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Search Results: 1 - 10 of 466763 matches for " SAAD Mário José Abdalla "
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Estudo da libera??o renal de glicose em coelhos submetidos a hepatectomia total funcional e infus?o de noradrenalina
FRANCHI-TEIXEIRA, Antonio Roberto;JORGE, Gracinda L.;LEONARDI, Luís Sérgio;SAAD, Mário José Abdalla;
Arquivos de Gastroenterologia , 2001, DOI: 10.1590/S0004-28032001000300008
Abstract: aim ? to study the possible endogenous sources of glucose in the absence of the liver (equivalent to the anhepatic period of liver transplantation). material and methods - a experimental model of total functional hepatectomy in anesthetised rabbits was developed. the aorta and the right renal vein were catheterised in order to collect blood samples to measure glucose contents. the animals were divided into two groups: group 1, 5 animals underwent only norepinephrine infusion; group 2, 15 animals underwent norepinephrine infusion and submitted to total functional hepatectomy. results - in group 2, before the hepatectomy, arterial glucose levels were higher than venous ones and after the liver removal, the venous levels became higher than the arterial ones. this pattern showed an inversion in the glicemic curves. in group 1 this pattern was not observed. conclusion - the glicemic curves behavior observed in group 2 is not due to norepinephrine infusion, but represents renal glucose release after total functional hepatectomy.
Determination of glucose levels using dried filter paper blood spots: new perspective in home monitoring
Ward, Laura Sterian;Novis, Renata Britto;Nascimento, Veridiana Toledo;Nóbrega, Miriam Siesler;Saad, Mário José Abdalla;
Sao Paulo Medical Journal , 1996, DOI: 10.1590/S1516-31801996000100008
Abstract: we present a method for the determination of blood glucose using dried filter paper blood spots.to validate this method, we compared our results using filter paper and simultaneously collected venous blood. we demonstrated that there is a linear relationship between the filter paper glucose levels and those determined in whole blood (r=0.98). there was no significant difference between the results of the two methods (p>0.05).this method is a cheap alternative which may improve the control of diabetes mellitus, and may also be very useful in the diagnosis of postprandial hypoglycemia and other special situations.
Estudo da libera o renal de glicose em coelhos submetidos a hepatectomia total funcional e infus o de noradrenalina
FRANCHI-TEIXEIRA Antonio Roberto,JORGE Gracinda L.,LEONARDI Luís Sérgio,SAAD Mário José Abdalla
Arquivos de Gastroenterologia , 2001,
Abstract: Objetivo - Estudar as prováveis fontes endógenas de glicose na ausência do fígado (equivalente à fase anepática do transplante de fígado). Material e Métodos - Criou-se um modelo experimental de hepatectomia total funcional em coelhos anestesiados. A aorta e a veia renal direita foram cateterizadas para colheita de glicemias seriadas. Os animais foram divididos em dois grupos: grupo 1, com 5 animais submetidos apenas a infus o de noradrenalina e grupo 2, constando de 15 animais também submetidos a infus o de noradrenalina e tiveram seus fígados retirados. Resultados - Demonstram que, no grupo 2, antes da hepatectomia, as dosagens de glicemias arteriais foram maiores que as venosas, e após a retirada do órg o, estes valores se tornaram menores. Isto configurou invers o das curvas das glicemias. No grupo 1 n o foi observada essa invers o. Conclus o - Conclui-se que esse comportamento das curvas de glicemia observadas nos animais do grupo 2 n o se deve à a o da noradrenalina e significa libera o renal de glicose após a hepatectomia.
Autoimmune features caused by dengue fever: a case report
Jardim, Denis Leonardo Fontes;Tsukumo, Daniela Miti Lemos;Angerami, Rodrigo N.;Carvalho Filho, Marco Antonio de;Saad, Mário José Abdalla;
Brazilian Journal of Infectious Diseases , 2012, DOI: 10.1590/S1413-86702012000100018
Abstract: dengue virus is the most important mosquito-borne viral disease in the world. co-circulation of the four types of dengue viruses and expansion of dengue epidemic gave rise to infection enhancement and a big expansion of clinical aspects of the disease. herein we report a case of a 25-year-old white woman with dengue fever and numerous associated autoimmune features. our patient had proteinuria, an extensive right pleural effusion, a thin pericardial effusion and ascites. she had a low c3 level and positive antinuclear antibody; cryoglobulins were also positive. the numerous autoimmune features of this patient were a diagnostic challenge, since she was a young woman and could be easily mistaken for a rheumatologic patient in a newly open disease. dengue infection probably was a triggering event causing an abnormal immune response. therefore, dengue should be suspected in patients with hematological disorders and autoimmune features in endemic regions or those who have travelled to those regions.
Espessamento médio-intimal da carótida e fun??o endotelial na doen?a arterial coronariana
Chequer, Graziela;Nascimento, Bruno Ramos;Navarro, Túlio Pinho;Falqueto, Eduardo Belisário;Alencar, Maria Clara N.;Miranda, Márcio Cristiano R. de;Mandil, Ari;Saad, Jamil Abdalla;Fonseca, Cirilo;Ribeiro, Ant?nio Luiz Pinho;
Arquivos Brasileiros de Cardiologia , 2006, DOI: 10.1590/S0066-782X2006001500004
Abstract: objective: to investigate the correlation between the endothelial function and the carotid intimal-medial thickening (imt) in a population of patients with coronary artery disease, as well as that between the endothelial function and carotid imt with the severity of the coronary lesions. methods: forty-three patients aged 60.5±9.2 years, (67.4% males) with coronary artery disease at the coronariography were studied. endothelial function was assessed using the brachial artery reactivity test (bart), which measured the percentage of flow-mediated dilatation (%fmd). the carotid imt was evaluated through vascular ultrasound. results: the mean %fdm was 4.7 ± 3.6 and the mean carotid imt was 1.08 ± 0.23 mm. the carotid mit and %fmd measurements showed a statistically significant correlation, with spearman?s coefficient of 0.315, p= 0.042, demonstrating that lower %fmd values corresponded to an increased carotid imt (r = -0.315, p = 0.042). there was no correlation between %fmd or imt and the severity of coronary lesions. conclusions: the presence of a correlation between carotid imt and %fmd demonstrates a concomitance of anatomical and functional vascular alterations in coronary artery disease, regardless of the severity of the atherosclerotic lesions.
Fyn Mediates Leptin Actions in the Thymus of Rodents
Alessandra Girasol,Gabriela G. Albuquerque,Eli Mansour,Eliana P. Araújo,Giovanna Degasperi,Raphael G. Denis,José B. Carvalheira,Mário J. Saad,Lício A. Velloso
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0007707
Abstract: Several effects of leptin in the immune system rely on its capacity to modulate cytokine expression and apoptosis in the thymus. Surprisingly, some of these effects are dependent on signal transduction through the IRS1/PI3-kinase, but not on the activation of JAK2. Since all the well known effects of leptin in different cell types and tissues seem to be dependent on JAK2 activation, we hypothesized that, at least for the control of thymic function, another, unknown kinase could mediate the transduction of the leptin signal from the ObR towards the IRS1/PI3-kinase signaling cascade.
一些含三氮杂茂偶氮染料o,n供体的zr(ⅱ)配合物的合成、表征和抗微生物活性
Abdalla M Khedr?,Mohamed Gaber?,Khalil M Saad-allah?
无机化学学报 , 2014,
Abstract: 合成了9种3-(2-羟基萘基-1-偶氮)-1,2,4-三氮唑(hl1),3-(2,4-二羟苯基-1-偶氮)-1,2,4-三氮唑(hl2),3-(2-羟基-3-羧基萘基-1-偶氮)-1,2,4-三氮唑(hl3),3-(2-羟基-5-溴苯基-1-偶氮)-1,2,4-三氮唑(hl4)和3-(2-羟基-5-甲基苯基-1-偶氮)-1,2,4-1,2,4-三氮唑(hl5)的zr(ⅱ)配合物并用元素分析,摩尔电导,磁矩,ir,uv-vis,1h-nmr以及热分析(tga和dta)对其进行了表征。结果表明hl1-hl5以二齿一元配体方式通过偶氮的氮原子和羟基基团的氧原子与zr(ⅱ)离子配位生成单核配合物。用4种革兰氏阴性菌,即大肠杆菌(escherichiacoli),粘质沙雷氏菌(serratiamarcescens),阴沟肠杆菌(enterobactercloacae)和普通变形杆菌(proteusvulgaris),以及2种真菌,即白色念珠菌(candidaalbicans)和黑曲霉菌(aspergillusniger)对配体及其配合物的生物学活性进行了研究。最小抑菌浓度(mics)用纸上杯碟琼脂扩散法测定,结果表明在大多数情况下,金属化的配合物的抗微生物活性与自由配体相比有所增强。
Diretriz para realiza o de exames diagnósticos e terapêuticos em hemodinamica
Saad Jamil Abdalla,Garcia José Carlos de Faria,Guimar?es Jorge Ilha
Arquivos Brasileiros de Cardiologia , 2004,
Abstract:
Cross-talk das vias de sinaliza??o de insulina e angiotensina II: implica??es com a associa??o entre diabetes mellitus e hipertens?o arterial e doen?a cardiovascular
Carvalho-Filho, Marco A. de;Carvalheira, José Barreto C.;Velloso, Lício Augusto;Saad, Mario José Abdalla;
Arquivos Brasileiros de Endocrinologia & Metabologia , 2007, DOI: 10.1590/S0004-27302007000200008
Abstract: insulin (ins) and angiotensin ii (aii) play pivotal roles in the control of two vital and closely related systems: the metabolic and the circulatory, respectively. a failure in the proper action of each of these hormones results, to a variable degree, in the development of two highly prevalent and commonly overlapping diseases - diabetes mellitus (dm) and hypertension (ah). in recent years, a series of studies has revealed a tight connection between the signal transduction pathways that mediate ins and aii actions in target tissues. this molecular cross-talk occurs at multiple levels and plays an important role in phenomena that range from the action of anti-hypertensive drugs to cardiac hypertrophy and energy acquisition by the heart. at the extracellular level, the angiotensin-converting enzyme controls aii synthesis but also interferes with ins signaling through the proper regulation of aii and the accumulation of bradykinin. at an early intracellular level, aii, acting through jak-2/irs-1/pi3-kinase, jnk and erk, may induce the serine phosphorylation and inhibition of key elements of the ins-signaling pathway. finally, by inducing the expression of the regulatory protein socs-3, aii may impose a late control on the ins signal. this review will focus on the main advances obtained in this field and will discuss the implications of this molecular cross-talk in the common clinical association between dm and ah.
Fixa??o intramedular das fraturas do fêmur na infancia e na adolescência com hastes flexíveis
Janovsky, César;Aoyagui, Alexandre Yoiti;Pierami, Rafael;Saad, Eduardo Abdalla;Dobashi, Eiffel Tsuyoshi;Pinto, José Antonio;Milani, Carlo;
Revista Brasileira de Ortopedia , 2011, DOI: 10.1590/S0102-36162011001000008
Abstract: objective: to evaluate the surgical treatment results using intramedullary retrograde ender nails in isolated unilateral femur fractures. methods: the authors performed a retrospective study of 31 patients (32 femurs), 22 (71%) males and 9 (29%) females with the mean age of 11,3 years (8 to 16 years old). according to the trauma mechanism we observed: 13 (42%) car accidents, 5 (16%) motorcycle accidents, 4 (13,%) running over accidents, 6 (19 %) falls from height and 3(10%) bicycle falls. the follow up varied from 1,6 to 6,3 years (average of 2,7 years). the period of hospitalization was 6,81 days varying from 3 to 19 days. after 1 year we performed clinical evaluation (pain, range of motion, gait) and scanogram do evaluate ldd. results: we obtained 28 (90,3%) satisfactory and 3 (9,6%) unsatisfactory results. the following complications were recognized: lld in 8 (25,8%), pain 2(6,4%), limited range of knee flexion in 1 (3,2,%) patients. conclusions: the authors still consider small the population studied although the higher rate of satisfactory results. the treatment with ender nails was effective, safe, unexpensive and can be indicated to treat isolated stable femur fractures.
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