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Rese a de "Buenos Aires en Armas. La revolución de 1880" (Hilda Sábato). Buenos Aires, Siglo XXI Editores, 2008, 333 páginas.
Inés Rojkind
HIb Revista de Historia Iberoamericana , 2009,
Abstract:
La revolución está vencida, pero el gobierno está muerto . Crisis política, discursos periodísticos y demostraciones callejeras en Buenos Aires, 1890
Rojkind, Inés
Anuario de Estudios Americanos , 2012,
Abstract: This paper addresses the crisis of the régimen conservador in 1890, in the context of a failed armed rebellion and the resignation of President Miguel Juárez Celman. It seeks to explain how the expansion and diversification of political participation helped to undermine the legitimacy of the existing order. The paper analyzes a series of street demonstrations that, fed by press articles and parliamentary debates, took place in the city of Buenos Aires along several days. Este trabajo aborda la crisis que atravesó en 1890 el régimen conservador, en el contexto de una fallida rebelión armada y de la renuncia del presidente Miguel Juárez Celman. La intención es explicar el modo en que la ampliación y la diversificación de la participación política contribuyeron a profundizar los cuestionamientos que corroían la legitimidad del orden vigente. Se analizan las demostraciones callejeras que, alimentadas por los discursos de la prensa y por los debates parlamentarios, se sucedieron en la ciudad de Buenos Aires durante varios días.
Colchicine reduces procollagen III and increases pseudocholinesterase in chronic liver disease
Sergio Muntoni, Marcos Rojkind, Sandro Muntoni
World Journal of Gastroenterology , 2010,
Abstract: AIM: To test whether colchicine would be an effective antifibrotic agent for treatment of chronic liver diseases in patients who could not be treated with α-interferon.METHODS: Seventy-four patients (46 males, 28 females) aged 40-66 years (mean 53 ± 13 years) participated in the study. The patients were affected by chronic liver diseases with cirrhosis which was proven histologically (n = 58); by chronic active hepatitis C (n = 4), chronic active hepatitis B (n = 2), and chronic persistent hepatitis C (n = 6). In the four patients lacking histology, cirrhosis was diagnosed from anamnesis, serum laboratory tests, esophageal varices and ascites. Patients were assigned to colchicine (1 mg/d) or standard treatment as control in a randomized, double-blind trial, and followed for 4.4 years with clinical and laboratory evaluation.RESULTS: Survival at the end of the study was 94.6% in the colchicine group and 78.4% in the control group (P = 0.001). Serum N-terminal peptide of type III procollagen levels fell from 34.0 to 18.3 ng/mL (P = 0.0001), and pseudocholinesterase levels rose from 4.900 to 5.610 mU/mL (P = 0.0001) in the colchicine group, while no significant change was seen in controls. Best results were obtained in patients with chronic hepatitis C and in alcoholic cirrhotics.CONCLUSION: Colchicine is an effective and safe antifibrotic drug for long-term treatment of chronic liver disease in which fibrosis progresses towards cirrhosis.
Resistencia a Hormonas Tiroideas (RHT): Descripción de una nueva mutación Resistance to Thyroid Hormones (RTH): Description of a new mutation
A Rojkind,D Pezzutti,F Viale,C Rivolta
Revista Argentina de Endocrinología y Metabolismo , 2009,
Abstract: Introducción: La resistencia a hormonas tiroideas (RHT) es un desorden genético de transmisión dominante poco frecuente, caracterizado por una respuesta reducida de los tejidos blanco a las hormonas tiroideas. RHT está ligada al gen del receptor beta de hormona tiroidea (TRβ). El síndrome se identifica por niveles persistentemente elevados de T4 y T3 totales y libres en presencia de TSH no suprimida. Materiales y Métodos: Paciente femenina de 62 a os de edad con antecedente de hemitiroidectomía a los 22 a os por bocio. Clínicamente, la mujer se encontraba eutiroidea y hemodinámicamente estable. En los exámenes complementarios se constató la presencia de nódulo tiroideo, con estudio citológico benigno y en el laboratorio hormonas tiroideas totales y libres elevadas con TSH no suprimida. La impresión diagnóstica fue RHT, siendo el principal diagnóstico diferencial el tirotropinoma. Se realizó perfil tiroideo completo en el caso índice y en dos familiares de primer grado. Se dosaron gonadotropinas y prolactina, y se realizó RMN de hipófisis en el caso índice. Se estudiaron mutaciones del gen TRβ en ADN genómico en la paciente y en uno de sus familiares. Resultados: Avalando la impresión diagnóstica, tanto el caso índice como los dos familiares mostraron un perfil tiroideo compatible con RHT. El estudio genético identificó una nueva mutación en el exón 10: c.1339C>A que resulta en una sustitución p.P447T. La misma fue observada tanto en el caso índice como en el familiar estudiado. Conclusión: La historia de esta paciente con RHT, al igual que otros casos descriptos en la bibliografía, remarcan la importancia de un diagnóstico adecuado y temprano de esta patología poco frecuente para evitar conductas terapéuticas iatrogénicas y con consecuencias relevantes en la vida de estos pacientes. Paralelamente, se describe una nueva mutación genética en esta familia. Introduction: Resistance to thyroid hormones (RTH) is an unusual autosomal dominant inherited disorder characterized by a reduced target organ responsiveness to thyroid hormones. RTH is linked to the gene encoding the thyroid receptor β (TR β). This syndrome is characterized by persistent high levels of total and free T4 and T3 while TSH is not inhibited. Materials and Methods: 62 years old female who underwent a partial thyroidectomy because of goiter forty years ago. Clinically, she seemed to be an euthyroid patient and her hemodynamic status was normal. The exams revealed the existence of a benign thyroid nodule, high levels of total and free thyroid hormones and normal values of TSH. Our diagnostic im
Resistencia a Hormonas Tiroideas (RHT): Descripción de una nueva mutación
Rojkind,A; Pezzutti,D; Viale,F; Rivolta,C; Olcese,C; Targovnik,H; Gauna,A;
Revista argentina de endocrinolog?-a y metabolismo , 2009,
Abstract: introduction: resistance to thyroid hormones (rth) is an unusual autosomal dominant inherited disorder characterized by a reduced target organ responsiveness to thyroid hormones. rth is linked to the gene encoding the thyroid receptor β (tr β). this syndrome is characterized by persistent high levels of total and free t4 and t3 while tsh is not inhibited. materials and methods: 62 years old female who underwent a partial thyroidectomy because of goiter forty years ago. clinically, she seemed to be an euthyroid patient and her hemodynamic status was normal. the exams revealed the existence of a benign thyroid nodule, high levels of total and free thyroid hormones and normal values of tsh. our diagnostic impression was rth, though differential diagnosis with thyrotropin secreting pituitary adenoma was mandatory. complete assays of thyroid hormones were performed in the patient and in two first degree relatives. basal lh, fsh and prolactin were assayed in the patient; and a magnetic resonance imaging of her pituitary gland was obtained. finally we performed genetic testing in patient's dna and a relative's dna to demonstrate gene defect. results: according to our diagnostic impression, not only the patient's laboratory was compatible with rth, but so was the laboratory of the two relatives. dna mutation analisys demonstrated a new mutation in exon 10: c.1339c>a responsible for the substitution p.p447t. this mutation was found in dna of the patient and dna of her relative. conclusion: this patient with rth, as well as other reported cases, reminds us about the importance of a certain and early diagnosis of this rare disorder in order to avoid iatrogenic treatments. a new mutation is described in this family.
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