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Search Results: 1 - 10 of 68463 matches for " SEVERO Luiz Carlos "
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Stability of the biological science: toward an evolutionist epistemology, without refutations and revolutions
SEVERO Luiz Carlos
Revista do Instituto de Medicina Tropical de S?o Paulo , 2003,
Histoplasmose pulmonar cavitária cr?nica simulando tuberculose
Unis, Gisela;Severo, Luiz Carlos;
Jornal Brasileiro de Pneumologia , 2005, DOI: 10.1590/S1806-37132005000400009
Abstract: objective: to evaluate cases of chronic pulmonary histoplasmosis diagnosed in recent years at the complexo hospitalar santa casa in porto alegre, in the state of rio grande do sul, brazil. methods: cases diagnosed at the santa casa hospital complex within the last 25 years were reviewed. four cases in which the diagnosis was made through histopathological analysis or culture and confirmed by with serologic testing are described. cases from the brazilian literature are also discussed. results: the principal clinical manifestations were cough, dyspnea, fever, anorexia and weight loss. among the radiological findings were emphysema, cystic cavities, bronchiectasis and pleural thickening. all patients had an epidemiological history of contact with chicken feces. one of the patients presented aspergillus fumigatus colonization of cavities. conclusion: chronic pulmonary histoplasmosis must be considered in patients with chronic obstructive pulmonary disease presenting cavitary lesions of the lung, sputum smear microscopy negative for acid-fast bacilli and negative tuberculin skin test. hemoptysis occurring in the presence of cured or fading pulmonary lesions is suggestive of aspergillus colonization.
Capítulo 7 - Zigomicose
Severo, Cecília Bittencourt;Guazzelli, Luciana Silva;Severo, Luiz Carlos;
Jornal Brasileiro de Pneumologia , 2010, DOI: 10.1590/S1806-37132010000100018
Abstract: zygomycosis (mucormycosis) is a rare but highly invasive infection caused by fungi belonging to the order mucorales, which includes the genera rhizopus, mucor, rhizomucor, absidia, apophysomyces, saksenaea, cunninghamella, cokeromyces and syncephalastrum. this type of infection is usually associated with hematologic diseases, diabetic ketoacidosis and organ transplantation. the most common form of presentation is rhinocerebral mucormycosis, with or without pulmonary involvement. pulmonary zygomycosis is more common in patients with profound, prolonged neutropenia and can present as segmental or lobar infiltrates, isolated nodules, cavitary lesions, hemorrhage or infarction. the clinical and radiological manifestations are often indistinguishable from those associated with invasive aspergillosis. this article describes the general characteristics of pulmonary zygomycosis, emphasizing laboratory diagnosis, and illustrates the morphology of some lesions.
Histoplasmose disseminada em pacientes com Síndrome de Imunodeficiência Adquirida (SIDA): estudo de 25 casos
Rocha, Marineide Melo;Severo, Luiz Carlos;
Revista do Instituto de Medicina Tropical de S?o Paulo , 1994, DOI: 10.1590/S0036-46651994000200013
Abstract: twenty five cases of disseminated histoplasmosis in patients with aids are presented. mucocutaneous involvement established the diagnosis of disseminated histoplasmosis in 68% of the cases. we point out the importance of histoplasmosis as an opportunistic infection in patients with hiv.
Paracoccidioidomycosis in organ transplant recipient: case report
Zavascki, Alexandre Prehn;Bienardt, Jo?o Carlos;Severo, Luiz Carlos;
Revista do Instituto de Medicina Tropical de S?o Paulo , 2004, DOI: 10.1590/S0036-46652004000500009
Abstract: paracoccidioidomycosis is a common disease in latin america but it is rare in organ transplant recipient patients. we report on a case of such mycosis in a renal transplant recipient. the patient presented with a large lung cavity on the left lower lobe, a rare radiological presentation of paracoccidioidomycosis. unusual clinical and radiological manifestations of paracoccidioides brasiliensis infection can occur in immunocompromised patients.
Mediastinal histoplasmosis: report of the first two Brazilian cases of mediastinal granuloma
Severo, Luiz Carlos;Lemos, Antonio Carlos Moreira;Lacerda, Heloisa Ramos;
Revista do Instituto de Medicina Tropical de S?o Paulo , 2005, DOI: 10.1590/S0036-46652005000200009
Abstract: this report documents the first two brazilian cases of mediastinal granuloma due to histoplasmosis, presenting selected aspects on the diagnosis. tissue samples revealing histoplasmosis were obtained from each of the patients by mediastinoscopy and thoracotomy. in the second patient, a subcarinal calcified mass eroded into the bronchial tree, leading to secondary bilateral aspiration pneumonitis one week after thoracotomy. although rare, histoplasmosis should be included in the differential diagnosis of mediastinal granuloma, specially if there are calcifications greater than 10 mm in dimension.
Coexistência de coloniza??o fúngica intracavitária (bola fúngica) e tuberculose ativa
Unis, Gisela;Picon, Pedro Dornelles;Severo, Luiz Carlos;
Jornal Brasileiro de Pneumologia , 2005, DOI: 10.1590/S1806-37132005000200009
Abstract: background: although pulmonary tuberculosis is the principal predisposing factor for intracavitary fungal colonization, the coexistence of the two diseases is rare. simultaneity of fungal colonization and active mycobacteriosis in the same cavity (acid-fast bacilli found among hyphal masses) is highly unusual. objective: to describe clinical findings, diagnostic procedures, radiographic aspects, accompanying conditions and evolution in patients with tuberculosis and fungus ball. method: we reviewed, retrospectively, the records of 625 patients diagnosed with fungus ball between 1974 and 2002. all of the patients had been diagnosed through immunodiffusion or mycological study, or both. the inclusion criterion was positivity for acid-fast bacilli in sputum smear microscopy or histopathology. results: the charts of 14 patients were selected. all had presented hemoptysis, followed by productive cough, dyspnea, weight loss, fever, asthenia and chest pain. in one patient colonized by aspergillus niger and in another colonized by scedosporium apiospermum (teleomorph, pseudallescheria boydii), active tuberculosis was seen concomitant to the fungus ball. in the remaining cases, the mycobacteria were found in the adjacent parenchyma or in the contralateral lung. conclusion: this study corrobates the assertion that antagonism exists between mycobacterium tuberculosis and aspergillus fumigatus. the potential for fungal colonization and mycobacteriosis to occur concomitantly is demonstrated in other fungal agents, s. apiospermum (p. boydii) and a. niger in particular.
Microepidemia de histoplasmose em Blumenau, Santa Catarina
Oliveira, Flávio de Mattos;Unis, Gisela;Severo, Luiz Carlos;
Jornal Brasileiro de Pneumologia , 2006, DOI: 10.1590/S1806-37132006000400018
Abstract: acute pulmonary histoplasmosis is rarely diagnosed and is often confused with tuberculosis. most knowledge of the disease has been derived from descriptions of epidemics in which a number of individuals were exposed to the same source of infection. isolation of histoplasma capsulatum var. capsulatum from soil samples is conclusive evidence of an epidemic focus. this is the first report of an outbreak of histoplasmosis, in which two cases were reported and the fungus was isolated at the focus of the epidemic, in the state of santa catarina. further epidemiological studies are needed in order to determine the prevalence of the infection statewide.
Histoplasmose pulmonar aguda no Rio Grande do Sul
Unis, Gisela;Roesch, Eliane Wurdig;Severo, Luiz Carlos;
Jornal Brasileiro de Pneumologia , 2005, DOI: 10.1590/S1806-37132005000100010
Abstract: background: acute pulmonary histoplasmosis is a respiratory infection occurring when an otherwise healthy individual inhales a large quantity of fungal propagules. length of exposure determines disease severity. an epidemic is influenced by factors affecting the growth and transmission of histoplasma capsulatum var. capsulatum in nature. objective: to identify epidemiological and clinical aspects of patients with acute pulmonary histoplasmosis in the state of rio grande do sul (rs) and compare these aspects with those of other cluster outbreaks reported in brazil. method: the charts of 212 patients diagnosed with histoplasmosis over a 25-year period (1977-2002) were obtained from the archives of the laboratório de micologia from complexo hospitalar santa casa (santa casa hospital mycology laboratory), in the city of porto alegre (rs). in reviewing these patient charts, we identified and included in the study cases of acute pulmonary histoplasmosis in which there was a positive culture and/or histopathological findings consistent with the diagnosis. outbreaks were defined as one confirmed case or positive immunodifusion histoplasma capsulatum with compatible clinical history. all reported brazilian outbreaks were reviewed. results: of the 212 patient charts reviewed, 18 (8.5%) were selected for inclusion in the study. among those 18 patients, ages ranged from 8 to 63 years (median, 35.4), and 67% were male. epidemiological histories were suggestive of the disease in 11 patients (61%). the most common disease type, seen in 17 patients (95%), was primary acute pulmonary histoplasmosis, and there was a predominance of isolated cases. conclusion: the identification of isolated cases and the presence of cluster outbreaks demonstrate the abundance of h. capsulatum in the soil and, together with the occurrence of all forms of the disease, confirms the assumption that rio grande do sul is a hyperendemic region for histoplasmosis.
Histoplasmose disseminada e SIDA: importancia do meio de cultivo para o espécime clínico-broncoscópico
Unis, Gisela;Silva, Vanusa Barroso da;Severo, Luiz Carlos;
Revista da Sociedade Brasileira de Medicina Tropical , 2004, DOI: 10.1590/S0037-86822004000300008
Abstract: fiberoptic bronchoscopy is a useful procedure in the diagnosis of histoplasmosis, when the clinical material is adequately processed. ten cases of disseminated histoplasmosis in patients with aids are presented here, with a mycological evaluation in culture, mycosel? and sabouraud's chloramphenicol agar of clinical specimens obtained through fiberoptic bronchoscopy. the yield of mycosel? culture was 60%, while in sabouraud's chloramphenicol agar it was 20%, supporting the importance of selective medium in the isolation of histoplasma capsulatum var capsulatum from potentially contaminated clinical specimens, as well as the importance of clinical information for the laboratory as the key for a correct diagnosis.
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