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Search Results: 1 - 10 of 10520 matches for " Rodrigo Tagle "
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Non-traditional risk factors for Atherosclerosis
Acevedo,Mónica; Tagle,Rodrigo; Simpfendorfer,Conrad;
Revista médica de Chile , 2001, DOI: 10.4067/S0034-98872001001000016
Abstract: during the last 10 years, several "non-traditional" risk markers for atherosclerosis have been identified. among them, new markers of lipoprotein metabolism (ie lipoprotein [ a]), endothelial dysfunction (ie homocysteine), hemostasis (ie fibrinogen) and inflammation (ie c-reactive protein) have been linked to an excessive risk of cardiovascular disease. these factors should help the clinician to better identify individuals at risk of premature atherosclerotic disease and/or improve the predictive value of established risk factors for atherosclerosis. finally, these factors are expected to improve the knowledge in the pathophysiology of cardiovascular diseases, and perhaps to impact future therapeutic decisions. in this review article, we will analyze the markers in which there are at least some evidence to support their acceptance as "non-traditional risk factors" for atherosclerotic disease (rev méd chile 2001; 129: 1212-21)
Las preguntas que el clínico debe hacerse en un paciente hipertenso al sospechar una Hipertensión Secundaria
Rodrigo Tagle V,Mónica Acevedo B
Revista Chilena de Cardiología , 2009,
Abstract:
Non-traditional risk factors for Atherosclerosis Factores de riesgo no-tradicionales en la aterosclerosis
Mónica Acevedo,Rodrigo Tagle,Conrad Simpfendorfer
Revista médica de Chile , 2001,
Abstract: During the last 10 years, several "non-traditional" risk markers for atherosclerosis have been identified. Among them, new markers of lipoprotein metabolism (ie lipoprotein [ a]), endothelial dysfunction (ie homocysteine), hemostasis (ie fibrinogen) and inflammation (ie C-reactive protein) have been linked to an excessive risk of cardiovascular disease. These factors should help the clinician to better identify individuals at risk of premature atherosclerotic disease and/or improve the predictive value of established risk factors for atherosclerosis. Finally, these factors are expected to improve the knowledge in the pathophysiology of cardiovascular diseases, and perhaps to impact future therapeutic decisions. In this review article, we will analyze the markers in which there are at least some evidence to support their acceptance as "non-traditional risk factors" for atherosclerotic disease (Rev Méd Chile 2001; 129: 1212-21) Durante los últimos 10 a os se han identificado varios marcadores de riesgo "no-tradicionales" para la aterosclerosis. Entre ellos, se ha relacionado con un riesgo excesivo de enfermedad cardiovascular a nuevos marcadores del metabolismo de lipoproteínas (ej: lipoproteína [a]), disfunción endotelial (ej: homocisteína), hemostasis (ej: fibrinógeno) e inflamación (ej: proteína C-reactiva). Estos factores deberían ayudar al clínico a identificar mejor los individuos con riesgo de una enfermedad aterosclerótica prematura y/o mejorar el valor predictivo de los factores de riesgo de aterosclerosis ya conocidos. Finalmente, se espera que estos factores aumenten el conocimiento de la fisiopatología y el diagnóstico de las enfermedades cardiovasculares y, tal vez, tengan impacto en futuras decisiones terapéuticas. En este artículo de revisión se analizan aquellos marcadores sobre los cuales existen algunas evidencias que apoyen su aceptación como "factores no-tradicionales de riesgo" para la enfermedad aterosclerótica
Síndrome de lisis de glóbulos blancos después de un trasplante autólogo de células troncales hematopoyéticas en el tratamiento de la amiloidosis AL renal: Caso clínico
Gatica M,Antonio; Bertin C,Pablo; Tagle V,Rodrigo;
Revista médica de Chile , 2006, DOI: 10.4067/S0034-98872006000600013
Abstract: the treatment of al amyloidosis was not successful until the advent of myeloablative chemotherapy consisting of high-dose intravenous melphalan followed by autologous peripheral blood stem cell transplantation. this new treatment has achieved better survival rates and, remarkably, it has obtained complete remission. among patients with renal involvement, achievement of a complete hematological response was associated with a 50% reduction in proteinuria and stable creatinine clearance in more than 2/3 of patients. despite of these excellent results, this new therapy is associated with significant toxicity, including the development of acute renal failure due to white blood cell lysis syndrome. we report a 59 year-old female with a nephrotic syndrome due to primary amyloidosis successfully treated autologous stem cell transplantation who developed acute renal failure caused by white blood cell lysis syndrome. the patient required treatment with granulocytic colony stimulating factor and intermittent hemofiltration and was discharged 23 days after melphalan administration with a satisfactory renal function and white blood cell count. after one year of follow up, she maintains a good glomerular filtration rate, a proteinuria of less than, 1 g/day and normal hematological values
Hipotensión ortostática: una manifestación sugerente de feocromocitoma
Tagle V,Rodrigo; Acosta V,Pamela; Valdés S,Gloria;
Revista médica de Chile , 2003, DOI: 10.4067/S0034-98872003001200010
Abstract: pheochromocytoma, though an uncommon cause of hipertension, can be a lethal condition. because of this it is mandatory to diagnose it or rule it out in presence of suggestive symptoms. typical symptoms are palpitations, sweating, severe headaches and hypertension. however, there are other suggestive symptoms of this dangerous endocrine entity, one of which is the orthostatic hypotension. we report the case of a 65 years old female patient with long standing hypertension in whom the pheochromocytoma was suspected after episodes of orthostatic hypotension. although this manifestation was described almost fifty years ago, its frequency and pathophysiology has not yet been well established and fully elucidated. moreover, it has meaningful implications in relation to preoperatory management and the timing of surgery (rev méd chile 2003; 131: 1429-33)
Hipertensión arterial en la mujer adulta Hypertension in women
Rodrigo Tagle V,Mónica Acevedo,Gloria Valdés
Revista médica de Chile , 2013,
Abstract: The present review examines the types of hypertension that women may suffer throughout life, their physiopathological characteristics and management. In early life, the currently used low-dose oral contraceptives seldom cause hypertension. Pregnancy provokes preeclampsia, its main medical complication, secondary to inadequate transformation of the spiral arteries and the subsequent multisystem endothelial damage caused by deportation of placental factors and microparticles. Hypertension in preeclampsia is an epiphenomenon which needs to be controlled at levels that reduce maternal risk without impairing placental perfusion. The hemodynamic changes of pregnancy may unmask a hypertensive phenotype, may exacerbate a chronic hypertension, or may complicate hypertension secondary to lupus, renovascular lesions, and pheochromocytoma. On the other hand a primary aldosteronism may benefit from the effect of progesterone and present as a postpartum hypertension. A hypertensive pregnancy, especially preeclampsia, represents a risk for cardiac, vascular and renal disease in later life. Menopause may mimic a pheochromocytoma, and is associated to endothelial dysfunction and salt-sensitivity. Among women, non-pharmacological treatment should be forcefully advocated, except for sodium restriction during pregnancy. The blockade of the renin-angiotensin system should be avoided in women at risk of pregnancy; betablockers could be used with precautions during pregnancy; diuretics, ACE inhibitors and angiotensin receptor antagonists should not be used during breast feeding. Collateral effects of antihypertensives, such as hyponatremia, cough and edema are more common in women. Thus, hypertension in women should be managed according to the different life stages.
Síndrome de lisis de glóbulos blancos después de un trasplante autólogo de células troncales hematopoyéticas en el tratamiento de la amiloidosis AL renal: Caso clínico White blood cell lysis syndrome after autologous peripheral blood stem cell transplantation in the treatment of renal AL amyloidosis: Case report
Antonio Gatica M,Pablo Bertin C,Rodrigo Tagle V
Revista médica de Chile , 2006,
Abstract: The treatment of AL amyloidosis was not successful until the advent of myeloablative chemotherapy consisting of high-dose intravenous melphalan followed by autologous peripheral blood stem cell transplantation. This new treatment has achieved better survival rates and, remarkably, it has obtained complete remission. Among patients with renal involvement, achievement of a complete hematological response was associated with a 50% reduction in proteinuria and stable creatinine clearance in more than 2/3 of patients. Despite of these excellent results, this new therapy is associated with significant toxicity, including the development of acute renal failure due to white blood cell lysis syndrome. We report a 59 year-old female with a nephrotic syndrome due to primary amyloidosis successfully treated autologous stem cell transplantation who developed acute renal failure caused by white blood cell lysis syndrome. The patient required treatment with granulocytic colony stimulating factor and intermittent hemofiltration and was discharged 23 days after melphalan administration with a satisfactory renal function and white blood cell count. After one year of follow up, she maintains a good glomerular filtration rate, a proteinuria of less than, 1 g/day and normal hematological values
Hipotensión ortostática: una manifestación sugerente de feocromocitoma Orthostatic hypotension as an unusual manifestation of pheochromocytoma: Report of one case
Rodrigo Tagle V,Pamela Acosta V,Gloria Valdés S
Revista médica de Chile , 2003,
Abstract: Pheochromocytoma, though an uncommon cause of hipertension, can be a lethal condition. Because of this it is mandatory to diagnose it or rule it out in presence of suggestive symptoms. Typical symptoms are palpitations, sweating, severe headaches and hypertension. However, there are other suggestive symptoms of this dangerous endocrine entity, one of which is the orthostatic hypotension. We report the case of a 65 years old female patient with long standing hypertension in whom the pheochromocytoma was suspected after episodes of orthostatic hypotension. Although this manifestation was described almost fifty years ago, its frequency and pathophysiology has not yet been well established and fully elucidated. Moreover, it has meaningful implications in relation to preoperatory management and the timing of surgery (Rev Méd Chile 2003; 131: 1429-33)
Hipokalemia, hipovolemia y repercusión electrocardiográfica secundarias a ingesta prolongada de furosemida: Caso clínico Hypokalemia, hypovolemia and electrocardiographic changes due to furosemide abuse: Report of one case
César Aravena,Ignacio Salas,Rodrigo Tagle,Aquiles Jara
Revista médica de Chile , 2007,
Abstract: Hypokalemia (serum K+ < 3.5 mEq/1) is a potentially serious adverse effect of diuretic ingestión. We report a 27 year-old woman admitted with muscle weakness, a serum potassium of 2.0 mEq/1, metabolic alkalosis and EKG abnormalities simulating cardiac ischemia, that reverted with potassium chloride administration. She admitted high dose furosemide self-medication for edema. Glomerular filtration rate, tubular sodium reabsortion, potassium secretion, the renin-aldosterone system, total body water distribution and capillary permeability, were studied sequentially until 90 days after her admission. There was hyperactivity of the renin-aldosterone axis, reduction in extracellular and intracellular volumes, normal capillary permeability and high sodium tubular reabsorption, probably explained by a "rebound" salt retention associated with her decreased extracellular volume
Microalbuminuria y excreción urinaria de albúmina en la práctica clínica Microalbuminuria and urinary albumin excretion in clinical practice
Rodrigo Tagle,Fernando González,Mónica Acevedo
Revista médica de Chile , 2012,
Abstract: Background: Microalbuminuria is a new tool in the management of patients with diabetes mellitus or hypertension. Microalbuminuria is an easily measured biomarker in a urine sample. Urinary albumin to creatinine ratio in first morning urine sample correlates with 24 hours urinary albumin excretion, but it is easier to obtain, and can identify hypertensive or diabetic patients with high risk for cardiovascular events. Therapeutic interventions such as renin angiotensin system blockade have demonstrated their usefulness in reducing urinary albumin excretion in clinical studies. It would be advisable to incorporate urinary albumin to creatinine ratio to the routine clinical monitoring of patients with cardiovascular risk, such as those with hypertension and diabetes mellitus.
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