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Search Results: 1 - 10 of 284 matches for " Rubertsson Sten "
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Pulmonary influences on early post-operative recovery in patients after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy treatment: a retrospective study
Arakelian Erebouni,Torkzad Michael R,Bergman Antonina,Rubertsson Sten
World Journal of Surgical Oncology , 2012, DOI: 10.1186/1477-7819-10-258
Abstract: Background The combination of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) is a curative treatment option for peritoneal carcinomatosis (PC). There have been few studies on the pulmonary adverse events (AEs) affecting patient recovery after this treatment, thus this study investigated these factors. Methods Between January 2005 and December 2006, clinical data on all pulmonary AEs and the recovery progress were reviewed for 76 patients with after CRS and HIPEC. Patients with pulmonary interventions (thoracocenthesis and chest tubes) were compared with the non-intervention patients. Two senior radiologists, blinded to the post-operative clinical course, separately graded the occurrence of pulmonary AEs. Results Of the 76 patients, 6 had needed thoracocentesis and another 6 needed chest tubes. There were no differences in post-operative recovery between the intervention and non-intervention groups. The total number of days on mechanical ventilation, the length of stay in the intensive care unit, total length of hospital stay, tumor burden, and an American Society of Anesthesiologists (ASA) grade of greater than 2 were correlated with the occurrence of atelectasis and pleural effusion. Extensive atelectasis (grade 3 or higher) was seen in six patients, major pleural effusion (grade 3) in seven patients, and signs of heart failure (grade 1–2) in nine patients. Conclusions Clinical and radiological post-operative pulmonary AEs are common after CRS and HIPEC. However, most of the pulmonary AEs did not affect post-operative recovery.
The Study Protocol for the LINC (LUCAS in Cardiac Arrest) Study: a study comparing conventional adult out-of-hospital cardiopulmonary resuscitation with a concept with mechanical chest compressions and simultaneous defibrillation
Rubertsson Sten,Silfverstolpe Johan,Rehn Liselott,Nyman Thomas
Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine , 2013, DOI: 10.1186/1757-7241-21-5
Abstract: Background The LUCAS device delivers mechanical chest compressions that have been shown in experimental studies to improve perfusion pressures to the brain and heart as well as augmenting cerebral blood flow and end tidal CO2, compared with results from standard manual cardiopulmonary resuscitation (CPR). Two randomised pilot studies in out-of-hospital cardiac arrest patients have not shown improved outcome when compared with manual CPR. There remains evidence from small case series that the device can be potentially beneficial compared with manual chest compressions in specific situations. This multicentre study is designed to evaluate the efficacy and safety of mechanical chest compressions with the LUCAS device whilst allowing defibrillation during on-going CPR, and comparing the results with those of conventional resuscitation. Methods/design This article describes the design and protocol of the LINC-study which is a randomised controlled multicentre study of 2500 out-of-hospital cardiac arrest patients. The study has been registered at ClinicalTrials.gov (http://clinicaltrials.gov/ct2/show/NCT00609778?term=LINC&rank=1). Results Primary endpoint is four-hour survival after successful restoration of spontaneous circulation. The safety aspect is being evaluated by post mortem examinations in 300 patients that may reflect injuries from CPR. Conclusion This large multicentre study will contribute to the evaluation of mechanical chest compression in CPR and specifically to the efficacy and safety of the LUCAS device when used in association with defibrillation during on-going CPR.
Hypoxia Due to Cardiac Arrest Induces a Time-Dependent Increase in Serum Amyloid β Levels in Humans
Henrik Zetterberg, Erik M?rtberg, Linan Song, Lei Chang, Gail K. Provuncher, Purvish P. Patel, Evan Ferrell, David R. Fournier, Cheuk W. Kan, Todd G. Campbell, Ray Meyer, Andrew J. Rivnak, Brian A. Pink, Kaitlin A. Minnehan, Tomasz Piech, David M. Rissin, David C. Duffy, Sten Rubertsson, David H. Wilson, Kaj Blennow
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0028263
Abstract: Amyloid β (Aβ) peptides are proteolytic products from amyloid precursor protein (APP) and are thought to play a role in Alzheimer disease (AD) pathogenesis. While much is known about molecular mechanisms underlying cerebral Aβ accumulation in familial AD, less is known about the cause(s) of brain amyloidosis in sporadic disease. Animal and postmortem studies suggest that Aβ secretion can be up-regulated in response to hypoxia. We employed a new technology (Single Molecule Arrays, SiMoA) capable of ultrasensitive protein measurements and developed a novel assay to look for changes in serum Aβ42 concentration in 25 resuscitated patients with severe hypoxia due to cardiac arrest. After a lag period of 10 or more hours, very clear serum Aβ42 elevations were observed in all patients. Elevations ranged from approximately 80% to over 70-fold, with most elevations in the range of 3–10-fold (average approximately 7-fold). The magnitude of the increase correlated with clinical outcome. These data provide the first direct evidence in living humans that ischemia acutely increases Aβ levels in blood. The results point to the possibility that hypoxia may play a role in the amyloidogenic process of AD.
Mellan profession och akademi. Reflektioner kring arkitekturforskningens egenart
Sten Gromark
FORMakademisk , 2009,
Abstract: Sammanfattning Artikeln vill belysa fr gan om arkitekturforskningens egenart som forskningsdisciplin med h nsyn till dess kritiska betydelse f r arkitektyrkets professionella och akademiska framtid. Fr gan str cker sig l ngt utanf r den arkitektoniska eller konstn rliga v rldens begr nsningar och uppfordrar till att inom hela forskningssamh llet pr va radikalt nya begrepp om vetenskaplighet och kanske i synnerhet pr va gr nserna f r var skillnaden g r mellan strikt vetenskaplig sanning i en absolut mening och vad som r en professionsrelevant kunskap. Kan det vara s att den nya profil f r forskning i och om arkitektur som ser ut att v xa fram h ller p att bryta ny mark och ppna nya forskningsfronter ur metodologisk synvinkel inom ett vidare vetenskapssamh lle? Kan vi g ra en skillnad mellan forskning om arkitektur och den utforskande handling som ryms i den gestaltande akten som s dan, i en utforskande arkitektur? Framst llningen bygger p ett underlag av ett antal aktuella avhandlingar i det nordiska och europeiska sammanhanget d r f rfattaren varit indragen i olika roller som medlem av jury, som opponent eller handledare.
Tempus som tre uafh ngige tr k
Sten Vikner
Tidsskrift for Sprogforskning , 2003,
Abstract: Zum einen m chte ich dafür argumentieren, dass acht Tempusformen für die Analyse von Tempus in der Sprache relevant sind, besonders in Hinblick auf die temporalen Relationen, die von den Tempusformen ausgedrückt werden. Zum anderen will ich mit Ausgangspunkt in Reichenbach (1947) versuchen zu zeigen, dass es angemessen ist, für jede Tempusform nicht nur einen u erungszeitpunkt und einen Ereigniszeitpunkt anzunehmen, sondern darüber hinaus zwei verschiedene Referenzzeitpunkte. Erst diese Analyse erlaubt es, eine vollst ndige Korrespondenz zwischen morphologischen und semantischen Eigenschaften für jede Tempusform herzustellen.
NATO’s Enduring Challenge: Matching American Primacy and European Ambitions
Sten Rynning
UNISCI Discussion Papers , 2005,
sve 'te Konu an Kitaplar - G rme zürlüler in Geli mekte Olan Bir Olanak
Sten Gustavsso
Türk Kütüphanecili?i , 1996,
The influence of women’s fear, attitudes and beliefs of childbirth on mode and experience of birth
Helen M Haines, Christine Rubertsson, Julie F Pallant, Ingegerd Hildingsson
BMC Pregnancy and Childbirth , 2012, DOI: 10.1186/1471-2393-12-55
Abstract: Prospective longitudinal cohort design with self report questionnaires containing a set of attitudinal statements regarding birth (Birth Attitudes Profile Scale) and a fear of birth scale (FOBS). Pregnant women responded at 18-20?weeks gestation and two months after birth from a regional area of Sweden (n?=?386) and a regional area of Australia (n?=?123). Cluster analysis was used to identify a set of profiles. Odds ratios (95% CI) were calculated, comparing cluster membership for country of care, pregnancy characteristics, birth experience and outcomes.Three clusters were identified – ‘Self determiners’ (clear attitudes about birth including seeing it as a natural process and no childbirth fear), ‘Take it as it comes’ (no fear of birth and low levels of agreement with any of the attitude statements) and ‘Fearful’ (afraid of birth, with concerns for the personal impact of birth including pain and control, safety concerns and low levels of agreement with attitudes relating to women’s freedom of choice or birth as a natural process). At 18 -20?weeks gestation, when compared to the ‘Self determiners’, women in the ‘Fearful’ cluster were more likely to: prefer a caesarean (OR?=?3.3 CI: 1.6-6.8), hold less than positive feelings about being pregnant (OR?=?3.6 CI: 1.4-9.0), report less than positive feelings about the approaching birth (OR?=?7.2 CI: 4.4-12.0) and less than positive feelings about the first weeks with a newborn (OR?=?2.0 CI 1.2-3.6). At two months post partum the ‘Fearful’ cluster had a greater likelihood of having had an elective caesarean (OR?=?5.4 CI 2.1-14.2); they were more likely to have had an epidural if they laboured (OR?=?1.9 CI 1.1-3.2) and to experience their labour pain as more intense than women in the other clusters. The ‘Fearful’ cluster were more likely to report a negative experience of birth (OR?=?1.7 CI 1.02- 2.9). The ‘Take it as it comes’ cluster had a higher likelihood of an elective caesarean (OR 3.0 CI 1.1-8.0).In this study three
The power to detect artificial selection acting on single loci in recently domesticated species
Sten Karlsson, Thomas Moen
BMC Research Notes , 2010, DOI: 10.1186/1756-0500-3-232
Abstract: Two simulation models were pursued: 1) screening for loci displaying higher genetic differentiation than expected (high-FST outliers), from neutral evolution between a pool of domesticated populations and a pool of wild populations; 2) screening for loci displaying lower genetic differentiation (low-FST outliers) between domesticated strains than expected from neutral evolution. The premise for both approaches was that the isolated domesticated strains are subjected to the same breeding goals. The power to detect outlier loci was calculated under the following parameter values: number of populations, effective population size per population, number of generations since onset of selection, initial FST, and the selection coefficient acting on the locus. Among the parameters investigated, selection coefficient, the number of generation since onset of selection, and number of populations, had the largest impact on power. The power to detect loci subjected to directional in breeding programmes was high when applying the between farmed and wild population approach, and low for the between farmed populations approach.A simulation tool was developed for estimating the power to detect artificial selection acting directly on single loci. The simulation tool should be applicable to most species subject to domestication, as long as a reasonable high accuracy in input parameters such as effective population size, number of generations since the initiation of selection, and initial differentiation (FST) can be obtained. Identification of genetic loci under artificial selection would be highly valuable, since such loci could be used to monitor maintenance of genetic variation in the breeding populations and monitoring possible genetic changes in wild populations from genetic interaction between escapees and their wild counterpart.Massive parallel sequencing/re-sequencing technologies have already provided thousands or even tens of thousands of DNA markers for a number of species,
Methods to find out the expression of activated genes
Sten Z Cekan
Reproductive Biology and Endocrinology , 2004, DOI: 10.1186/1477-7827-2-68
Abstract: In previous reviews, methods for the measurement of receptors and their interactions with other transcription factors and genes were described [1-3]. In this review, gene activation is discussed with a particular emphasis on the methods enabling detection of the activated, turned-on, genes. The action of the hormone 17beta-estradiol (E2) is taken as an example of the function of many other small-molecule compounds in gene activation and in the expression of the activated gene.The life of humans and animals is influenced by the activity of a series of genes that are kept in a silent state, or are activated, depending on the temporary needs of the body. This switching on and off of each gene is executed by an assembly of transcription factors forming a transcription initiation complex (TIC).Examples of such transcription factors are estrogen receptors (ER-alpha, ER-beta, and possibly other isomers) that, before being incorporated into a TIC, have to be activated by E2. This hormone itself is synthesized, when an initial signal is given, by virtue of an activation of a series of appropriate genes. Via ER, E2 has manifold biological effects. Biological targets of E2 are, inter alia, blood vessel walls [4-8], blood platelets [9], bone [7,10-12], breast cancer cells [13], central nervous system [7,14,15], retinal pigment epithelium [16], synthesis of clotting factors [17].It is evident that E2 is associated with many biological effects and that many genes must be involved. Consequently, ER must be able to bind to DNA segments, called response elements, in the neighborhood of various genes. The response elements participate, together with other transcription factors, in the formation of TICs that are specific for each gene.An important problem, currently studied in many laboratories, is to find out which genes are activated in various circumstances. The methods that solve this problem are based on a comparative (differential) approach. A test (target) sample, containing ac
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