oalib

Publish in OALib Journal

ISSN: 2333-9721

APC: Only $99

Submit

Any time

2018 ( 1 )

2016 ( 1 )

2015 ( 17 )

2014 ( 23 )

Custom range...

Search Results: 1 - 10 of 347 matches for " Rohilla Ankur "
All listed articles are free for downloading (OA Articles)
Page 1 /347
Display every page Item
Adverse drug reactions: An Overview
Ankur Rohilla,Singhraj Yadav
International Journal of Pharmacological Research , 2013, DOI: 10.7439/ijpr.v3i1.41
Abstract: Adverse drug reactions (ADR’s) are defined the effects created by drugs producing unintended or noxious response. Also, an ADR is a response to a medicine which is noxious and unintended, and which occurs at doses normally used in man for the prophylaxis, diagnosis, or therapy of disease or for the modification of a physiological function. The evaluation of ADRs adapts various factors that can predispose patients to adverse reactions. The types of adverse reaction can be studies in two main headings, i.e., more common ADRs including type A and B reactions; and less common ADRs which include type C, D and E reactions. The present review article explains about the various types and mechanisms of adverse reactions.
CARDIOPROTECTION WITH SIMVASTATIN: AN APPRAISAL
Rohilla Ankur,Rohilla Seema,Singh Gurfateh,Kumar Ashok
International Research Journal of Pharmacy , 2011,
Abstract: Statins, commonly known as 3-hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase inhibitors are recognized as the foremost drug therapy to show cardioprotection in pathological conditions like dyslipidemia and hyperlipidemia by significantly reducing blood cholesterol levels. Additionally, a number of beneficial effects have been shown by statins apart from lipid lowering that are referred to as their pleiotropic effects. Simvastatin, a potent member of statins class, has been widely used for lowering blood cholesterol levels by inhibiting HMG-CoA reductase both experimentally and clinically. Simvastatin has been well documented to be an effective drug therapy for the treatment of dyslipidemias. In addition, simvastatin has been shown to possess a variety of other pleiotropic effects in way of its potentiality as a cardioprotective agent. The present review critically discusses about the various pleiotropic effects possessed by simvastatin in affording cardioprotection.
BIOPHARMACEUTICS CLASSIFICATION SYSTEM: A STRATEGIC TOOL FOR CLASSIFYING DRUG SUBSTANCES
Rohilla Seema,Rohilla Ankur,Marwaha RK,Nanda Arun
International Research Journal of Pharmacy , 2011,
Abstract: The biopharmaceutical classification system (BCS) is a scientific approach for classifying drug substances based on their dose/solubility ratio and intestinal permeability. The BCS has been developed to allow prediction of in vivo pharmacokinetic performance of drug products from measurements of permeability and solubility. Moreover, the drugs can be categorized into four classes of BCS on the basis of permeability and solubility namely; high permeability high solubility, high permeability low solubility, low permeability high solubility and low permeability low solubility. The present review summarizes the principles, objectives, benefits, classification and applications of BCS.
GASTRORETENTIVE DOSAGE FORMS: REVIEW ON FLOATING DRUG DELIVERY SYSTEMS
Dahiya Amarjeet,Rohilla Ankur,Rohilla Seema,Khan M.U
International Research Journal of Pharmacy , 2011,
Abstract: Gastroretentive drug delivery system has been a significant approach over the past few years that have been noted to prolong gastric residence time, thereby targeting site-specific drug release in the upper gastrointestinal (GI) tract for local or systemic effects. The present study has been investigated to compile the recent as well as past literature with special focus on various gastroretentive approaches that have recently become leading methodologies in the field of site-specific orally administered controlled release drug delivery. Floating systems have been considered as one of the imperative categories of drug delivery systems with gastric retentive behavior. The review article explains the various floating drug delivery systems that are formulated in order to enhance the drug bioavailability. Moreover, various gastroretentive approaches designed and developed such as high density, floating, bioadhesive, super porous hydrogel and magnetic systems have been clearly discussed in the article.
MITOCHONDRIAL PERMEABILITY TRANSITION PORES: ANOTHER VIEW
Manav Arti,Rohilla Ankur,Rohilla Seema,Dahiya Amarjeet
International Research Journal of Pharmacy , 2012,
Abstract: Mitochondria have been considered as the powerhouse of the cell that is mainly responsible for the cell energy by taking part in various biological reactions. Moreover, the mitochondria play an important role in the pathological conditions by increasing permeability transition of the mitochondrial membrane that may enhance the charge potential of the mitochondria. Mitochondrial permeability transition pores (MPTPs) are the pore present on the inner mitochondrial membrane. The components of the MPTP are adenine nucleotide translocase (ANT), cyclophillin-D (CyP-D) and voltage dependent anion channel (VDAC). They have been noted to open in order to maintain various pathological conditions such as cell apoptosis, ischemia/reperfusion (I/R) injury, heart failure and certain other cardiovascular diseases. It also plays an important role in various cytoprotective mechanisms. The present review explains about the structure and physiological functions associated with MPTP.
PHYLLANTHUS AMARUS: AN AMPLE THERAPEUTIC POTENTIAL HERB
Kiran Divya,Rohilla Ankur,Rohilla Seema,Khan M.U.
International Journal of Research in Ayurveda and Pharmacy , 2011,
Abstract: Herbal drugs have been one of the primarily used drugs since olden times for the treatment of a range of diseases. In addition, the medicinal plants have played a vital role in world health as the herbal plants still make an important contribution to health care. Phyllanthus amarus, a world-renowned botanical, has been used since ages because of its rich medicinal values and ethnomedical importance. Phyllanthus amarus is a small, erect, annual herb which is a rich source of phytochemicals that are attributed to biologically active lignans, glycosides, flavonoids, alkaloids, ellagitannins and phenylpropanoids that are present in the leaf, stem and root of the plant. It is a little wonder that the plant is used for so many purposes in herbal medicine systems and in clinical research over the years. Numerous studies have reported that Phyllanthus amarus have anti-inflammatory, antidiabetic, antimicrobial, antihyperlipidemic, antioxidant and anticancer activities. Moreover, studies have demonstrated hepatoprotective, antifertility, antidiarrhoeal, antiallodynic, antioedematogenic, antispasmodial, chemoprotective, antihypercalciuric, antiviral, antispasmodic, antinociceptive and diuretic properties associated with Phyllanthus amarus. The present review article summarizes the potent pharmacological properties exhibited by the plant.
Alpinia officinarum : Phytochemistry and Pleitropism
Arti Dixit,Ankur Rohilla,Vijender Singh
International Journal of Pharmaceutical and Phytopharmacological Research , 2012,
Abstract: Herbal drugs classification system represent as an important system of medicine for the treatment of a wide array of diseases. The medicinal plants from India provide a diverse source for health care moieties in order to prevent different pathological states. Alpinia officinarum, known as lesser galangal, is a world-renowned botanical, which has been used since ages because of its rich medicinal diversity. Alpinia officinarum, a plant from ginger family, originated in China and cultivated in Southeast Asia. The plant grows several feet high, with long leaves and reddish-white flowers alongwith spicy and aromatic rhizomes. Numerous studies reported Alpinia officinarum to possess anti-inflammatory, anticancer, chemoprotective, antibacterial, antifungal and diuretic properties associated with Phyllanthus amarus. The present review articles critically abridges about various phytochemicals associated with the plant alongwith numerous pleiotropic properties exhibited by the plant.
AMELIORATION OF MYOCARDIAL ISCHEMIA REPERFUSION INJURY BY SIMVASTATIN IN RATS
Rohilla Ankur,Singh Gurfateh,Khan M.U.,Khanam Razia
International Research Journal of Pharmacy , 2011,
Abstract: The present study has been designed to investigate the effect of Simvastatin, a 3-hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase inhibitor, on ischemia-reperfusion (I/R)-induced myocardial injury. The isolated Langendorff-perfused rat hearts were subjected to global ischemia for 30 min followed by reperfusion for 120 min. Myocardial injury was assessed by measuring myocardial infarct size alongwith release of lactate dehydrogenase (LDH) and creatine kinase (CK) in the coronary effluent. Additionally, the oxidative stress parameters were analyzed in the heart which was assessed by measuring lipid peroxidation, superoxide anion generation and reduced glutathione. I/R was noted to produce myocardial injury, as assessed in terms of increase in myocardial infarct size, LDH and CK in coronary effluent. Moreover, oxidative stress was noted to be increased due to I/R injury as assessed in terms of decreased TBARS (thiobarbituric acid-reactive substance) and superoxide anion generation levels alongwith increase in reduced glutathione levels in the heart. Treatment with Simvatstain at different concenterations (3 μMol, 10 μMol and 30 μMol) afforded cardioprotection against I/R-induced myocardial injury in rat hearts as assessed in terms of reductions in myocardial infarct size, LDH and CK levels in coronary effluent. Moreover, the high degree of oxidative stress produced as a result of I/R injury was noted to be reduced by Simvastatin treatment. It may be concluded that reductions in myocardial infarct size and oxidative stress may be responsible for the observed cardioprotective potential of Simvastatin against I/R-induced myocardial injury.
CARDIOPROTECTION OF FIBRATES IN RAT MODEL OF MYOCARDIAL ISCHEMIA: REPERFUSION
Singh Gurfateh,Rohilla Ankur,Khan M.U.,Khanam Razia
International Journal of Research in Ayurveda and Pharmacy , 2011,
Abstract: The present study was designed to investigate the effect of Clofibrate, an agonist of peroxisome proliferator activated receptor-α (PPAR-α), on ischemia-reperfusion (I/R)-induced myocardial injury. The isolated Langendorff-perfused rat hearts were subjected to global ischemia for 30 min followed by reperfusion for 120 min. Myocardial infarct size was assessed by volume methods using triphenyltetrazolium chloride staining. Coronary effluent was analyzed for the release of lactate dehydrogenase (LDH) and creatine kinase (CK) to assess the degree of cardiac injury. Moreover, oxidative stress in the heart was assessed by measuring lipid peroxidation, superoxide anion generation and reduced glutathione. I/R was noted to produce myocardial injury, as assessed in terms of increase in myocardial infarct size, LDH and CK in coronary effluent. Moreover, oxidative stress was noted to be increased due to I/R injury as assessed in terms of decreased TBARS (thiobarbituric acid-reactive substance) and superoxide anion generation levels alongwith increase in reduced glutathione levels in the heart. Treatment with Clofibrate showed cardioprotection against I/R-induced myocardial injury in rat hearts as assessed in terms of reductions in myocardial infarct size, LDH and CK levels in coronary effluent. Moreover, I/R-induced oxidative stress was noted to be reduced by Clofibrate treatment. It may be concluded that the observed cardioprotective potential of Clofibrate against I/R-induced myocardial injury was due to the reductions in infarct size and oxidative stress .
Musculoskeletal Manifestations of Atypical Mycobacterium: Case Reports  [PDF]
Mujeeeb Rohilla, Khalid Khan, Husnain Raza
Surgical Science (SS) , 2014, DOI: 10.4236/ss.2014.51006
Abstract:

Musculoskeletal manifestations of atypical Mycobacterium are very rare and they can be easily missed by the junior doctors. We are presenting two cases of atypical Mycobacterium: the first one was infected by cleaning a fish tank and the other was immune-compromised patients. Both the cases were treated with broad spectrum antiboitics initially, with no results, unless the specimen cultures were obtained surgically and the specific cultures were asked. The treatment was started after obtaining the culture results. Both the patients were started on antituberculous treatment for 3 -

Page 1 /347
Display every page Item


Home
Copyright © 2008-2017 Open Access Library. All rights reserved.