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Search Results: 1 - 10 of 625375 matches for " S. M. Mari "
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Die casting process assessment using single minute exchange of dies (SMED) method
M. Perini?,M. Ikoni?,S. Mari?i?
Metalurgija , 2009,
Abstract: Die casting process uses high productive level machines. Machine capacity utilization is a key goal in achieving minimum time consumption. Changeover procedure during die casting process is recognized as possible area for reducing time consumption. The SMED method has been improved by additional procedures simultaneously applying the 5S method. Their contribution is evident in recognition of internal and external activities, particularly while transferring internal activities into external ones in as many numbers as possible, by minimizing at the same moment the internal ones. The validity of the method and procedures are verified by an example application of die casting foundry for casting automobile parts. Significant time savings have been achieved with minimum investment.
One-dimensional simulation of fire injection heights in contrasted meteorological scenarios with PRM and Meso-NH models
S. Strada,S. R. Freitas,C. Mari,K. M. Longo
Geoscientific Model Development Discussions , 2013, DOI: 10.5194/gmdd-6-721-2013
Abstract: Wild-fires release huge amounts of aerosol and hazardous trace gases in the atmosphere. The residence time and the dispersion of fire pollutants in the atmosphere can range from hours to days and from local to continental scales. These various scenarios highly depend on the injection height of smoke plumes. The altitude at which fire products are injected in the atmosphere is controlled by fire characteristics and meteorological conditions. Injection height however is still poorly accounted in chemistry transport models for which fires are sub-grid scale processes which need to be parametrised. Only recently, physically-based approaches for estimating the fire injection heights have been developed which consider both the convective updrafts induced by the release of fire sensible heat and the impact of background meteorological environment on the fire convection dynamics. In this work, two different models are used to simulate fire injection heights in contrasted meteorological scenarios: a Mediterranean arson fire and two Amazonian deforestation fires. A Eddy-Diffusivity/Mass-Flux approach, formerly developed to reproduce convective boundary layer in the non-hydrostatic meteorological model Meso-NH, is compared to the 1-D Plume Rise Model. For both models, radiosonde data and re-analyses from the European Center for Medium-Range Weather Forecasts (ECMWF) have been used as initial conditions to explore the sensitivity of the models responses to different meteorological forcings. The two models predict injection heights for the Mediterranean fire between 1.7 and 3.3 km with the Meso-NH/EDMF model systematically higher than the 1-D PRM model. Both models show a limited sensitivity to the meteorological forcings with a 20–30% difference in the injection height between radiosondes and ECMWF data for this case. Injection heights calculated for the two Amazonian fires ranges from 5 to 6.5 km for the 1-D PRM model and from 2 to 4 km for the Meso-NH/EDMF model. The difference of smoke plume heights between the two models can reach 3–4 km. A large difference is obtained for the windy-wet Amazonian fire by the 1-D PRM model with a injection height 1.5 km higher when ECMWF re-analyses are used compared to the run with the radiosonde forcing. For the Mediterranean case, both models forecast a plume injection height above the boundary layer, although there are evidences that this particular fire propagated near the surface, highlighting the current limitations of the two approaches.
Intracardiac injection of a capsid-modified Ad5/35 results in decreased heart toxicity when compared to standard Ad5
Toivonen Raine,Koskenvuo Juha,Merentie Mari,S?derstr?m Mirva
Virology Journal , 2012, DOI: 10.1186/1743-422x-9-296
Abstract: Background Clinical gene therapy trials for cardiovascular diseases have demonstrated the crucial role of efficient gene delivery and transfection technologies in achieving clinically relevant results. We hypothesized that the use of tropism-modified adenoviruses would improve transduction efficacy and to this end we analyzed the transduction efficiency and toxicity of standard Ad5 and tropism-modified Ad5/35 in combination with ultrasound-guided intramyocardial gene delivery. Methods Ultrasound-guided intracardiac injections were used to deliver 1 × 1010 pfu/ml Ad5-lacZ and Ad5/35-lacZ vectors into mouse left ventricle wall. Since Ad5/35 uses human CD46 as its primary receptor, we used transgenic hCD46Ge mice expressing human CD46 at levels comparable to man. Mice were sacrificed 6 or 14 days post-injection and immunohistochemistry and X-gal staining were used to detect transgene and viral receptor expression. Virus-induced cardiac toxicity was evaluated by a pathologist. Results The intramyocardial injection was well tolerated and both Ad5-lacZ and Ad5/35-lacZ were able to give robust transgene expression after a single injection. Interestingly, while Ad5-lacZ was able to generate greater transgene expression than Ad5/35-lacZ, it also evoked more severe tissue damage with large areas of interstitial inflammatory cell infiltration and myocyte necrosis. Conclusions Ultrasound-guided intramyocardial injection is an effective and safe way to deliver vectors to the heart. The observed severe tissue damage of Ad5-lacZ greatly undermines the efficient transgene expression and suggests that Ad5/35 capsid modification can result in safer adenoviral vectors for cardiovascular gene therapy, although at the cost of some vector transduction efficacy.
The effect of structural changes on magnetic permeability of amorphous powder Ni80Co20
Mari?i? A.,Spasojevi? M.,Arnaut S.,Mini? D.
Science of Sintering , 2008, DOI: 10.2298/sos0803303m
Abstract: The structural changes of Ni80Co20 amorphous powder were tested during heating. The alloy was obtained by electrolysis from ammonia solution sulfate of cobalt and nickel on the titanium cathode. The differential scanning calorimetry (DSC) method was used to detect that the crystallization process of powder occurred in two stages with crystallization peaks temperatures of the first stage at 690 K and of the second stage at 790 K. The effect of structural relaxation and crystallization of powder on magnetic properties was predicted by measurement of the relative magnetic permeability change in isothermal and nonisothermal conditions. On the basis of the time change of relative magnetic permeability at a defined temperature in the temperature range of the first and second crystallization peak on the thermogram, the kinetics of crystallization was defined. It was predicted, that in the initial time interval, in the range of the first crystallization peak, the rate of crystallization is determined by the rate of nucleation of the amorphous part of the powder. However, in the second time interval, the crystallization rate is determined by the rate of diffusion. In the range of the second peak, in the beginning the rate of crystal growth is determined by activation energy of the atom pass from smaller to bigger crystal grain. In second time interval, the rate of crystal grain growth is determined by the diffusion rate of atoms to the location of integration into bigger crystal grains. For all processes which determine the rate of crystallization in temperature ranges of both crystallization peaks, the Arrhenius temperature dependence of rate for those processes is obtained. The relative magnetic permeability of crystallized powder at 873 K, is smaller for about 30 % than the relative magnetic permeability of fresh powder at room temperature. However, structurally relaxed powder at 573 K has an about 22 % larger magnetic permeability than the same fresh powder at room temperature.
Correlation between the crystallization process and change in electron density of states in amorphous powder of the Ni80Co20 alloy
Ran?i? S.,Mari?i? A.,Rafailovi? L.,Spasojevi? M.
Science of Sintering , 2006, DOI: 10.2298/sos0602139r
Abstract: The method of differential scanning calorimetry (DSC) was employed to examine the crystallization process of amorphous powder of the Ni80Co20 alloy in the temperature interval from room temperature to 1000K. It is shown that the crystallization process of this alloy's powder proceeds in two stages at temperatures T1=690K and T2=790K. The relative changes in the electron density of states in the vicinity of Fermi level were determined from the changes in the slope of the thermo-electromotive force (TEMF) temperature coefficient before and after each stage of crystallization process. The obtained results show that the relative change in the electron density of states is 34.9% after the first crystallization stage and 38.9% after the second one. The changes in the specific electrical resistance of the pressed powder as a function of temperature are fully correlated with the change in the electron density of states and results of the DSC method. The observed rapid decrease in the specific electrical resistance after each crystallization stage is caused by the increase of the mean free electron path and increase in the electron density of states.
The Cosmic Ray p+He energy spectrum in the 3-3000 TeV energy range measured by ARGO-YBJ
S. M. Mari,P. Montini,for the ARGO-YBJ Collaboration
Physics , 2015,
Abstract: The ARGO-YBJ experiment is a full coverage air shower detector operated at the Yangbajing International Cosmic Ray Observatory. The detector has been in stable data taking in its full configuration since November 2007 to February 2013. The high altitude and the high segmentation and spacetime resolution offer the possibility to explore the cosmic ray energy spectrum in a very wide range, from a few TeV up to the PeV region. The high segmentation allows a detailed measurement of the lateral distribution, which can be used in order to discriminate showers produced by light and heavy elements. In this work we present the measurement of the cosmic ray light component spectrum in the energy range 3-3000 TeV. The analysis has been carried out by using a two-dimensional unfolding method based on the Bayes' theorem.
Performance of RPCs operated at the YangBaJing Laboratory
ARGO-YBJ Collaboration,:,presented by S. M. Mari
Physics , 1999,
Abstract: The ARGO-YBJ experiment will be installed at YangBaJing Cosmic Ray Laboratory (Tibet, P.R. China), 4300 m a.s.l. . It consists of a full coverage of about 10^4 m^2 realized with RPC chambers. A small carpet of about 50 m^2 has been operated at YangBaJing in order to check the RPC performance in these high altitude conditions. Results concerning efficiency and time resolution are reported.
DARU : Journal of Pharmaceutical Sciences , 1999,
Abstract: In this prospective, randomized study, in the general intensive care unit at Shanatee teaching hospital, we evaluated twenty patients, mean age 52+18 years and mean acute physiology and chronic health evaluation II score of 20±8, who were experiencing atrial tachyarrhythmias for more than 1 hour. After correction of their plasma potassium concentration to more than 4.0 mmof/1, patients were randomized to receive either 40 mg/kg magnesium sulfate bolus followed by 30 mg/kg/hr or 5mg/kg amiodarone bolus and 10 mg/kg/24hr infusion. Therapeutic end point was conversion to sinus rhythm over 24 hours. By logistic regression, the probability of conversion to sinus rhythm was significantly better for magnesium than for amiodarone at time 0-4 (0.6 vs.0.4), 12 (0.72 vs 0.45), and 24 (0.72vs.0.45) hours. In patients not converting to sinus rhythm, a significant decrease in ventricular response rate occurred at time zero to 0.5 hour (mean decrease 22 beats/min, P=0.0001), but there was no specific treatment effect between the magnesium and the amiodarone groups. Magnesium sulfate is superior to amiodarone in the conversion of acute atrial tachyarrhythmias, while initial slowing of ventricular response rate in non-converters appears equally efficacious with both agents.
Effect of triiodothyronine on the maxilla and masseter muscles of the rat stomatognathic system
Mariúba, M.V.;Goulart-Silva, F.;Bordin, S.;Nunes, M.T.;
Brazilian Journal of Medical and Biological Research , 2011, DOI: 10.1590/S0100-879X2011007500063
Abstract: the maxilla and masseter muscles are components of the stomatognathic system involved in chewing, which is frequently affected by physical forces such as gravity, and by dental, orthodontic and orthopedic procedures. thyroid hormones (th) are known to regulate the expression of genes that control bone mass and the oxidative properties of muscles; however, little is known about the effects of th on the stomatognathic system. this study investigated this issue by evaluating: i) osteoprotegerin (opg) and osteopontine (opn) mrna expression in the maxilla and ii) myoglobin (mb) mrna and protein expression, as well as fiber composition of the masseter. male wistar rats (~250 g) were divided into thyroidectomized (tx) and sham-operated (so) groups (n = 24/group) treated with t3 or saline (0.9%) for 15 days. thyroidectomy increased opg (~40%) and opn (~75%) mrna expression, while t3 treatment reduced opg (~40%) and opn (~75%) in tx, and both (~50%) in so rats. masseter mb mrna expression and fiber type composition remained unchanged, despite the induction of hypo- and hyperthyroidism. however, mb content was decreased in tx rats even after t3 treatment. since opg and opn are key proteins involved in the osteoclastogenesis inhibition and bone mineralization, respectively, and that mb functions as a muscle store of o2 allowing muscles to be more resistant to fatigue, the present data indicate that th also interfere with maxilla remodeling and the oxidative properties of the masseter, influencing the function of the stomatognathic system, which may require attention during dental, orthodontic and orthopedic procedures in patients with thyroid diseases.
The validity and 4-year test-retest reliability of the Brazilian version of the Eating Attitudes Test-26
Nunes, M.A.;Camey, S.;Olinto, M.T.A.;Mari, J.J.;
Brazilian Journal of Medical and Biological Research , 2005, DOI: 10.1590/S0100-879X2005001100013
Abstract: in a cross-sectional study conducted four years ago to assess the validity of the brazilian version of the eating attitudes test-26 (eat-26) for the identification of abnormal eating behaviors in a population of young females in southern brazil, 56 women presented abnormal eating behavior as indicated by the eat-26 and the edinburgh bulimic investigation test. they were each matched for age and neighborhood to two normal controls (n = 112) and were re-assessed four years later with the two screening questionnaires plus the composite international diagnostic interview (cidi). the eat results were then compared to diagnoses originating from the cidi. to evaluate the temporal stability of the two screening questionnaires, a test-retest design was applied to estimate kappa coefficients for individual items. given the prevalence of eating disorders of 6.2%, the cidi psychiatry interview was applied to 161 women. of these, 0.6% exhibited anorexia nervosa and 5.6%, bulimia nervosa (10 positive cases). the validity coefficients of the eat were: 40% sensitivity, 84% specificity, and 14% positive predictive value. cronbach's coefficient was 0.75. for each eat item, the kappa index was not higher than 0.344 and the correlation coefficient was lower than 0.488. we conclude that the eat-26 exhibited low validity coefficients for sensitivity and positive predictive value, and showed a poor temporal stability. it is reasonable to assume that these results were not influenced by the low prevalence of eating disorders in the community. thus, the results cast doubts on the ability of the eat-26 test to identify cases of abnormal eating behaviors in this population.
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