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Search Results: 1 - 10 of 4093 matches for " Ryan Beni "
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Drinking Water Disparities in Tennessee: The Origins and Effects of Toxic Heavy Metals  [PDF]
Ryan Beni, Sujata Guha, Shwan Hawrami
Journal of Geoscience and Environment Protection (GEP) , 2019, DOI: 10.4236/gep.2019.76012
Abstract:
Several toxic metals, commonly present in drinking water, are believed to play important roles in the development of cancerous tumors. Although the US Safe Drinking Water Act requires drinking water to meet health standards set by the Environmental Protection Agency, violations occur regularly. In this study, we have investigated the role of the two predominant toxic heavy metals identified in the drinking water sources in Tennessee: copper and lead. We have analyzed the levels of copper and lead, as well as the total water hardness among different counties of Tennessee, with different socioeconomic backgrounds. We determined that the effects of lead and copper in drinking water were random, although counties with typically lower average household incomes typically had higher levels of the metals. The contaminant levels were found to remain below the threshold established by the Environmental Protection Agency and the State of Tennessee. Water from the Cumberland River was harder than water obtained from other rivers in Tennessee. Furthermore, the total hardness of water did not correlate with the average household income of the various counties.
The Effect of Trihalomethanes in Contaminating the Major Watersheds of Middle Tennessee  [PDF]
Sujata Guha, Paige Harlin, Ryan Beni
Natural Science (NS) , 2019, DOI: 10.4236/ns.2019.117023
Abstract: We have analyzed the contamination of the three major watersheds in Middle Tennessee (Middle Cumberland River Watershed, Stones River Watershed, and Harpeth River Watershed) by trihalomethanes, such as chloroform, bromodichloromethane, dibromochloromethane, and bromoform. These chemicals play an important role in the develop-ment of cancer and adverse reproductive outcomes, and were found to be present above the threshold established by the Environmental Protection Agency. Certain portions of each watershed were found to be contaminated by the trihalomethanes, and deemed un-healthy. The household incomes in the major areas in the three watershed regions were also examined to determine a possible relationship with the level of water contamination. We concluded that income did not necessarily relate to water quality. Specific areas within each watershed that had lower average household incomes were found to have a higher concentration of the trihalomethanes in their drinking water, while other high-income areas were also affected by unhealthy water. However, these effects were random, and the level of contamination remained below the guidelines regulated by the State of Tennessee.
Synthesis and Antiproliferative Activities of Triphenylmethanol Conjugates of Leuprorelin  [PDF]
Ryan Beni, William Boadi, Kaleh Karim, Jawzah Alnakhli, Samiyah Alhamed
Open Journal of Medicinal Chemistry (OJMC) , 2019, DOI: 10.4236/ojmc.2019.92002
Abstract: Leuprorelin® (LEP) is an FDA drug for breast cancer and prostate cancer treatment. There are several reported adverse effects such as transient hypertension, excessive salivation, and increased dysuria during treatment with LEP. In this study, the efficacy and toxicity of LEP were modified by using a drug delivery system to adjust the physicochemical properties. In this regard, Leuprorelin® conjugates of triphenylmethanol derivatives (TPMs) were synthesized as prodrugs. Comparative antiproliferative assays showed that LEP-TPMs conjugates had significantly higher antiproliferative activities than the corresponding non-covalent physical mixtures of the TPMs and LEP against human invasive ductal carcinoma (BT-549), human prostate carcinoma (PC3), human lung cancer (A549) and mouse pre-adipocytes (3T3-L1) cells.
Triphenylmethanol Conjugates of Triptorelin as Anti-Lipid Peroxidation Prodrugs  [PDF]
Samiyah Alhamed, Jawzah Alnakhli, William Boadi, Ryan Beni
Open Journal of Medicinal Chemistry (OJMC) , 2019, DOI: 10.4236/ojmc.2019.93003
Abstract: Antioxidants are substances that can prevent or slow damage to cells caused by free radicals, unstable molecules that the body produces as a reaction to environmental and other pressures. Free radicals may play a role in heart disease, cancer and other diseases. If the body cannot process and remove free radicals efficiently, oxidative stress can result. This can harm cells and body function. Free radicals are also known as reactive oxygen species (ROS). In this research, Triptorelin® (TRP) conjugates of triphenylmethanol derivatives (TPMs) were synthesized to evaluate their in vitro lipid peroxidation potency. Comparative lipid peroxidation assays between TRP-TPMs conjugates and the corresponding TPMs derivatives were measured using thiobarbituric reactive substance (TBARS) in a dose- and time-dependent manner following the Fenton’s pathway. Overall, TBARS decreased between 20% - 30% for the treated samples of synthesized conjugates compared to their respective control physical mixtures. These data suggest that TRP-TPMs derivatives can be used to improve the biological activity of TRP.
Stochastic Approach on Forest Fire Spatial Distribution from Forest Accessibility in Forest Management Units, South Kalimantan Province, Indonesia  [PDF]
Beni Raharjo, Nobukazu Nakagoshi
Journal of Environmental Protection (JEP) , 2014, DOI: 10.4236/jep.2014.56055
Abstract:

This study explores stochastic approach to analyzing the forest fire spatial distribution from forest accessibility using 2-parameters Weibull distribution model. MODIS firespot data, as a proxy for forest fire location, from 2001 to 2012 was analyzed by correlating its spatial distribution with the distance from settlement and road/lake in 11 Forest Management Units (FMUs) in South Kalimantan Province, Indonesia. (For more information,please refer to the PDF.)

The Future Relevancy of University Institutions’ Teaching in the Digital Era  [PDF]
Nitza Davidovitch, Beni Reuven Levy
Creative Education (CE) , 2017, DOI: 10.4236/ce.2017.86070
Abstract: The paper focuses on the structured and well-planned design and execution of courses in academic studies in general, and in architecture in particular, based on the great relevance of the learning-centered approach for teaching in universities in the digital era, related to the traditional teaching-centered approach applied in the majority of academic institutions today. The design of a course according to the learning-centered approach has unique value, particularly in the information era, with computers virtually and instantaneously transmitting endless knowledge. In the learning-centered approach, unlike frontal transfer of information, a dialogue is formed between academic faculty and students, leading to compatibility between learning outcomes (course goals) and teaching methods. stressing the value of course design according to the learning-centered approach are necessary as a result of social, cultural, and technological changes in the current information highway era and the consequent status of knowledge as possessed by everyone, while noting and emphasizing the special needs involved in the challenges of teaching and learning in this era. The paper also depicts the significance of recording learning outcomes, and the benefits and challenges associated with the formulation of learning goals. To illustrate this topic, development of a course in the “backward design” method, consistent with the learning-centered paradigm, shall be presented. The challenges of this method shall also be portrayed, with the possibility of generalization to varied disciplines. This paper shall emphasize the main potential advantage of physical academic institutions and universities, where students and teachers meet, talk, and hold direct and unmediated discussions, and through the learning-centered approach, versus the virtual knowledge and teaching centers have recently emerged as an alternative to traditional academic institutions and are seemingly threatening to obviate the justification for universities. It is particularly important also, in light of disturbing data indicating a considerable drop in university registration rates, in Israel and elsewhere, with the current young generation finding gradually less interest in universities as capable of shaping their personal and professional future. Therefore, with the gradual increase in accessible knowledge, instructors are required to bring with them added value to the teaching process. This is a complicated requirement that compels instructors to relinquish traditional teaching patterns. Planning a course in this
Information storage capacity of discrete spin systems
Beni Yoshida
Physics , 2011, DOI: 10.1016/j.aop.2013.07.009
Abstract: Understanding the limits imposed on information storage capacity of physical systems is a problem of fundamental and practical importance which bridges physics and information science. There is a well-known upper bound on the amount of information that can be stored reliably in a given volume of discrete spin systems which are supported by gapped local Hamiltonians. However, all the previously known systems were far below this theoretical bound, and it remained open whether there exists a gapped spin system that saturates this bound. Here, we present a construction of spin systems which saturate this theoretical limit asymptotically by borrowing an idea from fractal properties arising in the Sierpinski triangle. Our construction provides not only the best classical error-correcting code which is physically realizable as the energy ground space of gapped frustration-free Hamiltonians, but also a new research avenue for correlated spin phases with fractal spin configurations.
Physical interpretation of the dressed Polyakov loop in the Nambu--Jona-Lasinio model
Sanjin Beni
Physics , 2013, DOI: 10.1103/PhysRevD.88.077501
Abstract: We investigate the rapid rise of the dressed Polyakov loop in the Nambu--Jona-Lasinio (NJL) model as a function of temperature. In QCD such a behaviour is interpreted as a confinement- deconfinement phase transition. However, we demonstrate that in the NJL model this is simply a remnant of the chiral transition.
Exotic topological order in fractal spin liquids
Beni Yoshida
Physics , 2013, DOI: 10.1103/PhysRevB.88.125122
Abstract: We present a large class of three-dimensional spin models that possess topological order with stability against local perturbations, but are beyond description of topological quantum field theory. Conventional topological spin liquids, on a formal level, may be viewed as condensation of string-like extended objects with discrete gauge symmetries, being at fixed points with continuous scale symmetries. In contrast, ground states of fractal spin liquids are condensation of highly-fluctuating fractal objects with certain algebraic symmetries, corresponding to limit cycles under real-space renormalization group transformations which naturally arise from discrete scale symmetries of underlying fractal geometries. A particular class of three-dimensional models proposed in this paper may potentially saturate quantum information storage capacity for local spin systems.
Topological color code and symmetry-protected topological phases
Beni Yoshida
Physics , 2015, DOI: 10.1103/PhysRevB.91.245131
Abstract: We study $(d-1)$-dimensional excitations in the $d$-dimensional color code that are created by transversal application of the $R_{d}$ phase operators on connected subregions of qubits. We find that such excitations are superpositions of electric charges and can be characterized by fixed-point wavefunctions of $(d-1)$-dimensional bosonic SPT phases with $(\mathbb{Z}_{2})^{\otimes d}$ symmetry. While these SPT excitations are localized on $(d-1)$-dimensional boundaries, their creation requires operations acting on all qubits inside the boundaries, reflecting the non-triviality of emerging SPT wavefunctions. Moreover, these SPT-excitations can be physically realized as transparent gapped domain walls which exchange excitations in the color code. Namely, in the three-dimensional color code, the domain wall, associated with the transversal $R_{3}$ operator, exchanges a magnetic flux and a composite of a magnetic flux and loop-like SPT excitation, revealing rich possibilities of boundaries in higher-dimensional TQFTs. We also find that magnetic fluxes and loop-like SPT excitations exhibit non-trivial three-loop braiding statistics in three dimensions as a result of the fact that the $R_{3}$ phase operator belongs to the third-level of the Clifford hierarchy. We believe that the connection between SPT excitations, fault-tolerant logical gates and gapped domain walls, established in this paper, can be generalized to a large class of topological quantum codes and TQFTs.
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