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Transient Ischemic Attacks and Presence of an Acute Brain Lesion in Diffusion-Weighted MRI: Study of 50 Patients
M Sabeti,A Naser Moghadasi,M Aloosh,SM Paknejad
Tehran University Medical Journal , 2012,
Abstract: Background: Finding an acute brain lesion by diffusion-weighted (DW) MRI upon an episode of transient ischemic attack (TIA) is a predictor of imminent stroke in the near future. Therefore, exploring risk factors associated with lesions in DW-MRI of the brain is important in adopting an approach to TIA management. In the current study, we tried to determine the risk factors associated with lesions in DW-MRI of the brain in patients experiencing TIA episodes.Methods: Fifty patients with TIA were recruited consecutively in Sina Hospital, Tehran, Iran, over a 6-month period between July 2008 and January 2009. All of the patients underwent a complete neurological examination and laboratory tests. Brain DW-MRIs were performed for all the patients within 72 hours of a TIA episode.Results: DW-MRI revealed an acute lesion in 16% of the participants. There was a significant correlation between presence of an acute lesion in DW-MRI and TIA duration, history of diabetes mellitus and presence of unilateral facial palsy (P=0.0003, P=0.02 and P=0.008, respectively). Other variables such as age, hypertension, hyperlipidemia, past history of TIA, headache, vertigo, and sensory or visual disturbances had no significant relation with the presence of an acute lesion in DW-MRI.Conclusion: Duration of TIA, presence of diabetes mellitus and unilateral facial palsy are risk factors for an acute lesion in DW-MRI, meaning that patients with such risk factors are at risk for stroke in the near future.
Evaluation of length of the root trunk in first and second molars in population of Tehran
Paknejad M.,Amini R.
Journal of Dental Medicine , 1999,
Abstract: The root trunk (RT) of molar teeth is important diagnostic parameter that has a key roll in"ndiagnosis and treatment planning."nThe purpose of this study is presenting a normal index of RT in mandibular molar teeth in different"nbuccal (B). distal (D), Lingual (Li) and mesial (M) entrances, and to compare them with each other."nIt is a case series study that 351 extracted molar teeth, after removal of soft tissue and debridement of"ncalculus, evaluated with gauge (with accuracy 0.1 mm)"nAccording to our measurement:"nIn maxilla: M-side: 3.88± 0.15 mm, B-side: 4.7± 1.7. D- side: 4.87± 0.13mm. So with P.value <0.05 M"nand D RT are longer than and M RT is shorter than D RT."nIn mandibule: B- side: 2.73± 0.11mm and L side: 4.03±- 0.13mm. So with P.value < 0.01 Li RT is longer"nthan B RT."nAccording to ochsenbine classification our studying teeth have medium to long RT. We prescribe for"neducating the crater therapy in periodontal surgery the emphasize must be focused on craters with"nmedium and long RT."nThe shortness of RT in B-side of lower molars needed the most attention during osteoctomy in resective"nprocedures. Because RT not depended to underlying factors such as age, social and economic situation,"nand for large amount of sample size in our study, the result could be extended in Tehran.
Growth factors and new periodontology
Paknejad M,Ranjbar R
Journal of Dental Medicine , 1999,
Abstract: Growth factors are biological mediators that have a key roll in proliferation, chemotaxy and"ndifferentiation by acting on specific receptors on the surface of cells and regulating events in wound"nhealing.They can be considered hormones that are not released in to the blood stream but have one a"nlocal action. Some of these factors can regulate premature change in GO to Gl phase in cell devesion"ncycle and even may stimulate synthesis of DNA in suitable cells, Growth substances, primarily secreted"nby fibroblasts, endothelia! cells, macrophages and platelet, include platelet derived growth factor"n(PDGF), insulin like growth factor (IGF) transforming growth factor (TGF)a and (3 and bone"nmorphogenetic proteins BMPs that approximately are the most important of them. (BMP)s could be"nused to control events during periodontal, craniofacial and implant wound healing through favoring bone"nformation"nAccording toLynch, combination of PGDF and IGF1 would be effective in promoting growth of all the"ncomponents of the periodontium."nThe aim of this study was to characterize growth factor and review the literature to determine the"nmechanism of their function, classification and application in implant and periodontal treatment.
Selective Cytotoxicity and Apoptogenic Activity of Hibiscus Sabdariffa Aqueous Extract Against MCF-7 Human Breast Cancer Cell Line  [PDF]
Shahnaz Khaghani, Mohsen Mohammadian Yajloo, Malihe Paknejad, Ahmad Shariftabrizi, Parvin Pasalar, Farideh Razi
Journal of Cancer Therapy (JCT) , 2011, DOI: 10.4236/jct.2011.23054
Abstract: Background: Herbal compounds are attractive anticancer candidates due to their low toxicity. Pervious studies have demonstrated that Hibiscus sabdariffa is promising as an anticancer agent against several cancer types; however, its potential therapeutic role in breast cancer remains to be investigated. Materials and Methods: In the present study, the cytotoxic effects of Hibiscus sabdariffa aqueous extract (HSE) on a human breast adenocarcinoma cell line (MCF-7) and fetal foreskin fibroblast (HFFF) were investigated. Different concentrations of water extract of calyces were added and the percentage of cell survival was determined after 24, 48, and 72 hours using an MTT assay. Apoptosis induction was assessed by DNA fragmentation. Results: At the concentration of 0.5 mg/ml of the extract and following 72 hours of incubation, the number of viable MCF-7 cells was less than 50%. The extract was not cytotoxic against normal HFFF cells in all tested concentrations. Also, HSE induced apoptosis only in MCF-7 cells. Conclusions: These results suggest that HSE inhibits the growth of MCF-7 cells selectively in a concentration- and time-dependent manner. As this herbal substance has been shown to be nontoxic at very high doses in experimental animals, it might be a good anticancer drug candidate for breast cancer treatment.
Quality improvement in an inventory model with finite-range stochastic lead times
Javad Paknejad,Farrokh Nasri,John F. Affisco
Advances in Decision Sciences , 2005, DOI: 10.1155/jamds.2005.177
Abstract: Typically, traditional inventory models operate under the assumption of perfect quality. In this paper we modify an inventory model with finite-range stochastic lead time to allow for a random number of defective units in a lot. However, there is an extra cost for holding the defective items in the lot for the period before it is returned to the supplier. This paper also considers the option of investment to improve quality. Closed-form relationships are obtained for a quality-adjusted model as well as a quality improvement model. Numerical examples confirm that the option of investment in quality improvement results in significant cost savings. Sensitivity analysis shows that the quality improvement model is robust.
Investing in Lead-Time Variability Reduction in a Quality-Adjusted Inventory Model with Finite-Range Stochastic Lead-Time
Farrokh Nasri,Javad Paknejad,John Affisco
Advances in Decision Sciences , 2008, DOI: 10.1155/2008/795869
Abstract: We study the impact of the efforts aimed at reducing the lead-time variability in a quality-adjusted stochastic inventory model. We assume that each lot contains a random number of defective units. More specifically, a logarithmic investment function is used that allows investment to be made to reduce lead-time variability. Explicit results for the optimal values of decision variables as well as optimal value of the variance of lead-time are obtained. A series of numerical exercises is presented to demonstrate the use of the models developed in this paper. Initially the lead-time variance reduction model (LTVR) is compared to the quality-adjusted model (QA) for different values of initial lead-time over uniformly distributed lead-time intervals from one to seven weeks. In all cases where investment is warranted, investment in lead-time reduction results in reduced lot sizes, variances, and total inventory costs. Further, both the reduction in lot-size and lead-time variance increase as the lead-time interval increases. Similar results are obtained when lead-time follows a truncated normal distribution. The impact of proportion of defective items was also examined for the uniform case resulting in the finding that the total inventory related costs of investing in lead-time variance reduction decrease significantly as the proportion defective decreases. Finally, the results of sensitivity analysis relating to proportion defective, interest rate, and setup cost show the lead-time variance reduction model to be quite robust and representative of practice.
The association between methacholine challenge test and respiratory symptoms: a study on 146 patients
Paknejad O,Hojjati SA,Pazoki M
Tehran University Medical Journal , 2011,
Abstract: "nBackground: Asthma is a life-threatening disease that can cause death due to bronchospasm. In addition to clinical symptoms such as wheezing, acute paroxysmal dyspnea, chronic cough after exposure to cold air or cough after exercise, spirometry is also necessary for the diagnosis of asthma. The association between respiratory symptoms and a positive methacholine challenge test (MCT) is still controversial. The aim of this study was to determine the association between methacholine test results and respiratory symptoms and allergy."n "nMethods: One hundred and forty-six patients with respiratory symptoms and normal baseline pulmonary function tests were enrolled in this cross-sectional study. The participants were divided into two groups according to their positive or negative response to MCT. The association between MCT and the clinical symptoms and allergy was later evaluated statistically."n "nResults: Out of 146 participants of the study 59 (40.4%) were female and 87 (59.6%) were male. The mean age of the participants was 33.8±13.8 years. Sixty-one patients (41.8%) had positive results for the test. There was an association between a history of allergy, wheezing and age with positive MCT results. The other clinical signs had no association with the test."n "nConclusion: Methacholine challenge test is the best diagnostic test for ruling out asthma in patients with normal pulmonary function tests in whom we cannot definitely rule out asthma based solely on clinical symptoms. Nevertheless, in adults with a history of allergy, wheezing and also in patients below 30, the probability for a positive MCT is high.
The effects of aerobic and strength exercises on pulmonary function tests and quality of life in asthmatic patients
Fesharaki M,Paknejad O,Kordi R
Tehran University Medical Journal , 2010,
Abstract: "nBackground: Asthma is a major health condition in Iran. This randomized clinical trial was aimed for the comparison of the effects of two exercise protocols (aerobic and aerobic-strength) on the pulmonary indices and quality of life of asthmatic patients."n "nMethods: The study was conducted in pulmonary ward of Dr Shariati Hospital in Tehran, and Research Center of Exercise Medicine of Tehran in 2009. Fifty six asthmatic patients were selected and after two weeks of education, their spirometric parameters were recorded and the St George's respiratory questionnaire was completed. Then patients were randomly assigned to two groups of A and B. For ten weeks group A did the aerobic-strength exercises and group B did only the aerobic ones at home. At the end, again their spirometric parameters were recorded and the questionnaire was completed. Finally 42 patients completed the study. "n "nResults: After the intervention, FEV1 and FVC but not FEV1/FVC increased in group A. There were no changes in these parameters in group B. In addition, post-intervention FEV1 and FVC were significantly higher in group A than group B. All scores of St George's respiratory questionnaire were significantly improved in both groups but they were not different between them."n "nConclusions: Our findings showed that regular aerobic exercises, individually or concomitant with strength exercises, could improve vital signs and quality of life of mild to moderate asthmatic patients. However, only aerobic exercises with strength ones improve spirometric parameters. Therefore, a combination of both aerobic and strength exercises could be considered in treatment protocols of asthmatic patients.
Free Gingival Grafting; Epiglu VS. Silk Thread Suturing: A Comparative Study
M. Paknejad,Y. Soleymani Shayesteh,A. Esmaielieh
Journal of Dentistry of Tehran University of Medical Sciences , 2004,
Abstract: Statement of the Problem: The routine procedure for immobilization of free gingival graft (FGG) is suturing. Due to the successful application of tissue adhesives their employment has also become the subject of interest.Purpose: The aim of present clinical trial was to compare using Epiglu (E.g) versus silk thread suturing in FGG.Materials and Methods: This study was a split mouth clinical trial. The study group comprised of 12 patients with symmetrical loss of attached gingiva whom were referred to Faculty of Dentistry, Tehran University of Medical science. In test group, the gingivalgraft were placed on cellophane and after applying one drop of Eg then placed in the proper position. In control group silk suturing was used.Results: The degree of pain had no significant differences in two groups (P>0.05). The rate of bleeding was insignificant at the first day (P=0.5), but in the second (P=0.0425)and the third day (P=0.0313) less bleeding was observed in the test group. 10 days after the surgery, grafts in the test group had better healing (P=0.0425), while 3 month later no significant differences observed (P>0.05). Although the mean tissue shrinkage were 41%and 38% for control and test group respectively, Wilcoxon test showed no significant differences 30 days after surgery (P>0.05). The tissue shrinkage also was not significant 3 months after surgery. In addition, no displacement, infection or hypersensitivity werenoted in either of two groups.Conclusion: In FGG, Epiglu is more effective than suturing.
Association between Asthma and Periodontal Disease
S. Yaghobee,M. Paknejad,A. Khorsand
Journal of Dentistry of Tehran University of Medical Sciences , 2008,
Abstract: Objective: An association between poor oral health and chronic lung disease has recently been reported. The purpose of this study was to explore this potential association between asthma and periodontal disease.Materials and Methods: This is a descriptive case controlled study. The samples were selected from patients referred to respiratory disease clinic in a hospital in Tehran, Iran. The study population comprised of one hundred individuals: fifty asthmatics and fifty asthmatic controls evaluated for Plaque index (PI), Gingival index (GI), Papillary Bleed-ing index (PBI), Periodontal Disease index (PDI) and Calculus index (CI). The data were analyzed by SPSS software.Results: There were significant differences between asthmatics and non-asthmatic sam-ples in PI, GI, BOP, and PDI (P<0.01). However, there was no such differences in CI be-tween the two groups (P=0.084).Conclusion: The results of the present study support recent published reports advocating a relationship between respiratory disease and periodontal health status.
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