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Search Results: 1 - 10 of 326216 matches for " S. Ikeda "
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Procalcitonin level as a marker of severe sepsis and septic shock patients who required polymyxin-B immobilized fiber with direct hemoperfusion
T Ikeda, K Ikeda, S Suda
Critical Care , 2012, DOI: 10.1186/cc11692
Abstract: We evaluated the levels of procalcitonin (PCT) and markers of sepsis (IL-6, IL-8, IL-1ra and PAI-1) in 159 patients who had severe sepsis and septic shock. Before starting the polymyxin-B immobilized fiber with direct hemoperfusion (PMX-DHP) treatment, patients were divided into three groups according to their PCT levels (L group: 0.5 10.0 ng/ml).Sixty-two percent of the patients showed high PCT levels (>10.0 ng/ml). The APACHE II score and Sequential Organ Failure Assessment score tended to be high in the H group, but there was no significant difference among the groups. The survival rate declined with high PCT levels. The levels of inflammatory (IL-6 and IL-8) and anti-inflammatory (IL-1ra) cytokines tended to be high in the H group, but there was no statistically significant difference among the groups. On the other hand, the PAI-1 level was significantly increased in the H group (498 ± 499 ng/ml) compared with the L group (157 ± 103 ng/ml) and M group (311 ± 319 ng/ml).Sixty-two per cent of patients who required PMX-DHP treatment had high PCT levels. PCT might be a mediator of sepsis and sepsis markers. PCT can potentially affect sepsis-related markers.
Empirical analysis of Japanese flood risk acceptability within multi-risk context
G. Zhai,S. Ikeda
Natural Hazards and Earth System Sciences (NHESS) & Discussions (NHESSD) , 2008,
Abstract: This paper establishes a framework of a multi-risk context for analyzing acceptable risk beyond single-risk context and empirically examines how other risks affects flood risk acceptability based on Rational Action Paradigm (RAP) by using a survey conducted in the Toki-Shonai River region of Japan. The main findings obtained by cross-sectional analysis and covariance structure analysis within a multi-risk context can be summarized as follows. – Nearly half of the respondents accept no flood risk at all. – Flood risk acceptability depends on not only on the factors of flood risk itself (e.g. frequency, consequence, and characteristics), but also other types of risks involved in our technological society. – Flood risk acceptability is associated with a multi-risk context. Whether a risk is accepted depends on its perceived importance relative to others as well as the balance of its cost and benefit. Providing budget information and ensuring preparedness for flood risk may also affect the acceptability.
O(a^2) improvement of the overlap-Dirac operator
H. Ikeda,S. Hashimoto
Physics , 2009,
Abstract: We construct an $O(a^2)$-improved overlap-Dirac operator by designing an improved overlap kernel, based on the Symanzik improvement program. Field rotation terms are also identified to improve off-shell amplitudes for both massless and massive fermions. We check the free dispersion relation and propagator, and show that improved results become to close to the continuum ones at low momentum region. We test the effect of improvement on the full-QCD gauge configuration and find that the relativistic dispersion relation is satisfied within a few percent error up to $m_qa \approx 0.5$.
Dynamic Characteristics of Selemion CMV-Based IPMC Actuators in High Humidity Environment  [PDF]
H. Ngetha, M. Sasaki, H. Tamagawa, S. Ito, K. Ikeda
Journal of Computer and Communications (JCC) , 2014, DOI: 10.4236/jcc.2014.211006

Electrically-induced bending of Selemion IPMC is caused by the charge induced into the IPMC. This induced charge quantity is susceptible to the absolute humidity of environment. There are two types of charges, the charge causing bending and the rest of charge that causes no bending. In the high humidity environments, where absolute humidity is above 10 gm-3, the quantity of charge causing no bending accounts for the large part of whole charge induced into the Selemion IPMC, while quantity of such charge is negligibly small at the absolute humidity of less than 10 gm-3. Estimating the quantity of those two types of charges individually, we successively analyzed the bending stability of Selemion IPMC at the absolute humidity above 10 gm-3. Consequently, we deduced the following conclusions. 1) There exists a large time delay in the current in response to the voltage input, 2) Current is highly dumping, and 3) Bending behavior is marginally stable under the input of any frequency.

Defects in Actin Dynamics Lead to an Autoinflammatory Condition through the Upregulation of CXCL5
Angela M. Verdoni, Richard S. Smith, Akihiro Ikeda, Sakae Ikeda
PLOS ONE , 2008, DOI: 10.1371/journal.pone.0002701
Abstract: Background Destrin (DSTN) is a member of the ADF/cofilin family of proteins and is an important regulator of actin dynamics. The primary function of destrin is to depolymerize filamentous actin into its monomeric form and promote filament severing. While progress has been made in understanding the biochemical functions of the ADF/cofilin proteins, the study of an animal model for cells deficient for DSTN provides an opportunity to investigate the physiological processes regulated by proper actin dynamics in vivo. A spontaneous mouse mutant, corneal disease 1(corn1), is deficient for DSTN, which causes epithelial hyperproliferation and neovascularization in the cornea. Dstncorn1 mice exhibit an actin dynamics defect in the cornea as evidenced by the formation of actin stress fibers in the epithelial cells. Previously, we observed a significant infiltration of leukocytes into the cornea of Dstncorn1 mice as well as the upregulation of proinflammatory molecules. In this study, we sought to characterize this inflammatory condition and explore the physiological mechanism through which a loss of Dstn function leads to inflammation. Methodology/Principal Findings Through immunofluorescent analyses, we observed a significant recruitment of neutrophils and macrophages to the Dstncorn1 cornea, demonstrating that the innate immune system is spontaneously activated in this mutant. The inflammatory chemokine, CXCL5, was ectopically expressed in the corneal epithelial cells of Dstncorn1 mice, and targeting of the receptor for this chemokine inhibited neutrophil recruitment. An inflammatory reaction was not observed in the cornea of allelic mutant strain, Dstncorn1-2J, which has a milder defect in actin dynamics in the corneal epithelial cells. Conclusions/Significance This study shows that severe defects in actin dynamics lead to an autoinflammatory condition that is mediated by the expression of CXC chemokines.
New sepsis-related marker: endotoxin activity assay
T Ikeda, K Ikeda, H Taniuchi, M Hiramatsu, S Suda
Critical Care , 2010, DOI: 10.1186/cc9115
Abstract: The EAA was studied in a cohort of 153 septic patients admitted to the ICU. At the same time, IL-6 (chemiluminescent enzyme immunoassay), C-reactive protein (CRP), procalcitonin (PCT, chemiluminescent enzyme immunoassay) and plasminogen activator inhibitor-1 (PAI-1, latex photometric immunoassay) were measured within 24 hours after ICU admission. The patients were divided into the following three groups: L group: EAA < 0.4, M group: 0.4 ≤ EAA < 0.6, H group: 0.6 ≤ EAA. Nonrepeated-measures ANOVA was used to compare over three groups or conditions. Statistical significance was assumed for values of P < 0.05. Normally distributed data are presented as mean ± SD, and abnormally distributed data are presented as median values.Of the 153 patients, the L group contained 61 patients, M group 41 patients, and H group 51 patients, respectively. On the day of ICU admission, the rate of EAA ≥0.4 was 60.1% (MEDIC study: 57.2%). APACHE score in the L group was 21.0 ± 7.9, M group 24.8 ± 8.4, H group 26.4 ± 8.9, and SOFA score in the L group was 8.2 ± 4.3, M group 8.9 ± 4.1, H group 9.5 ± 4.3, respectively. There was no statistically significant difference among the groups. The median value of PCT in the L group was 1.1 ng/ml, M group 5.9 ng/ml, H group 8.5 ng/ml, respectively. PCT values of the M and H groups were significantly higher than those of the L group. Median IL-6 level of the H group was significantly higher than that of the L group (H group: 2,635 pg/ml, L group: 177 pg/ml).EAA has no significant correlation with other sepsis-related markers, but may be associated with body insults (inflammation or infection).
Sentinel Lymph Node Biopsy as Guidance for Lateral Neck Dissection in Patients with Papillary Thyroid Carcinoma  [PDF]
Yoshifumi Ikeda
Surgical Science (SS) , 2011, DOI: 10.4236/ss.2011.22012
Abstract: Introduction: The surgical management of lateral lymph nodes in differentiated thyroid carcinoma is controversies. Therefore, we analyzed whether sentinel lymph nodes (SLN) biopsy of the first draining nodes in the jugulo-carotid chain is an accurate technique to select patients with true-positive but nonpalpable lymph nodes for selective lateral node dissection. Materials and Methods: From January 2009 to December 2009, 12 patients with solitary papillary carcinoma measuring 2 cm by ultrasonography were included in this study. After the thyroid gland was exposed to avoid injuring the lateral thyroid lymphatic connection, approximately 0.2 ml of 5mg/ml indocyanine green was injected into the parenchyma of upper and lower thyroid gland. Some stained lymph nodes in the jugulo-carotid chain could be identified following the stained lymphatic duct and dissected as the SLN. After that, thyroidectomy with modified neck dissection was performed. Results: The mean tumor size was 22.1 ± 4.6 mm. Identification and biopsy of stained SLN in the ipsilateral jugulo-carotid chain was successful in all 12 cases. In 6 cases, histopathological analysis of SLNs revealed metastases of the papillary thyroid carcinoma. Among them, 2 cases had additional metastatic lymph nodes in the ipsilateral compartment. Of the 6 patients who had negative lymph node metastasis (LNM) in SLNs, all patients had negative LNM in the ipsilateral compartment. Conclusions: The method may be helpful in the detection of true-positive but nonpalpable lymph nodes and may support a decision to perform a selective lateral node dissection in patients with papillary thyroid carcinoma.
Time-reversal Characteristics of Quantum Normal Diffusion
Hiroaki S. Yamada,Kensuke S. Ikeda
Physics , 2011, DOI: 10.1140/epjb/e2011-20811-8
Abstract: This paper concerns with the time-reversal characteristics of intrinsic normal diffusion in quantum systems. Time-reversible properties are quantified by the time-reversal test; the system evolved in the forward direction for a certain period is time-reversed for the same period after applying a small perturbation at the reversal time, and the separation between the time-reversed perturbed and unperturbed states is measured as a function of perturbation strength, which characterizes sensitivity of the time reversed system to the perturbation and is called the time-reversal characteristic. Time-reversal characteristics are investigated for various quantum systems, namely, classically chaotic quantum systems and disordered systems including various stochastic diffusion systems. When the system is normally diffusive, there exists a fundamental quantum unit of perturbation, and all the models exhibit a universal scaling behavior in the time-reversal dynamics as well as in the time-reversal characteristics, which leads us to a basic understanding on the nature of quantum irreversibility.
Universal Irreversibility of Normal Quantum Diffusion
Hiroaki S. Yamada,Kensuke S. Ikeda
Physics , 2010, DOI: 10.1103/PhysRevE.82.060102
Abstract: Time-reversibility measured by the deviation of the perturbed time-reversed motion from the unperturbed one is examined for normal quantum diffusion exhibited by four classes of quantum maps with contrastive physical nature. Irrespective of the systems, there exist a universal minimal quantum threshold above which the system completely loses the past memory, and the time-reversed dynamics as well as the time-reversal characteristics asymptotically trace universal curves independent of the details of the systems.
Analyticity of Quantum States in One-Dimensional Tight-Binding Model
Hiroaki S. Yamada,Kensuke S. Ikeda
Physics , 2013, DOI: 10.1140/epjb/e2014-50210-6
Abstract: Analytical complexity of quantum wavefunction whose argument is extended into the complex plane provides an important information about the potentiality of manifesting complex quantum dynamics such as time-irreversibility, dissipation and so on. We examine Pade approximation and some complementary methods to investigate the complex-analytical properties of some complex quantum states such as impurity states, Anderson-localized states and localized states of Harper model. The impurity states can be characterized by simple poles of the Pade approximation, and the localized states of Anderson model and Harper model can be characterized by an accumulation of poles and zeros of the Pade approximated function along a critical border, which implies a natural boundary (NB). A complementary method based on shifting the expansion-center is used to confirm the existence of the NB numerically, and it is strongly suggested that the both Anderson-localized state and localized states of Harper model have NBs in the complex extension. Moreover, we discuss an interesting relationship between our research and the natural boundary problem of the potential function whose close connection to the localization problem was discovered quite recently by some mathematicians. In addition, we also examine the usefulness of the Pade approximation for numerically predicting the existence of NB by means of two typical examples, lacunary power series and random power series.
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