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Search Results: 1 - 10 of 672703 matches for " S. A. Smagulova "
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Luminescence and deep-level transient spectroscopy of grown dislocation-rich Si layers
I. I. Kurkina,I. V. Antonova,A. A. Shklyaev,S. A. Smagulova
AIP Advances , 2012, DOI: 10.1063/1.4748863
Abstract: The charge deep-level transient spectroscopy (Q-DLTS) is applied to the study of the dislocation-rich Si layers grown on a surface composed of dense arrays of Ge islands prepared on the oxidized Si surface. This provides revealing three deep-level bands located at EV + 0.31 eV, EC – 0.35 eV and EC – 0.43 eV using the stripe-shaped p-i-n diodes fabricated on the basis of these layers. The most interesting observation is the local state recharging process which proceeds with low activation energy (~50 meV) or without activation. The recharging may occur by carrier tunneling within deep-level bands owing to the high dislocation density ~ 1011 - 1012 cm-2. This result is in favor of the suggestion on the presence of carrier transport between the deep states, which was previously derived from the excitation dependence of photoluminescence (PL) intensity. Electroluminescence (EL) spectra measured from the stripe edge of the same diodes contain two peaks centered near 1.32 and 1.55 μm. Comparison with PL spectra indicates that the EL peaks are generated from arsenic-contaminated and pure areas of the layers, respectively.
State partnership with non-commercial organizations in the Kazakhstan
Zubirash Smagulova
Perspectives of Innovations, Economics and Business , 2009,
Abstract: The paper discusses the ways to develop partnership between state and non-governmental organizations in Kazakhstan. It is argued that funding channels of NGO’s activity should be extended and their new services should be developed using international experience. Tax stimulus to business, state purchases of NGO’ social services, greater involvement of NGOs to provision of public services are recommendations put forward in the article.
Hydrophobic Sand on the Basis of Superhydrophobic Soot Synthesized in the Flame  [PDF]
B. T. Lesbayev, M. Nazhipkyzy, N. G. Prikhodko, M. G. Solovyova, G. T. Smagulova, G. O. Turesheva, M. Auyelkhankyzy, T. T. Mashan, Z. A. Mansurov
Journal of Materials Science and Chemical Engineering (MSCE) , 2014, DOI: 10.4236/msce.2014.21011
Abstract:

The paper presents the results of studies on the synthesis of superhydrophobic soot, and on the development of its technology-based production of bulk material (sand), which has hydrophobic properties. The hydrophobic properties of sand had attached by fixing soot having superhydrophobic properties of nanoscale layer on the surface of the grains of sand. The resulting sand was examined by scanning electron microscopy to determine the structural and morphological parameters. The resulting composite material is characterized by good water repellent and resistant to external corrosive environments, which allows it to be used in civil and road construction, water-resistant layer for reclamation in hot and arid regions, and in areas where there is a need for bulk materials with hydrophobic properties.

Functional Model of Higher Educational Institution Library Building up
Murat K. Baimul'din,Asemgul' S. Smagulova,Gulnur B. Abildaeva,Zagira B. Saimanova
European Researcher , 2013,
Abstract: The article presents the technology of integrated data processing, related to academic and library-bibliographic activities for specialties work programs development and book sufficiency estimation in integrated research and information system of higher educational institution. The model of higher educational institution library building up, based on monitoring of educational process book sufficiency and literature demand is introduced
Multilingual Education as One of Priority Directions of Educational System Development in the Republic of Kazakhstan
Shara Mazhitaeva,Gulnara Smagulova,Bahytgul Tuleuova
European Researcher , 2012,
Abstract: Multilingual education is one of the priority directions of educational system development in the Republic of Kazakhstan. This paper addresses the problem of multilingual education formation and development on the example of Karaganda State University named after academician EA Buketov, describes the prospectivity of this direction during the implementation of the state project "Trinity of Languages".
EFFECTIVENESS OF I AND II LINE CHEMO-TARGETED THERAPY ACCORDING TO THE SCHEME OXALIPLATIN +CAPECITABINE + BEVACIZUMAB (XELOX+BEV) IN PATIENTS WITH METASTATIC COLORECTAL CANCER (MCRC)
KALDYGUL SMAGULOVA,NINO CHICHUA,ZHETKERGEN ARZYKULOV,SURIYA YESENTAYEVA
Medical and Health Science Journal , 2011,
Abstract: The research involved 38 mCRC patients, aged 23-73 (medium age -55 years). Patients with mCRC were randomized into two groups. This mode of chemo-targeted therapy was conducted in the first group (20 patents) in a second line, since these patients previously were treated by the chemotherapy schemes FOLFIRIor FOLFOX. Patients were treated in the mode: Capecitabine in 2000mg/m2 2 times a day from the 1st to the 14th day, 2-hour infusion of capsular Oxaliplatin 130mg/m2, day 1, Bevacizumab 5mg/kg 1 time per 14 days. The overall objective effect was obtained in 15 patients (39.5±7.9) %: in group 1 - in 7 patients (35.0 + 10.6%), in the 2group - 8 cases (44.4±11.7%), of which complete regression - in 1 (5%) and 2 (11.1%) cases, respectively. In 30% of cases the partial response and a greater number of stabilization (50% and 44.5% respectively) were reported. Progression of the process was observed at 15% in a group 1 and 11.1% of cases in group 2. Terms of remission were group 1 - 8.2 months, group 2 - 12.1 months. Thus, XELOX + BEV shows the sufficient efficacy in patients with mCRC, both in I and II lines of chemotherapy, with an acceptable toxicity profile.
GATA4/FOG2 transcriptional complex regulates Lhx9 gene expression in murine heart development
Fatima O Smagulova, Nikolay L Manuylov, Lyndsay L Leach, Sergei G Tevosian
BMC Developmental Biology , 2008, DOI: 10.1186/1471-213x-8-67
Abstract: Here we report identification of the Lhx9 gene as a direct target of the GATA4/FOG2 complex. We demonstrate that the developing mouse heart normally expresses truncated isoforms of Lhx9 – Lhx9α and Lhx9β, and not the Lhx9-HD isoform that encodes a protein with an intact homeodomain. At E9.5 Lhx9α/β expression is prominent in the epicardial primordium, septum transversum while Lhx9-HD is absent from this tissue; in the E11.5 heart LHX9α/β-positive cells are restricted to the epicardial mesothelium. Thereafter in the control hearts Lhx9α/β epicardial expression is promptly down-regulated; in contrast, mouse mutants with Fog2 gene loss fail to repress Lhx9α/β expression. Chromatin immunoprecipitation from the E11.5 hearts demonstrated that Lhx9 is a direct target for GATA4 and FOG2. In transient transfection studies the expression driven by the cis-regulatory regions of Lhx9 was repressed by FOG2 in the presence of intact GATA4, but not the GATA4ki mutant that is impaired in its ability to bind FOG2.In summary, the Lhx9 gene represents the first direct target of the GATA4/FOG2 repressor complex in cardiac development.Unlike many developing organs that remain dormant until the time of birth, a properly functioning embryonic heart is essential for embryo survival. Hence, defects in cardiac function are a common cause for embryonic lethality. Gene targeting in mice revealed multiple genes that are required for cardiac development and function; however, the interplay between these genes often remains a mystery. This is especially true for genes encoding for transcription factors which are expressed in a dynamic fashion in various cellular compartments that constitute the developing heart.Friend of GATA, member 2 gene (FOG2, ZFPM2 – Mouse Genome Informatics) is prominently expressed in multiple cell types that constitute the embryonic heart [1]. To examine the function for FOG2 in cardiac development gene-targeted mice have been generated [2]. Fog2-/- (null) embryos die at
Intracellular HIV-1 Gag localization is impaired by mutations in the nucleocapsid zinc fingers
Boyan Grigorov, Didier Décimo, Fatima Smagulova, Christine Péchoux, Marylène Mougel, Delphine Muriaux, Jean-Luc Darlix
Retrovirology , 2007, DOI: 10.1186/1742-4690-4-54
Abstract: We previously reported a role for the first NC zinc finger in virion structure and replication [1]. To investigate the role of both NC zinc fingers in intracellular Gag trafficking, and in virion assembly, we generated series of NC zinc fingers mutations. Results show that all Zinc finger mutations have a negative impact on virion biogenesis and maturation and rendered defective the mutant viruses. The NC zinc finger mutations caused an intracellular accumulation of Gag, which was found either diffuse in the cytoplasm or at the plasma membrane but not associated with endosomal membranes as for wild type Gag. Evidences are also provided showing that the intracellular interactions between NC-mutated Gag and the gRNA were impaired.These results show that Gag oligomerization mediated by gRNA-NC interactions is required for correct Gag trafficking, and assembly in HIV-1 producing cells and the release of infectious viruses.The retroviral Gag polyprotein precursor is formed of three essential domains, namely the matrix (MA), the capsid (CA) and the nucleocapsid (NC), which upon protease mediated processing of Gag constitute the architecture of the infectious mature viral particle. The three Gag domains contain the critical determinants that orchestrate virus assembly in the infected cell, via membrane-MA, CA-CA and NC-gRNA interactions [2-8]. In the mature virus, the MA protein is located under the virion envelope, which derives from the infected cell membrane. In the case of HIV-1, MA is myristoylated and contains basic amino acids within its N-terminus required for Gag-membrane binding and determinants that specifically interact with the cellular adaptator proteins AP-3 and AP-2. These AP proteins contribute to the intracellular transport of Gag to endosomal compartments and retroviral budding [9-11]. The CA molecules form the outer shell of the viral core while NC molecules extensively coat and condense the gRNA in the interior of the virion core [2]. HIV-1 NC contains
A Comparative Investigation of Lead Sulfate and Lead Oxide Sulfate Study of Morphology and Thermal Decomposition  [PDF]
S. A. A. Sajadi
American Journal of Analytical Chemistry (AJAC) , 2011, DOI: 10.4236/ajac.2011.22024
Abstract: The compound lead oxide sulfate PbSO4.PbO was prepared in our laboratory. The Thermal behavior of PbSO4 was studied using techniques of Thermogravimetry under air atmosphere from 25 to 1200°C. The identity of both compounds was confirmed by XRD technique. Results obtained using both techniques support same decomposition stages for this compound. The electron microscopic investigations are made by SEM and TEM. The compound is characterized by XRD and the purity was determined by analytical Methods. Also a series of thermogravimetric analysis is made and the ideal condition is determined to convert this compound to pure lead oxide.
Metal ion-binding properties of L-glutamic acid and L-aspartic acid, a comparative investigation  [PDF]
S. A. A. Sajadi
Natural Science (NS) , 2010, DOI: 10.4236/ns.2010.22013
Abstract: A comparative research has been developed for acidity and stability constants of M(Glu)1, M(Asp)2 and M(Ttr)3 complexes, which have been determined by potentiometric pH titration. Depending on metal ion-binding properties, vital differences in building complex were observed. The present study indicates that in M(Ttr) com-plexes, metal ions are arranged to the carboxyl groups, but in M(Glu) and M(Asp), some metal ions are able to build chelate over amine groups. The results mentioned-above demonstrate that for some M(Glu) and M(Asp) complexes, the stability constants are also largely determined by the affinity of metal ions for amine group. This leads to a kind of selectivity of metal ions, and transfers them through building complexes accompanied with glutamate and aspartate. For heavy metal ions, this building complex helps the absorption and filtration of the blood plasma, and consequently, the excursion of heavy metal ions takes place. This is an important method in micro-dialysis. In this study the different as-pects of stabilization of metal ion complexes regarding to Irving-Williams sequence have been investigated.
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