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Search Results: 1 - 10 of 411378 matches for " S. O. Ita "
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The Relationship between Nigerian Bonnylight Crude Oil-Induced Hypoglycaemia and Endogenous Serum Insulin Concentration in Male Wistar Rats: The Role of Antioxidant Vitamins C and E  [PDF]
S. O. Ita, E. O. Aluko, T. H. Olubobokun, U. A. Okon, A. B. Antai, E. E. Osim
American Journal of Molecular Biology (AJMB) , 2014, DOI: 10.4236/ajmb.2014.42010
Abstract:

The relationship between Nigerian Bonny Light crude oil (NBLCO) induced hypoglycaemia and endogenous serum insulin concentration; the role of antioxidant vitamin C or E supplementation was the focus of this study. Forty adult male Wistar rats were randomly divided into group I, which served as the control, group II, which was oral gavaged 6 ml/kg of NBLCO, groups III and IV, which were in addition to 6 ml/kg of NBLCO supplemented with 9 ml/kg and 1 mg/kg of vitamin E or C, respectively for 28 days. Results showed that NBLCO significantly (p < 0.05) lower body weight and food intake compared with control. These effects exerted by NBLCO were however significantly (p < 0.05) reversed by vitamin E or C supplementation. The NBLCO significantly (p < 0.05) reduced fasting blood glucose (FBG) when compared with control, the antioxidant vitamins supplementation significantly (p < 0.05) reversed the crude oil effect. The mean serum insulin level in NBLCO, vitamin E or C supplemented groups is not significantly different from the control. There was no significant correlation between FBG and fasting serum insulin concentrations in all the groups on day 28. It has been demonstrated in this study that direct oral ingestion of crude oil (NBLCO) could reduce food intake, body weight and cause hypoglycemia; the hypoglycemia may not be a function of serum insulin concentration. Interestingly, the hazardous effects of NBLCO could be ameliorated with antioxidant vitamin C or E supplementation.

Haematopoietic properties of ethanolic leaf extract of ageratum conyzoides (goat weed) in albino rats.
S.O Ita, O.E Etim, E.E Ben, O.F Ekpo
Nigerian Journal of Physiological Sciences , 2007,
Abstract: The potential haematological effects associated with the administration of ethanolic leaf extract of Ageratum conyzoides was investigated in rats. 27 rats were randomly divided into four groups. The first group had 6 rats and served as control, the remaining 3 experimental groups and had 7 rats each. These later groups were gavaged with the extract of Ageratum conyzoides in concentrations of 200mg/kg, 400mg/kg and 500mg/kg respectively for 30days at a dose of 0.1ml/body weight. The control group was gavaged with 0.9% sodium chloride at a dose of 0.1m1/body weight as placebo. The extract at the doses administered was found to increase in a dose-related fashion PCV and Hb (p<0.01 for 200mg/kg and p<0.001 for 400mg/kg and 500mg/kg), RBC (P<0.05 for 400mg/Kg and 500mg/kg) and marginal increases that were not significant (P>0.05 for 200mg/kg); MCH and MCV (P<0.05 and P<0.01 for 400mg/kg and 500mg/kg respectively) 200mg/kg was not significant. MCHC recorded no significant change. WBC recorded marginal increases that were not significant (P>0.05), similarly, the differential white blood cell recorded marginal increases that were not significant, except lymphocytes that recorded significant increase in group 4 (P<0.05). Marginal Decreases in body weight were also observed, these decreases were however not significant. The result of this study thus indicate haematopoietic potentials of the extract and could possibly remedy anaemia.
Acetaminophen Induced Hepatic Toxicity: Protective Role of Ageratum conyzoides
S.O. Ita,E.O. Akpanyung,B.I. Umoh,E.E. Ben
Pakistan Journal of Nutrition , 2009,
Abstract: The preventive potentials of ethanol leaf extract of Ageratum conyzoides (ACE) against acute acetaminophen and caffeinated acetaminophen over dose in Wister rats were investigated. Thirty Wister rats of both sexes were divided into 6 groups of 5 rats per group. There were two control groups. Animals in control group 1 were administered 600 mg/kg body weight of acetaminophen intraperitoneally (ip) whereas, animals in control group 2 in addition to acetaminophen were administered 100 mg/kg body weight of caffeine by oral gavage. Experimental groups 3 and 4 were treated with acetaminophen as in group 1 but in addition received 250 and 500 mg/kg body weight, respectively of ACE by oral gavage, The experimental groups 5 and 6 were treated as in control group 2 and in addition received 250 and 500 mg/kg body weight, respectively of ACE. The treatment lasted 14 days. Serum Aspartate Aminotransferase (AST) and Alanine aminotransferase (ALP) levels (U/L) significantly increased (p<0.001 and p<0.01, respectively) in group 2 than group 1 but dropped marginally in groups 3 and 4. Comparing group 2 with group 5, ALT, AST and Akaline Phospotase (ALP) (U/L) activities reduced significantly (p<0.01) in group 5 treated with 250 mg/kg of ACE. Similar significant reductions were observed in group 6 treated with 500 mg/kg of ACE, ALT activity (p<0.01), AST and ALP activities (p<0.001). Total serum protein level (g/100mL) was marginally increased in group 3 (acetaminophen plus 250 mg/kg ACE) than group 1 (acetaminophen only). Total serum protein was however increased significantly (p<0.01) in group 5 (acetaminophen plus caffeine plus 250 mg/kg ACE) and (p<0.05) group 6 (acetaminophen plus caffeine plus 500 mg/kg ACE) more than group 2 (acetaminophen plus caffeine). It is concluded from these findings that ACE offered protection against acetaminophen and caffeinated acetaminophen toxicity in rats.
Inhibition of the Corrosion of Zinc in H2SO4 by 9-deoxy-9a-aza-9a-methyl-9a-homoerythromycin A (Azithromycin)
Odoemelam,S.A.; Ogoko,E.C.; Ita,B.I.; Eddy,N.O.;
Portugaliae Electrochimica Acta , 2009,
Abstract: inhibition of the corrosion of zinc in various concentrations (0.01 to 0.05 m) of h2so4 was studied using weight loss and hydrogen evolution methods of monitoring corrosion. the results revealed that various concentrations of azithromycin (0.0001 to 0.0005 m) inhibited the corrosion of zinc in h2so4 at different temperatures (303 to 333 k). the concentration of h2so4 did not exert significant impact on the inhibition efficiency of azithromycin, but inhibition efficiencies were found to decrease with increase in the concentration of the inhibitor. values of inhibition efficiency obtained from the weight loss measurements correlated strongly with those obtained from the hydrogen evolution measurements. the activation energies for the corrosion of zinc inhibited by azithromycin were higher than the values obtained for the blank. thermodynamic data revealed that the adsorption of azithromycin on the surface of zinc was endothermic (values of enthalpies of adsorption were positive), spontaneous (values of free energies of adsorption were negative) and was consistent with the adsorption model of langmuir.
Adsorption and Inhibitive Properties of Lincomycin for the Corrosion of Zinc in 0.01 - 0.05 M H2SO4
Eddy,N.O.; Odoemelam,S.A.; Ogoko,E.C.; Ita,B.I.;
Portugaliae Electrochimica Acta , 2010,
Abstract: inhibition of the corrosion of zinc in various concentrations of h2so4 by lincomycin was studied using weight loss and hydrogen evolution methods. the results obtained indicated that lincomycin is a good adsorption inhibitor for the corrosion of zinc in h2so4 solutions. the inhibition efficiencies of lincomycin for the corrosion of zinc in h2so4 were found to range from 70.90 to 80.32 %, 69.25 to 77.70 % and from 52.11 to 67.49 % at 303, 313 and 323 k, respectively. the inhibition efficiencies decreased with increase in temperature and with increasing concentration of h2so4 but increased with increase in the concentration of lincomycin. the adsorption of lincomycin on zn surface is endothermic, spontaneous and is best described by langmuir adsorption isotherm. base on the trend in the variation of inhibition efficiency with temperature and the calculated values of the activation and free energies of adsorption, a physical adsorption mechanism is proposed for the adsorption of lincomycin on the surface of zinc.
Adsorption and Inhibitive Properties of Clarithromycin for the Corrosion of Zn in 0.01 to 0.05 M H2SO4
Ogoko,E.C.; Odoemelam,S.A.; Ita,B.I.; Eddy,N.O.;
Portugaliae Electrochimica Acta , 2009,
Abstract: the corrosion of zinc in 0.01 to 0.04 m h2so4 was studied using gravimetric and gasometric methods of monitoring corrosion. the results obtained indicate that clarithromycin is a good adsorption inhibitor for the corrosion of zinc in h2so4. the inhibition efficiency of clarithromycin increases with increasing concentration but decreases with increasing temperature. there was no significant difference between the inhibition efficiencies of clarithromycin obtained at various concentrations of h2so4 (p>0.5), but values of inhibition efficiency tend to decrease with increasing concentration of the acid. the adsorption of clarithromycin on zinc surface is endothermic, spontaneous and is best described by langmuir adsorption isotherm. calculated values of activation energies and free energies of adsorption indicate that the adsorption of clarithromycin on zinc surface supports the mechanism of physical adsorption.
Inhibition of the Corrosion of Zinc in 0.01 - 0.04 M H2SO4 by Erythromycin
Eddy,N.O.; Odoemelam,S.A.; Ogoko,E.C.; Ita,B.I.;
Portugaliae Electrochimica Acta , 2010,
Abstract: inhibition of the corrosion of zinc in 0.01 to 0.0 4 m h2so4 by erythromycin was studied using weight loss and hydrogen evolution methods. the results obtained indicate that erythromycin is a good adsorption inhibitor for the corrosion of zinc in h2so4 solutions. the inhibition efficiency of erythromycin increases with increasing concentration but decreases with increase in temperature. thermodynamic and adsorption studies reveal that the adsorption of erythromycin on zinc surface is exothermic, spontaneous and is characterised with increasing degree of orderliness. the adsorption characteristics of the inhibitor are best described by the langmuir adsorption model. from the variation of inhibition efficiency with temperature and the calculated values of the activation and free energies (which are within the limits expected for physical adsorption), we propose that the adsorption of erythromycin on zinc surface is consistent with the mechanism of physical adsorption.
The relative incidence of diabetes mellitus in abo/rhesus blood groups in south-eastern Nigeria
U.A Okon, A.B Antai, E.E Osim, S.O Ita
Nigerian Journal of Physiological Sciences , 2008,
Abstract: A total of 224 diabetics and 221 non-diabetics (control) were involved in this study, to determine the relative incidence of diabetes mellitus in ABO/Rhesus blood group. The current criteria for the diagnosis f diabetes mellitus were applied in differentiating the diabetics from the non-diabetics. Blood group, fasting blood sugar (FBS) and random blood sugar (RBG) were determined using standard methods. Type I, Type II and gestational diabetes mellitus were identified in this study. Biodata information were obtained during history taking and from subject hospital case note. The mean age of diabetics was 50.9 + 11.4 (SD) with age range of 24-72 years. Mean age for control was 49.21 + 9.25 with age range of 24-70 years. There were no significant differences between the mean ages of the two groups. Blood group O- and A+ were significantly (P<0.01) higher among the diabetics than non diabetics. Blood group O+ was significantly (P<0.01) lower in diabetics than in the control population. Blood group O- and A+ therefore appears to be more susceptible to diabetes mellitus.
Analysis of Egeria radiata and Thais coronata Shells as Alternative Source of Calcium for Food Industry in Nigeria
S.P. Malu,A.E. Abara,G.O. Obochi,B.I. Ita
Pakistan Journal of Nutrition , 2009,
Abstract: Egeria radiata and Thais coronata locally called Nkop and Nko nko respectively by the Efik, are widely eaten by Niger Delta Region of Nigeria. After consuming their soft-flesh, the empty shells are constantly thrown away as waste. This research therefore is to analyzed and ascertains the suitability of these shell wastes as raw materials for calcium supplements. Results of analysis show that these shell contain a high percentage (95.54%) of Calcium Oxide (CaO), 2.52% of Magnesium Oxide (MgO) and trace amount of other oxides. Calcium oxide has been a major source of calcium; it concluded that Egeria radiata and Thais coronata shells are suitable source raw materials for the production of calcium supplements by our indigenous food industry.
Adsorption and Inhibitive Properties of Clarithromycin for the Corrosion of Zn in 0.01 to 0.05 M H2SO4
E.C. Ogoko,S.A. Odoemelam,B.I. Ita,N.O. Eddy
Portugaliae Electrochimica Acta , 2009,
Abstract: The corrosion of zinc in 0.01 to 0.04 M H2SO4 was studied using gravimetric and gasometric methods of monitoring corrosion. The results obtained indicate that clarithromycin is a good adsorption inhibitor for the corrosion of zinc in H2SO4. The inhibition efficiency of clarithromycin increases with increasing concentration but decreases with increasing temperature. There was no significant difference between the inhibition efficiencies of clarithromycin obtained at various concentrations of H2SO4 (P>0.5), but values of inhibition efficiency tend to decrease with increasing concentration of the acid. The adsorption of clarithromycin on zinc surface is endothermic, spontaneous and is best described by Langmuir adsorption isotherm. Calculated values of activation energies and free energies of adsorption indicate that the adsorption of clarithromycin on zinc surface supports the mechanism of physical adsorption.
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