oalib

Publish in OALib Journal

ISSN: 2333-9721

APC: Only $99

Submit

Any time

2018 ( 14 )

2017 ( 18 )

2016 ( 12 )

2015 ( 217 )

Custom range...

Search Results: 1 - 10 of 3714 matches for " Roland Baron "
All listed articles are free for downloading (OA Articles)
Page 1 /3714
Display every page Item
Change-Point Analysis of Survival Data with Application in Clinical Trials  [PDF]
Xuan Chen, Michael Baron
Open Journal of Statistics (OJS) , 2014, DOI: 10.4236/ojs.2014.49062
Abstract: Effects of many medical procedures appear after a time lag, when a significant change occurs in subjects’ failure rate. This paper focuses on the detection and estimation of such changes which is important for the evaluation and comparison of treatments and prediction of their effects. Unlike the classical change-point model, measurements may still be identically distributed, and the change point is a parameter of their common survival function. Some of the classical change-point detection techniques can still be used but the results are different. Contrary to the classical model, the maximum likelihood estimator of a change point appears consistent, even in presence of nuisance parameters. However, a more efficient procedure can be derived from Kaplan-Meier estimation of the survival function followed by the least-squares estimation of the change point. Strong consistency of these estimation schemes is proved. The finite-sample properties are examined by a Monte Carlo study. Proposed methods are applied to a recent clinical trial of the treatment program for strong drug dependence.
Essential Function of Dynamin in the Invasive Properties and Actin Architecture of v-Src Induced Podosomes/Invadosomes
Olivier Destaing, Shawn M. Ferguson, Alexei Grichine, Christiane Oddou, Pietro De Camilli, Corinne Albiges-Rizo, Roland Baron
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0077956
Abstract: The large GTPase dynamin plays a key role in endocytosis but is also localized at numerous actin rich sites. We investigated dynamin functions at podosomes/invadosomes, actin-based cellular adhesion structures implicated in tissue invasion. Podosomes/invadosomes are constituted of long F-actin bundles perpendicular to the substratum (actin cores), connected to randomly arranged F-actin fibers parallel to the substratum (actin cloud). We show here that dynamin depletion in v-Src-transformed fibroblasts triggers a massive disorganization of podosomes/invadosomes (isolated or in rosettes), with a corresponding inhibition of their invasive properties. The action of dynamin at podosomes/invadosomes requires a functional full-length protein, suggesting that the effects of dynamin at these sites and in membrane remodelling during endocytosis are mediated by similar mechanisms. In order to determine direct effect of dynamin depletion on invadosome, an optogenetic approach based on the photosensitizer KillerRed was developed. Acute dynamin photo-inactivation leads to a very rapid disorganization of invadosome without affecting focal adhesions. Dynamin therefore is a key regulator of the architecture of actin in podosomes/invadosomes.
Wardrobe Malfunctions and the Measurement of Internet Behaviour  [PDF]
Roland Pfister
Psychology (PSYCH) , 2011, DOI: 10.4236/psych.2011.23042
Abstract: The wardrobe malfunction – an unanticipated exposure of bodily parts in the public – has become a prevailing issue in concerts, shows and other celebrity events that is reliably reported by the media. The internet as the fastest source for celebrity gossip allows measuring the impact of such wardrobe malfunctions on the public in-terest in a celebrity. This measurement in turn allows conclusions about intention, motivation, and internet be-haviour of a wide variety of internet users. The present study exemplifies the use of an innovative non-reactive measure of active interest – the Search Volume Index – to assess the impact of a variety of internet-related phe-nomena, including wardrobe malfunctions. Results indicate that interest in a celebrity increases immediately af-ter such an event and stays at a high level for about three weeks (the wardrobe plateau). This special form of ce-lebrity gossip thus meets a constant interest of a substantial proportion of internet users.
Flow and Ductility of Smectite Clay for Skin Treatment  [PDF]
Roland Pusch
Journal of Cosmetics, Dermatological Sciences and Applications (JCDSA) , 2014, DOI: 10.4236/jcdsa.2014.42010
Abstract:

It is important that pastes and creames for skin treatment have suitable rheological properties and ability to establish a good contact with the tissues while retaining their tightness. Thixotropy is desired for providing fluidity when agitated and a suitably degree of stiffening thereafter. This requires low shear resistance in the coating phase and microstructural reorganization when leaving the paste to rest. Following the principle of using only mineral components for skin treatment, use of expandable hydrophilic clay minerals should be considered. They sorb cations and positively charged organic molecules and are impermeable to fluids and gas under low pressure, hence providing oxygen-free micro-environment. They can balance pH and are excellent agents for cleaning skin.

Regulation of Early Adipose Commitment by Zfp521
Sona Kang,Peter Akerblad,Riku Kiviranta,Rana K. Gupta,Shingo Kajimura,Michael J. Griffin,Jie Min,Roland Baron,Evan D. Rosen
PLOS Biology , 2012, DOI: 10.1371/journal.pbio.1001433
Abstract: While there has been significant progress in determining the transcriptional cascade involved in terminal adipocyte differentiation, less is known about early events leading to lineage commitment and cell fate choice. It has been recently discovered that zinc finger protein 423 (Zfp423) is an early actor in adipose determination. Here, we show that a close paralog of Zfp423, Zfp521, acts as a key regulator of adipose commitment and differentiation in vitro and in vivo. Zfp521 exerts its actions by binding to early B cell factor 1 (Ebf1), a transcription factor required for the generation of adipocyte progenitors, and inhibiting the expression of Zfp423. Overexpression of Zfp521 in cells greatly inhibits adipogenic potential, whereas RNAi-mediated knock-down or genetic ablation of Zfp521 enhances differentiation. In addition, Zfp521?/? embryos exhibit increased mass of interscapular brown adipose tissue and subcutaneous white adipocytes, a cell autonomous effect. Finally, Ebf1 participates in a negative feedback loop to repress Zfp521 as differentiation proceeds. Because Zfp521 is known to promote bone development, our results suggest that it acts as a critical switch in the commitment decision between the adipogenic and osteogenic lineages.
Regulation of Early Adipose Commitment by Zfp521
Sona Kang,Peter Akerblad equal contributor,Riku Kiviranta equal contributor,Rana K. Gupta,Shingo Kajimura,Michael J. Griffin,Jie Min,Roland Baron,Evan D. Rosen
PLOS Biology , 2012, DOI: 10.1371/journal.pbio.1001433
Abstract: While there has been significant progress in determining the transcriptional cascade involved in terminal adipocyte differentiation, less is known about early events leading to lineage commitment and cell fate choice. It has been recently discovered that zinc finger protein 423 (Zfp423) is an early actor in adipose determination. Here, we show that a close paralog of Zfp423, Zfp521, acts as a key regulator of adipose commitment and differentiation in vitro and in vivo. Zfp521 exerts its actions by binding to early B cell factor 1 (Ebf1), a transcription factor required for the generation of adipocyte progenitors, and inhibiting the expression of Zfp423. Overexpression of Zfp521 in cells greatly inhibits adipogenic potential, whereas RNAi-mediated knock-down or genetic ablation of Zfp521 enhances differentiation. In addition, Zfp521?/? embryos exhibit increased mass of interscapular brown adipose tissue and subcutaneous white adipocytes, a cell autonomous effect. Finally, Ebf1 participates in a negative feedback loop to repress Zfp521 as differentiation proceeds. Because Zfp521 is known to promote bone development, our results suggest that it acts as a critical switch in the commitment decision between the adipogenic and osteogenic lineages.
Deficiency of Retinaldehyde Dehydrogenase 1 Induces BMP2 and Increases Bone Mass In Vivo
Shriram Nallamshetty, Hong Wang, Eun-Jung Rhee, Florian W. Kiefer, Jonathan D. Brown, Sutada Lotinun, Phuong Le, Roland Baron, Clifford J. Rosen, Jorge Plutzky
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0071307
Abstract: The effects of retinoids, the structural derivatives of vitamin A (retinol), on post-natal peak bone density acquisition and skeletal remodeling are complex and compartment specific. Emerging data indicates that retinoids, such as all trans retinoic acid (ATRA) and its precursor all trans retinaldehyde (Rald), exhibit distinct and divergent transcriptional effects in metabolism. Despite these observations, the role of enzymes that control retinoid metabolism in bone remains undefined. In this study, we examined the skeletal phenotype of mice deficient in retinaldehyde dehydrogenase 1 (Aldh1a1), the enzyme responsible for converting Rald to ATRA in adult animals. Bone densitometry and micro-computed tomography (μCT) demonstrated that Aldh1a1-deficient (Aldh1a1?/?) female mice had higher trabecular and cortical bone mass compared to age and sex-matched control C57Bl/6 wild type (WT) mice at multiple time points. Histomorphometry confirmed increased cortical bone thickness and demonstrated significantly higher bone marrow adiposity in Aldh1a1?/? mice. In serum assays, Aldh1a1?/? mice also had higher serum IGF-1 levels. In vitro, primary Aldh1a1?/? mesenchymal stem cells (MSCs) expressed significantly higher levels of bone morphogenetic protein 2 (BMP2) and demonstrated enhanced osteoblastogenesis and adipogenesis versus WT MSCs. BMP2 was also expressed at higher levels in the femurs and tibias of Aldh1a1?/? mice with accompanying induction of BMP2-regulated responses, including expression of Runx2 and alkaline phosphatase, and Smad phosphorylation. In vitro, Rald, which accumulates in Aldh1a1?/? mice, potently induced BMP2 in WT MSCs in a retinoic acid receptor (RAR)-dependent manner, suggesting that Rald is involved in the BMP2 increases seen in Aldh1a1 deficiency in vivo. Collectively, these data implicate Aldh1a1 as a novel determinant of cortical bone density and marrow adiposity in the skeleton in vivo through modulation of BMP signaling.
Description biométrique de la croissance pondérale de poules naines et normales, discrimination précoce sur le poids corporel (De 0 A 9 Semaines)
R Baron
Genetics Selection Evolution , 1972, DOI: 10.1186/1297-9686-4-2-159
Abstract:
Description biométrique de la croissance des poules naines et des poules normales et leur discrimination pondérale
R Baron
Genetics Selection Evolution , 1971, DOI: 10.1186/1297-9686-3-3-377
Abstract:
决策与判断研究中的个体分析
Jonathan,Baron
心理学报 , 2010,
Abstract: 决策与判断研究中(甚至是实验心理学研究中)的许多问题关注某效应是否真实存在, 及其背后的解释是什么。这些问题不关注该效应在某一特殊群体中是否显著。因此, 可以通过分析单个被试来检验效应的显著性。如果有一个被试表现出了该效应, 那么, 这个效应就是存在的。根据这一观点, 有时也可通过跨案例或者轮次(across cases or rounds)分析来验证效应的显著性, 而不需要进行跨被试分析(across subjects )。这一观点也暗示在一些实验中可能存在反方向的效应。本文建议通过进行基于被试个体的统计分析来检验这样的效应, 并介绍了一些不同形式的方法:PP 概率图(probability probability plots); P 值分布检验(tests of the distribution of p-values); 分层取样多重检验的矫正(correction for multiple testing with step-down resampling)。这些方法都可以用于处理在对同样假设进行多重检验时无法避免的问题。另外, 本文也列举了一些例子, 其中有一部分例子存在反方向的效应, 另一部分例子不存在。
Page 1 /3714
Display every page Item


Home
Copyright © 2008-2017 Open Access Library. All rights reserved.