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匹配条件: “S. J. Takate” ,找到相关结果约548343条。
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INHIBITION OF SPLEEN TYROSINE KINASE (SYK) IN SILICO BY THIAZOLE DERIVATIVES
S. J. Takate,S. S. Jadhav,Gaikar Rajendra Babasaheb,A. S. Burungale
International Research Journal of Pharmacy , 2013,
Abstract: Variously substituted thiazoles derivatives showed wide range of biological activity. The computational evaluation of the substituted thiazole containing derivatives as SYK inhibitor was performed. By using online servers applying different approaches the Tyrosine protein kinase (SYK) was identified as target for variously substituted thiazole containing derivatives. The molecular descriptor analysis was performed to identify drug likeness of the thiazole derivatives by Lipinski’s rule of five. Then docking analysis was performed by PyRx software using AutoDock vina 4. Derivatives showed comparatively significant binding energy value followed Lipinski’s rule. The study provides the base for further in vitro and in vivo study of substituted azoles containing compounds as SYK inhibitor and proposed drug to be used for allergic diseases.
Induction of synovial apoptosis by gene transfer and peptide mediated protein transduction
TJ Oligino, Q Yao, S Wang, JC Glorioso, CH Evans, SC Ghivizzani, R Takate, R Barton, PD Robbins
Arthritis Research & Therapy , 2001, DOI: 10.1186/ar353
Abstract:
Hepato-Protective activity of the aqueous extract of launaea intybacea (Jacq) Beauv against carbon tetrachloride-induced hepatic injury in Albino Rats
Takate.S.B,Pokharkar.R.D,Chopade.V.V,Gite.V.N
Journal of Pharmaceutical Science and Technology , 2010,
Abstract: The present study was conducted to evaluate the hepato-protective activity of aqueous extract of aerial parts of launaea intybacea are evaluated in carbon tetrachloride -induced hepatic injury in albino rats. Silymarin (200mg/kg) was given as reference standard. The hepatic injury of CCl 4 and the hepatoprotective effect of aqueous extract of launaea intybacea were estimated their liver function tests. The aqueous extract of aerial parts of launaea intybacea have shown very significant hepatoprotection against carbon tetrachloride -induced hepatic injury in albino rats in reducing serum total bilirubin, SALP, SGPT , SGOT levels and liver homogenates LPO, SOD,CAT, GPX, GST and GSH levels.
On the Origin of the Common Bean (Phaseolus vulgaris L.)  [PDF]
Andrés J. Cortés
American Journal of Plant Sciences (AJPS) , 2013, DOI: 10.4236/ajps.2013.410248
Abstract:

Phylogeographic methods provide the tools to accurately access the geographic origin and diversification of crop species. In the present commentary, I urge the common bean community to face those methods and a tree-thinking mentality with regards to the long standing debate of the origin of common bean. Such efforts will ultimately bring back interest into wild bean studies and reinforce the uniqueness of this species as a system to study diversification, domestication and adaptive processes across the two most diverse hotspots in the world.

Fatal Pulmonary Mycobacterium Celatum Infection in an Immunocompetent Patient. An Eight-Year Follow-Up of the First Case, a Review of the Literature and a Report of Beta-2 Microglobulin as a Potential Indicator of Disease Severity  [PDF]
S. Rustscheff, J. Darelid
Advances in Infectious Diseases (AID) , 2013, DOI: 10.4236/aid.2013.34038
Abstract:

Setting: Swedish county hospital. Objective: Pulmonary M. celatum infection has been previously described only twice in an immunocompetent individual with no pre-existing chest disease. We describe the first Swedish case report of unusual drug-related complications and review the literature. Discussion: Atypical mycobacteriosis is often difficult to treat. We describe a fatal case of m celatum pneumonia in a previously healthy patient, unusual side effects encountered during her treatment and also the report of the utility of beta-2-microglobulin as a way to measure disease activity in mycobacterial infections. Conclusions: M. celatum may cause fatal pneumonia in previously healthy individuals. Treating the disease may be fraught with difficulty and there is a risk for very severe side effects, all of which must be weighed before taking the decision to treat this disease.

 

Computational Analysis of Gas Phase Mixing in a Co-Fired Burner with Two Different Designs  [PDF]
J. Iqbal, S. Gao
Journal of Power and Energy Engineering (JPEE) , 2015, DOI: 10.4236/jpee.2015.34025
Abstract:

The study of swirling jet combustor for biomass coal co-firing is of great interest for energy industry. The biomass co-firing can serve as a NOx reduction method as well as the better use of renewable energy source. Large eddy simulation (LES) and RANS modelling have been performed with two different burner designs. Usually pulverized coal-biomass mixture enters the furnace along with primary air through primary pipe, and the secondary pipe provides necessary air and mixing for combustion. The improved model has three passages including primary, secondary and middle passage for swirling. The simulations on two geometries have been compared, and the aim is to design a better and improved burner model for better pre-combustion mixing in the biomass co- fired furnace. The results from two-way and three-way geometry have been compared with each other as well as with the results from the furnace model used by Apte and Mahesh [8].

Correlation between Hardness, Structure and Electrochemical Performance of an AlZnMnMg Alloy  [PDF]
S. Valdez, B. Campillo, J. J. Islas
Engineering (ENG) , 2012, DOI: 10.4236/eng.2012.49075
Abstract: In this work the structural changes induced by aged treatment have shown a connection with differences of hardness and electrochemical performance. Al-base alloys have been investigated by means of Vickers hardness, X-ray diffraction, scanning electron and short-term electrochemical test. X-ray diffraction result reveals the formation of (MgZn)49Al32 phase for two conditions, the first one is when the magnesium content is upper to 5.49% in as-cast condition and the second one after the thermal treatment carried out at 450?C for 5 h. In addition, the hardness and electrochemical performance has been influenced by the presence and quantity of the (MgZn)49Al32 phase. The addition of magnesium alloying modifies the microstructure, increases the content of (MgZn)49Al32 phase and provides a localized corrosion which conduced to the breakdown of the oxide film (?-Al2O3) formed on the Al alloy surface.
Phase Transformation in the Ball Milled Fe31Co31Nb8B30 Powders  [PDF]
S. Azzaza, S. Alleg, J. J. Su?ol
Advances in Materials Physics and Chemistry (AMPC) , 2013, DOI: 10.4236/ampc.2013.31A011
Abstract:

The mechanical alloying process has been used to prepare nanostructured Fe31Co31Nb8B30 (wt%) alloy from pure elemental powders in a high energy planetary ball-mill Retsch PM400. Microstructural changes, phase transformation and kinetics were studied by X-ray diffraction, differential scanning calorimetry and M?ssbauer spectrometry. The crystallite size reduction down the nanometer scale (~8 nm) is accompanied by the introduction of internal strains up to 1.8% (root-mean square strain, rms). Further milling time leads to the formation of partially paramagnetic amorphous structure in which bcc FeCo nanograins are embedded. The kinetics of amorphization during the milling process can be described by two regimes characterized by different values of the Avrami parameter n1 = 1.41 and n2 = 0.34. The excess enthalpy due to the high density of defects is released at temperatures below 300°C. The glass transition temperature increases with increasing milling time.

Evaluation of the Safety and Efficacy of a Novel Home-Use Device with Diode Arrays and Contact Heating for Facial Skin Rejuvenation  [PDF]
J. Shaoul, R. S. Mulholland
Journal of Cosmetics, Dermatological Sciences and Applications (JCDSA) , 2011, DOI: 10.4236/jcdsa.2011.14018
Abstract: Background: Phototherapy of photoaged skin has been attempted by lasers or intense pulsed light at the visible or near-infrared part of the spectrum. The use of red Light-Emitting Diodes (LED) delivering a low dose energy to the skin has been described for office and home use. Methods: In the present study, a portable home-use device is presented that combines fractional non-thermal red LED with mild contact heating. Forty subjects aged 30 - 55 presenting with facial lax skin, large pores, fine lines, wrinkles and brown pigmentation received 8 bi-weekly treatments for 4 weeks, using the Silk’n Reju/FaceFX device (Home Skinovations, Yokneam, Israel). Skin condition was evaluated before and 1, 2, and 3 months following the last treatment session. Grading of outcome was done according to an independent blinded evaluator and patient satisfaction. Results: Facial skin improvement of wrinkling and skin texture were apparent immediately and scored clinically after 3 months as excellent and considerable by >90% of patients. Pigmentation improvement was less apparent. Overall facial skin improvement was noted by 77% of patients. Conclusions: The combination of fractional red LED and mild contact heating, using an at home portable device, proved to be safe and effective method to improve the quality of photoaged skin.
Modelling of Fatigue-Type Seismic Damage for Nuclear Power Plants  [PDF]
Tamás János Katona
Open Journal of Safety Science and Technology (OJSST) , 2012, DOI: 10.4236/ojsst.2012.22006
Abstract: Assessment of seismic safety of the nuclear power plants requires knowledge of plant fragilities. In the paper, preliminary analysis is made on use of the cumulative absolute velocity in modelling of fatiguetype seismic damage. The dependence of the cumulative absolute velocity on the strong motion parameters is analysed. It is demonstrated that the cumulative absolute velocity is an appropriate damage indicator for fatigue failure mode. Failure criteria are defined in terms of cumulative absolute velocity using various fatigue failure theories.
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