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Search Results: 1 - 10 of 231948 matches for " Ruy R. Campos "
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Efeito de diferentes volumes de calda no controle do ácaro-da-leprose Brevipalpus phoenicis (Geijskes) em citros
Oliveira, Carlos A. L.;Campos Neto, Ruy R.;Fernandes, Carolina B.;
Anais da Sociedade Entomológica do Brasil , 1998, DOI: 10.1590/S0301-80591998000100015
Abstract: effect of different spray volumes in the control of citrus leprosis mite, brevipalpus phoenicis (geijskes), was studied. two field trials were conducted in citrus (citrus sinensis) orchards cv. pêra-rio located at bebedouro, sp. the following treatments were used in a randomized block design: fenbutatin-oxide (torque 500 fw) at 0.01, 0.02, 0.04 and 0.08% a.i., applied at 5, 10, 20 and 40 l per tree; water only, applied using the same volumes. population assessments were conducted during the trial previous and after application. ten fruits from each tree were sampled. mites were removed from the fruits by means of an mite-brushing machine and counted under a stereoscopic microscope. it was concluded that the mitecide fenbutatin-oxide at the different concentrations and spray volumes presented high control efficiency with reductions in number of mites during the period of the experiments, that varied from 88.2% to 100% up to 63 days after spraying (experiment 1) and from 75.4% to 100% up to 123 days (experiment 2). this efficiency was dependent of spray volume rather than concentration, with higher volumes yielding higher reductions in populations. spray volumes of 40 l/plant caused average reductions of 99.3% and 96.7%, independently of concentration.
Treadmill Exercise Training Prevents Myocardial Mechanical Dysfunction Induced by Androgenic-Anabolic Steroid Treatment in Rats
Danilo S. Bocalini, Abram Beutel, Cássia T. Bergamaschi, Paulo J. Tucci, Ruy R. Campos
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0087106
Abstract: Elevated concentrations of testosterone and its synthetic analogs may induce changes in cardiovascular function. However, the effects of the combination of anabolic/androgenic steroid (AAS) treatment and exercise training on systolic and diastolic cardiac function are poorly understood. In the present study, we aimed to investigate the effects of low-dose steroid treatment (stanozolol) on cardiac contractile parameters when this steroid treatment was combined with exercise training in rats and the effects of chronic steroid treatment on the Frank-Starling (length-tension curves) relationship. Male Wistar rats were randomly assigned to one of four groups: U (untrained), US (untrained and treated with stanozolol 5 mg/kg/week), T (trained, 16 m/min/1 h) and TS (trained and treated with stanozolol 5 mg/kg/week). Continuous exercise training was conducted 5 days/week for 8 consecutive weeks. The speed of the treadmill was gradually increased to a final setting of 16 m/min/1 h. Experiments were divided into two independent series: 1) central hemodynamic analysis for mean arterial blood pressure (MAP) and cardiac output (CO) measurements and 2) isolated papillary muscle preparation in Krebs solution. Stanozolol treatment significantly increased the MAP and the heart size in untrained and trained rats (U 113±2; T 106±2; US 138±8 and TS 130±7 mmHg). Furthermore, stanozolol significantly decreased developed tension and dT/dt (maximal and minimal) in U rats. However, the developed tension was completely restored by training. The Frank/Starling relationship was impaired in rats treated with stanozolol; however, again, training completely restored diastolic function. Taken together, the present data suggest that AAS treatment is able to decrease cardiac performance (systolic and diastolic functions). The combination of stanozolol and physical training improved cardiac performance, including diastolic and systolic functions, independent of changes in central hemodynamic parameters. Therefore, changes in ventricular myocyte calcium transients may play a cardioprotective role.
Participation of 5-HT and AT1 Receptors within the Rostral Ventrolateral Medulla in the Maintenance of Hypertension in the Goldblatt 1 Kidney-1 Clip Model
Cássia T. Bergamaschi,Nyam F. Silva,Jose G. Pires,Ruy R. Campos,Henrique A. Futuro Neto
International Journal of Hypertension , 2014, DOI: 10.1155/2014/723939
Abstract: The hypothesis that changes in neurotransmission within the rostral ventrolateral medulla (RVLM) are important to maintain the high blood pressure (BP) was tested in Goldblatt one kidney-one clip hypertension model (1K-1C). Male Wistar rats were anesthetized (urethane 1.2?g/kg, i.v.), and the effects of bilateral microinjections into the RVLM of the following drugs were measured in 1K-1C or control groups: glutamate (0.1?mol/L, 100?nL) and its antagonist kynurenic acid (0.02?mol/L, 100?nL), the angiotensin AT1 receptor antagonist candesartan (0.01?mol/L, 100?nL), and the nonselective 5-HT receptor antagonist methiothepin (0.06?mol/L, 100?nL). Experiments in 1K-1C rats were performed 6 weeks after surgery. In anesthetized rats glutamate response was larger in hypertensive than in normotensive rats (H: ; N: ?mmHg). In contrast, kynurenic acid microinjection into the RVLM did not cause any change in BP in either group. The blockade of either AT1 or 5-HT receptors within the RVLM decreased BP only in 1K-1C rats. A largest depressor response was caused by 5-HT receptor blockade. The data suggest that 5-HT and AT1 receptors act tonically to drive RVLM in 1K-1C rats, and these actions within RVLM contribute to the pathogenesis of this model of hypertension. 1. Introduction The importance of sympathetic nervous system activation in the pathogenesis of hypertension has been demonstrated, and the therapeutic value of sympathetic nervous inhibition in hypertensive patients is already evident and has been widely studied [1]. Ongoing activity of premotor rostral ventrolateral medulla (RVLM) neurons is responsible for the tonic generation of sympathetic vasomotor tone; inhibition of RVLM neurons causes a large decrease in both arterial blood pressure (BP) and sympathetic nervous system activity, while stimulation of this medullary region increases sympathetic vasomotor outflow and BP [2, 3]. Therefore, changes in the local neurotransmission within the RVLM can be a mechanism involved in the sympathetic activation in hypertension. Previous studies demonstrated that microinjection into the RVLM of excitatory amino acid (EAA) receptor antagonists has no effect on basal level of BP [4]. This fact has been interpreted as suggesting that the ongoing RVLM activity is not dependent on EAA inputs to the RVLM. However, we showed previously that, in Goldblatt 2-kidneys, one-clip (2K1C) model, microinjection of kynurenic acid, a broad spectrum EAA receptor antagonist, into the RVLM, reduced BP to the same extent as autonomic blockade [5]. Similar results were later shown in SHR
Role of the medulla oblongata in normal and high arterial blood pressure regulation: the contribution of Escola Paulista de Medicina - UNIFESP
Cravo, Sergio L.;Campos, Ruy R.;Colombari, Eduardo;Sato, M?nica A.;Bergamaschi, Cássia M.;Pedrino, Gustavo R.;Ferreira-Neto, Marcos L.;Lopes, Oswaldo U.;
Anais da Academia Brasileira de Ciências , 2009, DOI: 10.1590/S0001-37652009000300021
Abstract: several forms of experimental evidence gathered in the last 37 years have unequivocally established that the medulla oblongata harbors the main neural circuits responsible for generating the vasomotor tone and regulating arterial blood pressure. our current understanding of this circuitry derives mainly from the studies of pedro guertzenstein, a former student who became professor of physiology at unifesp later, and his colleagues. in this review, we have summarized the main findings as well as our collaboration to a further understanding of the ventrolateral medulla and the control of arterial blood pressure under normal and pathological conditions.
Role of the Rostral Ventrolateral Medulla in the Arterial Hypertension in Chronic Renal Failure
Adriana P. Castilho Dugaich,Elizabeth B. Oliveira-Sales,Nayda P. Abreu,Mirian A. Boim,Cássia T. Bergamaschi,Ruy R. Campos
International Journal of Hypertension , 2010, DOI: 10.4061/2010/219358
Abstract: Sympathetic activation in chronic renal failure (CRF) is a major mechanism leading to the progression of renal disease and hypertension. In the present study, we tested the hypothesis that in CRF increased reactive oxygen species (ROS) production in the RVLM mediated by enhanced circulating Angiotensin II (Ang II) is an important mechanism leading to hypertension in CRF. In CRF rats we found an increase in the abundance of p47phox and gp91phox mRNA within the RVLM associated with a reduction of Ang II type 1 receptors (AT1) mRNA in the brainstem compared to controls (C). Tempol but not candesartan into the RVLM decreased MAP in CRF but not in C rats. GABA into the RVLM decreased MAP in CRF (63±8 mmHg) more intensely than in C (33±3 mmHg). The results suggest that increased oxidative stress within the RVLM has an important participation to maintain hypertension in CRF rats apparently independently of AT1 Ang II receptors.
Methodology for the analysis of type 2 diabetes, metabolic syndrome and cardiovascular disease risk indicators in the ENSANUT 2006
Barquera,Simón; Campos-Nonato,Ismael; Carrión-Rábago,Citlali; Villalpando,Salvador; López-Ridaura,Ruy; Rojas,Rosalba; Aguilar-Salinas,Carlos A;
Salud Pública de México , 2010, DOI: 10.1590/S0036-36342010000700003
Abstract: objective: to describe: a) the methods used to quantify biochemical indicators of type 2 diabetes (t2d), and other cardiovascular risk indicators in the mexican national health and nutrition survey 2006 (ensanut 2006) and b) compare the sub-sample with the non-selected participants in diverse socio-demographic, anthropometric and health characteristics. material and methods: a sub-sample of 6 021 fasting adult participants was randomly selected from the total fasting participants (n=39 425). we compared diverse socio-demographic, anthropometric and health parameters between this sub-sample and the rest of the participants. results: no differences were found in sociodemographics characteristics, except age, between the sub-sample and from the rest of the fasting adults. in addition no difference were found between prevalences of overweight and obesity, central obesity, and previously diagnosed high blood pressure, t2d or hypertrigliceridemia. conclusions: the randomly selected sub-sample was not essentially different from the rest of the fasting subjects. thus, no bias is expected in the interpretation of cardiovascular risk indicators derived from these data.
Mesenchymal Stem Cells (MSC) Prevented the Progression of Renovascular Hypertension, Improved Renal Function and Architecture
Elizabeth B. Oliveira-Sales, Edgar Maquigussa, Patricia Semedo, Luciana G. Pereira, Vanessa M. Ferreira, Niels O. Camara, Cassia T. Bergamaschi, Ruy R. Campos, Mirian A. Boim
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0078464
Abstract: Renovascular hypertension induced by 2 Kidney-1 Clip (2K-1C) is a renin-angiotensin-system (RAS)-dependent model, leading to renal vascular rarefaction and renal failure. RAS inhibitors are not able to reduce arterial pressure (AP) and/or preserve the renal function, and thus, alternative therapies are needed. Three weeks after left renal artery occlusion, fluorescently tagged mesenchymal stem cells (MSC) (2×105 cells/animal) were injected weekly into the tail vein in 2K-1C hypertensive rats. Flow cytometry showed labeled MSC in the cortex and medulla of the clipped kidney. MSC prevented a further increase in the AP, significantly reduced proteinuria and decreased sympathetic hyperactivity in 2K-1C rats. Renal function parameters were unchanged, except for an increase in urinary volume observed in 2K-1C rats, which was not corrected by MSC. The treatment improved the morphology and decreased the fibrotic areas in the clipped kidney and also significantly reduced renal vascular rarefaction typical of 2K-1C model. Expression levels of IL-1β, TNF-α angiotensinogen, ACE, and Ang II receptor AT1 were elevated, whereas AT2 levels were decreased in the medulla of the clipped kidney. MSC normalized these expression levels. In conclusion, MSC therapy in the 2K-1C model (i) prevented the progressive increase of AP, (ii) improved renal morphology and microvascular rarefaction, (iii) reduced fibrosis, proteinuria and inflammatory cytokines, (iv) suppressed the intrarenal RAS, iv) decreased sympathetic hyperactivity in anesthetized animals and v) MSC were detected at the CNS suggesting that the cells crossed the blood-brain barrier. This therapy may be a promising strategy to treat renovascular hypertension and its renal consequences in the near future.
Role of the Rostral Ventrolateral Medulla in the Arterial Hypertension in Chronic Renal Failure
Adriana P. Castilho Dugaich,Elizabeth B. Oliveira-Sales,Nayda P. Abreu,Mirian A. Boim,Cássia T. Bergamaschi,Ruy R. Campos
International Journal of Hypertension , 2010, DOI: 10.4061/2010/219358
Abstract: Sympathetic activation in chronic renal failure (CRF) is a major mechanism leading to the progression of renal disease and hypertension. In the present study, we tested the hypothesis that in CRF increased reactive oxygen species (ROS) production in the RVLM mediated by enhanced circulating Angiotensin II (Ang II) is an important mechanism leading to hypertension in CRF. In CRF rats we found an increase in the abundance of p47phox and gp91phox mRNA within the RVLM associated with a reduction of Ang II type 1 receptors (AT1) mRNA in the brainstem compared to controls (C). Tempol but not candesartan into the RVLM decreased MAP in CRF but not in C rats. GABA into the RVLM decreased MAP in CRF ( ?mmHg) more intensely than in C ( ?mmHg). The results suggest that increased oxidative stress within the RVLM has an important participation to maintain hypertension in CRF rats apparently independently of AT1 Ang II receptors. 1. Introduction The chronic renal failure (CRF) is characterized by high circulating Angiotensin II (Ang II) that causes direct vasoconstriction, increases aldosterone secretion, enhances sympathetic nerve activity, and increases reactive oxygen species production (ROS), acting at peripheral and central sites [1]. There is increasing evidence to support the hypothesis that ROS play a major role in the pathophysiology of CRF [2]. In fact, Ang II action in the brain increases the activity of NAD(P)H oxidase, a major source of superoxide anion (O2) production [2]. NAD(P)H oxidase is composed of two membrane-bound subunits (gp91phox and p22phox), several cytoplasmic units (p40phox, p47phox, and p67phox), and the small G protein Racla [3]. After activation of Ang II type 1 (AT1) receptors, the cytoplasmic subunits bind to the membrane subunits and activate the enzyme, resulting in the intracellular production of O2-??[4]. Therefore, the first aim of the present study was to quantify the NADPH p47phox and gp91phox subunits expression within the RVLM. Considering that in CRF there is an increase in the brain Ang II, the expression of AT1 subtype receptor was also quantified in the RVLM. To functionally test the role of oxidative stress and AT1 receptors on hypertension in CRF rats we injected into the RVLM the superoxide mimetic-tempol and the AT1 antagonist-candesartan, respectively. Finally, the importance of RVLM in the maintenance of hypertension in CRF was evaluated by injection of GABA into the region. 2. Materials and Methods 2.1. General Procedures All experimental procedures were conducted according to the National Institutes of Health
Zero Curvature and generalization of Painlevé equation from AKNS/Lund-Regge model
Danilo V. Ruy,Genilson R. de Melo
Physics , 2012,
Abstract: We explain the relation between the mixed mKdV/sinh-Gordon model and the Kudryashov's equation. Then, we use the mixed AKNS/Lund-Regge model to find a system of ODEs which is candidate to define a new transcendental function. We also applied the perturbative Painlev\'e test and presented the local representation for the solution of the system.
Rooted $K_4$-Minors
Ruy Fabila-Monroy,David R. Wood
Mathematics , 2011,
Abstract: Let $a,b,c,d$ be four vertices in a graph $G$. A \emph{$K_4$-minor rooted} at $a,b,c,d$ consists of four pairwise-disjoint pairwise-adjacent connected subgraphs of $G$, respectively containing $a,b,c,d$. We characterise precisely when $G$ contains a $K_4$-minor rooted at $a,b,c,d$ by describing six classes of obstructions, which are the edge-maximal graphs containing no $K_4$-minor rooted at $a,b,c,d$. The following two special cases illustrate the full characterisation: (1) A 4-connected non-planar graph contains a $K_4$-minor rooted at $a,b,c,d$ for every choice of $a,b,c,d$. (2) A 3-connected planar graph contains a $K_4$-minor rooted at $a,b,c,d$ if and only if $a,b,c,d$ are not on a single face.
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