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Search Results: 1 - 10 of 461645 matches for " Saber A. Sakr "
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Microbiological Study on a Cyanobacterium Isolated from Fresh Water Fish Ponds with a Reference to its Hepatotoxic Effect
Mohamed T. Shaaban,Saber A. Sakr
Pakistan Journal of Biological Sciences , 2001,
Abstract: The present work deals with identification of a cyanobacterium found to be predominant causing blooms on the water surface in fresh water, fish ponds. The cyanobacterium blooms were found to be specially flourishing in parallel with low fish productivity. Microcystis aeruginosa was suspected to some biological studies including, the antibacterial effects of its cell free extract against Gram +ve and Gram -ve bacteria and hepatotoxic effect of the cell free extract on the liver of albino rats. Treatment with a single intraperitoneal dose (LC50) of the extract caused elevation of alkaline phosphatase and transaminase (GOT & GPT) in the animal sera. Histological examination of the liver of treated animals revealed congestion of blood vessels and abundance of leucocytic infiltration, a matter which may be due to one or more of microcystins present in this cyanobacterium.
Exploring Hepatotoxicity of Benomyl: Histological and Histochemical Study on Albino Rats
Saber A. Sakr,Hany A. Abdel Samei,Maha E. Soliman
Journal of Medical Sciences , 2004,
Abstract: Benomyl, a fungicide of the benzimidazole group applied against a wide range of fungal diseases of crops and vegetables. The effects of benomyl on the hepatic tissue of albino rats were investigated. Treating rats with benomyl at a dose level of 1/10 LD50 three times/week for three weeks induced various histopathological changes in the liver, such as hepatic tissue impairment, cytoplasmic vacuolization of the hepatocytes, leucocytic infiltrations, congestion of blood vessels and fatty degeneration. Histochemical investigations revealed reduction in total carbohydrates, total proteins and nucleic acids (DNA, RNA) in the hepatic cells. These alterations were time-dependent and were obvious in animals treated with benomyl for 3 weeks. It is speculated that one or more metabolites of benomyl may be responsible for the hepatotoxicity recorded in the present work.
Non-Enzymatic Graphene-Based Biosensors for Continuous Glucose Monitoring
Mohamed Serry,M. A. Sakr
Physics , 2015,
Abstract: A novel mediator-free, non-enzymatic electrochemical sensor, based on a graphene-Schottky junction, was fabricated for glucose detection. The sensor offers a promising alternative to the conventional enzyme-catalyzed electrochemical continuous glucose monitoring systems (CGM), as it overcomes many of the drawbacks attributed to the enzymatic nature; namely, irreversibility, drift, and interference with body fluids, which affect their accuracy, reliability and longevity. Enhanced performance of the sensors is demonstrated through the band interaction at the graphene-Schottky junction, which yields stronger forward/reverse currents in response to 50 {\mu}L glucose drop. Under optimized conditions, the linear response of the sensor to glucose concentration was valid in the range from 0 to 15 mmol/L with a detection limit of 0.5 mmol/L. The results indicated that the proposed sensor provided a highly sensitive, more facile method with good reproducibility for continuous glucose detection.
Potentiometric, spectrophotometric, conductimetric and thermodynamic studies on some transition metal complexes derived from 3-methyl-1-phenyl- and 1, 3-diphenyl-4-arylazo-5-pyrazolones  [PDF]
Samir A. AbdelLatif, Saber E. Mansour, Abdulrahman A. Fatouh
Natural Science (NS) , 2010, DOI: 10.4236/ns.2010.28100
Abstract: A new 3methyl1phenyl4arylazo5pyrazolone and 1, 3diphenyl4arylazo5pyrazolone have been synthesized and characterized by elemental analysis, IR, mass and 1H NMR spectra. The acid dissociation constants (pKa values) of the investigated ligands were determined potentiometrically and spectrophotometrically. The stability constants of the transition metal ions (VO2+, Cr3+, Mn2+, Co2+, Ni2+, Cu2+ and Zn2+) with the investigated ligands were determined potentiometrically at different ionic strengths (0.167, 0.1, 0.05 and 0.025 M) NaCl at 25oC and different temperature (25, 30, 35, and 45oC). The values of stability constants were found to decrease with increasing ionic strengths and temperature. The stoichiometries were studied using spectrophotometric and conductimetric methods, the results indicate the existence of 1:1 and 1:2 (M:L) metal:ligand species. The relationships between the stability constants of the complexes, ionization constants of the ligands have been discussed and correlated. The thermodynamic parameters (?G, ?H and ?S) and the thermodynamic stability constants for all of the investigated complexes were determined potentiometrically.
Sumithion Induced Hepatic Injury in the Toads Bufo tibamicus
S. A. Sakr,A.M. Hijji
Pakistan Journal of Biological Sciences , 2000,
Abstract: The present work studied the effect of the organophosphate insecticide, sumithion on the liver of toads Bufo tibamicus. Feeding toads with a daily dose of sumithion ( 40 mg / kg body weight ) for 10 days caused histological alterations in the liver . The normal structural organization of the hepatic acini was impaired , the hepatocytes showed cytoplasmic vacuolation and the blood vessels were congested . Moreover, elevations of transaminases ( GOT , GPT ) were recorded in the sera of treated animals . The obtained results collectively indicated that sumithion treatment induced liver injury in the toads .
Histopathological Alterations in the Liver and Kidney of Toads (Bufo regularis) Intoxicated with a Pyrethroid Insecticide
S. A. Sakr,S. M. Hanafy
Journal of Biological Sciences , 2002,
Abstract: The effect of the pyrethroid insecticide, fenvalerate, on the liver and kidney of toad (Bufo regularis) was studied. Feeding toads with a daily dose of fenvalerate (0.5 mg/kg body weight) for three weeks caused histopathological alterations in these organs. The normal structural organization of the hepatic acini was impaired, the hepatocytes showed cytoplasmic vacuolation, the blood vessels were congested and there was remarkable abundance of leucocytic infiltrations. In the kidney, the renal tubules were degenerated and the glomeruli were atrophied. Moreover, the transaminases enzymes GOT (glutamate-oxaloacetate transaminase) and GPT (glutamate-pyruvate transaminase) were elevated in the sera of treated animals. The magnitude of the changes was time-dependent being more prominent after the third week of treatment with fenvalerate.
Patient Safety in Delayed Diagnosis of Acute Appendicitis  [PDF]
Aly Saber, Mohammad A. Gad, Goda M. Ellabban
Surgical Science (SS) , 2011, DOI: 10.4236/ss.2011.26067
Abstract: Introduction: Acute appendicitis is the major surgical abdominal disease in emergency departments and is also among the five leading causes of litigation against emergency physicians. Delayed diagnosis of appendicitis is more likely to occur in patients, who present atypically, and those lack a thorough physical examination, or those received intramuscular narcotic analgesia. The aim of this study was to study the effect of delay in diagnosis of acute appendicitis as regard postoperative findings, length of hospital stay and post-operative complications. Patients & Methods: Patients with complicated appendicitis were subjected to the present study and treated by a single surgical team. The parameters of our study were incidence of perforation or gangrene at surgery, length of stay and post-operative complications. Results: The present study showed that delay in diagnosis of acute appendicitis is associated with a more advanced stage of disease and a higher morbidity. Conclusion: careful attention to the patient’s history; a thorough physical examination and early clinical review help to minimize the possibility of delayed diagnosis of appendicitis. Appendicitis with a delay in treatment usually leads to high perforation rates, and unfavorable outcome.
Anti-inflammatory Steroid (Prednisolone) and its Effect on the Adrenal Gland
A.E. Essay,S.A. Sakr,S.A. Sakr,A.T. Saleh
Pakistan Journal of Biological Sciences , 2000,
Abstract: Administration of an anti-inflammatory steroidal drug prednisolone- (0.85 mg/ kg body weight daily for 10 days) to adult toads Bufo tibamicus resulted in suppression of the function of the adrenal gland, as shown by a significant increase in the lipid droplets, autolysis of mitochondria and disorganization and degranulation of ER in the steriodogenic cells. Furthermore, chromaffin cells (catecholamines secreting cells), showed a marked decrease in the number of chronaffin granules and degenerative changes in the nuclei. These serious side effects should be taken into consideration when using this drug.
Hepatic Triacylglycerols and Serum Non-Esterified Fatty Acids, Vit. E and Selenium Levels in Cross Breed Cow in Tabirz City of Azarbaijan Province of Iran : An Abattoir Study
A.P. Rezaei Saber
Journal of Animal and Veterinary Advances , 2012, DOI: 10.3923/javaa.2011.1063.1068
Abstract: The aim of the present study was to compare the hepatic Triacyiglycerols (TAG) and serum Non-esterified Fatty Acids (NEFA) and serum vit. E and selenium in cows in different stages of productivity slaughtered at Tabriz abattoir. So, a total of 204 blood and liver samples were collected from the indigenous hybrid cows immediately after being slaughtered at the abattoir. The cows were divided into 4 groups according to their pregnancy statuses: 1-8 months pregnant, 8-9 months pregnant, less and more than 1 month of partunition. Percentage of TAG were measured in the liver and NEFA, vit. E and selenium were measured in the blood circulation. All the liver samples, in this study, show some degrees of fatty infiltration. The accumulation of that in the liver rose significantly (p<0.001) during the 1st month after parturition and returned to the same level of pregnancy after 1 month. We also noticed that serum NEFA concentration was significantly higher (p<0.001) during the 1st month of parturition and serum vit. E and selenium level was significantly lower (p<0.001) in newly calved group (<1 month after parturition). These results reveal that fatty liver is quite common in all the animals in the region especially in their early lactation. These findings indicate the necessity of reconsideration in the animal s food policies in the area and some especial approaches during the early phase of lactation.
Renal Lesions Induced by Pyrethroid Inhalation in Albino Rats
S. A. Sakr,H. A. Mahran,Y. A. Okdah
Journal of Biological Sciences , 2001,
Abstract: The effect of pyrethroid inhalation was studied on the kidney of Albino rats. The results revealed that animals inhaled tetramethrin for 15 days showed a significant increase in serum creatinine and blood urea nitrogen. Histological examination of the kidney of treated animals indicated marked symptoms of renal tissues impairment. The renal tubules lost their characteristic appearance and their linning epithelial cells appeared with cytoplasmic vacuolation. The glomeruli were degenerated and the renal blood vessels were congested. The intertubular spaces were infiltrated by inflammatory leucocytic cells. The magnitude of these changes was time-dependent, being more prominent after 15 days of treatment.
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