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An Electrosurgical Endoknife with a Water-Jet Function (Flushknife) Proves Its Merits in Colorectal Endoscopic Submucosal Dissection Especially for the Cases Which Should Be Removed En Bloc
Yoji Takeuchi,Toshio Shimokawa,Ryu Ishihara,Hiroyasu Iishi,Noboru Hanaoka,Koji Higashino,Noriya Uedo
Gastroenterology Research and Practice , 2013, DOI: 10.1155/2013/530123
Abstract: Background. Previously, we reported that the Flushknife (electrosurgical endoknife with a water-jet function) could reduce the operation time of colorectal endoscopic submucosal dissection (ESD) however, suitable situation for the Flushknife was obscure. This subgroup analysis of a prospective randomized controlled trial was aimed to investigate the suitable situation for the Flushknife. Methods. A total of 48 superficial colorectal neoplasms that underwent ESD using either the Flexknife or the Flushknife in a referral center were enrolled. The differences of operation time between the Flexknife and the Flushknife groups in each subgroup (tumor size, location, and macroscopic type) were analyzed. Results. Median (95% CI) operation time calculated using survival curves was significantly shorter in the Flushknife group than in the Flexknife group (55.5?min [41, 78] versus 74.0 [57, 90]?min; , Hazard Ratio HR: 0.53; 95% CI (0.29–0.97)). In particular, the HR in patients with laterally spreading tumors-nongranular type (LST-NG) in the Flushknife group was significantly smaller than in the Flexknife group (HR: 0.165 0.17; 95% CI (0.04–0.66)). There was a trend of decreasing HRs according to larger lesion size. Conclusions. The Flushknife proved its merits in colorectal ESD especially for the lesions which should be removed en bloc (LST-NG and large lesion). 1. Introduction Endoscopic submucosal dissection (ESD) is one of the standard treatments for large upper gastrointestinal superficial neoplasms in Japan and South Korea [1–5] because of its high en bloc resection (entire tumor resection in one piece) rate. ESD is also considered as a promising procedure in Western countries [6]. Although there are some reports on ESD for colorectal superficial neoplasms [7–9], ESD has not been a standard therapy for large colorectal superficial neoplasms, even in Japan. The reason is that it is time consuming, technically difficult, and related to a higher incidence of complications (perforation and bleeding) than conventional endoscopic mucosal resection (EMR) [10]. Flushknife (DK2618JN15, Fujifilm Medical, Tokyo, Japan) is a short needle electrosurgical endo-knife combined with a water-jet function (Figure 1(a)) [11]. We have reported that the Flushknife could reduce the operation time of colorectal ESD for patients with large colorectal superficial neoplasms [12], compared with a standard electrosurgical endo-knife (Flexknife; KD-630L, Olympus Medical Systems, Tokyo, Japan, Figure 1(b)) [13, 14]. In the study, we enrolled lesions larger than 20?mm and smaller than
Effects of Improving Public Services for Tourism Developments in Islands: The Case of Remote Islands in Nagasaki, Japan  [PDF]
Tadahiro Okuyama, Hayato Ishihara
Open Journal of Social Sciences (JSS) , 2015, DOI: 10.4236/jss.2015.36018
Abstract: Growths of numbers of tourists who stay long-term in tourism sites are an important policy for local governments in islands due to their locations that are far from urban areas. However, many tourists hesitate to stay long-term in islands owing to not only the expensive travel costs but also the lack of public services in islands. The purpose of this study is to examine effects of improving public services in islands for tourists’ willingness to pays (WTPs) and non-tourists’ attitudes for long-term stays. Data on tourism activity for islands, Nagasaki, Japan were used. Respondents were asked about their WTPs for long-term stays and their needs for public services of islands; reductions of costs for rent or purchasing houses for long-term stays and travel costs, easy to take a vacation, to enhance medical services, educational services and job search services. The logit model was used for estimations. Median and mean values of WTPs (per year) were calculated JPY 151,629 (USD 1184) and JPY 242,110 (USD 3008). Positive effects on five public services (without travel costs) were confirmed. For example, the median values of WTPs were increased to JPY 478,369 (USD 5943) when the medical services were improved, and JPY 1,484,704 (USD 18,446) when all public services were improved. The results showed that improvement of public services have the effect 1) to improve tourists’ benefits and 2) to change many non-tourists’ attitudes from the rejection of staying long term in islands to the acceptance. Thus, results indicate that it would be better for central and/or local governments in islands to enhance islands’ public services.
Abnormal Cystatin C Levels in Two Patients with Bardet-Biedl Syndrome
Makito Hirano, Mitsuru Ohishi, Toshihide Yamashita, Yasushi Ikuno, Hiromi Iwahashi, Toshiyuki Mano, Ryu Ishihara, Ichiro Tanaka, Keiko Yanagihara, Chiharu Isono, Hikaru Sakamoto, Yusaku Nakamura and Susumu Kusunoki
Clinical Medicine Insights: Case Reports , 2012, DOI: 10.4137/CCRep.S6622
Abstract: Bardet-Biedl syndrome (BBS) is an autosomal recessive disorder characterized by central obesity, mental impairment, rod-cone dystrophy, polydactyly, hypogonadism in males, and renal abnormalities. The causative genes have been identified as BBS1-14. In the Western countries, the prevalence of this disease ranges from 1/13,500 to 1/160,000, while only a few Japanese patients have been reported in the English-language literature. The incidence of renal dysfunction or anomalies in previous reports varies considerably ranging from ~20% to universal occurrence. We here report that two Japanese patients who had BBS with normal BUN and creatinine levels had elevated levels of cystatin C, a sensitive marker of glomerular filtration rate. A urine albumin level increased only in the elder patient. Thus, cystatin C may be useful for detecting renal abnormalities in patients with an apparent normal renal function. Because this disease is diagnosed by accumulation of symptoms, such a sensitive marker might help early diagnosis of BBS.
Temporal Prediction of Aircraft Loss-of-Control: A Dynamic Optimization Approach  [PDF]
Chaitanya Poolla, Abraham K. Ishihara
Intelligent Control and Automation (ICA) , 2015, DOI: 10.4236/ica.2015.64023
Abstract: Loss of Control (LOC) is the primary factor responsible for the majority of fatal air accidents during past decade. LOC is characterized by the pilot’s inability to control the aircraft and is typically associated with unpredictable behavior, potentially leading to loss of the aircraft and life. In this work, the minimum time dynamic optimization problem to LOC is treated using Pontryagin’s Maximum Principle (PMP). The resulting two point boundary value problem is solved using stochastic shooting point methods via a differential evolution scheme (DE). The minimum time until LOC metric is computed for corresponding spatial control limits. Simulations are performed using a linearized longitudinal aircraft model to illustrate the concept.
Mesocosm Assessment of Stability Habitat for Halophyte  [PDF]
Sunghoon Ryu, Incheol Lee
Journal of Geoscience and Environment Protection (GEP) , 2015, DOI: 10.4236/gep.2015.36003

In this paper, we constructed the halophyte Mesocosm experimental group which was used as a substrate material that consisted of tidal flat and dredged sediment. Depending on whether the ingredients of vegetation and substrate material of Mesocosm, we constructed Mesocosm A (tidal flat sediment + Salicornia herbecea), Mesocosm B (only dredged sediment), Mesocosm C (dredged sediment + Salicornia herbecea). Monitoring was carried out of seawater quality factors (Chemical Oxygen Demand (COD), Total Nitrogen (T-N), Total Phosphorus (T-P), temperature, salinity), sediment factors (Chemical Oxygen Demand (COD), Total (T-N), Total Phosphorus (T-P) and growth of Salricornia herbecea) in each Mesocosm. Habitat Stability Index of vegetation was calculating by using the monitoring results. HSI of Mesocosm C was calculated from 0.87 to 0.95 as compared to the relatively high HSI Mesocosm A, it was evaluated to be able to be used in the restoration of the coastal salt marsh with dredged sediment.

Fixture Design to Supplement Machining and Fuel Cell Education  [PDF]
Yeong Ryu, Hazem Tawfik
Engineering (ENG) , 2017, DOI: 10.4236/eng.2017.95022
Abstract: A vital part of enhancing the ability of students to learn about advanced fabrication techniques is identifying the barriers to the student’s entry and excelling in the manufacturing field. In the Manufacturing and Mechanical Technology fields, there exists an intimidating experience gap or barrier between professionals and novice students. The students’ participation in the design and fabrication of a fixture for manufacturing a mechanical part will aid in eliminating this barrier by making fuel cell’s bipolar plates production accessible to inexperienced technology students. The process of manufacturing a fixture for the production of hydrogen fuel cell and hydrogen purifier plates required a careful planning and step-by-step methodological implementation. Through the use of our designed fixture, it is now possible to teach students how to use a CNC milling machine with relative ease while also allowing for precision part machining. The setup of the fixture allows students to observe the necessary measures to properly machine a part while also teaching them the benefits of fixtures in the manufacturing industry. In summary, the purpose of this paper is to provide the students with applied learning experience through involving them in the design and fabrication of a multi-disciplinary mechanical fixture and the utilization of practice oriented teaching resources in a full scale learning environment.
A Comparative Study of Machine Learning Algorithms and Their Ensembles for Botnet Detection  [PDF]
Songhui Ryu, Baijian Yang
Journal of Computer and Communications (JCC) , 2018, DOI: 10.4236/jcc.2018.65010
Abstract: A Botnet is a network of compromised devices that are controlled by malicious “botmaster” in order to perform various tasks, such as executing DoS attack, sending SPAM and obtaining personal data etc. As botmasters generate network traffic while communicating with their bots, analyzing network traffic to detect Botnet traffic can be a promising feature of Intrusion Detection System. Although such system has been applying various machine learning techniques, comparison of machine algorithms including their ensembles on botnet detection has not been figured out. In this study, not only the three most popular classification machine learning algorithms—Naive Bayes, Decision tree, and Neural network are evaluated, but also the ensemble methods known to strengthen classifier are tested to see if they indeed provide enhanced predictions on Botnet detection. This evaluation is conducted with the CTU-13 public dataset, measuring the training time of each classifier and its F measure and MCC score.
Some adjunction properties of ample vector bundles II
Hironobu Ishihara
Le Matematiche , 2001,
Abstract: Let E be a vector bundle of rank r on a projective variety X of dimension n with only log-terminal singularities. We classify the couples (E,X) satisfying some conditions. We give some applications in case of sectional genus one.
Bioinspired phospholipid polymer biomaterials for making high performance artificial organs
K Ishihara
Science and Technology of Advanced Materials , 2000,
Abstract: Novel polymer biomaterials, which can be used in contact with blood, are prepared with strong inspiration from the surface structure of biomembrane. That is, the polymers with a phospholipid polar group in the side chain, 2-methacrylooyloxyethyl phosphorylcholine (MPC) polymers were synthesized. The MPC polymers can inhibit surface-induced clot formation effectively, when they are in contact with blood even in the absence of an anticoagulant. This phenomenon was due to the reduction of plasma protein and suppression of denaturation of adsorbed proteins, that is the MPC polymers interact with blood components very mildly. As the molecular structure of the MPC polymer was easily designed by changing the monomer units and their composition, it could be applied to surface modification of artificial organs and biomedical devices for improving blood and tissue compatibility. Thus, the MPC polymers are useful polymer biomaterials for manufacturing high performance artificial organs and biomedical devices to provide safe medical treatments.
Electronic Ferroelectricity and Frustration
Sumio Ishihara
Physics , 2009, DOI: 10.1143/JPSJ.79.011010
Abstract: Beyond a conventional classification of ferroelectricity, there is a class of materials where electronic degrees of freedom and electronic interactions are directly responsible for electric polarization and ferroelectric transition. This is termed electronic ferroelectricity. In this article, we review electronic ferroelectricity from a view point of frustration. Experimental and theoretical examinations in spin driven ferroelectric materials, recently termed multiferroics, are introduced. Spin frustration caused by competing magnetic interactions is of prime importance for this type of ferroelectricity. Charge driven ferroelectricity where electronic charge order induces electric polarization is reviewed. In particular, exotic dielectric and magneto-dielectric properties in layered iron oxides are focused on. Through a number of recent experimental and theoretical researches, charge fluctuation due to frustrated geometry plays essential roles on electronic ferroelectricity in this compound.
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