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Search Results: 1 - 10 of 325576 matches for " S. Griffiths "
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The evaluation of renal ischaemic damage: the value of CD10 monoclonal antibody staining and of biochemical assessments of tissue viability
S Tagboto, A Paul Griffiths
BMC Clinical Pathology , 2007, DOI: 10.1186/1472-6890-7-5
Abstract: To do this, freshly isolated rabbit kidney tissue was subjected to warm (37°C) or cold (1°C) ischaemia for 20 hours. Following this, the tissue was stained using Haematoxylin and Eosin (H+E), Periodic Schiff reagent (PAS) and the novel monoclonal antibody CD10 stain. Additionally, ischaemic damage to the kidneys was assessed by biochemical tests of tissue viability using formazan-based colorimetry.CD 10 antibody intensely stained the brush border of control kidney tissue with mild or no cytoplasmic staining. Cell injury was accompanied by a redistribution of CD10 into the lumen and cell cytoplasm. There was good correlation between a score of histological damage using the CD 10 monoclonal antibody stain and the biochemical assessment of viability. Similarly, a score of histological damage using traditional PAS staining correlated well with that using the CD10 antibody stain.In particular, the biochemical assay and the monoclonal antibody staining techniques were able to demonstrate the efficacy of Soltran (this solution is used cold to preserve freshly isolated human kidneys prior to transplantation) in preserving renal tissue at cold temperatures compared to other randomly selected solutions.We conclude that the techniques described using the CD10 monoclonal antibody stain may be helpful in the diagnosis and assessment of ischaemic renal damage. In addition, biochemical tests of viability may have an important role in routine histopathological work by giving additional information about cellular viability which may have implications on the function of the organ.Renal histopathology is an invaluable clinical tool. It is used to diagnose the cause of dysfunction of native and transplanted kidneys and to offer predictions about the likely course of renal disease. Nevertheless, studies on acute tubular necrosis and other renal diseases have consistently reported that there is often disparity between structural changes in the kidney and function of the organ [1]. This s
Signature sequences in diverse proteins provide evidence for the late divergence of the Order Aquificales
Griffiths,Emma; Gupta,Radhey S.;
International Microbiology , 2004,
Abstract: the aquificales species are presently believed to be the earliest branching lineage within bacteria. however, the branching order of this group in different phylogenetic trees is highly variable and not resolved. in the present work, the phylogenetic placement of aquificales was examined by means of a cladistic approach based on the shared presence or absence of definite signature sequences (consisting of conserved inserts or deletions) in many highly conserved and important proteins, e.g. rna polymerase β (rpob), rna polymerase β′ (rpoc), alanyl-trna synthetase (alars), ctp synthase, inorganic pyrophosphatase (ppase), hsp70 and hsp60. for this purpose, fragments of the above genes that contained the signature regions were cloned from different aquificales species (calderobacterium hydrogenophilum, hydrogenobacter marinus, and thermocrinis ruber) and the sequence data were compared with those available from all other species. the presence in aquificales species of distinctive inserts in hsp70 and hsp60 that are not found in any firmicutes, actinobacteria, or thermotoga-clostridium species excluded them from these groups of bacteria. the shared presence of prominent indels in the rpob (>100 amino acids), rpoc (>100 amino acids) and alars (4 amino acids) proteins, which are only found in the various aquificales species, the chlamydiae, the cfbg (cytophaga-flavobacteria-bacteroides-green sulfur bacteria) group, and proteobacteria, strongly suggests their placement within these groups of bacteria. a specific relationship between proteobacteria and aquificales is suggested by the presence in inorganic pyrophosphatase of a 2-amino-acid insert that is uniquely found in these phyla. however, the aquificales species lacked a number of other protein signatures (e.g. indels in ctp synthase and hsp70) that are characteristic of proteobacteria, indicating that they constitute a distinct phylum related to proteobacteria. these results provide strong and consistent evidence that t
Soliton Solutions with Real Poles in the Alekseev formulation of the Inverse-Scattering method
S. Micciche,J. B. Griffiths
Physics , 1999, DOI: 10.1088/0264-9381/17/1/301
Abstract: A new approach to the inverse-scattering technique of Alekseev is presented which permits real-pole soliton solutions of the Ernst equations to be considered. This is achieved by adopting distinct real poles in the scattering matrix and its inverse. For the case in which the electromagnetic field vanishes, some explicit solutions are given using a Minkowski seed metric. The relation with the corresponding soliton solutions that can be constructed using the Belinskii-Zakharov inverse-scattering technique is determined.
The extensions of gravitational soliton solutions with real poles
J. B. Griffiths,S. Micciche
Physics , 1998, DOI: 10.1023/A:1026638305384
Abstract: We analyse vacuum gravitational "soliton" solutions with real poles in the cosmological context. It is well known that these solutions contain singularities on certain null hypersurfaces. Using a Kasner seed solution, we demonstrate that these may contain thin sheets of null matter or may be simple coordinate singularities, and we describe a number of possible extensions through them.
Estimate for the fractal dimension of the Apollonian gasket in d dimensions
R. S. Farr,E. Griffiths
Physics , 2010, DOI: 10.1103/PhysRevE.81.061403
Abstract: We adapt a recent theory for the random close packing of polydisperse spheres in three dimensions [R. S. Farr and R. D. Groot, J. Chem. Phys. {\bf 131} 244104 (2009)] in order to predict the Hausdorff dimension $d_{A}$ of the Apollonian gasket in dimensions 2 and above. Our approximate results agree with published values in $2$ and $3$ dimensions to within $0.05%$ and $0.6%$ respectively, and we provide predictions for dimensions $4$ to $8$.
Studying the Perturbative Reggeon
S. Griffiths,D. A. Ross
Physics , 1999, DOI: 10.1007/s100529900240
Abstract: We consider the flavour non-singlet Reggeon within the context of perturbative QCD. This consists of ladders built out of ``reggeized'' quarks. We propose a method for the numerical solution of the integro-differential equation for the amplitude describing the exchange of such a Reggeon. The solution is known to have a sharp rise at low values of Bjorken-x when applied to non-singlet quantities in deep-inelastic scattering. We show that when the running of the coupling is taken into account this sharp rise is further enhanced, although the Q^2 dependence is suppressed by the introduction of the running coupling. We also investigate the effects of simulating non-perturbative physics by introducing a constituent mass for the soft quarks and an effective mass for the soft gluons exchanged in the t-channel.
Acute presentation of a solitary caecal diverticulum: a case report
Ewen A Griffiths, Ravindra S Date
Journal of Medical Case Reports , 2007, DOI: 10.1186/1752-1947-1-129
Abstract: A 67 years old man was admitted with a 24 hour history of pain in right iliac fossa. A pre-operative diagnosis of acute appendicitis was made but at operation a 2.5 cm inflamed and gangrenous solitary diverticulum of caecum was found. This was treated by right hemicolectomy as there was the suspicion of underlying malignancy.Caecal diverticulitis, although rare in the Western population, should be considered in the differential diagnosis of patients complaining of right iliac fossa pain. The surgical approach should be tailored to the clinical scenario but may include conservative management, diverticulectomy, limited ileocaecal resection or right hemicoloectomy.Right iliac fossa pain, nausea and vomiting are common symptoms that require acute surgical assessment. The differential diagnosis is vast and includes acute appendicitis, gastroenteritis, ureteric colic, ectopic pregnancy, rupture ovarian cyst, and pelvic inflammatory disease. Solitary caceal diverticulitis is a rare cause of abdominal pain in Western patients and is more common in the Oriental population [1-3]. The symptoms and signs of the disease closely mimic acute appendicitis [1,3,4]. As such the condition is often misdiagnosed and only correctly diagnosed on exploration for suspected acute appendicitis.We describe a patient who was thought to have acute appendicitis pre-operatively, however at operation an inflamed and gangrenous solitary caecal diverticulum was found. We review the literature surrounding the role of pre-operative radiology in this condition and review the controversial surgical management. As the condition is frequently misdiagnosed and often mistreated, our aim is to improve awareness of this condition amongst surgical trainees to ensure it is appropriately treated when encountered unexpectedly.A 67 years old man was admitted with a 24 hour history of pain in right iliac fossa. He was previously healthy and had no significant past medical history. He had no other symptoms. On exami
Thermodynamic Limit for Dipolar Media
S. Banerjee,R. B. Griffiths,M. Widom
Statistics , 2000, DOI: 10.1023/B:JOSS.0000026729.83187.79
Abstract: We prove existence of a shape and boundary condition independent thermodynamic limit for fluids and solids of identical particles with electric or magnetic dipole moments. Our result applies to fluids of hard core particles, to dipolar soft spheres and Stockmayer fluids, to disordered solid composites, and to regular crystal lattices. In addition to their permanent dipole moments, particles may further polarize each other. Classical and quantum models are treated. Shape independence depends on the reduction in free energy accomplished by domain formation, so our proof applies only in the case of zero applied field. Existence of a thermodynamic limit implies texture formation in spontaneously magnetized liquids and disordered solids analogous to domain formation in crystalline solids.
Thermodynamic Limit for Polydisperse Fluids
S. Banerjee,R. B. Griffiths,M. Widom
Statistics , 2000,
Abstract: We examine the thermodynamic limit of fluids of hard core particles that are polydisperse in size and shape. In addition, particles may interact magnetically. Free energy of such systems is a random variable because it depends on the choice of particles. We prove that the thermodynamic limit exists with probability 1, and is independent of the choice of particles. Our proof applies to polydisperse hard-sphere fluids, colloids and ferrofluids. The existence of a thermodynamic limit implies system shape and size independence of thermodynamic properties of a system.
Unconditional Positive Self-Regard (UPSR) and Self-Compassion, the Internal Consistency and Convergent/Divergent Validity of Patterson & Joseph’s UPSR Scale  [PDF]
Laura Jayne Griffiths, Christopher Alan Griffiths
Open Journal of Medical Psychology (OJMP) , 2013, DOI: 10.4236/ojmp.2013.24026
Abstract: Objectives: The purpose of this study is to test the psychometric properties and validity of the unconditional positive self-regard scale (UPSR) and its two subscales developed by Patterson & Joseph (2006). It also aims to examine and compare the concepts of UPSR with self-compassion and its relation to mental well-being. Design: Correlation survey design validations of the UPSR scale (Patterson & Joseph, 2006). Methods: The validation was conducted using an undergraduate and postgraduate student opportunity sample, n = 179. Internal consistency was assessed using Cronbach’s coefficient alpha and inter-item correlations. Convergent and divergent validity was explored in terms of correlations with self-compassion, depression (PHQ-9) and anxiety (GAD-7) scales. Results: There was good internal consistency for both the UPSR scale and the self-regard subscale and somewhat questionable internal consistency for the conditionality subscale. Overall the scale appears to be relatively consistent, supporting the previous findings reported by Patterson & Joseph (2006). The results supported the hypothesis that UPSR is positively correlated with a measure of self-compassion and negatively correlated with measures of depression (PHQ-9) and anxiety (GAD-7). Conclusions: The UPSR scale is a valid measure of the person-centred concept of unconditional positive self-regard. This supports the potential use of the UPSR scale for evaluating therapeutic change for client-centred practitioners through the use of this non-medicalized tool.
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