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Search Results: 1 - 10 of 325166 matches for " S. S. Tret'yakova "
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Possibility of “Comet-Like” Transport of Acetylcholine Receptors in Command Helix Neurons in Cellular Analog of Habituation  [PDF]
Arkady S. Pivovarov, Galina B. Murzina, Denis A. Makhnovsky, Mariya S. Tretyakova
World Journal of Neuroscience (WJNS) , 2014, DOI: 10.4236/wjns.2014.42016

The presence of \"comet-like\" radial transport of acetylcholine receptors by actin microfilaments without the participation of myosin motors in the depression of acetylcholine-induced inward chloric current (ACh-current) in command neurons of defensive behavior of the land snail, Helix lucorum, in a cellular analog of habituation was investigated. For that purpose the effects of CK548, CK-636 (inhibitors of actin-related protein complex Arp2/3, whose activation triggers rapid actin polymerization and the formation of the \"comet-like\" tail on the actinic filament) and wiskostatin (an N-WASP protein inhibitor, activating Arp2/3) on the depression of ACh-current were studied. The attenuation of ACh-current depression was observed upon the addition of CK548. At the same time, CK-636 and wiskostatin irreversibly strengthened the depression of this current and suppressed its spontaneous recovery. The results of CK-548 action and its mathematical modeling allow suggesting the presence of \"comet-like\" transport of acetylcholine receptors, initiated by Arp2/3 protein complex in receptor endo and exocytosis in command neurons of Helix lucorum in a cellular analog of habituation. Irreversible inhibition of vital metabolic processes of the neuron by wiskostatin and CK-636, which lead to the decrease in the level of ATP, could have caused irreversible effects of these blockers on current depression.

Genetic predictors of idiopathic sick sinus syndrome
A. A. Chernova,S. Yu. Nikulina,S. S. Tret'yakova
Rational Pharmacotherapy in Cardiology , 2012,
Abstract: Published data demonstrating genetic determination of sick sinus syndrome is presented. The definition of this pathology is presented; the main symptoms are described, as well as genes that influence the development of idiopathic sick sinus syndrome, their polymorphisms and role in disorders of the cardiovascular system.
Hereditary intraventricular conduction disorders in the family from Krasnoyarsk
A.A. Chernova,S.Yu. Nikulina,S.S. Tret'yakova,T.I. Ul'yanova
Rational Pharmacotherapy in Cardiology , 2011,
Abstract: Pedigree of the family from Krasnoyarsk city with hereditary disorders of intracardiac conduction was studied. The diagnosis of each family member was verified by electrocardiography (ECG), echocardiography, bicycle ergometry, ECG Holter monitoring. The family 10-year follow-up showed familial aggregation of intracardiac conduction disorders in grandson, niece, son of the proband niece, ie, in the III-degree relatives. Family history of III-degree relatives with intracardiac conduction disorders and discordant pathology is identified.
Increased proviral load in HTLV-1-infected patients with rheumatoid arthritis or connective tissue disease
Maria Yakova, Agnès Lézin, Fabienne Dantin, Gisèle Lagathu, Stéphane Olindo, Georges Jean-Baptiste, Serge Arfi, Raymond Césaire
Retrovirology , 2005, DOI: 10.1186/1742-4690-2-4
Abstract: HTLV-1 proviral load in the peripheral blood from 12 patients with RA and 6 patients with connective tissue disease was significantly higher than that in matched asymptomatic HTLV-1 carriers, but similar to that in matched HAM/TSP controls. HAM/TSP was seen in one-third of the HTLV-1-infected patients with RA or connective tissue disease, but did not account for the higher proviral load compared to the asymptomatic carrier group. The proviral load was increased in the synovial fluid and tissue from an HTLV-1-infected patient with RA, the values suggesting that the majority of infiltrated cells were HTLV-1-infected. In the peripheral blood from HTLV-1-infected patients with RA or connective tissue disease, HTLV-1 proviral load correlated with the percentages of memory CD4+ T cells and activated T cells, and these percentages were shown to be markedly higher in the synovial fluid than in the peripheral blood in an HTLV-1-infected patient with RA.These biological findings are consistent with a role of the retrovirus in the development of arthritis in HTLV-1-infected patients. A high level of HTLV-1-infected lymphocytes in the peripheral blood and their accumulation in situ might play a central role in the pathogenesis of HTLV-1-associated inflammatory disorders. Alternatively, the autoimmune arthritis, its etiological factors or treatments might secondarily enhance HTLV-1 proviral load.Human T-lymphotropic virus type 1 (HTLV-1) is endemic in southern Japan, intertropical Africa, Melanesia, Latin America, and the Caribbean basin [1]. HTLV-1 is the etiological agent of adult T-cell leukemia [2] and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), an inflammatory disease of the central nervous system [3,4], and has also been implicated in several other inflammatory disorders, such as polymyositis [5], uveitis [6], Sj?gren's syndrome [7], alveolitis [8], and infective dermatitis [9].The possibility that HTLV-1 may cause joint disease was initially raise
Study of the Structural and Electrical Properties of Cr-Doped BiFeO3 Ceramic  [PDF]
S. S. Arafat, S. Ibrahim
Materials Sciences and Applications (MSA) , 2017, DOI: 10.4236/msa.2017.810051
Abstract: Multiferroic BiFe1-xCrxO3 (x = 0.2 and 0.4) ceramics were synthesized in a single phase. The effects of Cr3+ substitution on the crystal structure, dielectric permittivity and leakage current were investigated. Preliminary X-ray structural studies revealed that the samples had a rhombohedral perovskite crystal structure. The dielectric constant ε' significantly increased while the dielectric loss tanδ was substantially decreased with the increase in Cr3+ substitution. The temperature effect on the dielectric properties exhibited an anomaly corresponding to magneto-electric coupling in the samples and was shifted to lower temperatures with the increase in Cr3+ substitution. The leakage current density also reduced in magnitude with the increase in the Cr3+ substitution.
Degree Splitting of Root Square Mean Graphs  [PDF]
S. S. Sandhya, S. Somasundaram, S. Anusa
Applied Mathematics (AM) , 2015, DOI: 10.4236/am.2015.66086
Abstract: Let \"\" be an injective function. For a vertex labeling f, the induced edge labeling \"\" is defined by, \"\" or \"\"; then, the edge labels are distinct and are from \"\". Then f is called a root square mean labeling of G. In this paper, we prove root square mean labeling of some degree splitting graphs.
A Parameter Estimation Model of G-CSF: Mathematical Model of Cyclical Neutropenia  [PDF]
S. Balamuralitharan, S. Rajasekaran
American Journal of Computational Mathematics (AJCM) , 2012, DOI: 10.4236/ajcm.2012.21002
Abstract: We investigate the FFT (Fast Fourier Transform) model and G-CSF (granulocyte colony-stimulating factor) treatment of CN (Cyclical Neutropenia). We collect grey collies and normal dog’s data from CN and analyze the G-CSF treatment. The model develops the dynamics of circulating blood cells before and after the G-CSF treatment. This is quite natural and useful for the collection of laboratory data for investigation. The proposed interventions are practical. This reduces the quantity of G-CSF required for potential maintenance. This model gives us good result in treatment. The changes would be practical and reduce the risk side as well as the cost of treatment in G-CSF.
Synthesis, Thermal Behaviour, XRD, and Luminescent Properties of Lighter Lanthanidethiodipropionate Hydrates Containing Aminogunidine as Neutral Ligand  [PDF]
S. Packiaraj, S. Govindarajan
Open Journal of Inorganic Chemistry (OJIC) , 2014, DOI: 10.4236/ojic.2014.43006
Aminoguanidine lanthanide thiodipropionate hydrates of composition [Ln(Agun)2(tdp)3·nH2O], Agun = Aminoguanidine, tdp = thiodipropionic acid, where Ln = La, Pr, Nd and Sm if n = 2, have been prepared and characterized by physic-chemical techniques.
Fuzzy Based Intelligent Monitoring of Critical Lines in the Restructured Power Market  [PDF]
S. Rajasekaran, S. Sathiyamoorthy
Circuits and Systems (CS) , 2016, DOI: 10.4236/cs.2016.79191
Abstract: Restructured electric market environment allows the power wheeling transactions between the power producers and customers to meet the growing load demand. This will lead to the possible of congestion in the transmission lines. The possible contingencies of power components further worsen the scenario. This paper describes the methodology for the identification of critical transmission line by computing the real power and reactive power performance indices. It also demonstrates the importance of fuzzy logic technique used to rank the transmission lines according to the severity and demonstrated on IEEE-30 bus system.
Error Correction Circuit for Single-Event Hardening of Delay Locked Loops  [PDF]
S. Balaji, S. Ramasamy
Circuits and Systems (CS) , 2016, DOI: 10.4236/cs.2016.79210
Abstract: In scaled CMOS processes, the single-event effects generate missing output pulses in Delay-Locked Loop (DLL). Due to its effective sequence detection of the missing pulses in the proposed Error Correction Circuit (ECC) and its portability to be applied to any DLL type, the ECC mitigates the impact of single-event effects and completes its operation with less design complexity without any concern about losing the information. The ECC has been implemented in 180 nm CMOS process and measured the accuracy of mitigation on simulations at LETs up to 100 MeV-cm2/mg. The robustness and portability of the mitigation technique are validated through the results obtained by implementing proposed ECC in XilinxArtix 7 FPGA.
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