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Homology modeling and ligand interaction of Cytochrome b protein
Rohith Kumar Anugolu,Shravan Kumar Gunda,Rajiv Varman Kakarla
Journal of Medical and Allied Sciences , 2011,
Abstract: Cytochrome b is a component of respiratory chain complex III, also known as the bc1 complex or ubiquinol-cytochrome c reductase. These complexes are involved in electron transport and the generation of ATP and thus play a vital role in the cell. The cytochrome bc1 complex is a membrane-bound enzyme that catalyses the transfer of electrons from ubiquinol to cytochrome c, coupling this process to the translocation of protons across the inner mitochondrial membrane. The function of proteins is generally determined by its three-dimensional (3D) structure. Thus, it would be useful to know the 3D structure of the thousands of protein sequences that are emerging from many genome projects. Structural studies on bio-molecules have changed our perception of the biological world in the last twenty years. A number of efforts have been made on structure prediction. One such technique that has found a wide appreciation is Homology modeling which aims at predicting the 3D structure of biomolecules, relying heavily on resources such as pattern/function and sequence. However, the three-dimensional structure of cytochrome b subunit protein (Accession number C4PKA1) from Homo sapiens remains unknown. In the present study, effort was made to generate the three-dimensional (3D) structure of the cytochrome b based on available template (1BGY) structural homologues from Protein Data Bank and the model validated with standard parameters (Procheck). With the predicted model, the ligand was subjected to docking study using FlexX docking tool. Flexible docking was carried out with the HEM - Protoporphyrin X [Heme] as ligand; which was found to bind at His267, Ile268 and Val343 residues on given generated protein. We therefore concluded that the above mentioned residues were the key residue sites for ligand binding. The predicted model showed better results than the template structure with 0% disallowed regions. This study will be used in broad screening of the protein in the respiratory process and can be further implemented in future drug designing.
Cylindrical and Spherical Membranes of Anodic Aluminum Oxide with Highly Ordered Conical Nanohole Arrays  [PDF]
Yantao Pang, Rohith Chandrasekar
Natural Science (NS) , 2015, DOI: 10.4236/ns.2015.75026
Abstract: Nanoporous anodic aluminum oxide (AAO) with uniform and controllable pore diameters and periods over a wide range has been explored for various applications due to relatively easy fabrication processes. Moreover, one of the interesting possibilities afforded by the anodization process is that the anodization can take place on aluminum films with arbitrary shape, such as a section of cylinder or sphere, which has not yet been well studied or applied in nanofabrication. In this paper, we report that highly ordered conical nanohole arrays prepared by the anodization of cylindrical and spherical Al films have been fabricated. As can be seen by scanning electron microscopy (SEM), straight nanohole arrays have been grown along the radical directions of the cylindrical or spherical alumina membrane without bending or branching at all, the diameter of the conical nanoholes and the diameter change along individual channels can be tuned by changing the curvature of the membrane. These new types of templates may open new opportunities in optical, electronic and electrochemical applications.
On Higgs bundles on Elliptic Surfaces
Rohith Varma
Mathematics , 2014,
Abstract: The aim of this paper is to establish an equivalence of certain categories of Higgs bundles on a non-isotrivial elliptic surface $\pi: X \rightarrow C$ with $\chi(X) > 0$ and certain categories of Parabolic Higgs bundles on $C$
Fodrin in Centrosomes: Implication of a Role of Fodrin in the Transport of Gamma-Tubulin Complex in Brain
Sasidharan Shashikala, Rohith Kumar, Nisha E. Thomas, Dhanesh Sivadasan, Jackson James, Suparna Sengupta
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0076613
Abstract: Gamma-tubulin is the major protein involved in the nucleation of microtubules from centrosomes in eukaryotic cells. It is present in both cytoplasm and centrosome. However, before centrosome maturation prior to mitosis, gamma-tubulin concentration increases dramatically in the centrosome, the mechanism of which is not known. Earlier it was reported that cytoplasmic gamma-tubulin complex isolated from goat brain contains non-erythroid spectrin/fodrin. The major role of erythroid spectrin is to help in the membrane organisation and integrity. However, fodrin or non-erythroid spectrin has a distinct pattern of localisation in brain cells and evidently some special functions over its erythroid counterpart. In this study, we show that fodrin and γ-tubulin are present together in both the cytoplasm and centrosomes in all brain cells except differentiated neurons and astrocytes. Immunoprecipitation studies in purified centrosomes from brain tissue and brain cell lines confirm that fodrin and γ-tubulin interact with each other in centrosomes. Fodrin dissociates from centrosome just after the onset of mitosis, when the concentration of γ-tubulin attains a maximum at centrosomes. Further it is observed that the interaction between fodrin and γ-tubulin in the centrosome is dependent on actin as depolymerisation of microfilaments stops fodrin localization. Image analysis revealed that γ-tubulin concentration also decreased drastically in the centrosome under this condition. This indicates towards a role of fodrin as a regulatory transporter of γ-tubulin to the centrosomes for normal progression of mitosis.
CASPER: Embedding Power Estimation and Hardware-Controlled Power Management in a Cycle-Accurate Micro-Architecture Simulation Platform for Many-Core Multi-Threading Heterogeneous Processors
Kushal Datta,Arindam Mukherjee,Guangyi Cao,Rohith Tenneti,Vinay Vijendra Kumar Lakshmi,Arun Ravindran,Bharat S. Joshi
Journal of Low Power Electronics and Applications , 2012, DOI: 10.3390/jlpea2010030
Abstract: Despite the promising performance improvement observed in emerging many-core architectures in high performance processors, high power consumption prohibitively affects their use and marketability in the low-energy sectors, such as embedded processors, network processors and application specific instruction processors (ASIPs). While most chip architects design power-efficient processors by finding an optimal power-performance balance in their design, some use sophisticated on-chip autonomous power management units, which dynamically reduce the voltage or frequencies of idle cores and hence extend battery life and reduce operating costs. For large scale designs of many-core processors, a holistic approach integrating both these techniques at different levels of abstraction can potentially achieve maximal power savings. In this paper we present CASPER, a robust instruction trace driven cycle-accurate many-core multi-threading micro-architecture simulation platform where we have incorporated power estimation models of a wide variety of tunable many-core micro-architectural design parameters, thus enabling processor architects to explore a sufficiently large design space and achieve power-efficient designs. Additionally CASPER is designed to accommodate cycle-accurate models of hardware controlled power management units, enabling architects to experiment with and evaluate different autonomous power-saving mechanisms to study the run-time power-performance trade-offs in embedded many-core processors. We have implemented two such techniques in CASPER– Chipwide Dynamic Voltage and Frequency Scaling, and Performance Aware Core-Specific Frequency Scaling, which show average power savings of 35.9% and 26.2% on a baseline 4-core SPARC based architecture respectively. This power saving data accounts for the power consumption of the power management units themselves. The CASPER simulation platform also provides users with complete support of SPARCV9 instruction set enabling them to run a full operating system software stack, and hence a wide variety of benchmarking applications.
Encryption of Binary and Non-Binary Data Using Chained Hadamard Transforms
Rohith Singi Reddy
Computer Science , 2010,
Abstract: This paper presents a new chaining technique for the use of Hadamard transforms for encryption of both binary and non-binary data. The lengths of the input and output sequence need not be identical. The method may be used also for hashing.
Key Management in Wireless Sensor Networks Using a Modified Blom Scheme
Rohith Singi Reddy
Computer Science , 2011,
Abstract: Key establishment between any pair of nodes is an essential requirement for providing secure services in wireless sensor networks. Blom's scheme is a prominent key management scheme but its shortcomings include large computation overhead and memory cost. We propose a new scheme in this paper that modifies Blom's scheme in a manner that reduces memory and computation costs. This paper also provides the value for secure parameter t such that the network is resilient.
Issues and concerns of health among call center employees
Sudhashree V,Rohith K,Shrinivas K
Indian Journal of Occupational and Environmental Medicine , 2005,
Abstract:
Information Warfare-Worthy Jamming Attack Detection Mechanism for Wireless Sensor Networks Using a Fuzzy Inference System
Sudip Misra,Ranjit Singh,S. V. Rohith Mohan
Sensors , 2010, DOI: 10.3390/s100403444
Abstract: The proposed mechanism for jamming attack detection for wireless sensor networks is novel in three respects: firstly, it upgrades the jammer to include versatile military jammers; secondly, it graduates from the existing node-centric detection system to the network-centric system making it robust and economical at the nodes, and thirdly, it tackles the problem through fuzzy inference system, as the decision regarding intensity of jamming is seldom crisp. The system with its high robustness, ability to grade nodes with jamming indices, and its true-detection rate as high as 99.8%, is worthy of consideration for information warfare defense purposes.
Disseminated tuberculosis presenting as mesenteric and cerebral abscess in HIV infection: case report
Pandit, Vinay;Valsalan, Rohith;Seshadri, Shubha;Bahuleyan, Shibu;
Brazilian Journal of Infectious Diseases , 2009, DOI: 10.1590/S1413-86702009000500014
Abstract: disseminated tuberculosis in hiv infection involves multiple organs. pulmonary and lymph node involvement are the commonest form of tuberculosis in hiv infection [1, 2]. other forms of tuberculosis in the absence of lung and lymph node involvement are rare. various forms of abdominal [3, 4] and neurological [5, 6] tubercular involvement in hiv infection have been reported. but tuberculosis presenting simultaneously with mesenteric and brain abscess has not been reported yet. we report a case of disseminated tuberculosis presenting as mesenteric and cerebral abscess in a hiv case without involving lung and lymph nodes. bone marrow smears and fine needle aspiration cytology (fnac) from mesenteric lesion were positive for acid fast bacilli (afb) and the diagnosis of tuberculosis was confirmed by positive polymerase chain reaction (pcr). he responded well to treatment with anti tubercular drugs.
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