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Search Results: 1 - 10 of 325236 matches for " S. Gazzana "
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Hipertens?o pulmonar: relato de seis casos e atualiza??o do tema
BARRETO, SéRGIO SALDANHA MENNA;GAZZANA, MARCELO BASSO;
Jornal de Pneumologia , 2000, DOI: 10.1590/S0102-35862000000600009
Abstract: pulmonary hypertension occurs when the pressure of the pulmonary artery is disproportionally high for a certain level of pulmonary blood flow. values of mean pulmonary artery pressure of more than 25 mm hg at rest or 30 mm hg during exercise allow the diagnosis of pulmonary hypertension. sustained or chronic pulmonary hypertension may be secondary to known diseases, mainly to those of cardiac or pulmonary nature, or may be a primary abnormality of the pulmonary circulation, with or without identification of associated conditions. advances in the knowledge of the mechanisms of vasoconstriction and vascular remodeling have brought better prospects for the treatment of the disease. the correct use of vasodilators and anticoagulants, the new vasodilators, as epoprostenol and its analogs, and surgical techniques have increased the survival of many patients. pneumologists can view cases of pulmonary hypertension as complications of pulmonary diseases or as a result of dyspnea investigation. despite its etiology, pulmonary hypertension represents a clear abnormality that affects the right ventricle and can be potentially fatal to patients. image methods have made the diagnosis of pulmonary hypertension more accessible and non-invasive. six cases of patients with pulmonary hypertension of different causes are presented and discussed. in conclusion, according to new concepts, idiopathic pulmonary hypertension is no longer an irreversible condition, and the identification of associated conditions with potential treatments can be favorable in the management of the patients with pulmonary hypertension.
Hipertens o pulmonar: relato de seis casos e atualiza o do tema
BARRETO SéRGIO SALDANHA MENNA,GAZZANA MARCELO BASSO
Jornal de Pneumologia , 2000,
Abstract: Hipertens o arterial pulmonar (HP) ocorre quando os níveis de press o da artéria pulmonar s o desproporcionalmente elevados para um dado nível de fluxo sanguíneo pulmonar. Valores de press o arterial pulmonar média superiores a 25mmHg em repouso ou 30mmHg em exercício permitem o diagnóstico de HP. A HP sustentada ou cr nica pode ser secundária a doen as conhecidas, principalmente de natureza cardíaca ou pulmonar, ou ser uma anormalidade primária da circula o pulmonar, com ou sem identifica o de condi es associadas. Pneumologistas podem enfrentar casos de HP como conseqüência de pneumopatias ou como achados de investiga es de dispnéia. Independente de sua etiologia, a HP representa uma anormalidade definida que afeta o ventrículo direito e tem conseqüências potencialmente fatais para os pacientes acometidos. Métodos de imagens têm tornado o diagnóstico de HP mais acessível e n o invasivo. Avan os no entendimento dos mecanismos de vasoconstri o e remodelamento vascular têm aberto melhores perspectivas para o tratamento. O uso criterioso de vasodilatadores tradicionais e de anticoagulantes, o surgimento de novos vasodilatadores, como o epoprostenol e seus análogos, e as técnicas cirúrgicas têm melhorado a sobrevida de parcela significativa de pacientes. Seis casos de pacientes com HP, de etiologias variadas, s o apresentados e suas abordagens discutidas. Conclui-se pelo conceito emergente de que a HP idiopática nem sempre é uma condi o irreversível e que a identifica o de condi es associadas potencialmente tratáveis exerce efeito favorável no manejo de pacientes com HP.
Fibrose pulmonar idiopática simultanea a enfisema em pacientes tabagistas
Silva, Denise Rossato;Gazzana, Marcelo Basso;Barreto, Sérgio Saldanha Menna;Knorst, Marli Maria;
Jornal Brasileiro de Pneumologia , 2008, DOI: 10.1590/S1806-37132008001000005
Abstract: objective: to describe the clinical and functional findings recently reported in the medical literature for patients diagnosed with emphysema involving the upper lobes and idiopathic pulmonary fibrosis (ipf) involving the lower lobes. methods: eleven patients with emphysema and ipf were identified retrospectively. all of the patients underwent high-resolution computed tomography of the lung and pulmonary function tests. results: of the 11 patients, 8 were male and 3 were female. the mean age was 70.7 ± 7.2 years (range, 61-86 years). all of the patients were smokers (mean smoking history, 61.5 ± 43.5 pack-years). the mean values of forced vital capacity (fvc), forced expiratory volume in one second (fev1) and fev1/fvc were 72.1% ± 12.7%, 68.2% ± 11.9% and 74.4 ± 10.8, respectively. lung volumes were normal in 7 patients. a restrictive pattern was observed in 3 patients, and hyperinflation was present in one. the diffusing capacity was moderately-to-severely reduced in all of the patients (mean, 27.7% ± 12.9% of predicted). ten of the 11 patients performed the six-minute walk test. the mean distance covered was 358.4 ± 143.1 m, and 9 of the 10 patients presented desaturation > 4%. echocardiographic findings suggestive of pulmonary hypertension were present in 4 patients (mean systolic pulmonary artery pressure, 61.8 mmhg; range, 36-84 mmhg). conclusions: the concomitant presence of emphysema and ipf causes characteristic changes on pulmonary function tests. the most significant finding is a discrepancy between diffusing capacity and spirometry results.
Fatores preditores da qualidade de vida relacionada à saúde física e mental em pacientes com doen?a pulmonar intersticial: uma análise multifatorial
Coelho, Ana Cláudia;Knorst, Marli Maria;Gazzana, Marcelo Basso;Barreto, Sérgio Saldanha Menna;
Jornal Brasileiro de Pneumologia , 2010, DOI: 10.1590/S1806-37132010000500007
Abstract: objective: to determine predictors of health-related quality of life (hrqol) in patients with interstitial lung disease (ild). methods: a cross-sectional study comprising 63 patients, all of whom underwent lung function testing and the six-minute walk test. the following instruments were used: the medical outcomes study 36-item shortform survey (sf-36), the saint george's respiratory questionnaire (sgrq), the beck anxiety inventory, the beck depression inventory, and the modified medical research council dyspnea scale. principal component analysis was used in order to reduce the dimensionality of the data, thereby identifying the predictor variables, and multiple linear regression analysis was used in order to identify the explanatory variables. results: of the 63 patients, 34 were female. the mean age was 60.1 ± 13.3 years, the mean fvc was 64.17 ± 15.54% of predicted, and the mean dlco was 44.21 ± 14.47% of predicted. all of the patients evaluated had impaired hrqol, scoring worst for the sf-36 physical functioning and sgrq activity domains. of the patients evaluated, 60.3% and 57.1% showed symptoms of anxiety and depression, respectively. the principal component analysis identified one predictor of physical hrqol and one predictor of mental hrqol. depression had a strong influence on the predictor of mental hrqol, and the degree of dyspnea had a strong influence on both predictors of hrqol in the patients evaluated. variables related to lung function, exercise capacity, and anxiety had no impact on these predictors. conclusions: in our sample of patients with ild, the degree of dyspnea had a major impact on the physical and mental hrqol, and depression had an impact on mental hrqol.
Síndrome hepatopulmonar em paciente com cirrose por vírus C e SIDA
FERREIRA, MARIA ANGéLICA PIRES;GAZZANA, MARCELO BASSO;BARRETO, SéRGIO SALDANHA MENNA;KNORST, MARLI MARIA;
Jornal de Pneumologia , 2001, DOI: 10.1590/S0102-35862001000100009
Abstract: hepatopulmonary syndrome is characterized by a triad consisting of liver disorder, pulmonary vascular dilatation, and hypoxemia. no case of hepatopulmonary syndrome associated with aids has been reported so far. in this study, the authors report the case of a 43-year woman with aids and virus c cirrhosis taking prophylactic cotrimoxazole for pneumocystosis and retroviral therapy. upon admission, the patient presented dyspnea, cyanosis, digital clubbing, vascular spiders, and normal chest examination. chest x-ray revealed bilateral interstitial infiltration and evidenced increased alveolar-arterial gradient and liver function impairment. intrapulmonary shunt was evidenced by contrast-enhanced echocardiography and radionuclide perfusion scanning, thus confirming hepatopulmonary syndrome.
Síndrome hepatopulmonar em paciente com cirrose por vírus C e SIDA
FERREIRA MARIA ANGéLICA PIRES,GAZZANA MARCELO BASSO,BARRETO SéRGIO SALDANHA MENNA,KNORST MARLI MARIA
Jornal de Pneumologia , 2001,
Abstract: A síndrome hepatopulmonar consiste na tríade de doen a hepática, dilata es vasculares intrapulmonares e hipoxemia. N o há relatos de síndrome hepatopulmonar associada com SIDA. Relatamos o caso de uma mulher de 43 anos portadora de SIDA e de cirrose hepática por hepatite C, em uso de cotrimoxazol profilático para pneumocistose e de terapia anti-retroviral, com dispnéia progressiva, cianose, baqueteamento digital, aranhas vasculares e exame do tórax normal. A radiografia do tórax mostrava infiltrado retículo-nodular, o gradiente alvéolo-arterial de oxigênio estava aumentado e a fun o hepática alterada. Shunt intrapulmonar foi evidenciado por ecocardiografia bidimensional transtorácica e por cintilografia pulmonar perfusional, confirmando-se a síndrome hepatopulmonar.
Distancia percorrida no teste de caminhada de seis minutos n?o se relaciona com qualidade de vida em pacientes com bronquiectasias n?o fibrocísticas
Jacques, Patrícia Santos;Gazzana, Marcelo Basso;Palombini, Dora Veronisi;Barreto, Sérgio Saldanha Menna;Dalcin, Paulo de Tarso Roth;
Jornal Brasileiro de Pneumologia , 2012, DOI: 10.1590/S1806-37132012000300010
Abstract: objective: to evaluate physical performance on the six-minute walk test (6mwt) in patients with non-cystic fibrosis bronchiectasis and to investigate its relationship with quality of life (qol). to identify predictors of exercise performance, we also investigated whether six-minute walk distance (6mwd) is associated with clinical and spirometric findings. methods: this was a cross-sectional study involving patients with non-cystic fibrosis bronchiectasis (age, > 18 years), with at least one respiratory symptom for > 2 years and an fev1 < 70% of predicted. patients underwent clinical evaluation, pulmonary function tests, the 6mwt, and qol assessment with the medical outcomes study 36-item short-form health survey (sf-36). results: we included 70 patients (48 females). mean age was 54.5 ± 17.7 years, and mean fev1 was 44.9 ± 14.5% of predicted. the patients were divided into two groups: 6mwd-low (6mwd below the predicted lower limit; n = 23); and 6mwd-norm (normal 6mwd; n = 47). the following variables were significantly lower in the 6mwd-low group than in the 6mwd-norm group: age; age at diagnosis of bronchiectasis; proportion of former smokers; body mass index (bmi); fev1% of predicted; and mep% of predicted. there were no significant differences in the sf-36 scores between the groups. in the logistic regression model, lower age and lower bmi were significantly associated with lower 6mwd. conclusions: in this sample, there was a high proportion of patients who presented a lower than expected 6mwd. although 6mwd was not related to qol, it was associated with age and bmi.
An update on the mouse liver proteome
Giuseppe Gazzana, Jürgen Borlak
Proteome Science , 2009, DOI: 10.1186/1477-5956-7-35
Abstract: This methodology was now applied to develop a mouse liver protein database.Liver proteins were extracted by two different lysis buffers in sequence followed by a liquid-phase IEF pre-fractionation and separation of proteins by 2 DE at two different pH ranges, notably 5-8 and 7-10. Based on 9600 in gel digests a total of 643 mouse liver proteins with high sequence coverage (> 20 peptides per protein) could be identified by MALDI-TOF-MS peptide mass finger printing. Notably, 255 proteins are novel and have not been reported so far by conventional two-dimensional electrophoresis proteome mapping. Additionally, the results of the present findings for mouse liver were compared to published data of the rat proteome to compile as many proteins as possible in a rodent liver database.Based on 2-DE MALDI-TOF-MS a significantly improved proteome map of mouse liver was obtained. We discuss some prominent members of newly identified proteins for a better understanding of liver biology.Life is incompatible without the liver as this organ performs essential metabolic functions. Estimates suggest an excess of > 10,000 biochemical reactions at any given time point, and this includes basic carbohydrate, fat and protein metabolism; storage of vitamins and minerals; many regulatory functions that control blood sugar and hormone levels. Indeed, the liver is the primary organ for the synthesis of many different proteins, such as plasma albumin, fibrinogen and most globulins, as well as lipids and lipoproteins (phospholipids, cholesterol) and is responsible for bile acid production and excretion. Being exposed to a wide range of xenobiotics and toxins the liver has the remarkable capacity for regenerative growth. In fact, up to 75% of the liver can be surgically removed, before it ceases to function [1], but will return to its original size through regenerative growth within a few weeks.It is of considerable importance that the human and mouse genome display > 99% DNA sequence similarity.
Hipertens?o arterial pulmonar e doen?as da tireoide
Silva, Denise Rossato;Gazzana, Marcelo Basso;John, ?ngela Beatriz;Siqueira, Débora Rodrigues;Maia, Ana Luiza Silva;Barreto, Sérgio Saldanha Menna;
Jornal Brasileiro de Pneumologia , 2009, DOI: 10.1590/S1806-37132009000200012
Abstract: recent studies have suggested an association between pulmonary arterial hypertension (pah) and thyroid diseases (hypothyroidism and hyperthyroidism). this combination has a good prognosis, because the increase in the pulmonary artery pressure is usually slight and reverses after the treatment of the thyroid disease. although the exact mechanism involved in the pathogenesis of this combination has not yet been established, it has been hypothesized that thyroid hormones and autoimmunity have a direct influence. due to the high prevalence of thyroid disease in patients with pah, thyroid function tests should be considered in the investigation of every patient with pah. in this review, we describe the prevalence of pah in patients with thyroid diseases and the prevalence of thyroid disease in patients with pah, as well as addressing the principal effects that thyroid diseases have on the respiratory system. in addition, we report the treatment effects in patients with these diseases.
Asma aguda em adultos na sala de emergência: o manejo clínico na primeira hora
DALCIN, PAULO DE TARSO ROTH;MEDEIROS, ALAN CASTOLDI;SIQUEIRA, MARCELO KURZ;MALLMANN, FELIPE;LACERDA, MARIANE;GAZZANA, MARCELO BASSO;BARRETO, SéRGIO SALDANHA MENNA;
Jornal de Pneumologia , 2000, DOI: 10.1590/S0102-35862000000600005
Abstract: asthma is a disease with high prevalence in our country and around the world. although new therapeutic approaches have been recently developed, there appears to be a worldwide increase in morbidity and mortality from asthma. in many institutions, asthma exacerbation is still a common medical emergency. clinical evidence demonstrates that the first hour of management of acute asthma in the emergency room entails crucial decisions that could be determinant in the clinical outcome. in this non-systematic review, the authors focus on the first hour assessment and treatment of patients with acute asthma and outline an appropriate strategy for their management. diagnosis, severity assessment, pharmacological treatment, complications, and the decision regarding the place where additional treatment will take place will be considered. it is reasonable to expect that these recommendations will help physicians make appropriate decisions about the first hour care of acute asthma in the emergency room.
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