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Search Results: 1 - 10 of 475703 matches for " Roberto M. González Suárez "
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Papel de la testosterona y el cortisol en el síndrome metabólico y la diabetes mellitus tipo 2
álvarez álvarez,Aimée M.; González Suárez,Roberto M.; Marrero Falcón,Miguel A.;
Revista Cubana de Endocrinolog?-a , 2010,
Abstract: introduction: metabolic syndrome and the type 2 diabetes mellitus are metabolic disorders fully approached in scientific literature due to its high incidence, as well as its association with a high morbidity and mortality. in past years new elements of potential impact in its physiopathology have been reviewed including the sexual steroids and the glucocorticoids. in present paper were reviewed and discussed the more current knowledges on the testosterone and cortisol role in the physiopathology of metabolic syndrome and type 2 diabetes mellitus in men. development: testosterone plays a significant role in modulation of sensitivity to insulin and in glucose homeostasis because of in men the low levels of testosterone are a predictor element of type 2 diabetes mellitus and of the metabolic syndrome. a bidirectional and reversible relation between androgen deficiency and the adiposity, as well as between the androgen deficiency and insulin resistance have been established. authors suggest that low levels of testosterone could predispose to abdominal obesity provoking an alteration of fat acid metabolism, which at the same time will promote the insulin resistance. cortisol and testosterone secretion are interrelated and have inverse effects on insulin resistance. in abdominal obesity the adrenal-hypophyseal-hypotalamic axis is hypersensitive leading to a frequent increase of cortisol secretion and a decrease of sexual steroids secretion. besides, a disproportionate increase of stress-physiologic response induces a cortisol secretion increase which could at the same time, to provoke the insulin resistance and the metabolic syndrome. one of the pathogenic mechanisms of insulin resistance is the increased flow of fat acids arriving to liver from the visceral fat metabolism. the cortisol/testosterone relation modulates among other hormones the visceral fat accumulation has been associated in men, with mortality and with the incidence of ischemic cardiovascular diseases thr
Papel de la testosterona y el cortisol en el síndrome metabólico y la diabetes mellitus tipo 2 Role of testosterone and cortisol in metabolic syndrome and type 2 diabetes mellitus
Aimée M. álvarez álvarez,Roberto M. González Suárez,Miguel A. Marrero Falcón
Revista Cubana de Endocrinología , 2010,
Abstract: INTRODUCCIóN: el síndrome metabólico y la diabetes mellitus tipo 2 son trastornos metabólicos que han sido ampliamente abordados en la literatura científica por su alta incidencia, así como la alta morbilidad y mortalidad que a ellos se asocia. En los últimos a os se han explorado nuevos elementos de posible impacto en su fisiopatogenia, dentro de los que se destacan los esteroides sexuales y los glucocorticoides. En este trabajo se revisaron y comentaron los conocimientos más actuales sobre el papel de la testosterona y el cortisol en la fisiopatogenia del síndrome metabólico y de la diabetes mellitus tipo 2 en los hombres. DESARROLLO: la testosterona desempe a un papel importante en la modulación de la sensibilidad a la insulina y en la homeostasis de la glucosa, de manera que en los hombres, los niveles bajos de testosterona resultan un elemento predictor de la diabetes mellitus tipo 2 y del síndrome metabólico. Se ha establecido la existencia de una relación bidireccional y reversible entre la deficiencia de andrógenos y la adiposidad, así como entre la deficiencia de andrógenos y la resistencia a la insulina. Se sugiere que los niveles bajos de testosterona podrían predisponer a la obesidad abdominal, que provoca una alteración del metabolismo de los ácidos grasos, lo cual a la vez promovería la resistencia a la insulina. La secreción de cortisol y la de testosterona están interrelacionadas y tienen efectos inversos sobre la resistencia a la insulina. En la obesidad abdominal el eje hipotalámico-hipofisario-adrenal se hipersensibiliza lo cual provoca aumento frecuente de la secreción de cortisol y disminución de la secreción de esteroides sexuales. Por otro lado, un aumento desproporcionado de la respuesta fisiológica al estrés, induce un incremento de la secreción de cortisol que podría a su vez causar la aparición de la resistencia a la insulina y del síndrome metabólico. Uno de los mecanismos patogénicos de la resistencia a la insulina es el flujo aumentado de ácidos grasos que llega al hígado a partir del metabolismo de la grasa visceral. La relación cortisol/testosterona modula, entre otras hormonas, la acumulación de la grasa visceral; ha sido asociada, en hombres, a la mortalidad y la incidencia de enfermedades cardiovasculares isquémicas, a través de una alteración de los componentes del síndrome metabólico. Esta razón pudiera ser un indicador temprano de la resistencia a la insulina y del síndrome metabólico. Este elemento introduce una nueva dimensión dentro de la fisiopatogenia del síndrome metabólico que merece ser estudiada, con la fina
Heterogeneidad de los trastornos metabólicos de las etapas iniciales de la diabetes mellitus 2
González Suárez,Roberto M.; Perich Amador,Pedro; Arranz Calzado,Celeste;
Revista Cubana de Endocrinolog?-a , 2009,
Abstract: backgrounds: the prediabetes has been defined as a risk situation related with the presence of future diabetes, preceding appearance of clinical ways of the disease, and it is provoked by disorders from insulin secretion and the sensitivity to insulin. objective: to establish a metabolic disorders profile from a group of subjects in the diabetes mellitus subclinical stage to identify subpopulations sensitive to specific interventions. methods: we used the information gathered on glucose tolerance stage, on insulin-sensitivity, and on insulin secretion in an initial study of 40 patients participating in a prospective research, which two years later were diagnosed with manifest diabetes. results: subjects with initial diabetes mellitus had a wide range of disorders related to a glucose tolerance (tolerance to normal glucose (22 %), tolerance to altered glucose (35 %), and tolerance to altered glucose + altered fast glycemia (43 %). the 95 % of the obese subjects and the 50% of the non-obese ones had a insulin resistance, whereas there was a decrease of insulin secretion in 50 % of subjects of both groups. there as not a association between deterioration level of tolerance to glucose and study metabolic disorders. conclusions: subjects in early stages of diabetes are a heterogeneous population with different levels of energy metabolism deterioration, where interventions to prevent diabetes in these persons need a diagnosis and personalized treatment.
Trastornos metabólicos asociados con la evolución hacia la diabetes mellitus tipo 2 en una población en riesgo
González Suárez,Roberto M.; Perich Amador,Pedro; Arranz Calzado,Celeste;
Revista Cubana de Endocrinolog?-a , 2010,
Abstract: abstract introduction: the clinical and metabolic state of persons in risk of suffer type 2 diabetes mellitus (dm2) is very heterogeneous. objective: to identify the factors influencing in progression to diabetes in subgroups of patients with different types and the severity of metabolic disorders. methods: a prospective study was conducted in 209 subjects in high risk of progression to type 2 diabetes mellitus (backgrounds of disorders related to glucose tolerance without fasting hyperglycemia) to examine the metabolic disorders associating with progression to diabetes. glucose tolerance, insulin secretion and insulin sensitivity were studied at onset and two years later. results: we found that the risk to develop diabetes mellitus was in a significant dependence of the deterioration degree of glucose tolerance present in the initial study (normal glucose tolerance, 10 %; altered glucose tolerance, 14,6 %; altered glucose tolerance + altered fasting glycemia, 56,7 %). in the group with a normal glucose tolerance the fundamental predictive factor of evolution to diabetes mellitus was the failure of initial insulin secretory response (or: 8,13; 95 % ci; 1,83 to 36,0). in the subjects with altered glucose tolerance with fasting altered glycemia and without it, determinant factor was the fasting glycemia (or: 5,41; 95 % ci; 2,15 to 13,6). the insulin resistance was not a significant predictive factor in any study subgroups. conclusions: postprandial glycemia disorders in early stages of evolution to type 2 diabetes mellitus are changeable or reversible and insufficient to base its early diagnosis and the preventive or therapeutical activities. appearance of an altered fasting glycemia is the onset of an accelerated progression stage to type 2 diabetes mellitus, thus, in this group it is necessary to intensify the measures to revert or slow the metabolic deterioration. in group with a high risk of diabetes and a normal glucose tolerance the only metabolic factor identif
Factores metabólicos asociados con la progresión hacia la diabetes mellitus en sujetos con tolerancia a la glucosa alterada
González Suárez,Roberto M.; Perich Amador,Pedro; Valdés Ramos,Eduardo; Arranz Calzado,Celeste;
Revista Cubana de Endocrinolog?-a , 2007,
Abstract: a prospective study was conducted in 84 patients with impaired glucose tolerance (igt) diagnosed 18 years before to identify metabolic factors found in the initial study that could be associated with the progression to diabetes mellitus (dm) detected in the evolutive study. the severity of the glucose tolerance disorder, the reduction or increase of insulin secretion on fasting or during an oral glucose tolerance test (ogtt), as well as the resistance to insulin detected on fasting or during the ogtt, were considered as risk factors. all of them were determined by methods and criteria of interpretation that were previously established and validated. it was observed that a low initial insulin response (reduced ii0-30) was significantly associated with the progression to diabetes in the group of studied individuals with igt. this finding was consistent with all the aspects of the evaluated phenomenon (absolute values of the variables in the group of subjects classified according to their evolution, risk of evolution toward diabetes mellitus and time elapsed until the diagnosis of dm) and agreed with the criteria that the genetically determined factor that conditions the development of dm is a defect of the initial capacity of the insulin secretory response to glycaemia changes.
Desarrollo de un método inmunoenzimático para determinar progesterona
González Suárez,Roberto M.; Arranz Calzado,María Celeste; García Dafonte,Gema;
Revista Cubana de Endocrinolog?-a , 2002,
Abstract: an immunoenzimatic, competitive liquid stage method , with separation by antibodies coupled to magnetizable particles was developed to determine progesterone in plasma, it is based on the competence for the binding sites of a monoclonal antibody between the hormone present in the sample and a hormone-enzime conjugate in the presence of blocking agents of the proteins transporting steroids from plasma. the antigen-antibody complex is trapped by a second mouse antiglobulin antibody coupled to magnetizable particles that allow to separate it from the non reacting components of the system and to develop in its surface the color reaction with which the analyte is quantified. this system does not require either extraction of the steroids from plasma with organic solvents or centrifugation and the final product of the reaction may be read in a conventional colorimeter. all this make it accessible to the equipment of a laboratory of conventional clinical biochemistry. the parameters of calibration and quality of both methods were studied and compared with 2 similar commercial analytic systems and with the results of progesterone determination in 200 samples. it was proved that there were no statistical differences between them. it was concluded that this system has all the necessary requirements to be incorporated as a routine method in the laboratories of the national health system.
Evaluación crítica del sistema de diagnóstico de la diabetes mellitus, propuesto por la Asociación Americana de Diabetes
González Suárez,Roberto M.; Arranz Calzado,María Celeste; Perich Amador,Pedro;
Revista Cubana de Endocrinolog?-a , 2002,
Abstract: a retrospective study was carried out in 370 subjects with glucose tolerance disorders aimed at evaluating the methodology for diagnosing type 2 diabetes mellitus that leaves out the oral glucose tolerance test (gtt) proposed by the ada, it was found that fasting glycaemia allowed to diagnose 27 % of the diabetics and 56 % of the individuals with glycaemia regulation disorders that would have been diagnosed according to the who criteria that include the gtt. the third part of those cases classified as normal based only in glycaemia during fasting presented some type of glucose tolerance disorder. it was proved that the diabetics detected by hyperglycemia at the second hour had higher levels of circulating glucose during the test evaluated by the total area under the glucose curve. the pattern of insulinic response of these cases was characterized by a diminished initial response that increased up to reaching maximum values at the second hour. the frequency of cases with low insulinic response and/or insulin resistance was high. it was concluded that the fasting glycaemia test by itself was not sensitive enough to detect glucose tolerance disorders, diabetes mellitus and those cases with postprandial hyperglycaemia, and that’s why they can only be detected by gtt. as these patients present important metabolic disorders that require an early detection and treatment, it is recommended the systematic use of gtt in the diagnosis of diabetes mellitus.
Estudio del efecto hipoglicemiante del Ocimun sanctun L. (albahaca morada) con el uso de un ensayo biológico en ratones
DEáS RODRíGUEZ,MARTHA; SEUC JO,ARMANDO; GONZáLEZ SUáREZ,ROBERTO M;
Revista Cubana de Plantas Medicinales , 1997,
Abstract: effect of ocimun sanctun l. (albahaca morada) on glycemia of normal mice, weighing from 20 to 25 g, was studied. hypoglycemic effect of intraperitoneal dose of ocimun sanctun (0,5-20 % ) within 2 and 4 hours, post-administration of extract, was measured. analysis of findings was based on a linear model to describe possible variatons of glycemia over the time. slopes of described straight lines to each of dose, showed that ocimun sanctun l. lead to decrease of glycemia (5 to 22 mg/dl/h). between study dose, there weren′t significant differences.
Desarrollo de un método inmunoenzimático para determinar progesterona Development of an immunoenzimatic method to determine progesterone
Roberto M. González Suárez,María Celeste Arranz Calzado,Gema García Dafonte
Revista Cubana de Endocrinología , 2002,
Abstract: Se desarrolló un método inmunoenzimático, competitivo, en fase líquida, con separación por anticuerpos acoplados a partículas magnetizables, para determinar progesterona en plasma; se basa en la competencia por los sitios de unión de un anticuerpo monoclonal, entre la hormona presente en la muestra y un conjugado hormona-enzima, en presencia de agentes bloqueadores de las proteínas de transporte de esteroides del plasma. El complejo antígeno-anticuerpo es atrapado por un segundo anticuerpo antiglobulina de ratón acoplado a partículas magnetizables que permite separarlo de los componentes no reaccionantes del sistema y desarrollar en su superficie la reacción de color con la que se cuantifica el analito. Este sistema no requiere extracción de los esteroides del plasma con solventes orgánicos, ni centrifugación y el producto final de la reacción puede ser leído en un colorímetro convencional. Todo lo anterior lo hace accesible al equipamiento de un laboratorio de bioquímica clínica convencional. Se estudiaron los parámetros de calibración y de calidad de ambos métodos, se compararon con 2 sistemas analíticos comerciales similares y con los resultados de la determinación de progesterona en 200 muestras y se comprobó que no existían diferencias estadísticas entre ellos. Se concluyó que este sistema cuenta con los requisitos necesarios para ser incorporado como método de rutina en los laboratorios del Sistema Nacional de Salud. An immunoenzimatic, competitive liquid stage method , with separation by antibodies coupled to magnetizable particles was developed to determine progesterone in plasma, It is based on the competence for the binding sites of a monoclonal antibody between the hormone present in the sample and a hormone-enzime conjugate in the presence of blocking agents of the proteins transporting steroids from plasma. The antigen-antibody complex is trapped by a second mouse antiglobulin antibody coupled to magnetizable particles that allow to separate it from the non reacting components of the system and to develop in its surface the color reaction with which the analyte is quantified. This system does not require either extraction of the steroids from plasma with organic solvents or centrifugation and the final product of the reaction may be read in a conventional colorimeter. All this make it accessible to the equipment of a laboratory of conventional clinical biochemistry. The parameters of calibration and quality of both methods were studied and compared with 2 similar commercial analytic systems and with the results of progesterone determination
Evaluación crítica del sistema de diagnóstico de la diabetes mellitus, propuesto por la Asociación Americana de Diabetes Critical evaluation of the diagnostic system of diabetes mellitus proposed by the American Diabetes Association
Roberto M. González Suárez,María Celeste Arranz Calzado,Pedro Perich Amador
Revista Cubana de Endocrinología , 2002,
Abstract: Se realizó un estudio retrospectivo en 370 sujetos con trastornos de tolerancia a la glucosa, para evaluar la metodología de diagnóstico de la diabetes mellitus tipo 2, que prescinde de la prueba de tolerancia a la glucosa oral (PTG), propuesto por la ADA. Se encontró que la glucemia en ayunas permitió diagnosticar el 27 % de los diabéticos y el 56 % de los sujetos con trastornos de la regulación de la glucemia, que se hubieran diagnosticado siguiendo los criterios de la OMS que incluyen la PTG; la tercera parte de los casos clasificados como normales según la glucemia en ayunas solamente, presentó algún tipo de trastorno de la tolerancia a la glucosa. Se comprobó que los diabéticos detectados mediante la hiperglucemia a la segunda hora de la PTG, presentan niveles superiores de glucosa circulante durante la prueba, evaluados por el área total bajo la curva de glucosa. El patrón de respuesta insulínica de estos casos se caracterizó por una respuesta inicial disminuida que se incrementó hasta alcanzar valores máximos a la segunda hora; la frecuencia de casos con baja respuesta insulínica y/o resistencia a la insulina fue alta. Se concluyó que la glucemia en ayunas, como única prueba, no tiene sensibilidad suficiente para detectar trastornos de la tolerancia a la glucosa y diabetes mellitus y los casos con hiperglucemia posprandial únicamente, y que por ello solo pueden ser detectados por la PTG, presentan trastornos metabólicos importantes que requieren su detección y tratamiento precoz por lo cual es recomendable el uso sistemático de la PTG en el diagnóstico de la diabetes mellitus. A retrospective study was carried out in 370 subjects with glucose tolerance disorders aimed at evaluating the methodology for diagnosing type 2 diabetes mellitus that leaves out the oral glucose tolerance test (GTT) proposed by the ADA, It was found that fasting glycaemia allowed to diagnose 27 % of the diabetics and 56 % of the individuals with glycaemia regulation disorders that would have been diagnosed according to the WHO criteria that include the GTT. The third part of those cases classified as normal based only in glycaemia during fasting presented some type of glucose tolerance disorder. It was proved that the diabetics detected by hyperglycemia at the second hour had higher levels of circulating glucose during the test evaluated by the total area under the glucose curve. The pattern of insulinic response of these cases was characterized by a diminished initial response that increased up to reaching maximum values at the second hour. The frequency of cases with low
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