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Search Results: 1 - 10 of 211074 matches for " Runjun D. Kumar "
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Prioritizing Potentially Druggable Mutations with dGene: An Annotation Tool for Cancer Genome Sequencing Data
Runjun D. Kumar, Li-Wei Chang, Matthew J. Ellis, Ron Bose
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0067980
Abstract: A major goal of cancer genome sequencing is to identify mutations or other somatic alterations that can be targeted by selective and specific drugs. dGene is an annotation tool designed to rapidly identify genes belonging to one of ten druggable classes that are frequently targeted in cancer drug development. These classes were comprehensively populated by combining and manually curating data from multiple specialized and general databases. dGene was used by The Cancer Genome Atlas squamous cell lung cancer project, and here we further demonstrate its utility using recently released breast cancer genome sequencing data. dGene is designed to be usable by any cancer researcher without the need for support from a bioinformatics specialist. A full description of dGene and options for its implementation are provided here.
Antioxidant and free radical scavenging activities of edible weeds
S Kumar, D Kumar
African Journal of Food, Agriculture, Nutrition and Development , 2009,
Abstract: Reactive oxygen species (ROS) such as superoxide anions, hydrogen peroxide, and hydroxyl, nitric oxide radicals, play an important role in oxidative stress related to the pathogenesis of various important diseases. Active (or reactive) oxygen species and free radical-mediated reactions are involved in degenerative or pathological processes. Antioxidants act as a major defense against radical mediated toxicity by protecting against the damages caused by free radicals. Antioxidant-based drugs/formulations for the prevention and treatment of complex diseases like atherosclerosis, stroke, diabetes, Alzheimer’s disease, and cancer have appeared during the last three decades. This has attracted a great deal of research interest in natural antioxidants. Flavonoids and phenolic compounds widely distributed in plants which have been reported to exert multiple biological effect, including antioxidant, free radical scavenging abilities, anti-inflammatory and anticarcinogenic activities. Recently there has been an upsurge of interest in the therapeutic potentials of medicinal plants as antioxidants in reducing such free radical induced tissue injury. The aim of the present investigation was to evaluate in vitro antioxidant and free radicals scavenging effect of two edible weeds. Certain weeds are nutritious and eaten as foods or vegetables. In the present study two weeds namely Chenopodium album and Vitis trifolia have been screened for their antioxidant potential by using various in vitro methods. Aqueous leaf extract Chenopodium album and methanolic fruit extract of Vitis trifolia exhibit significant reducing power and free radical scavenging effect on DPPH, hydroxyl, superoxide, hydrogen peroxide radicals. The extracts also inhibit nitric oxide production. All these antioxidant activities were concentration dependent which were compared with standard antioxidants such as BHA, α-tocopherol and ascorbic acid. In addition, total phenolic and total flavonoids contents were determined as gallic acid and catechin equivalents respectively. From the results, C. album leaf extract was found to contain 0.94 % total phenolic contents (gallic acid equivalent) and 0.27 % total flavonoid contents (catechin equivalent). Whereas V. trifolia fruit extract was found to contain 1.23 % phenolic compounds as gallic acid equivalent (GAE) and 0.38 % flavonoid content as catechin equivalent (CE).
On escaping sets of some families of entire functions and dynamics of composite entire functions
D. Kumar
Mathematics , 2014,
Abstract: We consider two families of functions $\mathcal{F}=\{f_{{\la},{\xi}}(z)= e^{-z+\la}+\xi: \la,\,\xi\in\C, \RE{\la}<0, \RE\xi\geq 1\}$ and $\mathcal{F}'=\{f_{{\mu},{\ze}}(z)= e^{z+\mu}+\ze: \mu,\,\ze\in\C, \RE{\mu}<0, \RE\ze\leq-1\}$ and investigate the escaping sets of members of the family $\mathcal F$ and $\mathcal F'.$ We also consider the dynamics of composite entire functions and provide conditions for equality of escaping sets of two transcendental entire functions.
Angiosarcoma of Maxillary Sinus: A Case Report  [PDF]
D. S. Deenadayal, B. Naveen Kumar, B. Hemanth Kumar
International Journal of Otolaryngology and Head & Neck Surgery (IJOHNS) , 2012, DOI: 10.4236/ijohns.2012.13017
Abstract: Purpose: To describe a rare malignancy involving the sinonasal cavities. To discuss the clinical, diagnostic, and treatment modalities. Study Design: A case report including histopathological, radiological analysis and review of literature. Method: A case report is described from a tertiary care centre. Histopathological and radiological details are reviewed. Results: This case report presents a 29 year old male with 3 days history of bleeding from the left nostril, blood stained saliva with post nasal discharge and head ache. Biopsy demonstrated poorly differentiated Angiosarcoma. On immune stains the tumor cells showed diffuse strong cytoplasmic membrane positivity with CD 31 and few cells are positive for CD34. FLI-1 is also positive. Conclusion: Angiosarcoma is a rare malignancy involving the sinonasal cavities. Multidisciplinary approach is essential to obtain clear diagnoses and appropriate treatment plans.
Immunological Variations in Epileptic Children  [PDF]
Sanjeev Kumar, Vinod Kumar, D. C. Jain, R. Mittal
Open Journal of Applied Sciences (OJAppS) , 2013, DOI: 10.4236/ojapps.2013.31012

Epilepsy is one of the most frequent neurological problems. Despite of the advances and improvements in treatment of seizure disorders, immunological alterations such as immunoglobulins and complements have been measured. The levels of IgG in epileptic patients are found to be higher than controls. The levels of IgA, IgM, C3 and C4 were found to be lower in all the controls. Student’s t-test were also applied. Multiple and regression analysis, have been also carried out. A trend has also set up in the present study. An alteration in the immune mechanism of epileptic patients is required. Ketogenic diet may be given and the balance of trace elements like Na, K, Zn, Fe, Ca, Mg and Cu may be maintained to alter the immune mechanism of the epileptic patients. Green leafy vegetables may be given to the patients to control the seizure. Immunity is related with the food we eat. By adjusting the immunity with proper diet the severity of epileptic attack or any disease may be reduced.

Trace Elemental Analysis in Epileptic Children  [PDF]
Sanjeev Kumar, V. Kumar, Reena Mittal, D. C. Jain
Open Journal of Applied Sciences (OJAppS) , 2013, DOI: 10.4236/ojapps.2013.38056

We have measured trace elements in epileptic patients. Levels of trace elements are very fluctuating in comparison to the healthy controls. The levels of Zn, Fe and Cu are higher in comparison to healthy normal children about 64%, 55% and 33% respectively. The levels of Cu are just fifty percent to levels of Zn. The levels of Ca, K and Mg are higher about 10%, 9.027% and 4.2% in comparison to normal children. Sodium levels were very low in comparison to all the trace elements and are higher about 3.2% than controls. The multiple correlation coefficients between Na, K and Ca, i.e. (RNa.KCa) has a value 0.4993 in comparison to healthy children. Multiple correlation coefficients between Fe, Cu and Zn, i.e. (RFe.CuZn) has a value 0.4366. The multiple correlation coefficients RNa.Kca and RFe.CuZn are found lower. These elements were strongly correlated with other. The multiple correlation coefficients such as RK.NaCa, RCa.K.Na, RMg.NaK, RNa.MgK, RK.MgNa, RCu.FeZn and RZn.FeCu were also evaluated and found on higher side from normal range. Trace elements may act as a catalytic agent for enzyme system of the cells. The minimum requirements of living objects for essential trace elements may be expressed in proportions or concentrations of the total dry food taken everyday. A tolerance of the human system may be fluctuated according to intake of these elements.

Estimation of Melt Contribution to Total Streamflow in River Bhagirathi and River DhauliGanga at Loharinag Pala and Tapovan Vishnugad Project Sites  [PDF]
Manohar Arora, D S Rathore, R D Singh, Rakesh Kumar, Amit Kumar
Journal of Water Resource and Protection (JWARP) , 2010, DOI: 10.4236/jwarp.2010.27073
Abstract: Many of the major rivers in India originate from the Himalayas. These rivers have significant contribution from snow and ice which makes these rivers perennial. Due to steep slopes, all such streams have potential sites for hydropower generation. There is a requirement of estimation of the contribution from snow and glacier melt, rainfall contribution and sub surface contribution in the total runoff for sustainable supply of water to the hydropower plants. Considering this aspects, in this study a snowmelt runoff simulation model SNOWMOD suitable for Himalayan basins developed earlier has been modified and applied for simulation of flows. Input to the model such as glacier cover, permanent snow cover, seasonal snow cover generated through remote sensing techniques were used in conjunction with daily maximum and minimum temperature, rainfall and discharge. Two hydropower dam sites on major tributaries (Bhagirathi and DhauliGanga) of River Ganga have been selected for determination of different runoff components. However, though the data available was for a very limited period but the results indicate that these tributaries have significant contribution from snow and ice for long term sustainability of flows to these schemes.
Traits for Screening and Selection of Cowpea Genotypes for Drought Tolerance at Early Stages of Breeding
Ashok Kumar,K. D. Sharma,D. Kumar
Journal of Agriculture and Rural Development in the Tropics and Subtropics , 2008,
Abstract: The association of leaf water content with yield-attributes such as pod setting and number of pods/plant and seed yield in cowpea was examined using midday drop of leaf relative water content (RWC) determined from morning (800 h) and midday (1330 h) measurements of RWC. Midday drop of RWC was significantly correlated to pod setting ratio (R2 = 0.80, P < 0.01), number of pods/plant (R2 = 0.87, P < 0.01) and seed yield (R2 = 0.37, P < 0.05). There was a significant genotypic variation for leaf water potential (LWP) at 800 and 1330 h and for RWC at 1330 h. Significant genotypic differences were also observed in pod setting ratio, number of pods/plant, number of seeds/pod, 1000-seed weight, biomass and seed yield. Pod setting ratio was significantly and positively correlated with number of pods/plant (R2 = 0.80, P < 0.01) and seed yield (R2 = 0.38, P < 0.05). These results showed that the genotypes with a smaller reduction in midday drop of RWC produced a larger number of pods/plant and consequently had higher seed yield as compared with a larger midday drop of RWC. The results also showed that there was a large genotypic variation in the midday drop of RWC, which was correlated with yield-attributes and seed yield. It may therefore be possible to use midday drop of RWC as a screening and selection trait for drought tolerance of cowpea genotypes.
Role of Intratympanic Steroids in the Management of Idiopathic Sudden Sensori Neural Hearing Loss— Our Experience of 67 Cases  [PDF]
D. S. Deenadayal, D. Vidyasagar, Vyshanavi Bommakanti, Madisetty Naveen Kumar, Nakirikanti Ravi Kumar, Ramesh Chintha
International Journal of Otolaryngology and Head & Neck Surgery (IJOHNS) , 2016, DOI: 10.4236/ijohns.2016.54028
Abstract: Objective: To assess the outcomes of intratympanic steroids in the management of idiopathic sudden sensorineural hearing loss. Study Design: Retrospective study. Setting: Academic tertiary care medical centre. Materials and Methods: A total of 67 patients with idiopathic sudden sensorineural hearing loss were included in our study. Pre- and post-injection audiograms were taken to assess the outcomes in improvement in hearing. Hearing outcomes were assessed with respect to duration of onset of treatment and age of the patient. Improvement in the speech discrimination score was also assessed. Results: A total of 67 patients were included in our study of which unilateral cases were 59 and bilateral cases were 8. Subjectively 35 patients reported improvement in hearing after the therapy while objectively we found 44 ears [41 patients] had improvement. The mean PTA pre ITS was 62.7 and after ITS it was 56.3. Maximum improvement was noted at 2000 Hz and 1000 Hz. Conclusion: Intratympanic steroids can be offered as a first line therapy for idiopathic sudden sensorineural hearing loss as it is minimally invasive, and can be performed as an office based procedure with no systemic side effects. No major complications have been reported in our study and results have been satisfactory.
Interpolation of generalized Biaxisymmetric potentials
D Kumar, GL Reddy
Ethiopian Journal of Education and Sciences , 2006,
Abstract: In this paper we study the chebyshev and interpolation error for a real valued generalized biaxisymmetric Potential (GBASP) which is regular in the open hyper sphere about the origin. The lower (p, q) order and lower generalized (p, q) – type have been characterized in terms of these approximation errors. Ethiopian Journal of Education and Science Vol. 2 (1) 2006: pp. 129-141
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