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Search Results: 1 - 10 of 199508 matches for " Roxana de la Caridad; Rodríguez Leyes "
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Estudios preliminares de estabilidad de un extracto lipídico de los frutos de Roystonea regia en frascos de vidrio ámbar
Sierra Pérez,Roxana de la Caridad; Rodríguez Leyes,Eduardo Antonio; González Canavaciolo,Víctor Luis; Marrero Delange,David; Vicente Murillo,Roxana;
Revista Cubana de Farmacia , 2010,
Abstract: the d004 is a new active ingredient extracted from the cuban real palm (roystonea regia), promising in the treatment of the benign prostatic hyperplasia. to determine its stability in amber glass flasks studies were conducted where samples underwent different conditions. in stress situations d004 is sensitive to the thermal and oxidative degradation. under accelerated conditions (40 ± 2 oc ad 75 ± 5 % of relative humidity) there weren't significant changes in any assessed parameters during 12 months allowing predicting a useful life time of at least 2 years under less drastic conditions. it was corroborated under climatic conditions ii (25 ± 2oc and 60± 5% of relative humidity and iv (30 ± 2 oc and 70 ± 5 % of relative humidity).
Estudios preliminares de estabilidad de un extracto lipídico de los frutos de Roystonea regia en frascos de vidrio ámbar Preliminary studies of a lipid extract stability from the fruits of Roystonea regia in amber glass flasks
Roxana de la Caridad Sierra Pérez,Eduardo Antonio Rodríguez Leyes,Víctor Luis González Canavaciolo,David Marrero Delange
Revista Cubana de Farmacia , 2010,
Abstract: El D004 es un nuevo ingrediente activo extraído de los frutos de la palma real cubana (Roystonea regia), promisorio en el tratamiento de la hiperplasia prostática benigna. Para determinar su estabilidad en frascos de vidrio ámbar, se realizaron estudios donde las muestras se sometieron a diferentes condiciones. En condiciones de estrés se observó que el D004 es susceptible a la degradación térmica y oxidativa. En condiciones aceleradas (40 ± 2 oC y 75 ± 5 % humedad relativa) no se observaron cambios significativos en ninguno de los parámetros evaluados durante 12 meses, lo que permitió predecir un tiempo de vida útil de al menos 2 a os en condiciones menos drásticas. Esto fue corroborado en las condiciones de las zonas climáticas II (25 ± 2 oC y 60 ± 5 % humedad relativa) y IV (30 ± 2 oC y 70 ± 5 % humedad relativa). The D004 is a new active ingredient extracted from the Cuban real palm (Roystonea regia), promising in the treatment of the benign prostatic hyperplasia. To determine its stability in amber glass flasks studies were conducted where samples underwent different conditions. In stress situations D004 is sensitive to the thermal and oxidative degradation. Under accelerated conditions (40 ± 2 oC ad 75 ± 5 % of relative humidity) there weren't significant changes in any assessed parameters during 12 months allowing predicting a useful life time of at least 2 years under less drastic conditions. It was corroborated under climatic conditions II (25 ± 2oC and 60± 5% of relative humidity and IV (30 ± 2 oC and 70 ± 5 % of relative humidity).
Tamizaje fitoquímico del Malvaviscus penduliflorus que crece en Cuba
Sierra Pérez,Roxana de la C; Gónzález Canavaciolo,Victor L; Rodríguez Leyes,Eduardo A; Marrero Delange,David;
Revista Cubana de Plantas Medicinales , 2010,
Abstract: introduction: the malvaviscus penduliflorus cav species flowers popularly known in cuba as "pasiflora" are used as sedative in the brew form. until now, however, there isn't any study on its chemical composition. objective: to perform a phytochemical screening of aqueous extracts from the flowers and leaves of m. penduliflorus species. methods: the dry fresh leaves and flowers were washed, disinfected to extract with water reflow (1:10) during 2 h in an independent way. extracts were filtered and underwent the phytochemical identification tests. results: among the compounds identified in the two groups were included the saponines, sugars, alkaloids and flavonoids. conclusions: taking into account the presence of compounds like the flavonoids and the alkaloids in aerial parts of m. penduliflorus, as well as the pharmacological effects reported for the extracts of this species, it will be interesting to perform new studies providing evidences on its effectiveness and safety, as a way to assess its traditional uses.
Análisis fitoquímico de la Salvia coccinea que crece en Cuba
Sierra Pérez,Roxana de la C; Gónzález Canavaciolo,Victor L; Marrero Delange,David; Rodríguez Leyes,Eduardo A;
Revista Cubana de Plantas Medicinales , 2011,
Abstract: introduction: the salvia coccinea l. species, known as banderilla, is used in cuba as an ornamental plant. nevertheless, some traditional medical uses have been reported in other countries without reports of pharmacological studies. no phytochemical study has been made with plants of this species growing in cuba. objective: to carry out the phytochemical study of hydroalcoholic extracts from stems, leaves and flowers of the salvia coccinea l. species. methods: stems, leaves and flowers were collected, washed, disinfected, dried at 40 °c and independently extracted under reflux with a etoh/h2o (60:40) mixture for 2 h at a solute-solvent ratio of 1:10. results: compounds identified in both extracts were saponins, sugars, bitter principles, phenols, tannins, amino groups, alkaloids and flavonoids. the lyophilized extract from leaves and flowers contained 9.02 % of total polyphenols. conclusions: several groups of compounds were found in the s. coccinea l. that grows in cuba, such as flavonoids and alkaloids, and they could be of potential pharmacological interest. these results encouraged to continue the study of extracts from this plant and to begin evaluating their pharmacological effects.
Tamizaje fitoquímico del Malvaviscus penduliflorus que crece en Cuba Phytochemical screening of Malvaviscus penduliflorus growing in Cuba
Roxana de la C Sierra Pérez,Victor L Gónzález Canavaciolo,Eduardo A Rodríguez Leyes,David Marrero Delange
Revista Cubana de Plantas Medicinales , 2010,
Abstract: INTRODUCCIóN: las flores de la especie Malvaviscus penduliflorus Cav., conocida popularmente en Cuba como "pasiflora", se emplean como sedante en forma de decocción. Hasta el momento, sin embargo, no ha sido publicado ningún estudio sobre su composición química. OBJETIVO: realizar un tamizaje fitoquímico de los extractos acuosos de las flores y hojas de la especie M. penduliflorus. MéTODOS: se recolectaron las hojas y las flores frescas, se lavaron, desinfectaron y extrajeron a reflujo con agua (1:10) durante 2 h, de forma independiente. Los extractos se filtraron y se les hicieron las pruebas fitoquímicas de identificación. RESULTADOS: entre los grupos de compuestos identificados en los 2 extractos se encontraron saponinas, azúcares, alcaloides y flavonoides. CONCLUSIONES: teniendo en cuenta la presencia de compuestos como flavonoides y alcaloides en las partes aéreas del M. penduliflorus, así como los efectos farmacológicos reportados para extractos de esta especie, sería interesante realizar nuevos estudios que aporten evidencias sobre su eficacia y seguridad, como forma de avalar sus usos tradicionales. INTRODUCTION: the Malvaviscus penduliflorus Cav species flowers popularly known in Cuba as "pasiflora" are used as sedative in the brew form. Until now, however, there isn't any study on its chemical composition. OBJECTIVE: to perform a phytochemical screening of aqueous extracts from the flowers and leaves of M. penduliflorus species. METHODS: the dry fresh leaves and flowers were washed, disinfected to extract with water reflow (1:10) during 2 h in an independent way. Extracts were filtered and underwent the phytochemical identification tests. RESULTS: among the compounds identified in the two groups were included the saponines, sugars, alkaloids and flavonoids. CONCLUSIONS: taking into account the presence of compounds like the flavonoids and the alkaloids in aerial parts of M. penduliflorus, as well as the pharmacological effects reported for the extracts of this species, it will be interesting to perform new studies providing evidences on its effectiveness and safety, as a way to assess its traditional uses.
Análisis fitoquímico de la Salvia coccinea que crece en Cuba Phytochemical study of the Salvia coccinea grown in Cuba
Roxana de la C Sierra Pérez,Victor L Gónzález Canavaciolo,David Marrero Delange,Eduardo A Rodríguez Leyes
Revista Cubana de Plantas Medicinales , 2011,
Abstract: Introducción: la especie Salvia coccinea L., conocida como banderilla, se emplea en Cuba solo como ornamental, aunque en otros países tiene algunos usos etnomédicos sin que se le hayan reportado estudios farmacológicos. A las plantas de esta especie que crecen en Cuba no se le han realizado estudios fitoquímicos. Objetivo: realizar un tamizaje fitoquímico de los extractos hidroalcohólicos de tallos, flores y hojas de la especie Salvia coccinea L. Métodos: se recolectaron los tallos, así como las hojas y flores, se lavaron, desinfectaron, secaron a 40 oC y extrajeron de forma independiente a reflujo con una mezcla EtOH/H2O (60:40) a una relación soluto-disolvente de 1:10 durante 2 h. Los extractos se filtraron y se les hicieron las pruebas fitoquímicas. Resultados: los grupos de compuestos identificados en los 2 extractos fueron saponinas, azúcares, principios amargos, fenoles, taninos, grupos amino, alcaloides y flavonoides. El extracto liofilizado de las hojas y flores presentó 9,02 % de polifenoles totales. Conclusiones: en la S. coccinea L. que crece en Cuba se encontraron varios grupos de compuestos, entre estos flavonoides y alcaloides, los que pudieran tener interés farmacológico potencial. Estos resultados conminan a continuar el estudio de los extractos de esta planta y a iniciar la evaluación de sus efectos farmacológicos. Introduction: the Salvia coccinea L. species, known as banderilla, is used in Cuba as an ornamental plant. Nevertheless, some traditional medical uses have been reported in other countries without reports of pharmacological studies. No phytochemical study has been made with plants of this species growing in Cuba. Objective: to carry out the phytochemical study of hydroalcoholic extracts from stems, leaves and flowers of the Salvia coccinea L. species. Methods: stems, leaves and flowers were collected, washed, disinfected, dried at 40 °C and independently extracted under reflux with a EtOH/H2O (60:40) mixture for 2 h at a solute-solvent ratio of 1:10. Results: compounds identified in both extracts were saponins, sugars, bitter principles, phenols, tannins, amino groups, alkaloids and flavonoids. The lyophilized extract from leaves and flowers contained 9.02 % of total polyphenols. Conclusions: several groups of compounds were found in the S. coccinea L. that grows in Cuba, such as flavonoids and alkaloids, and they could be of potential pharmacological interest. These results encouraged to continue the study of extracts from this plant and to begin evaluating their pharmacological effects.
Evaluación serológica de la inmunización pasiva-activa en la profilaxis de la transmisión perinatal de la hepatitis B
Marité Bello,Licel de los Angeles Rodríguez,Maura Nazco,María de la Caridad Montalvo
Vaccimonitor , 2012,
Abstract: La administración conjunta de gammaglobulina antihepatitis B y la vacuna se recomienda mundialmente para prevenir la transmisión perinatal en hijos de madres HBsAg(+). Se evaluó la inmunización pasiva-activa a los tres días, 7 y 18 meses de vida, como forma preventiva de esta transmisión. Se estudiaron 87 sueros de hijos demadres HBsAg(+), tomados a los 3 días, 7 y 18 meses de nacidos, para un total de 261 muestras. A los recién nacidos se les administró una dosis de inmunoglobulina humana antihepatitis B cubana (Ganmahep B) y de vacuna recombinante cubana Heberbiovac-HB antes de las 12 horas de nacidos y posteriormente a los 1, 2 y 12 meses, según el esquema de vacunación Los ni os fueron evaluados con los marcadores HBsAg y anti-HBs. Al tercer día el 8,0% de los ni os fueron HBsAg(+), el 92,5% de los ni os HBsAg(-) resultaron seroprotegidos. A los7 meses de edad el 1,1% fue HBsAg(+), la seroprotección de los ni os HBsAg(-) fue de 89,5%. El 3,4% fue HBsAg(+) a los 18 meses, con un 97,6% de seroprotección en los ni os HBsAg(-). Predominó la respuestanormoprotectora en los tres tiempos, con diferencias estadísticamente significativas en la seroprotección y títulos≥ 100 UI/L. Los títulos promedios geométricos (TPG) fueron 72,9 UI/L, 168,66 UI/L y 175,62 UI/L, respectivamente,con significación estadística entre ellos. Se sugiere que el uso de Ganmahep B,conjuntamente con la vacuna cubana reduce el riesgo de transmisión perinatal del VHB y es el primer estudio realizado en Cuba para evaluar la eficacia profiláctica en este grupo de riesgo.
Evaluación genotóxica del extracto hidroalcohólico de Tamarindus indica L. empleando el ensayo de micronúcleos en médula ósea de ratón
Remigio Montero,Antonia de la Caridad; Piloto Ferrer,Janet; Vega Hurtado,Yamilé; Rodríguez Ferralá,Carlos; Carballo,Caridad;
Revista Cubana de Plantas Medicinales , 2007,
Abstract: micronuclei assay in mouse bone marrow, test included in genotoxicity standard battery, was used to assess clastogenic and aneugenic potential of a hydroalcoholic extract of tamarindus indica l. we used nmri mice of both sexes, with administration by intragastric route at a rate of 10 ml/kg, in the space of 24 hours, sacrified 24 hours after last application. genotoxicity rate, polychromatic micronucleated erythrocyte percentage in a total of 1 000 polychromatic erythrocytes per animal. genotoxicity rates of treated groups using 500, 1000, and 2000 mg/kg extract/body weight were statistically significant as for group treated with control substance (h2o sterile). extract of tamarindus indica l was of clastogenic type, since give raise to a significant increase in micronuclei frequency of bone marrow polychromatic erythrocytes, and in ratios linear trend test showed a dosis-response relationship.
Estrategia de intervención para la prevención de la parálisis cerebral en ni?os pretérminos en Matanzas
Riesgo Rodríguez,Solangel de la Caridad; Robaina Castellanos,Gerardo Rogelio;
Revista M??dica Electr?3nica , 2009,
Abstract: the incidence of children born with < 1 500 grams has increased at the province of matanzas. it might be accompanied with an increase in the prevalence of congenital cerebral paralysis in few years. our objective was developing a plan of actions addressed to prevent and control the main risk factors of congenital cerebral paralysis in preterm children born at the province of matanzas. we propose an intervention strategy stating concrete measures to prevent and control the main risk facts of congenital cerebral paralysis identified in preterm children born in matanzas: maternal diseases, preterm delivery menace, and delivery induction, depression at birth, sepsis, infection and neonatal mechanic ventilation. putting into practice an intervention at the population level directed to control the risk facts of congenital cerebral paralysis in preterm children should have a positive impact in controlling the frequency of the entity′s emergency, but it's success requires the coordinated action of the doctor, the health system and the government instances.
Vigilancia de eventos adversos de la vacuna plisacárida meningocócica A y C durante una campa?a de vacunación en Níger
Rodríguez,Meiby de la Caridad; Cuevas,Iván Edelberto; Mirabal,Mayelín; Ruíz,Luis;
Vaccimonitor , 2011,
Abstract: immunoprophylaxis is the choice strategy for the prevention and control of meningococcal meningitis epidemics caused by neisseria meningitidis serogroup a in the so-called meningitis belt of africa, a disease that reaches high rates of morbidity and mortality. the lyophilized purified polysaccharide vaccine from neisseria meningitidis serogroups a and c was produced as a result of a collaboration agreement between finlay institute, center for research, development and production of vaccines, cuba and the institute of technology and bio-immunobiologicals manguinhos of brazil, at the request of the world health organization to meet the needs of the vaccine in african countries in health emergencies. in the vaccination campaign carried out during an outbreak in niger in 2009, a study of pharmacovigilance was conducted to describe the adverse events following the administration of this product to 303 037 people. two methods were used to collect adverse events (spontaneous reporting and intensive search in hospitals). a total of 81 adverse events were reported, only 11% were under the category ?induced by the vaccine? and considered ?very probably related? to this. the results show that the vaccine used in the immunization campaign in niger is safe, has low reactogenicity and their safety profile corresponds to that described in the sanitary medical registry in brazil.
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