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Search Results: 1 - 10 of 326601 matches for " S. Biswas "
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Theory of dynamic gravitational electromagnetism
S. Biswas
Advanced Studies in Theoretical Physics , 2012,
Abstract:
Associations of antifolate resistance in vitro and point mutations in dihydrofolate reductase and dihydropteroate synthetase genes of Plasmodium falciparum
Biswas S
Journal of Postgraduate Medicine , 2004,
Abstract: Background: Antifolate antimalarials like sulfadoxine-pyrimethamine are used as second-line treatment for Plasmodium falciparum malaria patients who fail to respond to chloroquine. The efficacy of the sulfa-pyrimethamine combination in the treatment is also compromised by the development of resistance in the parasite. Resistance to these drugs has been shown to encode with point mutations in dihydrofolate reductase and dihydropteroate synthetase genes. Settings: An experimental study. Maerial and methods: Forty clinical isolates collected from different geographical locations in India were used to assess the relationships between resistance to sulfadoxine-pyrimethamine (SP) and mutations in P. falciparum dihydrofolate reductase (DHFR) and dihydropteroate synthetase (DHPS). In vitro drug susceptibility and mutation-specific polymerase chain reaction (PCR) assays were also done. Results: It was observed that a number of isolates possessed mutant genotypes and showed low sensitivity to SP in vitro. Of the 40 clinical isolates studied, 87.5% had DHFR and 15% had DHPS gene mutations. As observed from PCR results, 55( (22/40) presented double mutation of DHFR Arg-59 and Asn-108 and 32.5 % (13/40) had single mutant type allele of Asn-108. Of the 40 isolates, 10 % (4/40) presented doubly mutated forms of DHPS Phe-436 and Thr-613 and single mutant type allele Gly-581 was detected in 5 % (2/40) isolates. Parasites carrying double or single mutant forms of DHFR/DHPS showed elevated minimum inhibitory concentration (MIC) values of both pyrimethamine (760-6754 nM; r=0.69) and sulfadoxine (108 - 540 mM; r=0.87) when compared to sensitive and resistant strains. Conclusion: Though there was a correlation between molecular techniques and in vitro drug sensitivity profiles, the relevance of these findings to the clinical efficacy of SP combination drugs needs to be established by controlled clinical trials.
In-vitro antimalarial activity of azithromycin against chloroquine sensitive and chloroquine resistant Plasmodium falciparum.
Biswas S
Journal of Postgraduate Medicine , 2001,
Abstract: BAKGROUND: The spread of drug resistance in Plasmodium falciparum has made the situation essential to look into new effective therapeutic agents like antibiotics. Azithromycin is a potential, chemotherapeutic agent which possesses antimalarial activity and favourable pharmacokinetic properties. It is an azalide microbiocide derived semi-synthetically from macrolide erythromycin. Like other antibiotics, the azalide azithromycin has ability to inhibit protein synthesis on 70S ribosomes. SETTINGS: Experimental study. SUBJECTS AND METHODS: The parasiticidal profile was studied in five chloroquine sensitive and five chloroquine resistant P. falciparum isolates obtained from various places of India. The antimalarial activity was evaluated in P. falciparum schizont maturation by short term culture for 24 hours and by exposing the parasites to the drug for 96 hours. Parasites synchronized at ring stage were put for culture with various concentrations of azithromycin dihydrate (0.01-40 micro/ml). RESULTS: At highest concentration (40 micro/ml), parasite growth was inhibited totally in all 10 isolates. Antimalarial activity at 96 hours was greater than at 24 hours in both chloroquine sensitive and resistant parasites, which may indicate that the inhibition of parasite growth may occur at clinically achievable concentration of the drug when parasites were exposed for several asexual cycles. CONCLUSION: Azithromycin shows a potential for eventual use alone or in combination in the treatment of chloroquine sensitive and resistant P. falciparum malaria.
Development of Geotourism in Kutch Region, Gujarat, India: An Innovative Approach  [PDF]
K. Swarna, S. K. Biswas, T. Harinarayana
Journal of Environmental Protection (JEP) , 2013, DOI: 10.4236/jep.2013.412157
Abstract:

Geotourism in Kutch has an exemplary potential of being designated as a site for perfect establishment of a National Geopark. The paper is aimed to describe the geological significance of the sites with basic concept of creation of geoparks and promote geotourism. The financial, infrastructural aspects, deliverables to the society are presented primarily focusing on the local economic and sustainable development of Kutch. The need for development of infrastructure for geotourism is urgently required as the rare geological heritage of Kutch region is eroding and being destroyed due to manmade activities.

Starobinsky Model in Schroedinger Description
S. Biswas,A. Shaw,D. Biswas
Physics , 1999, DOI: 10.1007/s12043-999-0115-7
Abstract: In the Starobinsky inflationary model inflation is driven by quantum corrections to the vacuum Einstein equation. We reduce the Wheeler-DeWitt equation corresponding to the Starobinsky model to a Schroedinger form containing time. The Schroedinger equation is solved with a Gaussian ansatz. Using the prescription for the normalization constant of the wavefunction given in our previous work, we show that the Gaussian ansatz demands Hawking type initial conditions for the wavefunction of the universe. The wormholes induce randomness in initial states suggesting a basis for time-contained description of the Wheeler-DeWitt equation.
Schroedinger Wheeler-DeWitt Equation In Multidimensional Cosmology
S. Biswas,A. Shaw,D. Biswas
Physics , 1999, DOI: 10.1142/S0218271801001372
Abstract: We study multidimensional cosmology to obtain the wavefunction of the universe using wormhole dominance proposal. Using a prescription for time we obtain the Schroedinger-Wheeler-DeWitt equation without any reference to WD equation and WKB ansatz for WD wavefunction. It is found that the Hartle-Hawking or wormhole-dominated boundary conditions serve as a seed for inflation as well as for Gaussian type ansatz to Schroedinger-Wheeler-DeWitt equation.
Generalised definitions of certain functions and their uses
Debasis Biswas,S. Biswas,Asoke P. Chattopadhyay
Mathematics , 2003,
Abstract: Generalised definitions of exponential, trigonometric sine and cosine and hyperbolic sine and cosine functions are given. In the lowest order, these functions correspond to ordinary exponential, trigonometric sine etc. Some of the properties of the generalised functions are discussed. Importance of these functions and their possible applications are also considered.
Mineral phosphate solubilizing bacterial community in agro-ecosystem
N Saha, S Biswas
African Journal of Biotechnology , 2009,
Abstract: The present communication deals with the assessment of phosphate solubilizing bacterial community structure across artificially created fertility gradient with regards to N, P and K status of soil in the experimental site. 20 randomly phosphate solubilizing bacteria from each fertility gradient were isolated, purified and characterized through their insoluble mineral phosphate-source utilization patterns. Four insoluble phosphate sources; purulia rock phosphate (PRP), mussourie rock phosphate (MRP), crystalline iron and aluminum phosphate were charged in basic Pikovskaia solid medium. Growth pattern of the isolates on those phosphate sources was recorded. Different communities utilized different P-sources in different magnitudes. Size of isolates of low fertility gradient showing greater utilization efficiency towards diverse phosphate sources gradually reduced along the gradient of fertility. Data thus obtained from the experiment were filed to compute community structure of phosphate solubilizing bacteria through principal component analysis (PCA). On the whole, the community composition of phosphate solubilizing bacteria reduced gradually under the influence of cultivation and fertilization in different fertility gradient soils.
Effect of Domestic Refrigeration on Keeping Quality of Buffalo Meat
G. Kandeepan,S. Biswas
Journal of Food Technology , 2013,
Abstract: Buffalo meat is the only future remedy for nutritional security in India. If the quality gets deteriorated, the meat preserved in refrigerator would impact greatly on the health of consumers. Hence meat samples from five year old sixteen buffalo bulls were analyzed in the fresh state (0 day) and after 4 and 7 days in chiller (4±°C) and 4, 7, 14, 30, 60 and 75 days in freezer ( 10±1°C) in a domestic refrigerator. The values of ERV, WHC and proximate composition decreased with increasing storage period. Whereas pH, TBA no., tyrosine value, chilling loss and drip loss showed an increasing trend. Thus it was concluded that a storage period upto 4 days in chiller and 30 days in freezer could satisfactorily maintain the buffalo meat quality.
Retinal detachment- Analysis of 160 cases during 1956-58
Biswas S,Sen K
Indian Journal of Ophthalmology , 1964,
Abstract:
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