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Search Results: 1 - 10 of 12 matches for " Rokaya Mouhibi "
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Using Multiple Linear Regression and Artificial Neural Network Techniques for Predicting CCR5 Binding Affinity of Substituted 1-(3, 3-Diphenylpropyl)-Piperidinyl Amides and Ureas  [PDF]
Rokaya Mouhibi, Mohamed Zahouily, Khalid El Akri, Na?ma Hanafi
Open Journal of Medicinal Chemistry (OJMC) , 2013, DOI: 10.4236/ojmc.2013.31002
Abstract:

Quantitative structure–activity relationship (QSAR) models were developed to predict for CCR5 binding affinity of substituted 1-(3, 3-diphenylpropyl)-piperidinyl amides and ureas using multiple linear regression (MLR) and artificial neural network (ANN) techniques. A model with four descriptors, including Hydrogen-bonding donors HBD(R7), the partition coefficient between n-octanol and water logP and logP(R1) and Molecular weight MW(R7), showed good statistics both in the regression and artificial neural network with a configuration of (4-3-1) by using Bayesian and Leven-berg-Marquardt Methods. Comparison of the descriptor’s contribution obtained in MLR and ANN analysis shows that the contribution of some of the descriptors to activity may be non-linear.

Physicochemical 2D-Qsar and 3D Molecular Docking Studies on N-Chlorosulfonyl Isocyanate Analogs as Sterol O-Acyl-Transferase-1 “Soat-1” Inhibitors  [PDF]
Khalid El Akri, Rokaya Mouhibi, Mohamed Zahouily, Na?ma Hanafi, Moulay Abdellah Bahlaoui
Open Journal of Medicinal Chemistry (OJMC) , 2013, DOI: 10.4236/ojmc.2013.34013
Abstract: A series of N-carbonyl-functionalized ureas, carbamates and thiocarbamates derivatives (or N-Chloro sulfonyl isocyanate
“N-CSI”) were involved in linear and nonlinear physicochemical quantitative structure-activity relationship
“QSAR” analysis to find out the structural keys to control the inhibition against Sterol O-Acyl-Transferase-1 “SOAT-1”.
The results indicate the important effects of geometrical and chemical descriptors on the inhibitory activity of SOAT-1.
The molecules were also screened for three-dimensional molecular docking on the crystal structure of ACAT-1 (1WL5
for ACAT-1, PDB). A comparison between 2D-QSAR and 3D molecular docking studies shows that the latter confirm
the first results and represent a good prediction of the chemical and physical nature of interactions between our drug
molecules and enzyme SOAT-1.
Fenómenos elementales y estabilizaciones en las psicosis maníaco-depresivas.
Fran?ois Sauvagnat,Rokaya Sauvagnat
Revista de la Asociación Espa?ola de Neuropsiquiatría , 1998,
Abstract: Sin resumen.
Utilization of plant resources in Dang district, West Nepal
S. R. Sigdel,M. B. Rokaya
Banko Janakari , 2011, DOI: 10.3126/banko.v21i2.9143
Abstract: This paper aims to highlight the uses of forest resources in Purandhara, Panchakule and Goltakuri Village Development Committees (VDCs) of Dang district, western Nepal. The ethnobotanical data was collected through Participatory Rural Appraisal (PRA) that involved discussion with local people and key informants, through semi-structured questions and informal conversations. Vulnerability of plants used in the study area was assessed by adapting the Rapid Vulnerability Approach (RVA). Altogether 85 plant species belonging to 79 genera and 56 families were recorded in the study areas. Twelve plant species were found to be used for various purposes other than medicinal. They were used as food, fodder, in construction, in religious purposes and even in yielding dyes. Seventy three plant species were found to be medicinal in properties for treating 144 different ailments. Remedies for 27 ailments were reported as new uses. The most common way of admission of medicine was oral (76.71 %) followed by external or topical (35.6 %) and nasal (1.27 %). The RVA test showed Dalbergia sissoo (with 15 scores) and Terminalia alata (with 14 scores) as most vulnerable ones.
Effect of Altitude and Maturity Stages on Quality Attributes of Mandarin (Citrus reticulata Blanco)  [PDF]
Pradeep Raj Rokaya, Dilli Ram Baral, Durga Mani Gautam, Arjun Kumar Shrestha, Krishna Prasad Paudyal
American Journal of Plant Sciences (AJPS) , 2016, DOI: 10.4236/ajps.2016.76091
Abstract: Mandarin (Citrus reticulata Blanco) is a premier fruit crop which ranks in first position of the total fruit industry in Nepal. Studies were conducted to assess the maturity indices and quality parameters of mandarin at three altitudes i.e. 1300 m·asl, 1000 m·asl, and 700 m·asl with six maturity stages i.e. 11 Oct, 21 Oct, 31 Oct, 10 Nov, 20 Nov, and 30 Nov. The most important and reliable judging criteria of fruit maturity in mandarin i.e. fruit weight, external fruit colour, firmness, TSS, acidity, and TSS/Acid ratio, and vitamin C were experimented. The experiment results revealed that 1000 m·asl location was showed the highest fruit weight (104.9 g) and juice percentage (55.23) followed by 1300 m·asl altitude (99.5 g and 53.75% respectively) at 20th of November. The maturity advanced at lower altitude with 50 percent yellow orange rind colour, 10.98 TSS/acid ratio and 4 kg/cm2 firmness from 10th
Effect of Pre-Harvest Application of Gibberellic Acid on Fruit Quality and Shelf Life of Mandarin (Citrus reticulata Blanco)  [PDF]
Pradeep Raj Rokaya, Dilli Ram Baral, Durga Mani Gautam, Arjun Kumar Shrestha, Krishna Prasad Paudyal
American Journal of Plant Sciences (AJPS) , 2016, DOI: 10.4236/ajps.2016.77098
Abstract: Mandarin (Citrus reticulata Blanco) is a promising fruit crop gaining popularity for its human nutrition and economic importance in Nepal. The qualitative losses during pre-harvest stage hinder the productivity and subsequently shorten the on-tree storability. An experiment was conducted to assess the effect of gibberellic acid on quality and shelf life of the mandarin fruit. GA3 at 10, 20, and 30 ppm as against of control were evaluated. Observations on fruit weight (g), fruit firmness (kg/cm2), rind colour (1 - 5 index), juice recovery (%), TSS/acid ratio, PLW (%), decay loss (%), and ascorbic acid (mg/100 ml) were recorded at three harvesting dates i.e. 20 Nov, 5 Dec, and 20 Dec and storage condition. It has been revealed that the fruits treated with GA3 at 20 ppm retained higher fruit weight (128.6 g), more firmness (3.54 kg/cm2), better juice recovery (57.75%), and greater TSS/acid ratio (21.24) at the end of study (20 December). The PLW was found less with GA3 at 30 ppm in both ambient (5.17%) and cellar (6.69%) condition as against untreated fruits (9.52% and 11.76%). Similarly, the decay loss was minimum in the fruits treated with GA3 at 30 ppm both with ambient (1.02%) and cellar condition (8.21%) as against control with ambient (5.54%) and cellar (21.58%).
Effect of Postharvest Treatments on Quality and Shelf Life of Mandarin (Citrus reticulata Blanco)  [PDF]
Pradeep Raj Rokaya, Dilli Ram Baral, Durga Mani Gautam, Arjun Kumar Shrestha, Krishna Prasad Paudyal
American Journal of Plant Sciences (AJPS) , 2016, DOI: 10.4236/ajps.2016.77105
Abstract: Nepal produces large quantity of mandarin (Citrus reticulata Blanco) annually but faces big losses due to improper postharvest treatments. The experiment was carried out during 2012-2013 with the objective of assessing the effect of different postharvest treatments on quality and shelf life of mandarin. The postharvest treatments were: wax emulsion at 10%, bavistin at 0.1%, wax at 10% with bavistin at 0.1%, calcium chloride at 1%, Jeevatu at 5% along with untreated fruits as a control. The experiment was conducted for four weeks of storage at ambient condition in Nepal Agricultural Research Council, Khumaltar, Kathmandu. Wax in combination with bavistin was found as the most effective in reducing the physiological loss in weight, whereas bavistin proved to reduce decay loss up to four weeks of storage. The fruits treated with wax alone and with combination of bavistin retained maximum firmness, juice percentage, vitamin C and palatability rating during the storage. The minimum total soluble solid and maximum titrable acidity were recorded in the fruits treated with wax plus bavistin. The present findings indicate that mandarin can be stored up to four weeks when treated with wax as well as wax with bavistin in the condition with 14°C - 18°C temperature and 45% - 73% relative humidity.
Ameliorative Potential of Mesenchymal Stem Cells and Hematopoietic Stem Cells against CCl4 Induced Chromosomal Abnormalities in Experimental Rat Liver Fibrosis  [PDF]
Rokaya H. Ahmed, Nagwa K. Roshdy, Hayam E. Saleh, Mohammed I. Aref, Nermeen M. Hassan, Noura R. Mohammed
Stem Cell Discovery (SCD) , 2014, DOI: 10.4236/scd.2014.44010
Abstract: Background and Objective: The liver is responsible for metabolism and detoxification of the most of components that enter the body. Once the liver became injured, its efficient treatment with famous chemical drugs was limited. Therefore, interest concerned the use of alternative medicines for the treatment of hepatic disease has been arisen. The present study was aimed to investigate the therapeutic effect of the two types of stem cells against chromosomal aberrations in bone marrow (BM) cells of rats treated with carbon tetrachloride (CCl4). Design and Method: BM-derived mesenchymal stem cells (MSCs) were isolated and propagated in culture for 2 weeks and were characterized morphologically. Human umbilical cord blood (UCB) cells were obtained after full-term caesarean delivery from healthy donors. Low-density mononuclear cells were separated over Ficoll-Paque, and CD34+ hematopoietic cells were isolated using a magnetic cell sorter. Rats were divided into 4 groups: control, CCl4, CCl4 plus MSC, and CCl4 plus CD34+. Liver tissue was examined histopathologically for all groups. Results: The results of the present study indicated a significant increase (p 0.05) in the number of metaphases with different types of chromosomal aberrations in CCl4 group. Treatment of the animals
Numerical techniques for the neutron diffusion equations in the nuclear reactors
A. Nahla,F. Al-Malki,M. Rokaya
Advanced Studies in Theoretical Physics , 2012,
Abstract:
Medicinal Orchids of Nepal: Are They Well Protected?
K.P. Acharya,M.B. Rokaya
Our Nature , 2010, DOI: 10.3126/on.v8i1.4315
Abstract: This paper aims to explore distribution pattern of orchids used for medicinal purpose and their conservation aspect. We compiled information on 82 species of orchids which are used as herbal medicine. Maximum richness of medicinal orchids was observed at an elevation of 1700 msl but, the maximum numbers of protected areas are located at an elevation of 3000 to 3500 msl. There is a negative correlation between number of protected areas and medicinal orchid species richness mentioning that the protected areas are less synchronized with medicinal orchids of Nepal. DOI: 10.3126/on.v8i1.4315
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