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Access to the health services in the context of economic restructuring. Case study: Brasov, Campulung and Ramnicu Sarat (Romania)
SIMONA SUDITU,MIHAELA PLOAIE,CRISTINA MOLDOVAN
Cinq Continents , 2012,
Abstract: Accesso ai servizi sanitari nel contesto della ristrutturazione economica nei municipi Ramnicu Sarat, Campulung e Brasov. Questo studio affronta una serie di questioni riguardanti l'accesso ai servizi sanitari delle persone nei municipi Ramnicu Sarat, Campulung, Brasov nel periodo post-comunista. I cambiamenti economici, politici e sociali dopo il 1990 hanno portato alla configurazione nella forma attuale del sistema sanitario, con effetti importanti sulla popolazione. L’ approccio comparativo delle situazioni nei tre municipi con caratteristiche diverse come numero di abitanti, posizione e livello di sviluppo economico, ha permesso l'identificazione di elementi comuni, come per esempio: il regresso del sistema sanitario pubblico a favore di quello privato, bassa qualit{ delle cure e diminuzione del personale medicale. L'accento è stato messo sull’analisi degli indicatori che rivela il grado di sviluppo del sistema sanitario riportato a 10000 persone.
Labour market- effects of economic restructuring in Ramnicu S rat, Brasov and Campulung municipalities
SIMONA SUDITU,MIHAELA PLOAIE,CRISTINA MOLDOVAN
Cinq Continents , 2012,
Abstract: Il mercato del lavoro: effetti di riorganizzazione economica nei municipi Ramnicu Sarat, Brasov si Campulung. I processi di ristrutturazione e privatizzazione hanno giocato un ruolo importante nella definizione di alcune caratteristiche del mercato del lavoro. L'evoluzione del mercato del lavoro dopo il 1990, riflette i cambiamenti nell'economia dopo il processo di ristrutturazione eprivatizzazione, sentiti sul mercato attraverso: la scomparsa dei posti di lavoro, la diminuzione del numero della popolazione occupata, significativa crescita della disoccupazione. L’analisi del mercato del lavoro ci mostra una serie di indicatori nel valutare il grado di coinvolgimento della popolazione o dei vari gruppi, nell'attivita’produttiva o non produttiva. La forza di lavoro, sia dal punto di vista quantitativo che qualitativo dipende dallo sviluppo economico e l'evoluzione della popolazione totale.
PERCUTANEOUS APPROACH IN OBSTRUCTIVE RENAL FAILURE – INDICATIONS, POSTOPERATIVE SURVEILLANCE
C. Ristescu,C. Costache,N. Suditu,C. Novac
Jurnalul de Chirurgie , 2011,
Abstract: Objective: The study aimed to identify the variation of biological parameters recorded at the patients with obstructive renal failure treated with percutaneous nephrostomy. Material and method: The retrospective study investigated the data of 244 patients admitted in our department and treated with percutaneous nephrostomy for obstructive renal failure during January 2005 – December 2007. Demographical data, investigation, operation notes, indication, biological parameters trends (creatinine, haematocrit, haemoglobin, kaliemia, alkaline reserve), complications and hospital stay were recorded. The biological parameter trends (creatinine, haematocrit, haemoglobin, kaliemia, alkaline reserve) was analysed. The median preoperative and postoperative values of those parameters was compared. Statistical analysis was performed.Results: The median preoperative/discharge values of creatinine were 8.29mg%(1.6-26.3 mg%) comparing to 3.63mg% (0.64-13 mg%). A return to normal renal function at the discharge time was noted in 23 patients (9.7%). Hyperpotasemia (K>5.1mEq/l) on admission was found in 134 patients (54.9%). The median preoperative/discharge values of potassium were 5.71mEq/l comparing to 4.8 mEq/l.The median hospitalization time was 8.7 days with a median ICU stay of 3.3 days. The recorded mortality was 3.2% (8 patients) with an average time of 5.8 days between the operatory time and exitus time. Conclusions: The most frequent causes of obstructive renal failure necessiting percutaneous nephrostomy are malignancies. After renal percutaneous drainage the renal function improvement is fast and significant. In the postoperative period the onset of severe hypokalemia call for aggressive treatment in the same time with volume repletion.
PLACE OF 5α-REDUCTASE IN THE THERAPY FOR BENIGN PROSTATIC HYPERPLASIA
C. Novac,N. Suditu,B. Novac,V.D. Radu
Jurnalul de Chirurgie , 2007,
Abstract: Twelve years ago, finasteride, the first 5α-reductase inhibitor, was introduced as drug therapy for benign prostatic hyperplasia, and more recently dutasteride has emerged as an alternative. The efficacy, safety and ability of these 5α-reductase inhibitors to reverse the natural progression of benign prostatic hyperplasia have been convincingly demonstrated and both drugs are now welt established in the medical armamentarium against the disease. Given the multifactorial etiology of benign hyperplasia, the usefulness of 5α-reductase inhibitors in combination with a adrenergic blockers has also been investigated and justified in select patients. Wider applications of 5α-reductase inhibitors are also emerging, though their perhaps most important new role as chemopreventive agents remains unclear.
Limited Bandwidths and Correlation Ambiguities: Do They Co-Exist in Galileo Receivers  [PDF]
Elena Simona Lohan
Positioning (POS) , 2011, DOI: 10.4236/pos.2011.21002
Abstract: Galileo is the Global Navigation Satellite System that Europe is building and it is planned to be operational in the next 3-5 years. Several Galileo signals use split-spectrum modulations, such as Composite Binary Offset Carrier (CBOC) modulation, which create correlation ambiguities when processed with large or infinite front-end bandwidths (i.e., in wideband receivers). The correlation ambiguities refer to the notches in the correlation shape (i.e., in the envelope of the correlation between incoming signal and reference modulated code) which happen within +/– 1 chip from the main peak. These correlation ambiguities affect adversely the detection probabilities in the code acquisition process and are usually dealt with by using some form of unambiguous processing (e.g., BPSK-like techniques, sideband processing, etc.). In some applications, such as mass-market applications, a narrowband Galileo receiver (i.e., with considerable front-end bandwidth limitation) is likely to be employed. The question addressed in this paper, which has not been answered before, is whether or not this bandwidth limitation can cope inherently with the ambiguities of the correlation function, to which extent, and which the best design options are in the acquisition process (e.g., in terms of time-bin step and ambiguity mitigation mechanisms).
Efficacy and tolerability of propolis special extract gh 2002 as a lip balm against herpes labialis: a randomized, double-blind three-arm dose finding study  [PDF]
Simona Holcová, Marie Hladiková
Health (Health) , 2011, DOI: 10.4236/health.2011.31010
Abstract: A dose-finding study was performed with respect to the clinical applicability and tolerability of three different concentrations of propolis special extract GH 2002 in a lip balm (0.1%, 0.5% and 1%). The trial was designed as a double-blind, randomized dermatological study in 150 outpatients with Herpes labialis. The primary parameter was the duration in days until painless incrustation in 50% or 90% of the patients (observable in 121 patients). Secondary parameters were local pain (assessed on a visual analogue scale), itching, burning and tension/ swelling on a verbal rating scale, and tolerability. Visits were performed on days 2/3, 5/6 and 8/9. Best efficacy results with shortest healing time (3.4 and 5.4 days in the 50th and 90th percentile, respectively; p = 0.008 vs. 1% and 0.09 vs. 0.1%) and good tolerability were observed with the 0.5% concentration. All three concentrations achieved highly significant therapeutic results in comparison with baseline values (p < 0.0005) for all secondary parameters as early as day 2/3. Analgesia was the most prominent effect for the patients. Conclusion: The 0.5 % concentration of propolis special extract GH 2002 in a lip balm was found to have the best risk-benefit ratio for the treatment of Herpes labialis.
Analysis on Long Precipitation Series in Piedmont (North-West Italy)  [PDF]
Fiorella Acquaotta, Simona Fratianni
American Journal of Climate Change (AJCC) , 2013, DOI: 10.4236/ajcc.2013.21002
Abstract:

This study analyses thirteen daily precipitation series of Piedmont, region of North-West Italy. The meteorological series have been chosen because they were meteorological observatories operating continuously from the beginning of 1900 until 2011. As the first step an historical research over each station has been carried out. In this way, the potential breaks, in the series, either due to changes of locations or instruments, have been determined and the missing values have been recovered. On the precipitation daily series a quality control have been effectuated and by metadata identification it was possible to assess the homogeneity of the meteorological series. In this way we have obtained the complete and correct series on which trends have been computed. In order to better understand the consequences of climate variations on our environment and society, we have calculated the climate indices proposed by “CCL/CLIVAR Working Group on Climate Change Detection” (dry and wet days, rainy days, intensity of precipitation…) over the time. The values of precipitation have also allowed beginning the climatic analysis with the aim at defining the principle local peculiarity in Piedmont.

Geographic Object-Based Image Analysis of Changes in Land Cover in the Coastal Zones of the Red River Delta (Vietnam)  [PDF]
Simona Niculescu, Chi Nguyen Lam
Journal of Environmental Protection (JEP) , 2019, DOI: 10.4236/jep.2019.103024
Abstract: The majority of the population and economic activity of the northern half of Vietnam is clustered in the Red River Delta and about half of the country’s rice production takes place here. There are significant problems associated with its geographical position and the intensive exploitation of resources by an overabundant population (population density of 962 inhabitants/km2). Some thirty years after the economic liberalization and the opening of the country to international markets, agricultural land use patterns in the Red River Delta, particularly in the coastal area, have undergone many changes. Remote sensing is a particularly powerful tool in processing and providing spatial information for monitoring land use changes. The main methodological objective is to find a solution to process the many heterogeneous coastal land use parameters, so as to describe it in all its complexity, specifically by making use of the latest European satellite data (Sentinel-2). This complexity is due to local variations in ecological conditions, but also to anthropogenic factors that directly and indirectly influence land use dynamics. The methodological objective was to develop a new Geographic Object-based Image Analysis (GEOBIA) approach for mapping coastal areas using Sentinel-2 data and Landsat 8. By developing a new segmentation, accuracy measure, in this study was determined that segmentation accuracies decrease with increasing segmentation scales and that the negative impact of under-segmentation errors significantly increases at a large scale. An Estimation of Scale Parameter (ESP) tool was then used to determine the optimal segmentation parameter values. A popular machine learning algorithms (Random Forests-RFs) is used. For all classifications algorithm, an increase in overall accuracy was observed with the full synergistic combination of available data sets.
Numerical Simulations of Fractionated Electrograms and Pathological Cardiac Action Potential
Simona Sanfelici
Computational and Mathematical Methods in Medicine , 2002, DOI: 10.1080/1027366021000041377
Abstract: The aim of this work is twofold. First we focus on the complex phenomenon of electrogram fractionation, due to the presence of discontinuities in the conduction properties of the cardiac tissue in a bidomain model. Numerical simulations of paced activation may help to understand the role of the membrane ionic currents and of the changes in cellular coupling in the formation of conduction blocks and fractionation of the electrogram waveform. In particular, we show that fractionation is independent of INA alterations and that it can be described by the bidomain model of cardiac tissue. Moreover, some deflections in fractionated electrograms may give nonlocal information about the shape of damaged areas, also revealing the presence of inhomogeneities in the intracellular conductivity of the medium at a distance.
Signaling-mediated control of ubiquitin ligases in endocytosis
Simona Polo
BMC Biology , 2012, DOI: 10.1186/1741-7007-10-25
Abstract: Ubiquitination modifies proteins in a variety of ways, the significance of which we only partially comprehend. Ubiquitin can be attached: as an individual moiety to a single or multiple lysine residues of substrate (mono- or multiple monoubiquitination); as chains of ubiquitin moieties that are interlinked through any one of the seven lysine residues of ubiquitin (for example K48- or K63-linked chains); or as branched chains, to name but a few [1]. The cell interprets each of these modifications as a distinct signal. The first described role of ubiquitination as mediating protein degradation through targeting to the proteasome has now been complemented with numerous other functions [2]. For example, the signal encoded by K63-linked chains can mediate functions as diverse as receptor endocytosis [3,4], activation of protein kinases in the NF-κB pathway and the initiation of error-free DNA repair [2].Signal transduction from transmembrane cell surface receptors to nuclear transcription factors is regulated at multiple levels by protein ubiquitination. The covalent attachment of one, or often more, ubiquitin moieties has emerged as the principal mechanism for termination of signaling, by targeting the receptor for endocytosis and, ultimately, degradation in the lysosome [3]. This device controls a vast array of mammalian signaling receptors, such as receptor tyrosine kinases, G-protein coupled receptors (GPCRs), growth hormone receptors, the major histocompatibility complex I, NOTCH, various channels and transporters, and cytokine and interferon receptors [3]. Receptors that are internalized after activation are directed first into the endosomes of the endocytic pathway, and then into multivesicular bodies (MVBs), which undergo a process of maturation that ends with fusion with the lysosome and delivery of the contents for degradation. Ubiquitination of the receptor provides the crucial signal for entering this pathway [3,5-7].Subsequent delivery of membrane receptors
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