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Search Results: 1 - 10 of 336616 matches for " S. Di; Giordano "
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The impact of the number of episodes on the outcome of Bipolar Disorder
S. Di Marzo,A. Giordano,I. Pacchiarotti,F. Colom
The European Journal of Psychiatry , 2006,
Abstract: BACKGROUND: Bipolar disorder is a highly recurrent severe psychiatric disorder. The number of episodes has been found consistently associated with poor outcome. It has been suggested that bipolar patients with long duration of illness and highly recurrent course show great impairment of global functioning. OBJECTIVES The aim of this study is to assess the clinical course and outcome of patients with bipolar disorder I and II with a high number of mood episodes. METHODS: We compared a group of bipolar I and II subjects whose number of episode was higher than ten (N = 167) with a similar-size representative sample of bipolar patients whose number of episodes was lower or equal than ten (N = 131). RESULTS: Bipolar patients with more than 10 episodes have a more severe outcome of bipolar disorder. Qualification and occupational status was clearly worse for the highly recurrent group which showed a predominance of depressive polarity. CONCLUSIONS: These data suggest that bipolar patients with a highly recurrent course have significant functional impairment. With the passing of time, bipolar illness tends to be ruled by depressive features. Treatment strategies may need to address this issue.
The impact of the number of episodes on the outcome of Bipolar Disorder
Marzo,S. Di; Giordano,A.; Pacchiarotti,I.; Colom,F.; Sánchez-Moreno,J.; Vieta,E.;
The European Journal of Psychiatry , 2006, DOI: 10.4321/S0213-61632006000100003
Abstract: background: bipolar disorder is a highly recurrent severe psychiatric disorder. the number of episodes has been found consistently associated with poor outcome. it has been suggested that bipolar patients with long duration of illness and highly recurrent course show great impairment of global functioning. objectives the aim of this study is to assess the clinical course and outcome of patients with bipolar disorder i and ii with a high number of mood episodes. methods: we compared a group of bipolar i and ii subjects whose number of episode was higher than ten (n = 167) with a similar-size representative sample of bipolar patients whose number of episodes was lower or equal than ten (n = 131). results: bipolar patients with more than 10 episodes have a more severe outcome of bipolar disorder. qualification and occupational status was clearly worse for the highly recurrent group which showed a predominance of depressive polarity. conclusions: these data suggest that bipolar patients with a highly recurrent course have significant functional impairment. with the passing of time, bipolar illness tends to be ruled by depressive features. treatment strategies may need to address this issue.
Granulocyte macrophage colony stimulating factor (GM-CSF) biological actions on human dermal fibroblasts
S Montagnani,L Postiglione,G Giordano-Lanza,F Di Meglio
European Journal of Histochemistry , 2009, DOI: 10.4081/1632
Abstract: Fibroblasts are involved in all pathologies characterized by increased ExtraCellularMatrix synthesis, from wound healing to fibrosis. Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF) is a cytokine isolated as an hemopoietic growth factor but recently indicated as a differentiative agent on endothelial cells. In this work we demonstrated the expression of the receptor for GM-CSF (GMCSFR) on human normal skin fibroblasts from healthy subjects (NFPC) and on a human normal fibroblast cell line (NHDF) and we try to investigate the biological effects of this cytokine. Human normal fibroblasts were cultured with different doses of GM-CSF to study the effects of this factor on GMCSFR expression, on cell proliferation and adhesion structures. In addition we studied the production of some Extra-Cellular Matrix (ECM) components such as Fibronectin, Tenascin and Collagen I. The growth rate of fibroblasts from healthy donors (NFPC) is not augmented by GM-CSF stimulation in spite of increased expression of the GM-CSFR. On the contrary, the proliferation of normal human dermal fibroblasts (NHDF) cell line seems more influenced by high concentration of GM-CSF in the culture medium. The adhesion structures and the ECM components appear variously influenced by GM-CSF treatment as compared to fibroblasts cultured in basal condition, but newly only NHDF cells are really induced to increase their synthesis activity. We suggest that the in vitro treatment with GM-CSF can shift human normal fibroblasts towards a more differentiated state, due or accompanied by an increased expression of GM-CSFR and that such “differentiation” is an important event induced by such cytokine.
Identità e omofobia in Cosa Nostra: un contributo gruppoanalitico soggettuale
Cecilia Giordano,Maria Di Blasi
Narrare i Gruppi , 2012,
Abstract: contribution proposes some reflections on identity, sexuality and homophobia in Mafia contexts. The studies on Mafia psychology have allowed so far to highlight how weak is the identity of people belonging to Mafia criminal organizations and the impossibility to conceive diversity in whatever form it presents itself. Homosexuality in particular represents in these contexts the terrifying fear of otherness and the dread of losing control of the impenetrable rigidity Mafia identity is based on.By using fragments of interviews to justice collaborators, the article highlights that what a man of mafia is really scared of is the essential experience of erotic possession (no matter whether heterosexual or homosexual). Each relationship that, like love, requires ability to get lost in the encounter with the other, terrifies the Mafia man who reacts to this threat of possession with the most primitive weapons of defense: submission and annihilation. The authors look at homophobia from a theoretical subjectual group-analysis perspective, which integrates both emotional, and cognitive and socio-cultural aspects.
First X-ray dectection of the young variable V1180 Cas
S. Antoniucci,A. A. Nucita,T. Giannini,D. Lorenzetti,B. Stelzer,D. Gerardi,S. Delle Rose,A. Di Paola,M. Giordano,L. Manni,F. Strafella
Physics , 2015, DOI: 10.1051/0004-6361/201526491
Abstract: V1180 Cas is a young variable that has shown strong photometric fluctuations (Delta_I~6mag) in the recent past, which have been attributed to events of enhanced accretion. The source has entered a new high-brightness state in Sept.2013, which we have previously analyzed through optical and near-IR spectroscopy. To investigate the current active phase of V1180 Cas, we performed observations with the Chandra satellite to study the X-ray emission from the object and its connection to accretion episodes. Chandra observations were performed in early Aug.2014. Complementary JHK photometry and J-band spectra were taken at our Campo Imperatore facility to relate the X-ray and near-IR emission from the target. We observe a peak of X-ray emission at the nominal position of V1180 Cas. This signal corresponds to an X-ray luminosity L_X(0.5-7 kev) in the range 0.8-2.2e30 erg/s. Based on the relatively short duration of the dim states in the light curve and on stellar luminosity considerations, we explored the possibility that the brightness minima of V1180 Cas are driven by extinction variations. From the analysis of the spectral energy distribution of the high state we infer a stellar luminosity of 0.8-0.9 Lsun and find that the derived L_X is comparable to the average X-ray luminosities of T Tauri stars. Moreover, the X-ray luminosity is lower than the X-ray emission levels of 5e30 -1e31 erg/s detected at outbursts in similar low-mass objects. Our analysis suggests that at least part of the photometric fluctuations of V1180 Cas might be extinction effects rather than the result of accretion excess emission. However, as the source displays spectral features indicative of active accretion, we speculate that its photometric variations might be the result of a combination of accretion-induced and extinction-driven effects, as suggested for other young variables, such as V1184 Tau and V2492 Cyg.
Symbolic Models and Control of Discrete-Time Piecewise Affine Systems: An Approximate Simulation Approach
Giordano Pola,Maria D. Di Benedetto
Computer Science , 2012,
Abstract: Symbolic models have been recently used as a sound mathematical formalism for the formal verification and control design of purely continuous and hybrid systems. In this paper we propose a sequence of symbolic models that approximates a discrete-time Piecewise Affine (PWA) system in the sense of approximate simulation and converges to the PWA system in the so-called simulation metric. Symbolic control design is then addressed with specifications expressed in terms of non-deterministic finite automata. A sequence of symbolic control strategies is derived which converges, in the sense of simulation metric, to the maximal controller solving the given specification on the PWA system.
Networked Embedded Control Systems: from Modelling to Implementation
Maria Domenica Di Benedetto,Giordano Pola
Computer Science , 2013, DOI: 10.4204/EPTCS.124.3
Abstract: Networked Embedded Control Systems are distributed control systems where the communication among plants, sensors, actuators and controllers occurs in a shared network. They have been the subject of intensive study in the last few years. In this paper we survey our contribution to this research topic.
Isospin Dynamics in Heavy Ion Collisions: from Coulomb Barrier to Quark Gluon Plasma
M. Di Toro,V. Baran,M. Colonna,G. Ferini,T. Gaitanos,V. Giordano,V. Greco,Liu Bo,M. Zielinska-Pfabe,S. Plumari,V. Prassa,C. Rizzo,J. Rizzo,H. H. Wolter
Physics , 2008, DOI: 10.1016/j.ppnp.2008.12.038
Abstract: Heavy Ion Collisions (HIC) represent a unique tool to probe the in-medium nuclear interaction in regions away from saturation. In this report we present a selection of new reaction observables in dissipative collisions particularly sensitive to the symmetry term of the nuclear Equation of State (Iso-EoS). We will first discuss the Isospin Equilibration Dynamics. At low energies this manifests via the recently observed Dynamical Dipole Radiation, due to a collective neutron-proton oscillation with the symmetry term acting as a restoring force. At higher beam energies Iso-EoS effects will be seen in Imbalance Ratio Measurements, in particular from the correlations with the total kinetic energy loss. For fragmentation reactions in central events we suggest to look at the coupling between isospin distillation and radial flow. In Neck Fragmentation reactions important $Iso-EoS$ information can be obtained from the correlation between isospin content and alignement. The high density symmetry term can be probed from isospin effects on heavy ion reactions at relativistic energies (few AGeV range). Rather isospin sensitive observables are proposed from nucleon/cluster emissions, collective flows and meson production. The possibility to shed light on the controversial neutron/proton effective mass splitting in asymmetric matter is also suggested. A large symmetry repulsion at high baryon density will also lead to an "earlier" hadron-deconfinement transition in n-rich matter. A suitable treatment of the isovector interaction in the partonic EoS appears very relevant.
Effects on respiratory function of the head-down position and the complete covering of the face by drapes during insertion of the monitoring catheters in the cardiosurgical patient
Massimo Bertolissi, Flavio Bassi, Adriana Di Silvestre, Francesco Giordano
Critical Care , 1999, DOI: 10.1186/cc345
Abstract: The contemporary application of the head-down position and the drapes over the face significantly increased PaO2 and SaO2 in all the patientssupplied with oxygen. Without the head-down position, leaving the drapes over the face, did not significantly change the two parameters in the coronary patients supplied with oxygen, but induced a significant increase in PaO2 and SaO2 in the patients with end-stage heart disease. In the coronary patients that were breathing room air, PaO2 and SaO2 were stable throughout the study.We conclude that the 30° head-down position and the complete covering of the face by drapes does not interfere with respiratory gas exchange and can be safely performed in coronary patients supplied with oxygen or breathing room air and in patients with end-stage heart disease supplied with oxygen (FiO2 of 0.4).The complete covering of the face by sterile drapes is a manoeuvre routinely used to cannulate the internal jugular vein and position the pulmonary artery catheter. The head-down position is a manoeuvre associated with that of sterile drapes when particular conditions (big and short neck, hypovolemia) make the cannulation of the jugular vein difficult [1]. Experimental and clinical studies have shown that the head-down position can interfere with respiratory function by reducing the functional residual capacity (FRC) and increasing the pulmonary blood volume [2,3,4]. A literature search found no data supporting a negative effect on respiratory function with the drapes covering the face; however, we hypothesized such a negative influence, supposing that the application of the sterile drapes over the face can favour the rebreathing of the expired gases. The aim of this study was to evaluate the effect on respiratory gas exchange of the two combined manoeuvres used during the insertion of monitoring catheters in the cardiosurgical patient before induction of anaesthesia.Fifty-four patients scheduled for elective coronary bypass grafting (CABG; 43 c
Meeting the Oral Health Needs of Immigrants: National Public Health Services Vs. Charitable Volunteer Services In Rome, Italy
Denise Corridore,Fabrizio Guerra,Domitilla Di Thiene,Guido Giordano
Italian Journal of Public Health , 2012, DOI: 10.2427/5633
Abstract: : Background: oral health is an important aspect of well-being. In Italy immigrants can have different access to health care services, and can opt for the national Health Service (nHS) and/ or private non- profit health care organizations. The purpose of this study was to develop an instrument to evaluate oral health in the immigrant population of rome and to investigate the differences between two different types of ser- vices: the First observation unit at the department of oral and Maxillo Facial Sciences, at the "Sapienza" university of rome (a nHS affiliate), and a charitable organization, the caritas dental center (cdc). Methods: a multiple-choice questionnaire was administered between the last trimester of 2006 and the first trimester of 2007. a chi square analysis was performed and the level of significance was set at p<0.05. reSulTS: The sample was composed of 250 people, of which 100 were patients of the cdc and 150 were patients of the nHS. The percentage of non-Italians was 80% (n=80) in the cdc sample, and only 16% (n=25) in the nHS sample. In the cdc, definitive resolving therapies, such as tooth extractions, prevailed (60% v’s 47% nHS; p=0.033). In addition, the frequency of consumption of sugary foods and drinks was significantly higher among cdc patients (31% reported to consume these over 9 times a day) compared to nHS patients (11% reporting this consumption). Discussion: the study shows a substantial under using of the national Health Service for oral health care needs by the immigrant population. The particular composition of the sample, with a high prevalence being of romanian nationality, might reflect specific conditions of this nationality. The results showed that immigrants were satisfied with the health care even though they encountered difficulties in terms of level of communication.
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