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HEPATOPROTECTIVE ACTIVITY OF POLYCARPEA CORYMBOSA
S.Ashok*
International Journal of Pharmacy and Technology , 2010,
Abstract: Aim of study: To evaluate the hepatoprotective activity of Polycarpea corymbosa whole plantextract against carbon tetra chloride (CCl4) –induced hepatotoxicity.Material and methods: Hepatotoxicity was induced in male wistar rats by administration of CCl4(1.25ml/kg/day for 7days). Methanolic extract of whole plant of Polycarpea corymbosa wereadministered to the experimental animals (20 mg/kg/day,p.o.for 7 days). The hepatoprotective effectof these extract was evaluated by the assay of liver function biochemical parameters (alanineaminotranferse, aspartte aminotranferse and alkaline aminotranferse) and histopathological studies ofthe liver.Results and Discussion: In methanol extract-treated animals, the toxic effect of CCl4 as controlledsignificantly by restoration of the levels of enzymes levels as compared to the normal and thestandard drug silymarin-treated groups. Histology of the liver section of the animals treated with theextract showed the presence of normal hepatic cords, absence of necrosis and fatty infiltration, whichfurther support the hepatoprotective activity.Conclusion: Methanol extract of the whole plant of P. corymbosa possesses significanthepatoprotective acivity.
Enzymatic Synthesis of Butyl Ferulate by Silica-Immobilized Lipase in a Non-Aqueous Medium  [PDF]
Chandresh Chandel, Ashok Kumar, Shamsher S. Kanwar
Journal of Biomaterials and Nanobiotechnology (JBNB) , 2011, DOI: 10.4236/jbnb.2011.24049
Abstract: Butyl ferulate was synthesized using a silica-immobilized commercial lipase (Steapsin) in dimethylsulfoxide (DMSO). Lipase-immobilized by surface adsorption onto silica pretreated with 1% glutaraldehyde showed 89% binding of protein. The esterification of butanol (100 mM) and ferulic acid (50 mM) by silica-bound biocatalyst was carried out at 45℃ for 6 h under shaking (120 rpm). The optimization of various reaction conditions like molar concentration of reactants, biocatalyst concentration, reaction time, temperature, addition of molecular sieves, salt ions, and repetitive bio-catalysis in DMSO were studied, consecutively. The bound lipase (15 mg/ml) catalyzed the esterification of ferulic acid and butanol with a yield of 64 mM under optimized reaction conditions. Among the salt ions Cu2+, Zn2+ and Al3+ ions moderately promoted the ester yield (66 mM) while Mg2+, NH4+, Fe2+ and Ca2+ were found to decrease the ester yield. The by-product (H2O) produced in the reaction was scavenged by the molecular sieves (10 mg/ml) added to the reaction mixture, which enhanced the formation of ester up to 74 mM. During the repetitive reactions, the bound lipase produced 32 mM ester after 4th cycle of esterification. On scaling-up the reaction volume to 30 ml, 32.5 mM butyl ferulate was synthesized under optimized conditions.
Successful Percutaneous Treatment of Coronary Artery Ectasia with Drug-Eluting Stent  [PDF]
Bhupesh Rajanikant Shah, Ashok S. Thakkar
International Journal of Clinical Medicine (IJCM) , 2014, DOI: 10.4236/ijcm.2014.520161
Abstract: Coronary artery ectasia is well-known but relatively uncommon finding with prevalence ranging from 1.2% to 5.3%. Coronary artery ectasia has been associated with atherosclerosis in approximately half of the cases. Here, we are presenting a case of male patient who experienced myocardial infarction and was diagnosed with coronary artery ectasia in proximal-mid junction of left anterior descending artery with stenotic lesion. The patient was successfully treated with percutaneous transluminal coronary angioplasty.
An intravenous organophosphate poisoning with intermediate syndrome: An unusual way of intoxication
Badhe Ashok,Sudhakar S
Indian Journal of Critical Care Medicine , 2006,
Abstract: Organophosphate (OP) poisoning is very common form of poisoning in Indian population because of its availability and easy access. Intoxication occurs following the absorption of OP agents through gastrointestinal tract, skin and respiratory tract and rarely by intramuscular or intravenous route. The clinical features depend on the amount of the poison consumed, it′s concentration, the route of administration and the time of instituting therapy. We are reporting a case of an intravenous monochrotophos poisoning, an unusual way of intoxication, which was managed in our ICU.
A STUDY OF CUSTOMER SATISFACTION ABOUT INDIVIDUALAGENTS OF LIC OF INDIAWITH SPECIAL REFERENCE TO KOLHAPUR DISTRICT
BANNE ASHOK S.
Indian Streams Research Journal , 2013,
Abstract: Distribution Channels are considered to be the veins of marketing activity of any business in delivering goods and services as well as customer satisfaction. Life insurance industry is not an exception to this. Even in liberalized era, in the marketing of life insurance products of LIC of India, the traditional channel of Individual Agents has been playing dominant role not only in selling insurance products but also servicing the customers. The Individual Agents of LIC of India procured 97.45 % of the new business of LIC in the year 2010-11 making LIC of India a leader in life insurance segment with market share of 68.85%. However, with the entry of Private players in life insurance sector in the year 2000, LIC of India is facing stiff competition to maintain its key position. The major way to survive and maintain the key position is to enhance satisfaction level of customers. One of the major factors that determine the satisfaction level of the customers of LIC is the quality of services provided by the individual agents to their policyholders. As life insurance is an intangible product and long term contract, it is essential to create confidence and trust in the minds of prospect and customer through personal selling and assured after sale services. Individual Life Insurance Agents are in direct touch with the policyholders, therefore, they are the right distribution channel to understand customers and satisfy them by providing efficient services. Considering the role of Individual Insurance Agents in customer satisfaction, this study is an attempt to assess the level of satisfaction of customers of LIC of India about the Individual agents.
Comment on "Supersymmetry in the half-oscillator - revisited"
Ashok Das,S. Pernice
Physics , 2002,
Abstract: We point out the flaw in the analysis of Gangopadhyaya and Mallow, hep-th/0206133, where it is claimed that supersymmetry is broken in the SUSY half-oscillator, even with a regularization respecting supersymmetry.
Gene Expression Profiling during Wilting in Chickpea Caused by Fusarium oxysporum F. sp. Ciceri  [PDF]
Gayatri S. Gurjar, Ashok P. Giri, Vidya S. Gupta
American Journal of Plant Sciences (AJPS) , 2012, DOI: 10.4236/ajps.2012.32023
Abstract: Fusarium oxysporum f. sp. ciceri (Foc), one of the most important fungal pathogen of chickpea, is a constant threat to this crop plant. In the present study gene expression analysis of chickpea roots during Foc infection was performed using various approaches. cDNAs derived from total mRNA during infection process of susceptible (JG62)and resistant (Digvijay) cultivars, were amplified using random oligonucleotides. Sequence characterization of differentially expressed transcripts revealed their homology with many plant genes essential for various metabolic functions including defense. Further, expression patterns of specific candidate gene transcripts were analyzed in the Foc inoculated and uninoculated resistant and susceptible chickpea cultivars, on day 6 of infection. Semiquantitative RT-PCR analysis of defense related genes was performed using gene specific oligonucleotides in resistant and susceptible chickpea cultivars. The expression of fungal pathogenesis related genes and their race specific response was determined throughout the course of chickpea-Foc interaction. Temporal expression and race specific response of plant defense related and fungal virulence genes were studied in the resistant and susceptible cultivars of chickpea inoculated with three races of Foc highlighting the host-pathogen interactions. Few genes, involved in chickpea defense against Fusarium wilt which were not reported previously were unveiled in this study.
Impact of Integrated Nutrient, Crop Residue and Tillage Management on Soil Aggregates and Organic Matter Fractions in Semiarid Subtropical Soil under Soybean-Wheat Rotation  [PDF]
Milkha S. Aulakh, Ashok K. Garg, Shrvan Kumar
American Journal of Plant Sciences (AJPS) , 2013, DOI: 10.4236/ajps.2013.411267
Abstract:

Various physical, chemical and biological soil properties in surface (0-5 cm) and subsurface (5-15 cm) soil were determined in a 4-year field experiment conducted at Punjab Agricultural University Ludhiana, India with sixteen treatments consisted of different combinations of fertilizer N (0, 20 and 25 kg N ha-1), P (0, 60 and 75 kg P2O5 ha-1), FYM (0 and 10 t·ha-1) and wheat (Triticum aestivum L.) residue (WR) (0 and 6 t·ha-1) applied to summer-grown soybean (Glycine max L.) and fertilizer N (0, 120 and 150 kg N ha-1), P (0, 60 and 75 kg P2O5 ha-1), and soybean residue (SR) (0 and 3 t·ha-1) applied to winter-grown wheat crop continuously in both conventional tillage (CT) and conservation agriculture (CA), arranged in a split-split plot

Selective Processing and Metabolism of Disease-Causing Mutant Prion Proteins
Aarthi Ashok,Ramanujan S. Hegde
PLOS Pathogens , 2009, DOI: 10.1371/journal.ppat.1000479
Abstract: Prion diseases are fatal neurodegenerative disorders caused by aberrant metabolism of the cellular prion protein (PrPC). In genetic forms of these diseases, mutations in the globular C-terminal domain are hypothesized to favor the spontaneous generation of misfolded PrP conformers (including the transmissible PrPSc form) that trigger downstream pathways leading to neuronal death. A mechanistic understanding of these diseases therefore requires knowledge of the quality control pathways that recognize and degrade aberrant PrPs. Here, we present comparative analyses of the biosynthesis, trafficking, and metabolism of a panel of genetic disease-causing prion protein mutants in the C-terminal domain. Using quantitative imaging and biochemistry, we identify a misfolded subpopulation of each mutant PrP characterized by relative detergent insolubility, inaccessibility to the cell surface, and incomplete glycan modifications. The misfolded populations of mutant PrPs were neither recognized by ER quality control pathways nor routed to ER-associated degradation despite demonstrable misfolding in the ER. Instead, mutant PrPs trafficked to the Golgi, from where the misfolded subpopulation was selectively trafficked for degradation in acidic compartments. Surprisingly, selective re-routing was dependent not only on a mutant globular domain, but on an additional lysine-based motif in the highly conserved unstructured N-terminus. These results define a specific trafficking and degradation pathway shared by many disease-causing PrP mutants. As the acidic lysosomal environment has been implicated in facilitating the conversion of PrPC to PrPSc, our identification of a mutant-selective trafficking pathway to this compartment may provide a cell biological basis for spontaneous generation of PrPSc in familial prion disease.
Mucocele in Lower Lip as a Result of Improper Use of Feeding Bottle: A Case Report
S. Ashok Kumar,Mahesh Ramakrishnan
Case Reports in Dentistry , 2013, DOI: 10.1155/2013/520425
Abstract:
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