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Search Results: 1 - 10 of 27991 matches for " Robert Doyle "
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Factors affecting nutrition behavior among middle-class adolescents in urban area of Northern region of Brazil
Doyle,Eva I.; Feldman,Robert H. L.;
Revista de Saúde Pública , 1997, DOI: 10.1590/S0034-89101997000400003
Abstract: introduction: brazil has been called a nation in nutrition transitional because of recent increases in the prevalence of obesity and related chronic diseases. with overweight conditions already prevalent among middle-income populations, there exists a need to identify factors that influence nutrition behavior within this group. objective: to address this subject, a research study was implemented among middle-class adolescents attending a large private secondary school in manaus, amazonas, brazil. the study determined the availability and accessibility of snack foods as well as subjects? attitudes and preferences towards, and the influence of family and friends on healthy (high-nutrient density) snack choices. methods: the 4-stage process included: (a) a nutrition expert focus group discussion that reported local nutrition problems in general and factors related to adolescent nutrition, (b) an adolescent pilot survey (n=63) that solicited information about snacking preferences and habits as well as resources for nutrition information and snack money; (c) a survey of various area food market sources to determine the availability and accessibility of high nutrient density snacks; and (d) a follow-up adolescent survey (n=55) that measured snack food preferences and perceptions about their cost and availability. results: results included the finding that, although affordable high nutrient density snacks were available, preferences for low nutrient density snacks prevailed. the adolescents were reportedly more likely to be influenced by and obtain nutrition information from family members than friends. conclusion: from study results it is apparent that a focus on food availability will not automatically result in proper nutritional practices among adolescents. this fact and the parental influence detected are evidence of a need to involve adolescents and their parents in nutrition education campaigns to improve adolescent snack food choices.
Factors affecting nutrition behavior among middle-class adolescents in urban area of Northern region of Brazil
Doyle Eva I.,Feldman Robert H. L.
Revista de Saúde Pública , 1997,
Abstract: INTRODUCTION: Brazil has been called a nation in nutrition transitional because of recent increases in the prevalence of obesity and related chronic diseases. With overweight conditions already prevalent among middle-income populations, there exists a need to identify factors that influence nutrition behavior within this group. OBJECTIVE: To address this subject, a research study was implemented among middle-class adolescents attending a large private secondary school in Manaus, Amazonas, Brazil. The study determined the availability and accessibility of snack foods as well as subjects' attitudes and preferences towards, and the influence of family and friends on healthy (high-nutrient density) snack choices. METHODS: The 4-stage process included: (a) a nutrition expert focus group discussion that reported local nutrition problems in general and factors related to adolescent nutrition, (b) an adolescent pilot survey (n=63) that solicited information about snacking preferences and habits as well as resources for nutrition information and snack money; (c) a survey of various area food market sources to determine the availability and accessibility of high nutrient density snacks; and (d) a follow-up adolescent survey (n=55) that measured snack food preferences and perceptions about their cost and availability. RESULTS: Results included the finding that, although affordable high nutrient density snacks were available, preferences for low nutrient density snacks prevailed. The adolescents were reportedly more likely to be influenced by and obtain nutrition information from family members than friends. CONCLUSION: From study results it is apparent that a focus on food availability will not automatically result in proper nutritional practices among adolescents. This fact and the parental influence detected are evidence of a need to involve adolescents and their parents in nutrition education campaigns to improve adolescent snack food choices.
Configuration of the Crucial Set for a Quadratic Rational Map
John R. Doyle,Kenneth Jacobs,Robert Rumely
Mathematics , 2015,
Abstract: Let $K$ be a complete, algebraically closed non-archimedean valued field, and let $\varphi(z) \in K(z)$ have degree two. We describe the crucial set of $\varphi$ in terms of the multipliers of $\varphi$ at the classical fixed points, and use this to show that the crucial set determines a stratification of the moduli space $\mathcal{M}_2(K)$ related to the reduction type of $\varphi$. We apply this to settle a special case of a conjecture of Hsia regarding the density of repelling periodic points in the non-archimedean Julia set.
An open-label trial of divalproex sodium extended release for pediatric bipolar spectrum disorder in children age 6 - 12 years  [PDF]
Janet Wozniak, Paul Hammerness, Robert Doyle, Gagan Joshi, K. Yvonne Woodworth, Joseph Biederman
Open Journal of Psychiatry (OJPsych) , 2012, DOI: 10.4236/ojpsych.2012.22017
Abstract: Objective: To estimate the rate of response to divalproex sodium extended release in pediatric bipolar spectrum disorder in young children age 6 - 12. Methods: This was an 8-week, open-label treatment of youth with DSM-IV bipolar disorder with divalproex sodium extended release (ER) monotherapy. Severity of mania was assessed weekly with the Young Mania Rating Scale (YMRS). Results: The sample was 8.9 ± 2.0 years of age and predominantly male (83%). At study entry the mean YMRS score was 26.3 ± 4.5. Of the 18 subjects enrolled, 7 (39%) completed the 8 week course. We failed to find a clinically or statistically significant improvement with divalproex sodium ER. Pre-post comparisons at endpoint (LOCF) indicated an average response reduction of 6.1 ± 2.6 in the YMRS to a mean of 20.3 ± 8.1. Weight increased by 1.36 ± 0.7 kg (p = 0.08) from baseline to endpoint. Conclusion. Divalproex sodium ER monotherapy was associated with poor tolerability, was associated with clinically concerning weight gain but had modest therapeutic benefits in the management of symptoms of mania and depression in children with pediatric bipolar disorder.
Impact of Long-Term Treatment with OROS Methylphenidate on Pubertal Development in Adolescents with ADHD  [PDF]
Paul Hammerness, Daniel Geller, Gagan Joshi, Anna Georgiopoulos, Robert Doyle, Thomas Spencer, Carter Petty, Laura Mahoney, Joseph Biederman
Open Journal of Psychiatry (OJPsych) , 2014, DOI: 10.4236/ojpsych.2014.42019
Abstract:

The objective of this study was to examine whether stimulants impact pubertal development in adolescent Attention Deficit Hyperactivity Disorder (ADHD), an understudied subject. Pubertal staging data were collected during a 2-year open study of extended release methylphenidate in adolescents (N = 111) with ADHD. Tanner stages were compared to national estimates. The sample was primarily male, Caucasian, and a mean age of 14.8 years at baseline. The baseline Tanner stage for 70% of subjects was consistent with chronological age. For the majority of subjects who reached 12 - 20 months (N = 25) or 24 months (N = 21) endpoints, the Tanner stage at respective endpoints was consistent with age. We found that progression in Tanner stage was not associated with OROS MPH duration or dose (p >

The Toronto Extremity Salvage Score in Unoperated Controls: An Age, Gender, and Country Comparison
Mark Clayer,Simon Doyle,Nicole Sangha,Robert Grimer
Sarcoma , 2012, DOI: 10.1155/2012/717213
Abstract: The Toronto Extremity Salvage Score (TESS) is widely used for the functional assessment of patients following surgery for musculoskeletal tumours. The aim of this study was to determine if there are gender and/or age-specific changes, unrelated to surgery, that may influence this score and the appropriateness of the questions. The TESS for lower limb was carried out in two different countries to see if there was variation between them. There were no statistically significant differences between the scores obtained between the respondents from Australia or Britain either in total or between the corresponding age groups. There were statistically significant differences in the TESS obtained between age groups with a lower score at older age groups but there was no difference between the sexes. Patients in the age group 70
Targeting Gallium to Cancer Cells through the Folate Receptor
Nerissa Viola-Villegas, Anthony Vortherms and Robert P. Doyle
Drug Target Insights , 2012,
Abstract: The development of gallium(III) compounds as anti-cancer agents for both treatment and diagnosis is a rapidly developing field of research. Problems remain in exploring the full potential of gallium(III) as a safe and successful therapeutic agent or as an imaging agent. One of the major issues is that gallium(III) compounds have little tropism for cancer cells. We have combined the targeting properties of folic acid (FA) with long chain liquid polymer poly(ethylene glycol) (PEG) ‘spacers’. This FA-PEG unit has been coupled to the gallium coordination complex of 1,4,7,10-tetraazacyclo-dodecane-N,N′,N′′,N′′′-tetraacetic acid (DOTA) through amide linkages for delivery into target cells overexpressing the folate receptor (FR). In vitro cytotoxicity assays were conducted against a multi-drug resistant ovarian cell line (A2780/AD) that overexpresses the FR and contrasted against a FR free Chinese hamster ovary (CHO) cell line. Results are rationalized taking into account stability studies conducted in RPMI 1640 media and HEPES buffer at pH 7.4.
Risperidone treatment for ADHD in children and adolescents with bipolar disorder
Joseph Biederman,Paul Hammerness,Robert Doyle,Gagan Joshi
Neuropsychiatric Disease and Treatment , 2008,
Abstract: Joseph Biederman, Paul Hammerness, Robert Doyle, Gagan Joshi, Megan Aleardi, Eric MickPediatric Psychopharmacology Research Department, Massachusetts General Hospital, Boston, MA, USAObjective: Children and adolescents with bipolar disorder are also at high risk of having comorbid attention-deficit hyperactivity disorder (ADHD). The objective of this study was to estimate improvement in ADHD symptoms in children with bipolar disorder.Methods: This was an open-label, study of risperidone monotherapy for the treatment of pediatric bipolar disorder. Thirty-one children and adolescents 4–15 years of age (7.2 ± 2.8 years) of both sexes (71%, N = 22 male) with pediatric bipolar disorder (YMRS score = 32.9 ± 8.8) and ADHD (ADHD-RS score = 37.9 ± 8.9) were included in these analyses.Results: Improvement in ADHD symptoms was contingent on improvement in manic symptoms. Although both hyperactive/impulsive ( 7.5 ± 5.5.6, p < 0.05) and inattentive ( 6.8 ± 5.0, p < 0.05) ADHD symptoms were significantly improved with risperidone, improvement was modest, and only 29% of subjects (N = 6) showed a 30% reduction in ADHD rating scale scores and had a CGI-I ≤ 2.Conclusions: These results suggest that that treatment with risperidone is associated with tangible but generally modest improvement of symptoms of ADHD in children with bipolar disorder.Keywords: ADHD, bipolar disorder, children, risperidone
Targeting Gallium to Cancer Cells through the Folate Receptor
Nerissa Viola-Villegas,Anthony Vortherms,Robert P. Doyle
Drug Target Insights , 2008,
Abstract: The development of gallium(III) compounds as anti-cancer agents for both treatment and diagnosis is a rapidly developing field of research. Problems remain in exploring the full potential of gallium(III) as a safe and successful therapeutic agent or as an imaging agent. One of the major issues is that gallium(III) compounds have little tropism for cancer cells. We have combined the targeting properties of folic acid (FA) with long chain liquid polymer poly(ethylene glycol) (PEG) ‘spacers’. This FA-PEG unit has been coupled to the gallium coordination complex of 1,4,7,10-tetraazacyclo-dodecane-N,N′,N′′,N′′′-tetraacetic acid (DOTA) through amide linkages for delivery into target cells overexpressing the folate receptor (FR). In vitro cytotoxicity assays were conducted against a multi-drug resistant ovarian cell line (A2780/AD) that overexpresses the FR and contrasted against a FR free Chinese hamster ovary (CHO) cell line. Results are rationalized taking into account stability studies conducted in RPMI 1640 media and HEPES buffer at pH 7.4.
Software Development Process Changes in the Telecommunications Industry
John Kevin Doyle,Robert S. Janek,M. David Long
Journal of Systemics, Cybernetics and Informatics , 2006,
Abstract: The tremendous changes in the telecommunications business in the last several years drove changes in the software development processes of telecommunications equipment providers. We compare changes in these very large projects, in two companies, with those proposed in the Theory of Constraints / Critical Chains, Extreme Programming, and Agile development models. The 2000s have been a time of significant challenge in the telecommunications equipment business. Telecommunications service providers have excess equipment capacity. Many are waiting for next generation telephone switches that will simultaneously lower operating costs and enable additional revenue generation. The large service providers have drastically reduced their capital and expense purchases. Many small service providers, particularly the dot-coms, went bankrupt; much of their equipment is on the secondary market, at a fraction of the original cost. Thus the equipment market has significantly shrunk, and the equipment providers have been reducing expenses, while continuing to deliver software and hardware equipment at the high quality level required by the service providers. This drove many changes in the software development process. While the process changes are reported in two telecommunication equipment development organizations, the changes are applicable in any product development organization.
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