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Impairment and Differential Expression of PR3 and MPO on Peripheral Myelomonocytic Cells with Endothelial Properties in Granulomatosis with Polyangiitis
Susann Patschan,Daniel Patschan,Elvira Henze,Sabine Blaschke,Johannes T. Wessels,Gerhard Anton Müller
International Journal of Nephrology , 2012, DOI: 10.1155/2012/715049
Abstract: Background. Granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA) are autoimmune-mediated diseases characterized by vasculitic inflammation of respiratory tract and kidneys. Clinical observations indicated a strong association between disease activity and serum levels of certain types of autoantibodies (antineutrophil cytoplasm antibodies with cytoplasmic [cANCA in GPA] or perinuclear [pAN CA in MPA] immunofluorescence). Pathologically, both diseases are characterized by severe microvascular endothelial cell damage. Early endothelial outgrowth cells (eEOCs) have been shown to be critically involved in neovascularization under both physiological and pathological condition. Objectives. The principal aims of our study were (i) to analyze the regenerative activity of the eEOC system and (ii) to determine mPR3 and MPO expression in myelo monocytic cells with endothelial characteristics in GPA and MPA patients. Methods. In 27 GPA and 10 MPA patients, regenerative activity blood-derived eEOCs were analyzed using a culture-forming assay. Flk-1+, CD133+/Flk-1+, mPR3+, and Flk-1+/mPR3+ myelomonocytic cells were quantified by FACS analysis. Serum levels of Angiopoietin-1 and TNF- were measured by ELISA. Results. We found reduced eEOC regeneration, accompanied by lower serum levels of Angiopoietin-1 in GPA patients as compared to healthy controls. In addition, the total numbers of Flk-1+ myelomonocytic cells in the peripheral circulation were decreased. Membrane PR3 expression was significantly higher in total as well as in Flk-1+ myelomonocytic cells. Expression of MPO was not different between the groups. Conclusions. These data suggest impairment of the eEOC system and a possible role for PR3 in this process in patients suffering from GPA. 1. Introduction Granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA) are autoimmune diseases characterized by systemic necrotizing vasculitis mainly affecting the respiratory tract and the kidneys [1]. Histopathological analysis reveals severe structural alterations of microvascular endothelial cells, leading to impaired microcirculation in skin, joints, respiratory tract, and kidneys, respectively. Endothelial damage has been suggested to result from interactions between primed neutrophils and ANCA with the endothelium followed by endothelial detachment from the basement membrane [2]. A number of different studies showed increased levels of both, circulating mature endothelial cells and endothelial microparticles in GPA and MPA [3, 4]. Thus, patients with GPA and MPA suffer from
Abschied von der S kularisierungslegende. Daten zur Karrierekurve der Religion (1800-1970) im zweiten konfessionellen Zeitalter: eine Parabel
Blaschke, Olaf
Zeitenblicke , 2006,
Effective Field Theories for Hot and Dense Matter
Blaschke D.
EPJ Web of Conferences , 2010, DOI: 10.1051/epjconf/20100701003
Abstract: The lecture is divided in two parts. The rst one deals with an introduction to the physics of hot, dense many-particle systems in quantum eld theory [1, 2]. The basics of the path integral approach to the partition function are explained for the example of chiral quark models. The QCD phase diagram is discussed in the mean eld approximation while QCD bound states in the medium are treated in the rainbow-ladder approximation (Gaussian uctuations). Special emphasis is devoted to the discussion of the Mott e ect, i.e. the transition of bound states to unbound, but resonant scattering states in the continnum under the in uence of compression and heating of the system. Three examples are given: (1) the QCD model phase diagram with chiral symmetry ¨ restoration and color superconductivity [3], (2) the Schrodinger equation for heavy-quarkonia [4], and (2) Pions [5] as well as Kaons and D-mesons in the nite-temperature Bethe-Salpeter equation [6]. We discuss recent applications of this quantum eld theoretical approach to hot and dense quark matter for a description of anomalous J/ψ supression in heavy-ion collisions [7] and for the structure and cooling of compact stars with quark matter interiors [8]. The second part provides a detailed introduction to the Polyakov-loop Nambu–Jona-Lasinio model [9] for thermodynamics and mesonic correlations [10] in the phase diagram of quark matter. Important relationships of low-energy QCD like the Gell-Mann–Oakes–Renner relation are generalized to nite temperatures. The e ect of including the coupling to the Polyakov-loop potential on the phase diagram and mesonic correlations is discussed. An outlook is given to e ects of nonlocality of the interactions [11] and of mesonic correlations in the medium [12] which go beyond the mean eld description.
Jeff Wall : Near Documentary . Proche de l’image documentaire
Estelle Blaschke
Conserveries Mémorielles : Revue Transdisciplinaire de Jeunes Chercheurs , 2009,
Abstract: L’artiste photographe canadien Jeff Wall est avant tout connu pour son interrogation riche et complexe sur les traditions pictorales et les régimes visuels de la peinture et du film. Ce questionnement se fait avec les moyens de la mise en scène photographique. Cet article se concentre cependant sur un aspect curieusement négligé dans la réception de l’ uvre de l’artiste : les références au médium de la photographie et à son langage visuel, résumé dans l’expression Near Documentary (proche de l’image documentaire). Ce concept de rapprochement et les problèmes qui en résultent sont analysés et discutés à l’aide de deux exemples, deux photographies : Man with a Rifle (2000) et Forest (2001).
Cluster virial expansion for quark and nuclear matter
David Blaschke
Physics , 2015,
Abstract: We employ the $\Phi-$ derivable approach to many particle systems with strong correlations that can lead to the formation of bound states (clusters) of different size. We define a generic form of $\Phi-$ functionals that is fully equivalent to a selfconsistent cluster virial expansion up to the second virial coefficient for interactions among the clusters. As examples we consider nuclei in nuclear matter and hadrons in quark matter, with particular attention to the case of the deuterons in nuclear matter and mesons in quark matter. We derive a generalized Beth-Uhlenbeck equation of state, where the quasiparticle virial expansion is extended to include arbitrary clusters. The approach is applicable to nonrelativistic potential models of nuclear matter as well as to relativistic field theoretic models of quark matter. It is particularly suited for a description of cluster formation and dissociation in hot, dense matter.
Colored condensates deep inside neutron stars
David Blaschke
Physics , 2014, DOI: 10.1051/epjconf/2014787003
Abstract: It is demonstrated how in the absence of solutions for QCD under conditions deep inside compact stars an equation of state can be obtained within a model that is built on the basic symmetries of the QCD Lagrangian, in particular chiral symmetry and color symmetry. While in the vacuum the chiral symmetry is spontaneously broken, it gets restored at high densities. Color symmetry, however, gets broken simultaneously by the formation of colorful diquark condensates. It is shown that a strong diquark condensate in cold dense quark matter is essential for supporting the possibility that such states could exist in the recently observed pulsars with masses of 2 $M_\odot$.
Cooling of Color Superconducting Compact Stars
David Blaschke
Physics , 2006,
Abstract: We review the status of research on the cooling of compact stars, with emphasis on the influence of color superconducting quark matter phases. Although a consistent microscopic approach is not yet available, severe constraints on the phase structure of matter at high densities come from recent mass and cooling observations of compact stars.
Preparation of coal slurries deposited in ground settling ponds
Wies?aw Blaschke,Zofia Blaschke
Acta Montanistica Slovaca , 2005,
Abstract: As a result of the hard coal washing process, considerable quantities of coal slimes are generated. They belong to grain size classes below 1, 0 mm (with the majority of grains below 0,035 mm) and are often sold in order to prepare blends for the power generation. It is assessed that in Poland about 11 mln tons of such slimes were deposited. The slimes of a low ash content can be exploited and sold. The slime of high ash content must be washed. In Poland there is one coal preparation plant for slurries. The article describes the technology and presents the results of a simplified economic analysis of exploitation of the slurries and their washing.
A Cognitive Radio Receiver Supporting Wide-Band Sensing  [PDF]
Volker BLASCHKE, Tobias RENK, Friedrich K. JONDRAL
Wireless Sensor Network (WSN) , 2009, DOI: 10.4236/wsn.2009.13018
Abstract: The specification of IEEE 802.22 defines the world-wide first cognitive radio (CR) standard. Within a range of 40 MHz to 910 MHz CR systems are allowed to allocate spectrum besides the currently established radio services like radio and TV broadcasting. In order to fulfill the regulative guidelines of interference limita-tions, a capable spectral sensing and user detection has to be provided. Due to the wide frequency range specified in IEEE 802.22 and the high dynamic range of signals allocated in this band there are high de-mands on the CR receiver’s front-end. Especially the performance requirements on analog-to-digital con-verters increase significantly compared to current wireless systems. Based on measurements taken in this frequency range requirements to CR’s ADCs are figured out. Furthermore, the measurement results are ana-lyzed regarding expectable allocation scenarios and their impacts to spectral sensing. Derived from this re-sults and a comparison of general spectral sensing mechanisms an approach for a CR receiver supporting wide-band sensing is presented. Considering the apriori information resulting from scenario analysis and including adapted information processing in the terminal the ADC’s performance requirements can be re-duced.
Can Bibliographic Pointers for Known Biological Data Be Found Automatically? Protein Interactions as a Case Study
Christian Blaschke,Alfonso Valencia
Comparative and Functional Genomics , 2001, DOI: 10.1002/cfg.91
Abstract: The Dictionary of Interacting Proteins (DIP) (Xenarios et al., 2000) is a large repository of protein interactions: its March 2000 release included 2379 protein pairs whose interactions have been detected by experimental methods. Even if many of these correspond to poorly characterized proteins, the result of massive yeast two-hybrid screenings, as many as 851 correspond to interactions detected using direct biochemical methods.
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