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匹配条件: “Ron A. Adelman” ,找到相关结果约462174条。
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Bevacizumab vs. Ranibizumab in Preserving or Improving Vision in Patients with Wet, Age-Related Macular Degeneration: A Cost-effectiveness Review
Chukwuemeka C. Nwanze, Abumere Akinwale and Ron A. Adelman
Clinical Medicine Insights: Therapeutics , 2012, DOI: 10.4137/CMT.S7439
Abstract: Objective: To evaluate the cost-effectiveness of monthly and as-needed dosing protocols using ranibizumab or bevacizumab for the treatment of neovascular age-related macular degeneration (AMD), when the treatment costs of severe ocular and systemic adverse events are considered. Methods: A Markov model was developed to assess the cost effectiveness of each of the following protocols: monthly ranibizumab, monthly bevacizumab, as-needed ranibizumab and as-needed bevacizumab. Direct costs and utilities were assessed from the perspective of a third-party payer or an insurance company. Cost effectiveness was evaluated in 2011 US dollars per quality-adjusted life year (QALY). Results: Considering the treatment costs of severe medical and ocular adverse events, the cost effectiveness of each protocol is as follows: monthly ranibizumab $63,333/QALY, ranibizumab as needed $18,571/QALY, bevacizumab monthly $2,676/QALY and bevacizumab as needed $3,333/QALY. Sensitivity analysis of the treatment costs of medical and ocular adverse events demonstrated minimal impact on relative cost-effectiveness. Conclusion: At current prices, monthly bevacizumab is the most cost-effective anti-VEGF AMD treatment protocol. Ranibizumab is as cost effective as bevacizumab at a maximum price of $158 per dose.
Bevacizumab vs. Ranibizumab in Preserving or Improving Vision in Patients with Wet, Age-Related Macular Degeneration: A Cost-effectiveness Review
Chukwuemeka C. Nwanze,Abumere Akinwale,Ron A. Adelman
Clinical Medicine Insights: Therapeutics , 2012,
Abstract:
ZIP4H (TEX11) Deficiency in the Mouse Impairs Meiotic Double Strand Break Repair and the Regulation of Crossing Over
Carrie A. Adelman,John H. J. Petrini
PLOS Genetics , 2008, DOI: 10.1371/journal.pgen.1000042
Abstract: We have recently shown that hypomorphic Mre11 complex mouse mutants exhibit defects in the repair of meiotic double strand breaks (DSBs). This is associated with perturbation of synaptonemal complex morphogenesis, repair and regulation of crossover formation. To further assess the Mre11 complex's role in meiotic progression, we identified testis-specific NBS1-interacting proteins via two-hybrid screening in yeast. In this screen, Zip4h (Tex11), a male germ cell specific X-linked gene was isolated. Based on sequence and predicted structural similarity to the S. cerevisiae and A. thaliana Zip4 orthologs, ZIP4H appears to be the mammalian ortholog. In S. cerevisiae and A. thaliana, Zip4 is a meiosis-specific protein that regulates the level of meiotic crossovers, thus influencing homologous chromosome segregation in these organisms. As is true for hypomorphic Nbs1 (Nbs1ΔB/ΔB) mice, Zip4h?/Y mutant mice were fertile. Analysis of spermatocytes revealed a delay in meiotic double strand break repair and decreased crossover formation as inferred from DMC1 and MLH1 staining patterns, respectively. Achiasmate chromosomes at the first meiotic division were also observed in Zip4h?/Y mutants, consistent with the observed reduction in MLH1 focus formation. These results indicate that meiotic functions of Zip4 family members are conserved and support the view that the Mre11 complex and ZIP4H interact functionally during the execution of the meiotic program in mammals.
Evaluation of long-acting somatostatin analog injection devices by nurses: a quantitative study
Adelman DT, Burgess A, Davies PR
Medical Devices: Evidence and Research , 2012, DOI: http://dx.doi.org/10.2147/MDER.S37831
Abstract: luation of long-acting somatostatin analog injection devices by nurses: a quantitative study Original Research (735) Total Article Views Authors: Adelman DT, Burgess A, Davies PR Published Date December 2012 Volume 2012:5 Pages 103 - 109 DOI: http://dx.doi.org/10.2147/MDER.S37831 Received: 06 September 2012 Accepted: 01 November 2012 Published: 17 December 2012 Daphne T Adelman,1 Andrea Burgess,2 Philippa R Davies,3 1Feinberg School of Medicine, Northwestern University, Chicago, IL, USA; 2Neuroendocrine Tumor Department, The Christie, Manchester, UK; 3Neuroendocrine Tumor Unit, Royal Free Hospital, London, UK Abstract: The somatostatin analogs (SSAs) lanreotide Autogel/Depot and octreotide long-acting release are used to treat acromegaly and neuroendocrine tumors. The present study evaluated opinions on SSA injection devices, including a recently approved lanreotide new device (lanreotide-ND), among nurses in Europe and the USA. Nurses injecting SSAs for at least three patients per year (n = 77) were interviewed regarding SSA devices. Device attributes were rated via questionnaire; nurses were then timed administering test injections with lanreotide-ND and octreotide long-acting release. The most important delivery system attributes were easy/convenient preparation and injection (ranked in the top five by 70% of nurses), low clogging risk (58%), and high product efficacy (55%). Compared with the octreotide long-acting release device, lanreotide-ND scored higher on 15/16 attributes, had shorter mean preparation and administration time (329 versus 66 seconds, respectively; P ≤ 0.01) and a higher overall preference score (70 versus 114, respectively; P ≤ 0.01). The five most important lanreotide-ND attributes were: prefilled device, confidence a full dose was delivered, low clogging risk, easy/convenient preparation and injection, and fast administration. These device features could lead to improvements in clinical practice and benefit patients/caregivers who administer SSAs at home.
Evaluation of long-acting somatostatin analog injection devices by nurses: a quantitative study
Adelman DT,Burgess A,Davies PR
Medical Devices: Evidence and Research , 2012,
Abstract: Daphne T Adelman,1 Andrea Burgess,2 Philippa R Davies,31Feinberg School of Medicine, Northwestern University, Chicago, IL, USA; 2Neuroendocrine Tumor Department, The Christie, Manchester, UK; 3Neuroendocrine Tumor Unit, Royal Free Hospital, London, UKAbstract: The somatostatin analogs (SSAs) lanreotide Autogel/Depot and octreotide long-acting release are used to treat acromegaly and neuroendocrine tumors. The present study evaluated opinions on SSA injection devices, including a recently approved lanreotide new device (lanreotide-ND), among nurses in Europe and the USA. Nurses injecting SSAs for at least three patients per year (n = 77) were interviewed regarding SSA devices. Device attributes were rated via questionnaire; nurses were then timed administering test injections with lanreotide-ND and octreotide long-acting release. The most important delivery system attributes were easy/convenient preparation and injection (ranked in the top five by 70% of nurses), low clogging risk (58%), and high product efficacy (55%). Compared with the octreotide long-acting release device, lanreotide-ND scored higher on 15/16 attributes, had shorter mean preparation and administration time (329 versus 66 seconds, respectively; P ≤ 0.01) and a higher overall preference score (70 versus 114, respectively; P ≤ 0.01). The five most important lanreotide-ND attributes were: prefilled device, confidence a full dose was delivered, low clogging risk, easy/convenient preparation and injection, and fast administration. These device features could lead to improvements in clinical practice and benefit patients/caregivers who administer SSAs at home.Keywords: nurse, somatostatin analog, device, lanreotide, octreotide
Retinal vascular tortuosity in obstructive sleep apnea
Mohsenin A,Mohsenin V,Adelman RA
Clinical Ophthalmology , 2013,
Abstract: Amir Mohsenin,1 Vahid Mohsenin,2 Ron A Adelman1 1Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, Connecticut, USA; 2Yale Center for Sleep Medicine, Department of Medicine, Yale University School of Medicine, New Haven, Connecticut, USA Purpose: Endothelial dysfunction and vascular disease are common in obstructive sleep apnea (OSA). We sought to examine the retinal vascular manifestations of OSA. Methods: Nine consecutive patients with OSA underwent ophthalmic examination regardless of any ocular complaints. Seven patients without OSA matched for demographics were used as controls. Fundus photographs from both eyes were used to quantitate retinal vascular tortuosity of the temporal arterial and venous arcades using ImageJ digital analysis software. The tortuosity of each vessel from the optic disc rim to the crossing point of a 5 disc diameter (5DD) circle and 10 disc diameter (10DD) circle centered on the optic disc were quantitated. Results: The mean age of patients with OSA in the study was 52 years ± SD of 10 years and 67 years ± SD of 10 years in the control group. The apnea-hypopnea index in patients with OSA ranged from 12 to 102 events/hr of sleep. The nadir oxyhemoglobin saturation during sleep in patients with OSA ranged from 60% to 87%. There was no significant difference in the frequency of diabetes or hypertension between the groups. Total tortuosity was increased at the 5DD (P = 0.011) and 10DD (P = 0.004) marks. Arterial tortuosity was significantly increased at the 10DD mark (P = 0.016). Venular tortuosity was increased at both the 5DD (P = 0.001) and 10DD (P = 0.028) marks. Conclusion: Patients with OSA have increased retinal vascular tortuosity as compared to matched controls. Increased tortuosity of the retinal vasculature may be a novel association with OSA. A larger prospective study will be necessary to further explore this relationship and its clinical significance. Keywords: retinal vessel tortuosity, sleep apnea, retinal vasculature, retinal vascular tortuosity
Measurement of the Dipion Mass Spectrum in X(3872) -> J/Psi Pi+ Pi- Decays
A. Abulencia,D. Acosta,J. Adelman
Physics , 2005, DOI: 10.1103/PhysRevLett.96.102002
Abstract: We measure the dipion mass spectrum in X(3872)--> J/Psi Pi+ Pi- decays using 360 pb-1 of pbar-p collisions at 1.96 TeV collected with the CDF II detector. The spectrum is fit with predictions for odd C-parity (3S1, 1P1, and 3DJ) charmonia decaying to J/Psi Pi+ Pi-, as well as even C-parity states in which the pions are from Rho0 decay. The latter case also encompasses exotic interpretations, such as a D0-D*0Bar molecule. Only the 3S1 and J/Psi Rho hypotheses are compatible with our data. Since 3S1 is untenable on other grounds, decay via J/Psi Rho is favored, which implies C=+1 for the X(3872). Models for different J/Psi-Rho angular momenta L are considered. Flexibility in the models, especially the introduction of Rho-Omega interference, enable good descriptions of our data for both L=0 and 1.
Accurate computation of Galerkin double surface integrals in the 3-D boundary element method
Ross Adelman,Nail A. Gumerov,Ramani Duraiswami
Physics , 2015,
Abstract: Many boundary element integral equation kernels are based on the Green's functions of the Laplace and Helmholtz equations in three dimensions. These include, for example, the Laplace, Helmholtz, elasticity, Stokes, and Maxwell's equations. Integral equation formulations lead to more compact, but dense linear systems. These dense systems are often solved iteratively via Krylov subspace methods, which may be accelerated via the fast multipole method. There are advantages to Galerkin formulations for such integral equations, as they treat problems associated with kernel singularity, and lead to symmetric and better conditioned matrices. However, the Galerkin method requires each entry in the system matrix to be created via the computation of a double surface integral over one or more pairs of triangles. There are a number of semi-analytical methods to treat these integrals, which all have some issues, and are discussed in this paper. We present novel methods to compute all the integrals that arise in Galerkin formulations involving kernels based on the Laplace and Helmholtz Green's functions to any specified accuracy. Integrals involving completely geometrically separated triangles are non-singular and are computed using a technique based on spherical harmonics and multipole expansions and translations, which results in the integration of polynomial functions over the triangles. Integrals involving cases where the triangles have common vertices, edges, or are coincident are treated via scaling and symmetry arguments, combined with automatic recursive geometric decomposition of the integrals. Example results are presented, and the developed software is available as open source.
Semi-Analytical Computation of Acoustic Scattering by Spheroids and Disks
Ross Adelman,Nail A. Gumerov,Ramani Duraiswami
Physics , 2014, DOI: 10.1121/1.4901318
Abstract: Analytical solutions to acoustic scattering problems involving nonspherical shapes, such as spheroids and disks, have long been known and have many applications. However, these solutions require special functions that are not easily computable. For this reason, their asymptotic forms are typically used since they are more readily available. We explore these solutions and provide computational software for calculating their nonasymptotic forms, which are accurate over a wide range of frequencies and distances. This software, which runs in MATLAB, computes the solutions to acoustic scattering problems involving spheroids and disks by semi-analytical means, and is freely available from our webpage.
Software for Computing the Spheroidal Wave Functions Using Arbitrary Precision Arithmetic
Ross Adelman,Nail A. Gumerov,Ramani Duraiswami
Computer Science , 2014,
Abstract: The spheroidal wave functions, which are the solutions to the Helmholtz equation in spheroidal coordinates, are notoriously difficult to compute. Because of this, practically no programming language comes equipped with the means to compute them. This makes problems that require their use hard to tackle. We have developed computational software for calculating these special functions. Our software is called spheroidal and includes several novel features, such as: using arbitrary precision arithmetic; adaptively choosing the number of expansion coefficients to compute and use; and using the Wronskian to choose from several different methods for computing the spheroidal radial functions to improve their accuracy. There are two types of spheroidal wave functions: the prolate kind when prolate spheroidal coordinates are used; and the oblate kind when oblate spheroidal coordinate are used. In this paper, we describe both, methods for computing them, and our software. We have made our software freely available on our webpage.
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