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Search Results: 1 - 10 of 325456 matches for " S. Rezaee "
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Tensile strength of two soldered alloys (Minalux and Verabond2)
Mir Mohammad Rezaee S,Taghavi Nia A
Journal of Dental Medicine , 2002,
Abstract: Recently. Minalux alloy, a base metal free from Be, has been presented on the market while no special soldering has been recommended for it. On the other hand, based on the manufacturer's claim, this alloy is similar to Verabond2. The aim of this study was to investigate the tensile strength of Minalux and Verabond2, soldered by Verasolder. Twelve standard dambble shape samples, with the length of 18 mm and the diameter of 3mm, were prepared from each alloy. Six samples of each alloy were divided into two pieces with carboradom disk. Soldering gap distance was 0.3mm, measured by a special jig and they were soldered by Verasolder alloy. Six other samples, of both Iranian and foreign unsoldered alloys were considered as control group. Then samples were examined under tensile force and their tensile strength was recorded. Two- way variance analysis showed that the tensile strength of Minalux alloy and Verabond2 were not statistically significant (Verasoler 686, Minalux 723), but after soldering, such difference became significant (Minalux 308, Verabond2 432). Verabond2 showed higher tensile strength after soldering.
Agricultural Specialists' Attitude toward and Intention for Application of VRT-Spraying Technologies Using Structural Equation Modeling
S Salehi,K Rezaee Moghadam,A Ajili
Journal of Science and Technology of Agriculture and Natural Resources , 2009,
Abstract: Variable rate technology-spraying technologies are new aspect of sustainable agriculture. In these technologies, the chemical is applied in the needed level of farm where there is a high intensity of pests and weeds. The purpose of this paper was to study the agricultural specialists' attitude toward and intention to use variable rate technology-spraying technologies in Jihad-e-Keshavarzi organization of Fars and Khuzestan provinces. A survey was conducted using a stratified random sampling to collect data from 249 agricultural specialists. The results showed that the specialists of Fars and Khuzestan provinces have intentions to use the variable rate technology-spraying technologies. The variables including attitude toward application, trialing, perceived usefulness, compatibility, and attitude of confidence all influence the intentions to use the variable rate technology-spraying technologies. Based on high positive intention of agricultural specialists, we recommend the use of these technologies in agricultural practices of the two provinces.
Isolation, Identification and Cloning of the Penicillin G Acylase Gene from Shigella boydii Cloned in Escherichia coli
S.H. Montazam,S. Faragnia,R. Aboshof,H. Rezaee
Research Journal of Biological Sciences , 2012,
Abstract: Penicillin G Acylase (PGA) is an important enzyme in the bulk pharmaceutical industry. It is one of the most important industrial enzymes for the production of semi-synthetic penicillin. PGAs have been found in numerous bacteria and fungi. The PGA gene has been isolated from different organism displays distinct biochemical properties which may be important for industrial aspects. In this study, 250 non E. coli, Enterobacteriasea that were collected from environmental and clinical samples, Transported to the laboratory and subjected for routine microbiological tests for identification of isolates. After identification, non E. coli isolates were investigated by PCR for processing of PGA gene. In this method, a PGA positive strain from an isolate that identified as Shigella boydii by standard microbiological test. DNA extracted from Shigella boydii entered in PCR reactions using primers designed on conserved region of PGA genes. The gene were cloned in pGEM-Teasy vector and submitted for sequencing. The gene encoding a Penicillin G acylase from Shigella boydii isolate contain an open reading frame of 2534 nucleotide encoding 796 amino acids. Analysis of sequencing result showed that this gene contain 98% homology to previously reported PGA from a Shigella boydii strains.
Isolation, Identification and Cloning of the Penicillin G Acylase Gene from Shigella boydii Cloned in Escherichia coli
S.H. Montazam,S. Faragnia,R. Aboshof,H. Rezaee
Research Journal of Biological Sciences , 2008,
Abstract: Penicillin G Acylase (PGA) is an important enzyme in the bulk pharmaceutical industry. It is one of the most important industrial enzymes for the production of semi-synthetic penicillin. PGAs have been found in numerous bacteria and fungi. The PGA gene has been isolated from different organism displays distinct biochemical properties which may be important for industrial aspects. In this study, 250 non E. coli, Enterobacteriasea that were collected from environmental and clinical samples, Transported to the laboratory and subjected for routine microbiological tests for identification of isolates. After identification, non E. coli isolates were investigated by PCR for processing of PGA gene. In this method, a PGA positive strain from an isolate that identified as Shigella boydii by standard microbiological test. DNA extracted from Shigella boydii entered in PCR reactions using primers designed on conserved region of PGA genes. The gene were cloned in pGEM-Teasy vector and submitted for sequencing. The gene encoding a Penicillin G acylase from Shigella boydii isolate contain an open reading frame of 2534 nucleotide encoding 796 amino acids. Analysis of sequencing result showed that this gene contain 98% homology to previously reported PGA from a Shigella boydii strains.
Steady-state pharmacokinetic analysis of vancomycin in Iranian pediatric patients
T Safarnavadeh,S Rezaee,S Dashti-Khavidaki,H Khalili
DARU : Journal of Pharmaceutical Sciences , 2009,
Abstract: Background: Large inter-individual variability has been reported for vancomycin pharmacokinetics in pediatric patients. On the other hand, the pharmacokinetic parameters of vancomycin should be known in order to individualize its dosage regimen. Therefore, this study was designed and conducted to assess the steady-state vancomycin serum concentration and pharmacokinetics in a population of Iranian pediatric patients. Methods: Vancomycin serum concentration at steady-state was determined in 62 children who were treated with vancomycin intermittent intravenous infusion. Also individual steady-steady pharmacokinetic parameters (total body clearance, apparent volume of distribution and elimination half-life) were determined in 30 patients who had both peak and trough vancomycin levels assuming one-compartment model. Calculated pharmacokinetic parameters were compared among patients with different underlying diseases and also with the results of similar studies that used one-compartment pharmacokinetic model for description of serum concentration of vancomycin at steady-state. Results: More than half of the measured vancomycin serum concentrations were outside the recommended therapeutic range. Median trough concentration was significantly lower in critically ill patients as compared to patients of other disease categories. Although critically care patients showed greater values of apparent volume of distribution and also vancomycin clearance, no statistically significant difference of the calculated pharmacokinetic parameters could be detected among different groups of patients. While calculated volume of distribution for patients of this study was greater than those of similar studies, this difference could not be considered statistically significant in the majority of disease categories Conclusion: It may be concluded that design of vancomycin dosage regimens according to the recommended and general guidelines in literature (e.g. based on patient creatinine clearance) could not result in the desired therapeutic serum concentrations in the study population.
A biodistribution study of Hemiscorpius lepturus scorpion venom and available polyclonal antivenom in rats
Seyedian, R;Jalali, A;Babaee, MH;Pipelzadeh, MH;Rezaee, S;
Journal of Venomous Animals and Toxins including Tropical Diseases , 2012, DOI: 10.1590/S1678-91992012000400005
Abstract: the purpose of the present study was to investigate the biodistribution profile of the venom of hemiscorpius lepturus, the most dangerous scorpion in iran. blood and tissue samples were taken at various predetermined intervals during a 400-minute period for the venom and a 360-minute period for the antivenom in rats. the radio-iodination was carried out using the chloramine-t method. the results showed that the descending order of venom uptake was skin, kidneys and intestine, respectively. the descending order of polyclonal antivenom uptake was kidneys, intestine, heart and lungs. the calculated pharmacokinetic parameters of the venom were telimination half-life = 521.5 ± 12.6 minutes; vd/f (apparent volume of distribution) = 14.9 ± 3.3 ml; clearance (cl/f, apparent total clearance of the drug from plasma) 0.02 ± 0.005 ml/minute and for the antivenom telimination half-life = 113.7 ± 7.4 minutes; vd/f = 13 ± 1.2 ml and cl/f 0.08 ± 0.01 ml/minute. the pharmacokinetics profile comparison of the venom with that of the antivenom shows that serotherapy may be more effective if administered within 2-4 hours following envenomation by h. lepturus.
EVALUATION OF THE SWELLING, EROSION AND DRUG RELEASE FROM POLYSACCHARIDE MATRIX TABLETS BASED ON PECTIN AND INULIN
A Akhgari,MR Abbaspour,S Rezaee,A Kuchak
Jundishapur Journal of Natural Pharmaceutical Products , 2011,
Abstract: The aim of this study was to investigate swelling, erosion and drug release behavior of tablets containing pectin and inulin (polysaccharide) compared with different grades of hydroxy propyl methyl cellulose (HMPC) in the preparation of slow-release tablets. In this study, theophylline was used as a drug model. HPMC K100 and HPMC K4M and high methoxylated pectin were selected as extended release matrix formers. Tablets were prepared by using direct compression. After determination of mechanical properties, swelling, erosion and drug release studies of matrix tablets were carried out in simulated gastric fluid (SGF), simulated intestinal fluid (SIF) and distilled water. The results of study showed a pH-dependent formation of hydrogel for the pectin tablets so that swelling of tablets in SIF was much more compared to SGF. Tablets made of HPMC K100 released the total drug in 12 h while drug release from pectin-based tablets at the same time was only 65%. Other formulations released their drug less than 12 h. Among the formulations, tablets containing pectin and HPMC K100 had high swelling, low erosion and slow drug release and therefore they were suitable as extended release systems
Variation of the Chloroquine Resistance Transporter (Crt) Gene in Chloroquine-Resistant and Chloroquine-Sensitive Plasmodium berghei
N Ghobakhloo,M Nateghpour,S Rezaee,H Hajjaran
Iranian Journal of Parasitology , 2008,
Abstract: Background: The emergence and spread of chloroquine resistant Plasmodium falciparum in the world stimulated some investigators to consider different aspects of chloroquine resistance in human and rodent Plasmodia. Using animal Plasmo-dia, particularly primate and rodent Plasmodia can be useful model for human Plasmodia studies. In this study we have tried to consider and compare the sequence of chloroquine resistance transporter (crt) gene among chloroquine-resistant and chloroquine-sensitive strains of Plasmodium berghei. Methods: This experimental study was performed at the Malaria Laboratory of School of public health. DNA was ex-tracted from two strains of P. berghei which their resistance and sensitivity had been demonstrated in mice with treatment by chloroquine. By using specific primer for crt gene some parts of this gene were amplified by PCR, and obtained frag-ments were then sequenced and compared. Results: There were considerable differences in crt gene between two strains. Sequenced 1212 bp of crt gene fragment in the two strains showed 43 differences at nucleotides level and 16 differences in presumed coding amino acids. Conclusion: crt can be addressed as a considerable gene which involves in induction of resistance to chloroquine in P. berghei, as P. falciparum. The results increased such a promise that considering crt gene in chloroquine-sensitive and chlo-roquine-resistant P. berghei can prepare suitable and helpful fields for more understanding the molecular aspects of chloro-quine-resistance in Plasmodia and reversing the effectiveness of 4-aminoquinolines particularly chloroquine for treatment of drug resistant Plasmodia.
Unilateral Ptosis as Initial Manifestation of Acute Myeloid Leukemia
Besharati M R,Rezaee T,Hashemi A,Taghipour Zahir S
Iranian Journal of Pediatric Hematology Oncology , 2012,
Abstract: BackgroundIn Acute Myeloid Leukemia (AML), malignant clones of immature myeloid cells (primarily blasts) proliferate, replace bone marrow, circulate in blood and invade other tissues. The unique presentation of unilateral ptosis and unilateral eyelid swelling in AML has been reported during the present study.Case ReportA 7-year-old girl was encountered with progressively increasing unilateral right eyelid swelling and ipsilateral ptosis. There was no systemic manifestation of leukemia. Computed tomographic image reported right orbit anteromedial mass.A high total leucocytic count in cell blood count with low platelet, the bone marrow aspirate and biopsy showing leukemic blast cells confirmed the diagnosis of AML. After diagnosis, an orbital MRI was done, which revealed a mass lesion, antromedial of right orbit, related to soft-tissue tumor. The patient was treated by chemotherapeutic drugs associated with intravenous steroids.Conclusion Unilateral ptosis and eyelid swelling is an initial manifestation of AML that has not been reported previously. A peripheral blood smear with bone marrow aspirate and biopsy helps in the early detection of AML. We should consider AML in any orbital mass with unknown origin.
APPLICATION OF IMPREGNATED ALMOND SHELL ACTIVATED CARBON BY ZINC AND ZINC SULFATE FOR NITRATE REMOVAL FROM WATER
A. Rezaee, H. Godini, S. Dehestani, A. Khavanin
Iranian Journal of Environmental Health Science & Engineering , 2008,
Abstract: In this study impregnated almond shell activated carbon by Zn° and ZnSO4 were used as adsorbent with a particle size of 10-20 mesh. The objective of this research was to determine the ability of impregnated activated carbon in nitrate removal. The modified activated carbon had 1mm effective size, with a uniformity coefficient of 1.18. Potassium nitrate solution was used in batch adsorption experiments for nitrate removal from water. The effects of nitrate concentration, activated carbon dosage and time of contact were studied. Experimental data showed that modified activated carbon by Zn° and ZnSO4 was more effective than virgin almond activated carbon for nitrate removal. The maximum nitrate removal was 64%-80% and 5%-42% for modified activated carbon and virgin activated carbon, respectively. While virgin activated carbon used, nitrate-N decreased from 20 to 15mg/L in 30min reaction. The final nitrate concentration was not in the standard range of WHO recommendations for water quality; while impregnated activated carbons were used, nitrate drcreased to <10mg/L. Maximum removal was over 16-17mg nitrate-N per 1g activated carbon for impregnated activated carbon. The experiments were conducted at pH=6.2, 20oC and initial concentrations of 20mg/L nitrate-N. Increase in modified activated carbon dosage increased the nitrate removal efficiency. The equilibrium time was found to be 45min for modified activated carbon.
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