
Indian Journal of Ophthalmology , 1979,
Prevalance of the lattice degeneration and of the retinal breaks
Murthy K
Indian Journal of Ophthalmology , 1979,
Animal experimentation and research in India.
Murthy K
Journal of Postgraduate Medicine , 2000,
Co-Benefits and Risks of Implementation of Forestry Activities for Climate Change Mitigation in India  [PDF]
Indu K. Murthy, K. V. Devi Prasad
Natural Science (NS) , 2018, DOI: 10.4236/ns.2018.107028
Abstract: Implementation of forestry activities as a climate change mitigation option is likely to result in a range of outcomes in addition to carbon sequestration and these include changes with respect to environmental, social and economic aspects. These impacts to the extent when positive are deemed co-benefit and if adverse and uncertain, imply risk. It is important to recognize that implementation of forestry mitigation activities can have varied environmental, socio-economic co-benefits and/or risks. Further, there is no general agreement on attribution of co-benefits and risks to specific forestry mitigation activities. An overarching risk to mitigation potential that could be realised by implementation of forestry activities is climate change. But, overall, forestry mitigation activities also contribute to the sustainable development agenda. Maximizing co-benefits of forestry mitigation measures can increase efficiency in achieving the objectives of other international agreements.
Skin Sparing Mastectomy in Locally Advanced Breast Cancer: A Possibility?  [PDF]
Vijayashree Murthy, K. S. Gopinath, Anand Krishna
Surgical Science (SS) , 2012, DOI: 10.4236/ss.2012.34044
Abstract: Breast cancer is the second most common cause of cancer death in women in India in spite of advances in the adjuvant treatment of breast cancer. Locally advanced breast cancer (LABC) still represents the major presenting picture in many urban and rural institutions in our country. Skin Sparing Mastectomy (SSM) and primary reconstruction is a popular option for patients with breast cancer. There are similar local and distant recurrences in SSM compared to the traditional non-skin sparing mastectomy. A 57-year-old lady presented with a locally advanced left breast cancer. After undergoing neoadjuvant chemotherapy and a PET-CT to accurately detect residual disease in breast and axilla, she underwent skin sparing mastectomy with nipple-areola complex preservation and primary reconstruction with silicon prosthesis implant over a latissimus dorsi myocutaneous flap for primary reconstruction. SSM in LABC has not been reported in the literature so far. This patient is disease free for the past 24 months.
Improved Routing Protocol for Health Care Communications  [PDF]
Jayanthi K. Murthy, V. Sambasiva Rao
Open Journal of Applied Biosensor (OJAB) , 2013, DOI: 10.4236/ojab.2013.22006
Abstract: Wireless Body Area Network (WBAN) technology has significantly increased the potential of remote healthcare monitoring systems. The devices used for WBAN have limited energy resources. For most devices it is impossible to recharge or change the batteries. Since the data mostly consists of medical information, high reliability and low delay is required. The main objective of this simulation study is to evaluate the performance of routing protocol on static IEEE 802.15.4 to determine the most suitable routing protocol for Wireless Body Area Networks. Here, investigations on the various routing protocol suggest cluster topology and AODV as the probable candidate. About 16% improvement in the energy consumption was observed when modifications were made considering the energy and mobility, thus achieving high residual battery capacity and eliminating the need for recharging the batteries.
Characterization of Esterases of Tamarindus indica Seeds  [PDF]
S. Kantharaju, K. R. Siddalinga Murthy
Journal of Biosciences and Medicines (JBM) , 2014, DOI: 10.4236/jbm.2014.24009

Germinating seeds of Tamarindus indica synthesizes various enzymes which are required for the degradation of seed reserves such as xyloglucans, fatty acid esters and proteins. Among these, esterases, belonging to a group of hydrolytic enzymes catalyze the hydrolysis of various types of esters. They play an important role in cell expansion as well as detoxification of xenobiotics and many agrochemicals and insecticides. The esterases are extracted from the germinating tamarind seeds using 50 mM phosphate buffer, pH 7. The Km with α-naphthyl acetate as the substrate is 19.23 μM and the enzymes are optimally active at pH 7.0 to 7.5 and are stable between pH 5.0 to 9.0. The optimum temperature of esterase activity of tamarind seed is between 37?C - 50?C and is stable up to 40?C. The activity declined by 30% at 60?C and about 90% at 70?C. Highest esterase activity and specific activity are observed on the 21st day of germination. The polyacrylamide gel electrophoresis (PAGE) indicated the presence of nine isozymes of esterases. Band numbers 1, 5 and 6 are the major esterolytic bands present throughout the germination period while band numbers 2 & 3 are minor bands present only during the latter period of the germination. Based on substrate and inhibitor specificity in conjunction with electrophoresis, the esterases 1 to 8 have been classified as carboxylesterases sensitive to organophosphate inhibitor (OP) and PCMB (p-chloromercuribenzoate) while esterase 9 is classified as carboxylesterase sensitive to OP. These esterases are unaffected by carbamate inhibitor, eserine sulphate.

Studies on Xyloglucanase during the Germination of Seeds of Tamarindus indica  [PDF]
K. R. Siddalinga Murthy, S. Kantharaju
Journal of Biosciences and Medicines (JBM) , 2014, DOI: 10.4236/jbm.2014.24007

Germinating seeds of Tamarindus indica contain endo-β-1, 4-xyloglucanases which degrade tamarind xyloglucan, but not carboxymethylcellulose (CMC). The xyloglucanases are isolated from the germinating tamarind seeds using 50 mM acetate buffer, pH 5.5 containing 0.5 M NaCl. The Km value is 0.667 g/liter and the enzyme is optimally active at pH 5.5 and stable between pH 4 - 6.5. The optimum temperature is 45?C and is quite stable upto 50?C. The activity declined by 50% at 60?C and is completely inactivated at 70?C. Highest xyloglucanase activity and specific activity are observed on the 23rd day of germination. The polyacrylamide gel electrophoresis (PAGE) indicated the presence of five isozymes of xyloglucanases which are visualized by activity staining separately with congo red and grams iodine. Isozyme 2 is the major xyloglucanase present throughout the germination period.

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