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Search Results: 1 - 10 of 11289 matches for " Roca Cruz "
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The Degenerating Substantia Nigra as a Susceptible Region for Gene Transfer-Mediated Inflammation
Valeria Roca,Juan Cruz Casabona,Pablo Radice,Verónica Murta,Fernando Juan Pitossi
Parkinson's Disease , 2011, DOI: 10.4061/2011/931572
Abstract: Parkinson's disease (PD) is characterized by the progressive degeneration of neurons in the substantia nigra pars compacta (SN). The na?ve SN is highly susceptible to inflammation. In addition, microglial activation in the degenerating SN displays distinct characteristics that increase the reactivity of the region towards inflammatory stimuli. On the other hand, gene therapy for PD has recently move forward into clinical settings, with PD being the neurodegenerative disorder with the highest number of Phase I/II gene therapy clinical trials approved and completed. These clinical trials are not targeting the SN, but this region is a certain candidate for future gene therapy interventions. Here, the unique immune-related properties of the degenerating SN in the context of a putative gene therapy intervention are reviewed. Several variables affecting the host response to gene delivery such as vector type and dosage, age and stage of disease of patients, and method of gene delivery and transgene used are discussed. Finally, approaches to diminish the risk of immune-mediated toxicity by gene transfer in the SN are presented. 1. Introduction Parkinson’s disease (PD) is a neurodegenerative disorder characterised by the progressive loss of dopaminergic neurons in the substantia nigra pars compacta (SN) (reviewed in [1]). The aetiology of the most common forms of PD remains unknown. Current therapeutic treatments comprise pharmacological strategies to compensate for dopamine deficiency or surgical interventions that reduce the hyperactivity of specific regions within the basal ganglia (reviewed in [2]). However, dopamine replacement can lead to undesired side-effects 5–10 years after the beginning of treatment [3]. As no treatment is available that can prevent disease progression, the search for new therapeutic interventions is intense. In particular, gene therapy approaches have successfully reached the clinical trial stage in a number of cases [4]. Approved gene therapy clinical trials are based on restoring the activity of the basal ganglia by providing growth factors, inhibiting hyperactive regions, or enhancing dopamine synthesis [4]. Viral gene delivery seems to be the method of choice for gene therapy for PD due to its high efficiency for gene transduction. A drawback to the delivery of genes via viral vectors comes by introducing an antigenic load into the brain. These antigens will invariably elicit a transient innate immune response [5]. The nature and functional (toxic or protective) consequences of this response will vary depending on a number of
Evaluación de la variabilidad morfoagronómica de una colección cubana de maíz (Zea mays L.)
Martínez Cruz,Michel; Ortiz Pérez,Rodobaldo; Rios Labrada,Humberto; Acosta Roca,Rosa;
Cultivos Tropicales , 2011,
Abstract: in our country, the corn is cultivated from the time of the aboriginal ones and it constitutes a basic food in the human nutrition, of the livestock and the birds; it is the second cereal of importance and has high consumption preference for the population. in cuba, six races of corn exist with a high diversity, which has been broadly studied. the present work was carried out in a sample of 106 local varieties, these local varieties were included conserved in situ in peasants' properties and conserved ex situ. the objective of the study was to evaluate the degree of variability of the collection; using for it 16 characters. the obtained results allowed to detect the existence of variability in the sample. it was demonstrated that the evaluated collection of corn presented variability due to the difference among genotypes, to the plurality of origins, handling and environmental conditions in that this cultivation is developed in cuba. also, in the studied collection, the variability of the evaluated characters is moderate, due to the selection that the peasants carry out on them. the most variable characters were the incidence of spodoptera frugiperda (smith), height to the superior ear and weight of a hundred seeds.
Tratamiento nutricional del fallo intestinal y potenciales mecanismos de estimulación
Pérez de la Cruz,A. J.; Moreno-Torres Herrera,R.; Pérez Roca,C.;
Nutrición Hospitalaria , 2007,
Abstract: severe forms of intestinal failure represent one of the most complex pathologies to manage, in both children and adults. in adults, the most common causes are chronic intestinal pseudo-obstruction and severe short bowel syndrome following large intestinal resections, particularly due to massive mesenteric ischemic, within the context of cardiopathies occurring with atrial fibrillation. the essential management after stabilizing the patient consists in nutritional support, either by parenteral or enteral routes, with tolerance to oral diet being the final goal of intestinal adaptation in these pathologies. surgery may be indicated in some cases to increase the absorptive surface area. parenteral nutrition is an essential support measure that sometimes has to be maintained for long time, even forever, except for technique-related complications or unfavorable clinical course that would lead to extreme surgical alternatives such as intestinal transplantation. hormonal therapy with trophism-stimulating factors opens new alternatives that are already being tried in humans.
Contenido de plomo y cadmio en aceites de girasol
Roca Cruz, A.,Cabrera Vique, C.,Lorenzo Tovar, M. L.,López Martínez, M. C.
Grasas y Aceites , 2001,
Abstract: We have studied the lead and cadmium content in 21 samples of sunflower oil from Andalucía (Southern Spain). These elements are toxicological importance and the sunflower oil is widely consumed in Spain. Samples were mineralized with nitric acid and vanadium pentoxide as catalyst, and ana lyzed using electrothermal atomization atomic absorption spectroscopy. The temperature-time programme for the graphite furnace was optimized for each element, and the accuracy, precision, sensitivity and detection limit of the method were evaluated. Concentrations of lead ranged from not detectable to 167.58 g/kg and cadmium concentrations ranged from 0.87 to 8.30 g/kg. The data obtained are not excessive and similar to those mentioned by other authors; however, one sample of the total analyzed surpassed the limit of 0.1 ppm of lead proposed by the Spanish and European Legislation. A statistical significative correlation has been established between Pb and Cd levels (p < 0.05). The contribution of the sunflower oil to Pb and Cd dietary intake has been estimated as 0.84 and 0.09 g/day, respectively. Se ha determinado el contenido de plomo y cadmio en 21 muestras de aceite de girasol, todas ellas producidas en Andalucía (Sur de Espa a). Ambos elementos tienen una gran importancia toxicológica y el aceite de girasol es muy consumido en Espa a. Las muestras han sido mineralizadas con ácido nítrico, utilizando pentóxido de vanadio como catalizador, y analizadas mediante espectroscopia de absorción atómica con atomización electrotérmica. Se ha optimizado el programa temperatura-tiempo del horno de grafito para cada elemento y se ha evaluado la exactitud, precisión, sensibilidad y límite de detección del método. Las concentraciones de plomo han oscilado entre no detectables y 167.58 g/kg y las concentraciones de cadmio entre 0.87 y 8.30 g/kg. Estos datos no resultan excesivos y concuerdan con los aportados por otros autores; no obstante, una de las muestras analizadas supera el límite máximo de 0.1 ppm de Pb establecido en las Legislaciones Espa ola y Europea. Se ha comprobado una correlación estadísticamente significativa entre los niveles de Pb y de Cd (p<0.05). La contribución del consumo de aceite de girasol a la ingesta dietaria de Pb y Cd ha sido estimada en 0.84 y 0.09 g/día, respectivamente.
Tratamiento nutricional del fallo intestinal y potenciales mecanismos de estimulación Nutritional management of intestinal failure and potential stimulation mechanisms
A. J. Pérez de la Cruz,R. Moreno-Torres Herrera,C. Pérez Roca
Nutrición Hospitalaria , 2007,
Abstract: El Fallo Intestinal en sus formas graves representa una de las patologías de manejo más complejo, tanto en ni os como adultos. En adultos las causas más frecuentes son la Pseudoobstrucción Intestinal Crónica y el Síndrome del Intestino Corto severo que sigue a las grandes resecciones intestinales, sobre todo las debidas a isquemia mesentérica masiva, en el marco de cardiopatías que cursan con fibrilación auricular. El tratamiento fundamental tras la estabilización del paciente, está representado por el soporte nutricional por las vías parenteral y/o enteral, constituyendo la tolerancia a la dieta oral, el éxito final de la adaptación intestinal en estos procesos. La cirugía puede estar indicada en algunos casos para incrementar la superficie absortiva. La Nutrición Parenteral es una medida de apoyo fundamental, que a veces hay que mantener durante un tiempo prolongado, e incluso adquirir carácter permanente, salvo que complicaciones ligadas a la técnica, o la evolución clínica desfavorable, obliguen a alternativas quirúrgicas extremas como el trasplante intestinal. El tratamiento hormonal con factores estimulantes del trofismo abre nuevas alternativas que ya se están ensayando en humanos. Severe forms of intestinal failure represent one of the most complex pathologies to manage, in both children and adults. In adults, the most common causes are chronic intestinal pseudo-obstruction and severe short bowel syndrome following large intestinal resections, particularly due to massive mesenteric ischemic, within the context of cardiopathies occurring with atrial fibrillation. The essential management after stabilizing the patient consists in nutritional support, either by parenteral or enteral routes, with tolerance to oral diet being the final goal of intestinal adaptation in these pathologies. Surgery may be indicated in some cases to increase the absorptive surface area. Parenteral nutrition is an essential support measure that sometimes has to be maintained for long time, even forever, except for technique-related complications or unfavorable clinical course that would lead to extreme surgical alternatives such as intestinal transplantation. Hormonal therapy with trophism-stimulating factors opens new alternatives that are already being tried in humans.
El hombre del cuadro (fabulación para escépticos)
Roca Roca, Eduardo
Arbor : Ciencia, Pensamiento y Cultura , 2004,
Abstract: No disponible
Presentación
Roca Roca, Eduardo
Arbor : Ciencia, Pensamiento y Cultura , 2004,
Abstract:
Caracterización clínica del labio leporino con fisura palatina o sin ésta en Cuba
Roca Ortiz,. Joel Luis; Cendán Mu?iz,Isidro; Alonso Lotti,Francisca; Ferrero Oteiza,María Emilia; Lantigua Cruz,Aracely;
Revista Cubana de Pediatr?-a , 1998,
Abstract: 288 newborns with cleft lips with or without cleft palate, either associated or not to other types of defects, were detected among 8 004 malformed newborns included in the cuban birth defects register from april 1985 to december 1994. this defect alone was present in 77.4 % of cases whereas cleft palate was also present in two-thirds of cases. male newborns were predominant. left-hand anatomical defect location prevailed in both sexes. as to the associated defects, chromosomal syndromes accounting for 8 % were predominant from the pathogenic view point; in addition, the prevailing syndrome was trisomy 13 which was found in 21 cases.
Ventilación de alta frecuencia: primer reporte en recién nacidos cubanos
Domínguez Dieppa,Fernando; Roca Molina,María del Carmen; Millán Cruz,Yraida; Barrios Rentaría,Yamilé;
Revista Cubana de Pediatr?-a , 2006,
Abstract: la ventilación de alta frecuencia (vaf) está indicada en los neonatos críticamente enfermos cuando falla la ventilación mecánica convencional (vmc) o en el enfisema pulmonar intersticial. el objetivo de este trabajo es comunicar los resultados obtenidos al aplicar la vaf por primera vez en un grupo de recién nacidos cubanos. se realizó un trabajo retrospectivo y descriptivo en el servicio de neonatología del hospital ?ramón gonzález coro? de ciudad de la habana, en el período del 1.ero de octubre de 2002 al 31 de marzo de 2005. se estudiaron en 21 neonatos ventilados con vaf las variables siguientes: peso al nacer, edad gestacional, sexo, edad al inicio de la vaf según los diferentes diagnósticos, evolución según tiempo de ventilado, mortalidad por grupos de peso, causas de mortalidad y supervivencia. en el período de tiempo estudiado se registró un total de 8 482 nacidos vivos, de los que 124 fueron ventilados (1,5 %); de ellos sobrevivieron 104 (84 %). veintiún neonatos fueron tratados con la modalidad vaf, lo que representa 1 de cada 400 nacidos vivos. la letalidad global en vaf fue del 28 %, pero en los menores de 2 500 g resultó ser el 25 %; en tanto que en los de 2 500 g o más de peso al nacer fue del 33 %. la mortalidad fue del 60 % en los neonatos de muy bajo peso tratados con vaf. el porcentaje de supervivencia en vaf (72 %) se consideró adecuado, tomando en cuenta que se aplicó básicamente en neonatos con afecciones respiratorias graves y con falla en la vmc o cuando existió un bloqueo aéreo significativo en el curso de esta modalidad ventilatoria.
Neurodesarrollo de primeros neonatos cubanos ventilados con alta frecuencia
Domínguez Dieppa,Fernando; Cejas Pérez,Gianny; Roca Molina,María del Carmen; Millán Cruz,Yraida;
Revista Cubana de Pediatr?-a , 2009,
Abstract: introduction: the objective of present study was to describe the neurodevelopment during the first 2 years of life of the first cuban newborns underwent high frequency ventilation (hfv) in oscillatory modality. methods: a longitudinal and descriptive study was conducted in 19 newborns treated with hfv and the final assessment of neurodevelopment was related to some perinatal variables and to the ventilation type. results: there were neonates (21%) presenting with neurodevelopment alterations. course was normal in all those weighing less than 2000 g at birth, and in the 40% of the series weighing 2500 or more. there were alterations in the 13% of pre-term neonates and in the 50% of at-term births, as well as a slight predominance of normality in male sex (82% versus 75%). there was only one patient with a low and a sustained apgar score from the 4 with sequelae. neurodevelopment course was normal in 89% of those underwent to high frequency ventilation during 8 hours or more; in 30% we found alterations from those underwent to ventilation during less than 48 hours. almost all the neonates underwent to ventilation during more than 96 hours, including those presenting sequelae. conclusions: the fifth part of newborns underwent high frequency ventilation had neurodevelopment sequelae during the first 2 years of life with a predominance of the moderate ones. this ventilation modality by itself was not associated with a higher sequelae incidence, which were more frequent in neonates with higher weight and gestational age. with less time in high frequency and a total higher time in ventilation therapy, greater was the incidence of neurodevelopment alterations.
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