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Search Results: 1 - 10 of 51443 matches for " Rui Xu "
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The Differentiated Pricing Strategy or Hotel under Dual-Channel Reservation Forms  [PDF]
Xiaoyan Xu, Rui Zhao, Liang Xu
Open Journal of Social Sciences (JSS) , 2014, DOI: 10.4236/jss.2014.24039
Abstract: The modern information network environment largely changed consumer habits. Hotel Reservation way becomes increasingly diversified. By building the traditional and Internet booking ways’ demand functions which were linear in self- and cross-price effects and the hotel revenue function, we determine the optimal pricing strategy of the hotel’s Internet booking way. The effect of the optimal strategy is also discussed, and numerical simulation verifies that the optimal strategy can greatly improve the hotel revenue. All of the research propositions help hotel managers make deeper understanding of fixed room quantity’s influence on pricing strategies, and provide managers the basis of pricing strategy.
Baculovirus Mediated Experimental Research on Targeted Egr1-Kringle 5 Gene Radiotherapy in Lung Adenocarcinoma  [PDF]
Haoping Xu, Rui Guo, Biao Li
Journal of Cancer Therapy (JCT) , 2012, DOI: 10.4236/jct.2012.324052
Abstract: Objective: To investigate the feasibility of temporally and spatially restricted Kringle5 expression induced by radiation, as well as the dual effect of radiotherapy and antiangiogenic therapy in lung adenocarcinoma in vitro. Methods: We first constructed recombinant baculovirus vectors containing Egr1 promoter and human plasminogen Kringle5 gene (rhK5), then transfected them into lung adenocarcinoma cells (A549). Transfect efficiency of the baculovirus for gene transfer in A549 cells and the activity of Egr1 promoter induced by X-radiation were detected by fluorescence microscopy. The rhK5 mRNA transcription and rhK5 protein expression were detected by Real-time PCR and Western blot assay, respectively. The apoptosis asssay of human umbilical veins endothelial cells (HUVEC) was analyzed by flow cytometry. Results: The recombinant baculovirus were successfully transfected into A549 and HUVEC cells. As for the temporal regulation, the rhK5 mRNA transcription and rhK5 protein expression were elevated with the irradiation time significantly. And the HUVEC apoptotic percentage increased in relation to the irradiation time as well. As for the spatial regulation, rhK5 mRNA transcription level of A549 cell lines transfected with recombinant baculovirus Egr1-K5 was significantly higher than that of control groups after the same dose of X-radiation. When we analyzed the dose and frequency of X-radiation, no difference was observed among each dose after continuously three-times of irradiation. Conclusion: Baculovirus-mediated Egr1-K5 can be used in gene radiotherapy for its temporary and spatial controllable rhK5 expression by X-radiation and the consequent HUVEC apoptosis in vitro study. And low dose and more times of irradiation might be more effective. It would provide a promising way for the tumor treatment.
Fluid Flow and Heat Transfer Charateristics in a 180-deg Round Turned Channel with a Perforated Divider  [PDF]
Rui Xu, Rui Xu, Jinliang Hou, Li Wang, Yanfei Yu, Jiaxing Wei, Changfeng Li
Journal of Applied Mathematics and Physics (JAMP) , 2014, DOI: 10.4236/jamp.2014.26049
Abstract:

This study provided a new configuration of the 180-deg round turned channel with a perforated divider, as well as numerically investigated the effect of perforations, including the diameter of perforation and the angel of perforation, on the fluid flow and heat transfer. The numerical results appeared in good agreement with previous experimental data under the same operating conditions. The results indicated that large size and positive angle of perforation changed the fluid flow pattern and the local Nusselt-number distribution fundamentally. It is noteworthy that a more uniform distribution of Nusselt-number was achieved by increasing the diameter of perforation.

Synchronization between Bidirectional Coupled Nonautonomous Delayed Cohen-Grossberg Neural Networks
Qiming Liu,Rui Xu
Abstract and Applied Analysis , 2012, DOI: 10.1155/2012/481582
Abstract: Based on using suitable Lyapunov function and the properties of M-matrix, sufficient conditions for complete synchronization of bidirectional coupled nonautonomous Cohen-Grossberg neural networks are obtained. The methods for discussing synchronization avoid complicated error system of Cohen-Grossberg neural networks. Two numerical examples are given to show the effectiveness of the proposed synchronization method.
Periodic solution for a delayed three-species food-chain system with Holling type-II functional response
Qiming Liu,Rui Xu
International Journal of Mathematics and Mathematical Sciences , 2003, DOI: 10.1155/s0161171203211030
Abstract: A delayed three-species periodic food-chain system with Holling type-II functional response is investigated. By using Gaines and Mawhin's continuation theorem of coincidence degree theory, a set of easily verifiable sufficient conditions is derived for the existence of positive periodic solutions to the system.
Asymptotic Properties of a Hepatitis B Virus Infection Model with Time Delay
Xiaohong Tian,Rui Xu
Discrete Dynamics in Nature and Society , 2010, DOI: 10.1155/2010/182340
Abstract: A hepatitis B virus infection model with time delay is discussed. By analyzing the corresponding characteristic equations, the local stability of each of the feasible equilibria of the model is studied. By using comparison arguments, it is proved that if the basic reproduction ratio is less than unity, the infection-free equilibrium is globally asymptotically stable. If the basic reproduction ratio is greater than unity, by means of an iteration technique, sufficient conditions are derived for the global asymptotic stability of the virus-infected equilibrium. Numerical simulations are carried out to illustrate the theoretical results. 1. Introduction Hepatitis B is a potentially life-threatening liver infection caused by the hepatitis B virus. It is a major global health problem and the most serious type of viral hepatitis. It can cause chronic liver disease and puts people at high risk of death from cirrhosis of the liver and liver cancer. Worldwide, estimated two billion people have been infected with the hepatitis B virus (HBV), and more than 350 million have chronic (long-term) liver infections. In the past decade, therapy for HBV has been revolutionized by the advent of drugs that directly block replication of the HBV genome. All these drugs (to date) are nucleoside or nucleotide analogues that selectively target the viral reverse transcriptase. The first successful drug, lamivudine, emerged from screening for inhibitors of the HBV reverse transcriptase and was introduced into clinical practice for the management of HBV infection. Recently, mathematical models have been used frequently to study the transmission dynamics of HBV (see, e.g., [1–15]). In [1], Anderson and May used a simple mathematical model to illustrate the effects of carriers on the transmission of HBV. In an effort to model HBV infection dynamics and its treatment with the reverse transcriptase inhibitor lamivudine, Nowak and Bangham [7] and Bonhoeffer et al. [2] proposed the following basic HBV infection model: where and are numbers of uninfected cells, infected cells, and free-virus cells, respectively. Uninfected cells are assumed to be produced at a constant rate , die at rate , and become infected at rate in which is the mass action rate constant describing the infection process. Infected cells are killed by immune cells at rate and produce free virus at rate , here is the so-called burst constant. Free-virus cells are cleared at rate . It is assumed that parameters are positive constants. In [4], by constructing novel Lyapunov functions, it was proven that if the basic
Stability Analysis of a Delayed SIR Epidemic Model with Stage Structure and Nonlinear Incidence
Xiaohong Tian,Rui Xu
Discrete Dynamics in Nature and Society , 2009, DOI: 10.1155/2009/979217
Abstract: We investigate the stability of an SIR epidemic model with stage structure and time delay. By analyzing the eigenvalues of the corresponding characteristic equation, the local stability of each feasible equilibrium of the model is established. By using comparison arguments, it is proved when the basic reproduction number is less than unity, the disease free equilibrium is globally asymptotically stable. When the basic reproduction number is greater than unity, sufficient conditions are derived for the global stability of an endemic equilibrium of the model. Numerical simulations are carried out to illustrate the theoretical results.
Global Stability of a Virus Infection Model with Time Delay and Absorption
Xiaohong Tian,Rui Xu
Discrete Dynamics in Nature and Society , 2011, DOI: 10.1155/2011/152415
Abstract: In this paper, a virus infection model with time delay and absorption is studied. By analyzing the corresponding characteristic equations, the local stability of each of feasible equilibria of the model is established. By using comparison arguments, it is shown that the infection free equilibrium is globally asymptotically stable when the basic reproduction ratio is less than unity. When the basic reproduction ratio is greater than unity, sufficient conditions are derived for the global stability of the virus-infected equilibrium. Numerical simulations are carried out to illustrate the theoretical results.
Periodic Solutions of a Cohen-Grossberg-Type BAM Neural Networks with Distributed Delays and Impulses
Qiming Liu,Rui Xu
Journal of Applied Mathematics , 2012, DOI: 10.1155/2012/643418
Abstract: A class of Cohen-Grossberg-type BAM neural networks with distributed delays and impulses are investigated in this paper. Sufficient conditions to guarantee the uniqueness and global exponential stability of the periodic solutions of such networks are established by using suitable Lyapunov function, the properties of -matrix, and some suitable mathematical transformation. The results in this paper improve the earlier publications.
Molecular epigenetics: dawn of a new era of biomedical research
Rui-Ming Xu
Science China Life Sciences , 2009, DOI: 10.1007/s11427-009-0057-9
Abstract:
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