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Search Results: 1 - 10 of 382174 matches for " S. Yu. Nikulina "
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Genetic predictors of idiopathic sick sinus syndrome
A. A. Chernova,S. Yu. Nikulina,S. S. Tret'yakova
Rational Pharmacotherapy in Cardiology , 2012,
Abstract: Published data demonstrating genetic determination of sick sinus syndrome is presented. The definition of this pathology is presented; the main symptoms are described, as well as genes that influence the development of idiopathic sick sinus syndrome, their polymorphisms and role in disorders of the cardiovascular system.
Genetic aspects of congenital long QT syndrome
A.A. Chernova,S.Yu. Nikulina,A.V. Gul'bis
Rational Pharmacotherapy in Cardiology , 2012,
Abstract: The main symptoms and clinical types of long QT syndrome are described. Molecular genetic diagnostics and updated approaches to the management of patients with long QT syndrome are presented.
Hereditary intraventricular conduction disorders in the family from Krasnoyarsk
A.A. Chernova,S.Yu. Nikulina,S.S. Tret'yakova,T.I. Ul'yanova
Rational Pharmacotherapy in Cardiology , 2011,
Abstract: Pedigree of the family from Krasnoyarsk city with hereditary disorders of intracardiac conduction was studied. The diagnosis of each family member was verified by electrocardiography (ECG), echocardiography, bicycle ergometry, ECG Holter monitoring. The family 10-year follow-up showed familial aggregation of intracardiac conduction disorders in grandson, niece, son of the proband niece, ie, in the III-degree relatives. Family history of III-degree relatives with intracardiac conduction disorders and discordant pathology is identified.
Predictive role of connexin 40 in the pathogenesis of hereditary sick sinus syndrome
S.Yu. Nikulina,A.A. Chernova,V.A. Shulman,T.S.Kukushkina
Rational Pharmacotherapy in Cardiology , 2011,
Abstract: Aim. To study the association of hereditary sick sinus syndrome (SSS) with connexin 40 gene (Cx40) polymorphism.Material and methods. 29 families with hereditary SSS were involved into prospective study. Probands were 20 women and 9 men (aged 58±0.15). Relatives, I-III degree of kinship, were 65 men and 68 women (aged 39±0.13). Clinical and instrumental examination was performed in all probands and their relatives. Diagnosis of SSS was verified by transesophageal atrial electrostimulation. Molecular genetic investigation of SSS patients and their relatives was carried out in laboratory of medical genetics of Research Institute of Therapy, Siberian Branch of Russian Academy of Medical Sciences.Results. 71 SSS patients, 44 their healthy relatives, I-III degree of kinship, 197 subjects of control group were genotyped for the polymorphism of 44G>A of gene Cx40. According to allele-specific polymerase chain reaction 3 types of genotypes ADRA2B (II — homozygous wild, ID — heterozygous, DD — homozygous mutant) were found in SSS patients, their relatives and healthy subjects of control group.Conclusion. Significant predominance of the heterozygous genotype 44G>A was found in SSS (45,07±5,9%) patients in comparison with subjects of the control group (29,44±3,2%).
Age-dependent aspects of acute coronary heart disease incidence rate and mortality in men and women
S.A. Boytsov,S.S. Yakushin,N.N. Nikulina,G.I. Furmenko
Rational Pharmacotherapy in Cardiology , 2010,
Abstract: Aim. To study gender and age characteristics of incidence rate, mortality and lethality in acute coronary heart disease (ACHD).Material and Methods. Analysis of the ACHD (ICD-10 codes: I21.0-I22.9, I20.0, I24) morbidity, mortality and lethality, depending on sex and age was performed in the population (n=285 736; 46% men) of several city administrative districts of Voronezh, Ryazan and Khanty-Mansiysk. Morbidity, mortality and lethality were calculated on the basis of medical documentation as well as cases identified by the study protocol.Results. The ACHD morbidity and mortality in men were 1.99 and 1.79 times higher (p<0,001), respectively, than these in women. The studied parameters increase with age, reaching a maximum in 50-59 y.o., have a plateau in 60-79 y.o. and then they decrease. Morbidity and mortality in women increase with age, but reach a maximum in 70-79 y.o., being comparable with the male level, and then exceed it in ≥80 y.o. Age curve of lethality in men has J-alike shape with minimum in patients of 50-79 y.o. Women have a line age curve with minimum in patients of <50 y.o.Conclusion. The population of ACHD patients should be considered according to both the sex and age: <50, 50-79 and ≥80 y.o. Every of these population group has special epidemiological characteristics.
The polymorphism of α2B-adrenergic receptor gene — a new genetic marker of the hereditary sick sinus syndrome
S.Iu. Nikulina,V.A. Shulman,A.A. Chernova,D.A. Nikulin
Rational Pharmacotherapy in Cardiology , 2010,
Abstract: Aim. To study the association of the hereditary sick sinus syndrome (SSS) with gene α2B-adrenergic receptor (ADRA2B) polymorphism.Material and methods. 29 families with hereditary primary SSS from the database of the Chair of Therapy № 1 of Krasnoyarsk State Medical University named after prof. V.F. Voyno-Yasenetsky were included in the study. Group 1 included probands (20 women and 9 men, 58±0.15 y.o.), group 2 – proband relatives of I, II and III degree (65 males and 68 females, 39±0.13 y.o.), group 3 (control) — 89 healthy volunteers. Clinical examination (physical examination, ECG, bicycle ergometry, ECG monitoring, atropine test, electrophysiological study, echocardiography) was performed in all probands and their relatives. The diagnosis of SSS was confirmed by transesophageal left atrium stimulation in 75 individuals. Genotypic examination of gene ADRA2B I/D polymorphism was performed in 213 individuals: 75 SSS-patients, 49 their healthy relatives, 89 healthy volunteers.Results. 3 types of ADRA2B genotypes (II — homozygous wild, ID — heterozygous, DD — homozygous mutant) were founded by allele-specific polymerase chain reaction. Significant prevalence of the homozygous genotype of more rare alleles DD in SSS-patients (28±5.2%) compared to the control group (8.99±3.0%) was found.Conclusion. Study of the genetic marker can be used to identify predisposition to hereditary SSS in the population and individual-family level. SSS due to mutations in genes that regulate cell function of sinus node and the sinoatrial conduct occurs, apparently, extremely rarely.
Idiopathic sick sinus syndrome
S.Y. Nikulina,V.A. Schulman,A.A. Chernova
Rational Pharmacotherapy in Cardiology , 2007,
Abstract: Aim. To evaluate changes in hereditary burden of sick sinus syndrome (SSS) in families of patients with SSS and assess heart rate variability (HRV) in patients with SSS.Results. 33 families of patients with SSS were examined. Clinical study, ECG-Holter monitoring, atropine test, transesophageal left atrial stimulation, echocardiography, veloergometry were fulfilled in all probands and their relatives in 1990 and 2005-2006. Cardiorhythmography was done in patients with SSS only in 2005-2006.Results. Increase in hereditary burden with SSS from 31 to 35% is registered during 15 years. Significant growth of patients with SSS was observed among daughters (from 50 to 71%), nephews (from 33 to 50%) and nieces (from 0 to 20%). HRV analysis shows prevalence of sympathetic system activity in patients with SSS.Conclusion. Growth of hereditary burden with SSS especially among female relatives is shown. HRV analysis can be used for SSS diagnostics.
Clinical and genetic peculiarities of atrial fibrillation
S.Y. Nikulina,V.A. Schulman,O.O. Kuznetsova,N.V. Aksjutina
Rational Pharmacotherapy in Cardiology , 2008,
Abstract: Aim. To study inheritance patterns of atrial fibrillation (AF) and association of primary and secondary AFwith gene polymorphismof a1-adrenoreceptors.Material andmethods. 103 probands with AF and their 301 relatives of I, II, III degrees (basic group) and 82 probands without heart diseases and their 163 relatives of I and II degrees (control group) were examined. Examination included evaluation of electrophysiological indicators of sinoatrial node, electrocardiogram monitoring, veloergometry, echocardiography as well as assessment of gene polymorphism of a1-adrenoretseptors.Results. Accumulation of AF in probands families was founded. Segregation analysis of idiopathic AF revealed autosomal-dominant type of its inheritance.Сonclusion. The heterozygote genotype of gene β1-adrenoretseptors Ser49Gly is one of genetic predictors of primary and secondary AF.
Seasonal dynamics of phytoplankton in the inner Neva Estuary in the 1980s and 1990s
Vera N. Nikulina
Oceanologia , 2003,
Abstract: The phytoplankton in the inner Neva Estuary is described from data obtained from 1996 to 2000. The seasonal dynamics of the phytoplankton biomass are characterized by a bimodal curve with a summer maximum. The average seasonal biomass was approximately3 mg l-1, the maximum biomass was 8-11 mg l-1. The species composition and quantitative parameters were compared to those observed in the 1980s. A notable, nearly 1.5-2 fold, increase in the biomass in the summer-autumn period and the predominance of Oscillatoria species among the blue-greenalgae were observed. A decline in the nutrient load in the water body at the end of the 1990s appeared to be insufficient to bringabout a decrease in the proportion of Oscillatoria algae in the total species composition or a decline in the biomass ofthe entire phytoplankton community. In 2000 a certain change in the structural composition of the phytoplankton complex was noted. Species that had been predominantin the 1980s and had lost their advantage in the early 1990s, regained their earlier status.
Cardiovascular mortality: quality diagnostics analysis and causal statistics of lethal outcomes
Nikulina N.N.
Saratov Journal of Medical Scientific Research , 2011,
Abstract: The high cardiovascular mortality (CVM) proves the necessity of verification analysis of cardiovascular death causes. The research goal is to determine the quality, facilities and peculiarities of cardiovascular diseases (CVD) of postmortem diagnostics and statistical recording as a cause of death. 1972 successive cases of CVM in Voronezh, Ryazan and Khanty-Mansiysk have been analyzed. The majority of deaths caused by CVD were classified as fatalities occurring outside hospital and in the absence of medical care (88.0%). Incidence of cardiovascular deaths was confirmed by autopsy in 28.3% cases. With increasing age, the incidence of detecting CVD as a cause of death increased, while the frequency of referral to autopsy consistently decreased. Chronic Ischemic Heart Disease (IHD) forms comprising 48.3% of all CVM were confirmed by autopsy results only in 29.5% of cases. Acute IHD forms (including myocardial infarction) accounted for only 11.6% of CVM; however this diagnosis was based on autopsy results in 72.4% of cases. The high death rate outside hospital and in the absence of medical care with the rare referral to autopsy, especially for elderly having chronic CVD, does not provide reliable statistical information on CVM
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