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Search Results: 1 - 10 of 324906 matches for " S. Albani "
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Factor structure and psychometric properties of the trier inventory for chronic stress (TICS) in a representative german sample
Katja Petrowski, S?ren Paul, Cornelia Albani, Elmar Br?hler
BMC Medical Research Methodology , 2012, DOI: 10.1186/1471-2288-12-42
Abstract: The TICS was answered by N = 2,339 healthy participants aged 14 to 99. The sample was selected by random-route sampling. Exploratory factor analyses with Oblimin-rotated Principal Axis extraction were calculated. Confirmatory factor analyses applying Robust Maximum Likelihood estimations (MLM) tested model fit and configural invariance as well as the measurement invariance for gender and age. Reliability estimations and effect sizes are reported.In the exploratory factor analyses, both a two-factor and a nine-factor model emerged. Confirmatory factor analyses resulted in acceptable model fit (RMSEA), with model comparison fit statistics corroborating the superiority of the nine-factor model. Most factors were moderately to highly intercorrelated. Reliabilities were good to very good. Measurement invariance tests gave evidence for differential effects of gender and age on the factor structure. Furthermore, women and younger individuals, especially those aged 35 to 44, tended to report more chronic stress than men and older individuals.The proposed nine-factor structure could be factorially validated, results in good scale reliability, and heuristically can be grouped by two higher-order factors: "High Demands" and "Lack of Satisfaction". Age and gender represent differentiable and meaningful contributors to the perception of chronic stress.Stress research indicates that chronic stress increases the risk of acute illness and impaired physical health [1,2]. Chronic stress has an influence on sleeping disorders [3], acute coronary syndrome [4], and chronic pain [5]. It follows that the conceptualization and the operationalization via instruments investigating chronic stress are of relevance to the psychology of health [6].The concept of chronic stress is based on how frequently the stressors appear [7]. Chronic stress is defined as the repeated occurrence of different stressors with uncontrollable consequences or the absence of adaptive coping mechanisms [8,9]. In addit
Interpreting last glacial to Holocene dust changes at Talos Dome (East Antarctica): implications for atmospheric variations from regional to hemispheric scales
S. Albani,B. Delmonte,V. Maggi,C. Baroni
Climate of the Past Discussions , 2012, DOI: 10.5194/cpd-8-145-2012
Abstract: Central East Antarctica ice cores preserve stratigraphic records of mineral dust originating from remote sources in the Southern Hemisphere, and represent useful indicators of climatic variations on glacial-interglacial time scales. The peripheries of the East Antarctic Ice Sheet, where ice-free areas with the potential to emit dust exist, have been less explored from this point of view. Here we present a new profile of dust deposition flux and grain size distributions from an ice core drilled at Talos Dome (Northern Victoria Land, East Antarctica), where there is a significant input of dust from proximal Antarctic ice-free areas. We analyze dust and stable water isotopes variations from the Last Glacial Maximum to the Late Holocene, and compare them to the EPICA Dome C profiles from Central East Antarctica. The smaller glacial-interglacial variations at Talos Dome compared to Dome C, and a distinctive decreasing trend during the Holocene, characterize the TALDICE dust profile. By deciphering the composite dust signal from both remote and local sources, we show the potential of this combined proxy of source activity and atmospheric transport to give information on both regional and larger spatial scales. In particular, we show how a regional signal, which we related to the deglaciation history of the Ross Sea embayment, can be superimposed to the broader scale glacial-interglacial variability that characterizes other Antarctic sites.
Domains of disgust sensitivity: revisited factor structure of the questionnaire for the assessment of disgust sensitivity (QADS) in a cross-sectional, representative german survey
Katja Petrowski, S?ren Paul, Gabriele Schmutzer, Marcus Roth, Elmar Br?hler, Cornelia Albani
BMC Medical Research Methodology , 2010, DOI: 10.1186/1471-2288-10-95
Abstract: The QADS was answered by N = 2473 healthy subjects. The respective households and participants were selected using the random-route sampling method. Afterwards, the collected sample was compared to the information from the Federal Statistical Office to ensure that it was representative for the German residential population. With these data, an exploratory Promax-rotated Principal Axis Factor Analysis as well as comparative confirmatory factor analyses with robust Maximum Likelihood estimations were computed. Any possible socio-demographic influences were quantified as effect sizes.The data-driven and theoretically sound solution with the three highly interrelated factors Animal Reminder Disgust, Core Disgust, and Contamination Disgust led to a moderate model fit. All QADS scales had very good reliabilities (Cronbach's alpha) from .90 to .95. There were no age-differences found among the participants, however, the female participants showed remarkably higher disgust ratings.Based on the representative sample, the QADS factor structure was revised. Gender-specific standard percentages permit a population-based assessment of individual disgust sensitivity. The differences of the original QADS, the new solution, and the Disgust Scale - Revised will be discussed.Disgust sensitivity describes an individual's time-invariant, genetically-based personality trait, a predisposition to reacting to specific materials with disgust [[1], p.111; [2]]. The specific materials that trigger disgust can be grouped into five theoretically proposed categories of disgust elicitors [3]: badly tasting substances can produce Distaste, which protects the body from poisons. Core Disgust can be provoked by rotten food, body products, rodents, and other small vermin in order to protect the body from disease or infection. Animal Nature/Reminder Disgust refers to sex, death, poor hygiene, and body envelope violations for protection against death and mortality. Interpersonal-Contamination Disgust pr
Embarazo y carcinoma de cuello uterino en vidrio esmerilado: reporte de un caso.
Mario Nicolás Albani Pérez,Thamara Josefina Ortíz Maraima,Luis Bracamonte
CIMEL. Ciencia e Investigación Médica Estudiantil Latinoamericana , 2009,
Abstract: En Venezuela, el cáncer de cérvix es la primera causa de muerte por neoplasias en la mujer, con 2.500 defunciones anuales. Puede ser diagnosticado durante el embarazo, e incluso, histopatológicamente expresarse en variedades infrecuentes y agresivas como el carcinoma de cuello uterino en patrón de vidrio esmerilado. Se reporta un caso de gestante de 28 a os de edad, multípara, con embarazo de 17 semanas de evolución por ecosonograma transabdominal quien acude al Hospital Universitario "Dr. Luis Razetti", al presentar sangrado transvaginal y dolor en hipogastrio. Ingresa al servicio de Ginecología y Obstetricia con impresión diagnóstica de cáncer de cuello uterino estadio IIIA, y posteriormente el servicio de Anatomía Patológica reporta hallazgo histológico como carcinoma de cuello uterino con patrón celular en vidrio esmerilado, se plantea como medida terapéutica la interrupción del embarazo. Tras debate de equipo de médicos, se decide el progreso del embarazo y hospitalización de la paciente hasta la fecha de cesárea previamente acordada, así como la aplicación del tratamiento posterior a la misma. La cesárea se desarrolló a las 34 semanas de embarazo con previa colocación de inductores de la maduración pulmonar fetal, cursó sin complicaciones y se obtuvo un neonato vivo peque o para la edad gestacional. Se acordó tratamiento radioterápico al cabo de un mes postcesárea.
Differential Density Statistics of Galaxy Distribution and the Luminosity Function
Vinicius V. L. Albani,Alvaro S. Iribarrem,Marcelo B. Ribeiro,William R. Stoeger
Physics , 2006, DOI: 10.1086/510520
Abstract: This paper uses data obtained from the galaxy luminosity function (LF) to calculate two types of radial number densities statistics of the galaxy distribution as discussed in Ribeiro (2005), namely the differential density $\gamma$ and the integral differential density $\gamma^\ast$. By applying the theory advanced by Ribeiro and Stoeger (2003), which connects the relativistic cosmology number counts with the astronomically derived LF, the differential number counts $dN/dz$ are extracted from the LF and used to calculate both $\gamma$ and $\gamma^\ast$ with various cosmological distance definitions, namely the area distance, luminosity distance, galaxy area distance and redshift distance. LF data are taken from the CNOC2 galaxy redshift survey and $\gamma$ and $\gamma^\ast$ are calculated for two cosmological models: Einstein-de Sitter and an $\Omega_{m_0}=0.3$, $\Omega_{\Lambda_0}=0.7$ standard cosmology. The results confirm the strong dependency of both statistics on the distance definition, as predicted in Ribeiro (2005), as well as showing that plots of $\gamma$ and $\gamma^\ast$ against the luminosity and redshift distances indicate that the CNOC2 galaxy distribution follows a power law pattern for redshifts higher than 0.1. These findings bring support to Ribeiro's (2005) theoretical proposition that using different cosmological distance measures in statistical analyses of galaxy surveys can lead to significant ambiguity in drawing conclusions about the behavior of the observed large scale distribution of galaxies.
Die Bedeutung von Religion für die psychische Befindlichkeit: M gliche Erkl rungsans tze und allgemeines Wirkmodell
Constantin Klein,Cornelia Albani
Zeitschrift für Nachwuchswissenschaftler , 2011,
Abstract: Der vorliegende Artikel gibt einen überblick über Befunde zu saluto- wie pathogenen Effekten von Religiosit t auf die psychische Gesundheit. Dazu werden zun chst einige Punkte dargestellt, die in konzeptioneller und methodischer Hinsicht zu beachten sind; daran schlie t sich die Darstellung von Befunden an, die zu verschiedenen Bereichen der psychischen Gesundheit bzw. verschiedenen psychischen St rungen vorliegen. Dabei zeigt sich, dass Religiosit t insbesondere für Hochreligi se und für Menschen, die an einen wohlwollenden und gütigen Gott glauben, eine gesundheitliche Ressource darstellen kann, w hrend es eine kleinere Gruppe Gl ubiger zu geben scheint, deren Religiosit t und Gottesvorstellungen eher zu vermehrter psychischer Belastung beitragen.In einem weiteren Schritt werden sodann m gliche psychologische Mechanismen, die als Erkl rungsans tze für die dargestellten Befunde in der Forschungsliteratur diskutiert werden, vorgestellt. Verschiedene Facetten der Religiosit t kommen dabei sowohl als individuelle und soziale Ressourcen sowie als Lebensstilfaktoren und Coping-Strategien als auch als Risikofaktoren in Betracht. Abschlie end werden die beschriebenen Mechanismen in ein grundlegendes Modell zum differenzierten Verst ndnis der Bedeutung der Religiosit t für die psychische Gesundheit integriert, das sich als theoretischer Rahmen für zukünftige Forschung eignet.
Trombocitopenia de difícil manejo en ni o preescolar con LES: Reporte de un caso
Mario Nicolás Albani Pérez,Thamara Josefina Ortíz Maraima,Ramón Zarrelli Flores,Elizabeth Parada Sánchez
CIMEL. Ciencia e Investigación Médica Estudiantil Latinoamericana , 2009,
Abstract: El lupus eritematoso sistémico (LES) es una enfermedad autoinmune del tejido conectivo, infrecuente en el sexo masculino y durante la infancia. La trombocitopenia se presenta en 15% de los casos de LES, y como forma de inicio es poco común. Se reporta el caso de preescolar masculino de 3 a os de edad con inicio de enfermedad a los 18 meses de edad que presentó diarrea, rash cutáneo, equimosis y trombocitopenia, ameritando transfusión de concentrado plaquetario obteniendo mejoría parcial y en control con hematólogo. A los 2 a os de edad reaparece equimosis y se diagnostica Púrpura Trombocitopénica Idiopática, tratado con inmunoglobulinas y esteroides sin respuesta satisfactoria. Es referido a Inmunología donde solicitan estudios y los resultados son compatibles con LES, por lo cual recibió prednisona sin respuesta satisfactoria. En Febrero de 2009, presenta epistaxis requiriendo hospitalización y tratamiento con inmunoglobulinas. En Mayo de 2009, presenta otorragia derecha ameritando nuevamente hospitalización y tratamiento con inmunoglobulinas. Se emplea Danazol con buena respuesta. En caso que en el futuro no ofrezca mejoría, se plantea el uso alternativo de ciclosporinas o anticuerpos monoclonales Anti- CD20 (Rituximab) dejando como último recurso la esplenectomía. Se presenta el caso clínico considerando la importancia con respecto a la edad de presentación y el manejo no convencional que se debió adoptar para tratar al paciente.
Regulation of Peripheral Inflammation by Spinal p38 MAP Kinase in Rats
David L Boyle,Toni L Jones,Deepa Hammaker,Camille I Svensson,Sanna Rosengren,Salvatore Albani,Linda Sorkin,Gary S Firestein
PLOS Medicine , 2006, DOI: 10.1371/journal.pmed.0030338
Abstract: Background Somatic afferent input to the spinal cord from a peripheral inflammatory site can modulate the peripheral response. However, the intracellular signaling mechanisms in the spinal cord that regulate this linkage have not been defined. Previous studies suggest spinal cord p38 mitogen-activated protein (MAP) kinase and cytokines participate in nociceptive behavior. We therefore determined whether these pathways also regulate peripheral inflammation in rat adjuvant arthritis, which is a model of rheumatoid arthritis. Methods and Findings Selective blockade of spinal cord p38 MAP kinase by administering the p38 inhibitor SB203580 via intrathecal (IT) catheters in rats with adjuvant arthritis markedly suppressed paw swelling, inhibited synovial inflammation, and decreased radiographic evidence of joint destruction. The same dose of SB203580 delivered systemically had no effect, indicating that the effect was mediated by local concentrations in the neural compartment. Evaluation of articular gene expression by quantitative real-time PCR showed that spinal p38 inhibition markedly decreased synovial interleukin-1 and ?6 and matrix metalloproteinase (MMP3) gene expression. Activation of p38 required tumor necrosis factor α (TNFα) in the nervous system because IT etanercept (a TNF inhibitor) given during adjuvant arthritis blocked spinal p38 phosphorylation and reduced clinical signs of adjuvant arthritis. Conclusions These data suggest that peripheral inflammation is sensed by the central nervous system (CNS), which subsequently activates stress-induced kinases in the spinal cord via a TNFα-dependent mechanism. Intracellular p38 MAP kinase signaling processes this information and profoundly modulates somatic inflammatory responses. Characterization of this mechanism could have clinical and basic research implications by supporting development of new treatments for arthritis and clarifying how the CNS regulates peripheral immune responses.
Interpreting last glacial to Holocene dust changes at Talos Dome (East Antarctica): implications for atmospheric variations from regional to hemispheric scales
S. Albani, B. Delmonte, V. Maggi, C. Baroni, J.-R. Petit, B. Stenni, C. Mazzola,M. Frezzotti
Climate of the Past (CP) & Discussions (CPD) , 2012,
Abstract: Central East Antarctic ice cores preserve stratigraphic records of mineral dust originating from remote sources in the Southern Hemisphere, and represent useful indicators of climatic variations on glacial-interglacial time scales. The peripheries of the East Antarctic Ice Sheet, where ice-free areas with the potential to emit dust exist, have been less explored from this point of view. Here, we present a new profile of dust deposition flux and grain size distributions from an ice core drilled at Talos Dome (TALDICE, Northern Victoria Land, East Antarctica), where there is a significant input of dust from proximal Antarctic ice-free areas. We analyze dust and stable water isotopes variations from the Last Glacial Maximum to the Late Holocene, and compare them to the EPICA Dome C profiles from central East Antarctica. The smaller glacial-interglacial variations at Talos Dome compared to Dome C and a distinctive decreasing trend during the Holocene characterize the TALDICE dust profile. By deciphering the composite dust signal from both remote and local sources, we show the potential of this combined proxy of source activity and atmospheric transport to give information on both regional and larger spatial scales. In particular, we show how a regional signal, which we relate to the deglaciation history of the Ross Sea embayment, can be superimposed to the broader scale glacial-interglacial variability that characterizes other Antarctic sites.
Requirements for acquiring a high-quality house dust mite extract for allergen immunotherapy
Frati F, Incorvaia C, David M, Scurati S, Seta S, Padua G, Cattaneo E, Cavaliere C, Di Rienzo A, Dell'Albani I, Puccinelli P
Drug Design, Development and Therapy , 2012, DOI: http://dx.doi.org/10.2147/DDDT.S30908
Abstract: irements for acquiring a high-quality house dust mite extract for allergen immunotherapy Review (3363) Total Article Views Authors: Frati F, Incorvaia C, David M, Scurati S, Seta S, Padua G, Cattaneo E, Cavaliere C, Di Rienzo A, Dell'Albani I, Puccinelli P 30908 video abstract Views: 85 Published Date May 2012 Volume 2012:6 Pages 117 - 123 DOI: http://dx.doi.org/10.2147/DDDT.S30908 Received: 15 February 2012 Accepted: 29 March 2012 Published: 18 May 2012 Franco Frati,1 Cristoforo Incorvaia,2 Marie David,3 Silvia Scurati,3 Simona Seta,4 Guglielmo Padua,4 Eleonora Cattaneo,1 Carlo Cavaliere,5 Alessia Di Rienzo,6 Ilaria Dell'Albani,1 Paola Puccinelli1 1Medical and Scientific and Regulatory Department, Stallergenes, Milan, Italy; 2Allergy/Pulmonary Rehabilitation, ICP Hospital, Milan, Italy; 3Laboratoire Stallergenes, Antony, France; 4Marketing Department, Stallergenes, Milan, Italy; 5Ear, Nose and Throat Department, University Sapienza, Rome, Italy; 6Azienda Sanitaria Locale, Allergology Service, Frosinone, Italy Abstract: The house dust mite is a major cause of respiratory allergy worldwide. The management of mite allergy is based on avoidance measures, drug treatment, and allergen immunotherapy, but only allergen immunotherapy is able to modify the natural history of the disease. Injectable subcutaneous immunotherapy was introduced a century ago, while sublingual immunotherapy was proposed in the 1980s and emerged in the ensuing years as an effective and safe option to subcutaneous immunotherapy. However, the quality of the extracts to be used in allergen immunotherapy is crucial for the success of treatment. The mite extract for sublingual immunotherapy known as Staloral 300 was developed to offer optimal characteristics concerning the mite culture medium, standardization, and allergen dose. Double-blind, placebo-controlled trials with Staloral 300 have provided a substantial part of the clinical evidence analyzed in a meta-analysis of the efficacy of allergen immunotherapy in mite-induced rhinitis and asthma. Safety and tolerability are very good, mild local reactions in the mouth being the most common side effect. This makes it feasible to carry out sublingual immunotherapy for the 3–5-year duration needed to achieve long-lasting tolerance to the specific allergen. The performance of Staloral 300 may provide optimal conditions for an effective and safe sublingual immunotherapy in patients with mite-induced respiratory allergy.
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