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Search Results: 1 - 10 of 346190 matches for " Sánchez Castro Liliana Carolina "
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Sergei Mouraviev. Heraclitea (10 vols.). Sankt Agustin, Alemania: Academia Verlag, 1999-2006.
Sánchez Castro Liliana Carolina
Forma y Función , 2009,
Abstract:
Supervivencia de pacientes con cáncer de pulmón de célula no peque?a en cuatro instituciones de Colombia
Cardona,Andrés Felipe; Carranza,Hernán; Vargas,Carlos Alberto; Otero,Jorge Miguel; Reveiz,Ludovic; Reguart,Noemí; Carrasco,Esther; Ospina,Edgar; Sánchez,Oswaldo; Ospina,Vanessa; Cabrera,ángela Viviana; Ramírez,Diana Carolina; Pérez,Juan Carlos; Torres,Liliana Patricia; Vélez,Carolina; Serrano,Silvia Juliana; Castro,Carlos;
Revista Venezolana de Oncología , 2010,
Abstract: objective: describing results of treatment in patients suffering advanced no small cell according to routine clinical practice. the 70 % of patients suffering debut with advanced disease are determining less than 13 % overall survival in 5 years. methods: 176 patients treated in bogotá. results: the mean age was 64 years; 64 % were male 51 % had ≤1 ecog. the 90 % had metastasis, mainly in the lung and in central nervous system. 76 % received combined therapy as the first line of intervention; 126 subjects were treated with a platinum compounds (cisplatin 38/21.6 % carboplatin 88/50 %) plus some third generation agent or etoposide. thirty-four received monotherapy and eight erlotinib; 3.7 ± 1.7 cycles per patient were supplied on average, overall response rate was 29 %, clinical benefit 39 % and the median time to progression was 3.4 months. only the third part of the population received a second line intervention; in this group overall response was 15.8 %, clinical benefit 33.8 % and free time progression was 3.1 months. when follow-up finished, 69.3 % had died, median the overall survival was 9.2 months 26 % of the subjects lived for up to one year. some variables such gender, functional state, history of smoking, administering second line agent and a diagnosis of adenocarcinoma influenced in superlife. conclusions: clinical behaviour and outcomes treatment of patients included in this study were similar to those previously reported in the medical literature.
Animal cloning: advances and prospects
Chuaire Lilian,Sánchez Magda Carolina,Franco María Liliana
Colombia Médica , 2004,
Abstract: Few recent advances have revolutionized the developmental biology as the animal cloning has. Since the birth of Dolly, the sheep, in 1996, which was the first derived clone of a mature animal, a new scientific era began. It has been characterized by growing demystification that differentiated cells are unalterable entities in its nuclear organization and chromatin structure, and by a better understanding of the mechanisms that regulate the development. Throughout this paper, we will review some of the achievements and limitations of the techniques used, both in therapeutic and in the reproductive cloning, as well as the perspectives that its application allows to glimpse within a close future. At the same time, we will point out some considerations regarding the ethical debate that surrounds such a controversial issue.
Innovating Methodological Strategies in Planning for Development Innovando Estrategias metodológicas en planeación para el desarrollo
Villada Ríos María Alejandra,Serna Guzmán Carolina,Sánchez Mazo Liliana María
Bitácora Urbano-Territorial , 2011,
Abstract: From the research done during the 2009-2010 period, taking as a case study the Local Planning and Participative Program (PPPP), executed between 2004 and 2007 in the “Comuna 1”, neighborhood of the municipality of Medellín-Colombia, five guidelines for the construction of methodological strategies oriented to the dynamization and operation of planning for the territory development as social intervention process, were identified: communication as a democratic principle, citizenship education, organization towards participation, collective empowering of actors and territorial integration. These strategies additionally have, as their foundation, the theoretical approaches of the third focus, designed as a multiple socio- cultural, historical and territorially determined construction. This reflection recreates theoretical-empirical foundations of planning for development and its potentiality as a guide for the social intervention, so that, from the investigative experience mentioned, innovative methodological strategies that dynamize planning processes and contribute to extending the applied social sciences foundations can be found. A partir de la investigación realizada en el período 2009-2010, cuyo estudio de caso fue el Programa de Planeación Local y Presupuesto Participativo –PPPP-, ejecutado entre 2004 y 2007 en la Comuna 1 del municipio de Medellín, Colombia, se proponen cinco directrices para la construcción de estrategias metodológicas orientadas a la dinamización y operación de la planeación para el desarrollo del territorio como proceso de intervención social, a saber: comunicación como principio democrático, formación ciudadana, organización para la participación, empoderamiento colectivo de actores e integración territorial. Estas estrategias adicionalmente, tienen como base los planteamientos teóricos del tercer enfoque del desarrollo, designado como construcción sociocultural múltiple, histórica y territorialmente determinada. La reflexión recrea fundamentos teórico-empíricos de la planeación para el desarrollo y, su potencialidad como orientadora de la intervención social para, a partir de la experiencia investigativa aludida, derivar estrategias metodológicas novedosas que dinamicen los procesos de planeación y contribuyan a ampliar los fundamentos de las ciencias sociales aplicadas.
Evaluación de la función opsono fagocítica de los neutrófilos en pacientes infectados por el VIH Evaluation of the opsonophagocytic function of neutrophils in HIV-infected patients
Randelys Molina Castro,Alejandro álvarez García,Liliana Pérez Toledo,Lizet Sánchez Valdés
Revista Cubana de Hematolog?-a, Inmunolog?-a y Hemoterapia , 2002,
Abstract: La disfunción de los neutrófilos podría contribuir a la susceptibilidad a infecciones observada en los pacientes infectados por el virus de inmunodeficiencia humana (VIH). Se realizó un estudio de corte transversal para evaluar la opsono fagocitosis de los neutrófilos en estos pacientes, en el que participaron 104 individuo: 25 donantes de sangre (grupo control) y 79 VIH positivos (+). Estos últimos se dividieron en 3 grupos según su conteo global de linfocitos T CD4 + (CGLCD4): grupo 1 compuesto por 24 individuos con CGLCD43500 células/mm3; grupo 2 por 26 pacientes con CGLCD4 de 200 a 499 células/mm3; y grupo 3 por 29 casos con CGLCD4 < 200 células/mm.3 Se realizó la determinación de los valores absolutos de leucocitos y granulocitos y los valores relativos de linfocitos, la cuantificación de subpoblación linfoide T CD4 positiva (+) y la determinación del índice opsono fagocítico. Se encontró una disminución significativa (p < 0,05) del conteo absoluto de leucocitos y granulocitos, así como de la función opsono fagocítica, en los grupos de pacientes VIH+ con respecto al grupo control. Se constató una relación directa no lineal del conteo absoluto de linfocitos T CD4 + con el conteo global de leucocitos y de granulocitos y con la función opsono fagocítica The dysfunction of neutrophils could contribute to susceptibility to infections observed in HIV-infected patients. A cross-sectional study was conducted to evaluate the opsonophagocytosis of neutrophils in these patients. One hundred and four individuals participated in it: 25 blood donors (the control group) and 79 HIV-positive patients who were distributed into 3 groups according to the global count of CD4 lymphocytes (GLCCD4): Group 1 composed of 24 individuals with GLCCD43 500 cell/mm3, Group 2 with 26 patients with GLCCD4 of 200-499 cell/mm3 and Group 3 composed by 29 patients with GLCCD4 < 200 cell/mm3 . Absolute values of leukocytes and granulocytes and relative values of lymphocytes were determined, CD4+ lymphocyte T subset was quantified and the opsonophagocytic index was estimated. A significant reduction (p< 0,05) in absolute count of leukocytes and granulocytes and in the opsonophagocytic function was found in HIV-infected patients compared with the control group. There was a non-linear direct relation of the absolute count of CD4+ T lymphocytes with global count of leukocytes and granulocytes and the opsonophagocytic function
LA INNOVACIóN COMO FUENTE DE VENTAJA COMPETITIVA: Un análisis del Sector Metalmecánico de Pereira y Dosquebradas
JOHN JAIRO SáNCHEZ CASTRO,GRACE KELLY MOLINA G.,CAROLINA ARENAS G.
Scientia Et Technica , 2009,
Abstract: Este artículo permite identificar las principales características de innovación con que cuenta el Sector Metalmecánico de Risaralda Colombia.
Multiplexed methylation profiles of tumor suppressor genes and clinical outcome in lung cancer
Mónica Castro, Laura Grau, Patricia Puerta, Liliana Gimenez, Julio Venditti, Silvia Quadrelli, Marta Sánchez-Carbayo
Journal of Translational Medicine , 2010, DOI: 10.1186/1479-5876-8-86
Abstract: A multicandidate probe panel interrogated DNA for aberrant methylation status in 18 tumor suppressor genes in lung cancer using a methylation-specific multiplex ligation-dependent probe amplification assay (MS-MLPA). Lung cancer cell lines (n = 7), and primary lung tumors (n = 54) were examined using MS-MLPA.Genes frequently methylated in lung cancer cell lines including SCGB3A1, ID4, CCND2 were found among the most commonly methylated in the lung tumors analyzed. HLTF, BNIP3, H2AFX, CACNA1G, TGIF, ID4 and CACNA1A were identified as novel tumor suppressor candidates methylated in lung tumors. The most frequently methylated genes in lung tumors were SCGB3A1 and DLC1 (both 50.0%). Methylation rates for ID4, DCL1, BNIP3, H2AFX, CACNA1G and TIMP3 were significantly different between squamous and adenocarcinomas. Methylation of RUNX3, SCGB3A1, SFRP4, and DLC1 was significantly associated with the extent of the disease when comparing localized versus metastatic tumors. Moreover, methylation of HTLF, SFRP5 and TIMP3 were significantly associated with overall survival.MS-MLPA can be used for classification of certain types of lung tumors and clinical outcome prediction. This latter is clinically relevant by offering an adjunct strategy for the clinical management of lung cancer patients.Lung cancer is the third most frequent tumor, representing the leading cause of cancer death [1]. Non-small cell lung cancer (NSCLC) is the most common variant. NSCLC is the superseding term for various types of lung cancer such as the most common ones, adenocarcinomas and squamous carcinomas [2-4]. Even within patients at the earliest stages of the disease, a significant number recur after therapeutic surgery and adjuvant chemotherapy, and ultimately die from their disease. Lung cancer cure rate remains disappointing, with five-year survival rates limited to 15-20% [1]. Understanding the molecular basis of lung cancer will enable the identification of high-risk populations for effective ear
Anormalidades cromosómicas y esquizofrenia
Forero Castro,Ruth Maribel; Cortés Duque,Carolina; Sánchez Espinosa,Mayely Paola; Corredor Rozo,Zayda Lorena;
Revista Colombiana de Psiquiatría , 2009,
Abstract: introduction: schizophrenia is a mental disorder that affects the world population with a prevalence of 1% and a hereditability of up to 80% . four approaches have been postulated to identify susceptibility genes and to establish molecular markers associated with the disease: genetic linkage studies, genomic convergence, association, and chromosomal abnormalities. objective: to show chromosomal abnormalities reported in patients with schizophrenia as part of the genetic factors found in this condition. methods: a strategic selection was made of 68 articles published from 1954 to 2008 in scientific databases, and numerical, structural and mosaical type alterations were classified, taking into account their contributions to the study and relevance. results: the mainly involved chromosomes were, in order of frequency, 18, 9, 11, 1, x, 22 and 21. as to type of abnormalities, structural and numerical alterations were found, as well as mosaicims and polymorphisms. conclusions: with this review not only the calculation of the frequency of these findings was made more possible, but it also provided a reference of the type and frequency of these alterations to evaluate the genetic factor of schizophrenia, aimed at understanding its pathogeny
Anormalidades cromosómicas y esquizofrenia Cromosomal Abnormalities and Schizophrenia
Ruth Maribel Forero Castro,Carolina Cortés Duque,Mayely Paola Sánchez Espinosa,Zayda Lorena Corredor Rozo
Revista Colombiana de Psiquiatría , 2009,
Abstract: Introducción: La esquizofrenia es un trastorno mental que afecta a la población mundial, con una prevalencia del 1% y con heredabilidad hasta del 80%. Se han postulado cuatro enfoques para identificar genes de susceptibilidad y establecer marcadores moleculares asociados con la enfermedad: estudios de ligamiento genético, convergencia genómica, asociación y anormalidades cromosómicas. Objetivo: Mostrar anormalidades cromosómicas reportadas en pacientes con esquizofrenia como parte de los factores genéticos hallados en esta patología. Método: Se hizo una selección estratégica de 68 artículos publicados desde 1954 hasta 2008 en bases de datos científicas, clasificando las alteraciones de tipo numérico, estructural y mosaicos, tomando en cuenta sus contribuciones al estudio y relevancia. Resultados: Los cromosomas principalmente involucrados fueron, en orden de mayor a menor frecuencia, 18, 9, 11, 1, X, 22 y 21. En cuanto al tipo de anormalidad se encontraron alteraciones estructurales, mosaicismos, numéricas y también polimorfismos. Las anormalidades estructurales principalmente fueron translocaciones recíprocas balanceadas. Conclusiones: Con esta revisión no solamente se logró un acercamiento hacia la estimación de la frecuencia de estos hallazgos, sino tener un referente del tipo y frecuencia de estas alteraciones para evaluar el factor genético de la esquizofrenia, encaminados a comprender su patogenia. Introduction: Schizophrenia is a mental disorder that affects the world population with a prevalence of 1% and a hereditability of up to 80% . Four approaches have been postulated to identify susceptibility genes and to establish molecular markers associated with the disease: Genetic linkage studies, genomic convergence, association, and chromosomal abnormalities. Objective: To show chromosomal abnormalities reported in patients with schizophrenia as part of the genetic factors found in this condition. Methods: A strategic selection was made of 68 articles published from 1954 to 2008 in scientific databases, and numerical, structural and mosaical type alterations were classified, taking into account their contributions to the study and relevance. Results: The mainly involved chromosomes were, in order of frequency, 18, 9, 11, 1, X, 22 and 21. As to type of abnormalities, structural and numerical alterations were found, as well as mosaicims and polymorphisms. Conclusions: With this review not only the calculation of the frequency of these findings was made more possible, but it also provided a reference of the type and frequency of these alterations to e
ESTUDIO DE POLICONSUMO EN UNA MUESTRA DE CONDUCTORES DE BOGOTA, A?O 2005
Sánchez Cardozo,Oscar Armando; González O,Jorge Oswaldo; Dominguez Márquez,Carolina; López Castro,Adriana;
Revista Facultad de Medicina de la Universidad Nacional de Colombia , 2007,
Abstract: background. we do not know of studies in our city that indicate the degree of poly illicit drugs consumption in motor vehicles drivers. use of illicit drugs can explain in some cases the lack of agreement among measurement of breath alcohol test, blood alcohol concentration, and clinical examination in motor vehicles drivers when they are suspects of alcoholic intoxication. in this report we want to center on showing the use of illicit drugs and their clinical manifestations in a sample of motor vehicles drivers. objective. to determine the consumption of illicit drugs in a sample of motor vehicle drivers, when they are suspects of alcoholic intoxication. materials and methods. we took a representative sample within 68 motor vehicle drivers. we performed on all of them clinical examination, measurement of breath alcohol tests and blood alcohol concentration. also we collected urine samples. five (5) substances were investigated according to their high prevalence in our population: opiate, marijuana, cocaine, amphetamines and benzodiazepines. results.there were seven cases of illicit drug consumption: the most frequent combination found was (5-7 cases) alcohol plus marijuana. in three cases we found consumption of three illicit drugs: 2 cases have alcohol, marijuana and cocaine. only one case of alcohol, benzodiazepine and cocaine. conclusions. in the sample analyzed the use of illicit drugs was 10.14 %. the most common form of use is a depressor with a stimulant. if it is recent, it diminishes the neurological manifestations, but it does not affect the presentation nor the severity of the rotacional nystagmus. the alterations of the superior mental functions were seen to be associated with alcohol consumption plus benzodiazepines. combination of two depressors increases the motor alterations and seems that it alters the superior mental functions. in the negative clinical examinations it was concluded that there was no alcohol intoxication and no use of other psychoa
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