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Search Results: 1 - 10 of 314267 matches for " Rob G. H. H. Nelissen "
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Total Joint Replacement in the Past Does Not Relate to a Deteriorated Functional Level and Health Status in the Oldest Old
Wiebe Chr. Verra,Anton J. M. de Craen,Coen C. M. M. Jaspars,Jacobijn Gussekloo,Gerard Jan Blauw,Rudi G. J. Westendorp,Andrea B. Maier,Rob G. H. H. Nelissen
Journal of Aging Research , 2012, DOI: 10.1155/2012/968389
Abstract: Total hip or knee replacement is effective in improving joint function, quality of life, and pain reduction. The oldest old population with joint replacements (TJR) is underrepresented in current literature. We compared health-related and functional characteristics of oldest olds with and without TJR. Participants (aged 85 years) were divided into a group with and without TJR. Comorbidity, physical and joint functioning, daily living activities, quality of life, and mortality were recorded. Thirty-eight of 599 participants (6.3%) received a TJR in the past. Participants with a TJR had slightly less comorbidities, walked slower ( ?? = 0 . 0 0 6 ), and complained more about hip-pain ( ?? = 0 . 0 0 7 ). Mortality of those with a TJR was lower during the first 8-year followup ( ?? = 0 . 0 4 ). All other characteristics were comparable between groups. We conclude that subjects with a TJR performed equally well, besides showing a lower gait speed and a higher frequency of hip-pain. Except for the lower gaitspeed, having a TJR is not associated with poorer health. 1. Introduction The population of oldest olds (i.e., 85 years and older) is the fastest growing segment of the elderly population in the western society [1]. The health status decreases with increasing chronological age [2]. One of the major age-related diseases is osteoarthritis (OA), which is more common in females [3–5]. In subjects between 60 and 70 years of age, prevalences of symptomatic knee OA are reported of approximately 10 percent in males and 20 percent in females [4]. Prevalence of knee OA is comparable in subjects aged 80 years and older [4, 5]. Symptomatic OA of the hip is present in approximately five percent of the 60 to 70 years old females and up to 18 percent in females of 80 years and older. In males, prevalences are slightly lower [3, 4]. Due to the demographic changes, the number of total hip replacement (THR) and total knee replacement (TKR) procedures steadily increases [6]. Increasing age is associated with a higher complication and mortality rate after total joint replacement [6]. However, the results of total joint replacement in elderly patients have been proven effective in terms of pain reduction, functional improvement, and cost-effectiveness and show similar results compared to younger patients receiving total joint replacement [7, 8]. OA of the hip or the knee impairs physical activity [4]. Restriction of physical activity is associated with numerous detrimental effects on general health status, physical function, and quality of life [4, 9]. Maintaining physical
Genes Involved in the Osteoarthritis Process Identified through Genome Wide Expression Analysis in Articular Cartilage; the RAAK Study
Yolande F. M. Ramos, Wouter den Hollander, Judith V. M. G. Bovée, Nils Bomer, Ruud van der Breggen, Nico Lakenberg, J. Christiaan Keurentjes, Jelle J. Goeman, P. Eline Slagboom, Rob G. H. H. Nelissen, Steffan D. Bos, Ingrid Meulenbelt
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0103056
Abstract: Objective Identify gene expression profiles associated with OA processes in articular cartilage and determine pathways changing during the disease process. Methods Genome wide gene expression was determined in paired samples of OA affected and preserved cartilage of the same joint using microarray analysis for 33 patients of the RAAK study. Results were replicated in independent samples by RT-qPCR and immunohistochemistry. Profiles were analyzed with the online analysis tools DAVID and STRING to identify enrichment for specific pathways and protein-protein interactions. Results Among the 1717 genes that were significantly differently expressed between OA affected and preserved cartilage we found significant enrichment for genes involved in skeletal development (e.g. TNFRSF11B and FRZB). Also several inflammatory genes such as CD55, PTGES and TNFAIP6, previously identified in within-joint analyses as well as in analyses comparing preserved cartilage from OA affected joints versus healthy cartilage were among the top genes. Of note was the high up-regulation of NGF in OA cartilage. RT-qPCR confirmed differential expression for 18 out of 19 genes with expression changes of 2-fold or higher, and immunohistochemistry of selected genes showed a concordant change in protein expression. Most of these changes associated with OA severity (Mankin score) but were independent of joint-site or sex. Conclusion We provide further insights into the ongoing OA pathophysiological processes in cartilage, in particular into differences in macroscopically intact cartilage compared to OA affected cartilage, which seem relatively consistent and independent of sex or joint. We advocate that development of treatment could benefit by focusing on these similarities in gene expression changes and/or pathways.
Study protocol subacromial impingement syndrome: the identification of pathophysiologic mechanisms (SISTIM)
Pieter de Witte, Jochem Nagels, Ewoud RA van Arkel, Cornelis PJ Visser, Rob GHH Nelissen, Jurriaan H de Groot
BMC Musculoskeletal Disorders , 2011, DOI: 10.1186/1471-2474-12-282
Abstract: We believe patients should be treated according to their predominant etiological mechanism(s). Therefore, the objective of our study is to identify and discriminate etiological mechanisms occurring in SIS patients, in order to develop tailored diagnostic and therapeutic strategies.In this cross-sectional descriptive study, applied clinical and experimental methods to identify intrinsic and extrinsic etiologic mechanisms comprise: MRI-arthrography (eligibility criteria, cuff status, 3D-segmented bony contours); 3D-motion tracking (scapulohumeral rhythm, arm range of motion, dynamic subacromial volume assessment by combining the 3D bony contours and 3D-kinematics); EMG (adductor co-activation) and dynamometry instrumented shoulder radiographs during arm tasks (force and muscle activation controlled acromiohumeral translation assessments); Clinical phenotyping (Constant Score, DASH, WORC, and SF-36 scores).By relating anatomic properties, kinematics and muscle dynamics to subacromial volume, we expect to identify one or more predominant pathophysiological mechanisms in every SIS patient. These differences in underlying mechanisms are a reflection of the variations in symptoms, clinical scores and outcomes reported in literature. More insight in these mechanisms is necessary in order to optimize future diagnostic and treatment strategies for patients with SIS symptoms.Dutch Trial Registry (Nederlands Trial Register) NTR2283.The Subacromial Impingement Syndrome (SIS) can be defined as symptomatic irritation of the rotator cuff and subacromial bursa in the limited subacromial space. Clinical characteristics are pain with arm abduction (painful arc), decreased active range of motion (RoM) and loss of arm force and function [1-5]. It is the most frequently diagnosed shoulder disorder in primary health care, accounting for 44-65% of all shoulder complaints [3,6]. Symptoms can persist for months or years and the majority of patients are between 40 and 50 years old. Consequent
The Inter- and Intraindividual Anatomical Relationship of the Femoral Anteversion and Distal Femoral Rotation. A Cadaveric Study on the Femoral Anteversion Angle, Posterior and Inferior Condylar Angle Using Computed Tomography  [PDF]
H. M. J. van der Linden-van der Zwaag, L. C. D. Konijn, T. J. van der Steenhoven, H. J. L. van der Heide, M. C. de Ruiter, R. G. H. H. Nelissen
Advances in Computed Tomography (ACT) , 2015, DOI: 10.4236/act.2015.41002
Malrotation following Total Knee Arthroplasty (TKA) is directly related to poor outcome. Knowledge of the rotational axes (torsion) and angles is therefore important. The aim of the study was to determine whether an association existed between the Femoral Anteversion Angle (FAA) Posterior Condylar Angle (PCA) and the Inferior Condylar Angle (ICA) in individuals. A CT scan of 50 (25 paired) cadaver femora was made. The FAA, PCA and ICA were measured. Statistical analysis of comparative relationships between these different angles was examined by calculating Pearson correlation coefficients and a paired t-test. The mean FAA, PCA and ICA for the whole group were respectively 11.7° (range 0 - 32, SD 8.2), 5.18° (range 0 - 12, SD 2.4) and 4.4° (range 0 - 10, SD 2.1). A correlation of 0.82 (p = 0.01) of the FAA was found between left versus right. For the overall group a correlation coefficient between the PCA of the left and right femur was r = 0.59, p = 0.01. The Pearson correlation between the FAA and PCA in the whole group was r = 0.27, p = 0.06. In females this was r = 0.54 (p = 0.03). Although the difference of the mean ICA and PCA was very small (0.7°), there was no correlation between these angles (r = 0.14, p = 0.23). In conclusion, one should be aware that, considering the weak correlation of the FAA and PCA, an individual rotational variation exists. Furthermore, no correlation was found between the PCA and ICA. Therefore, for now, this angle cannot be assumed to be helpful in TKA. A more individual approach in total knee arthroplasty seems essential for future TKA.
Ecological networks and greenways in Europe: reasoning and concepts
Rob HGJongman,

环境科学学报(英文版) , 2003,
Abstract: The paper gives an overview of approaches towards ecological networks throughout Europe. It does not intend to present a complete picture, but to highlight common developments within countries and regions and show common principles and differences between countries and regions that have to be taken into account when developing a joint European initiative. Countries or regions that have not been included can be active in the same way, but information was not accessible to the authors for different reasons. This overview shows the comparable trends in decline of landscapes and the diversity in approaches to biodiversity conservation and nature conservation planning. Understanding the differences and common issues are of utmost importance to generalise common principles and to understand the way neighbours and other European partners approach problems.
Evaporation-triggered Wetting Transition for Water Droplets upon Hydrophobic Microstructures
Peichun Tsai,Rob G. H. Lammertink,Matthias Wessling,Detlef Lohse
Physics , 2009, DOI: 10.1103/PhysRevLett.104.116102
Abstract: When placed on rough hydrophobic surfaces, water droplets of diameter larger than a few millimeters can easily form pearls, as they are in the Cassie-Baxter state with air pockets trapped underneath the droplet. Intriguingly, a natural evaporating process can drive such a Fakir drop into a completely wetting (Wenzel) state. Our microscopic observations with simultaneous side and bottom views of evaporating droplets upon transparent hydrophobic microstructures elucidate the water-filling dynamics and the mechanism of this evaporation-triggered transition. For the present material the wetting transition occurs when the water droplet size decreases to a few hundreds of micrometers in radius. We present a general global energy argument which estimates the interfacial energies depending on the drop size and can account for the critical radius for the transition.
Identification of Free Nitric Oxide Radicals in Rat Bone Marrow: Implications for Progenitor Cell Mobilization in Hypertension
Marina A. Aleksinskaya, Ernst E. H. van Faassen, Jelly Nelissen, Ben J. A. Janssen, Jo G. R. De Mey, Roeland Hanemaaijer, Ton Rabelink, Anton Jan van Zonneveld
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0057761
Abstract: Nitric oxide (NO) has been implicated in matrix metallopeptidase 9 (MMP9)-dependent mobilization of hematopoietic stem and progenitor cells from bone marrow (BM). However, direct measurement of NO in the BM remained elusive due to its low in situ concentration and short lifetime. Using NO spin trapping and electron paramagnetic resonance (EPR) spectroscopy we give the first experimental confirmation of free NO radicals in rodent BM. NO production was quantified and attributed to enzymatic activity of NO synthases (NOS). Although endothelial NOS (eNOS) accounts for most (66%) of basal NO, we identified a significant contribution (23%) from inducible NOS (iNOS). Basal NO levels closely correlate with MMP9 bioavailability in BM of both hypertensive and control rats. Our observations support the hypothesis that inadequate mobilization of BM-derived stem and progenitor cells in hypertension results from impaired NOS/NO/MMP9 signalling in BM, a condition that may be corrected with pharmacological intervention.
Does Human Resource Management Help a Company’s Financial Operating Result?  [PDF]
Rob. C. H. van Otterlo
Journal of Service Science and Management (JSSM) , 2013, DOI: 10.4236/jssm.2013.65031

Human Resource Management (HRM) is widely believed to have a positive effect on the performance of company. However, empirical proof of this is hard to come by. In this study, we try to establish a linkage between HRM and financial output of two case studies in the profit sector. To do this, we have developed a performance measurement system that is tailored to the specific needs of measuring HRM-performance in for-profit of company. Although we do not try to generalize the outcome of this study, it looks promising in the way that more case studies should be conducted using this specific performance measurement system. If nothing else, management and controllers could use the system to evaluate the performance of their HRM-tools.

The effectiveness of the McKenzie method in addition to first-line care for acute low back pain: a randomized controlled trial
Luciana AC Machado, Chris G Maher, Rob D Herbert, Helen Clare, James H McAuley
BMC Medicine , 2010, DOI: 10.1186/1741-7015-8-10
Abstract: A multi-centre randomized controlled trial with a 3-month follow-up was conducted between September 2005 and June 2008. Patients seeking care for acute non-specific low back pain from primary care medical practices were screened. Eligible participants were assigned to receive a treatment programme based on the McKenzie method and first-line care (advice, reassurance and time-contingent acetaminophen) or first-line care alone, for 3 weeks. Primary outcome measures included pain (0-10 Numeric Rating Scale) over the first seven days, pain at 1 week, pain at 3 weeks and global perceived effect (-5 to 5 scale) at 3 weeks. Treatment effects were estimated using linear mixed models.One hundred and forty-eight participants were randomized into study groups, of whom 138 (93%) completed the last follow-up. The addition of the McKenzie method to first-line care produced statistically significant but small reductions in pain when compared to first-line care alone: mean of -0.4 points (95% confidence interval, -0.8 to -0.1) at 1 week, -0.7 points (95% confidence interval, -1.2 to -0.1) at 3 weeks, and -0.3 points (95% confidence interval, -0.5 to -0.0) over the first 7 days. Patients receiving the McKenzie method did not show additional effects on global perceived effect, disability, function or on the risk of persistent symptoms. These patients sought less additional health care than those receiving only first-line care (P = 0.002).When added to the currently recommended first-line care of acute low back pain, a treatment programme based on the McKenzie method does not produce appreciable additional short-term improvements in pain, disability, function or global perceived effect. However, the McKenzie method seems to reduce health utilization although it does not reduce patient's risk of developing persistent symptoms.Australian New Zealand Clinical Trials Registry: ACTRN12605000032651Current clinical guidelines [1-3] recommend the provision of advice, reassurance and simple an
Symposium: Redefinitions of Citizenship and Revisions of Cosmopolitanism—Transnational Perspectives
Günter H. Lenz,Rob Kroes,Rüdiger Kunow,Alfred Hornung
Journal of Transnational American Studies , 2011,
Abstract: The following set of essays consists of revised versions of contributions read at, or prepared for, a roundtable discussion at the 2009 convention of the American Studies Association in Washington, DC. The short contributions by the individual authors reflect on the boundaries, the perspectives, and the transdisciplinary dynamics of the field imaginary of transnational American Studies and the specific political role of new notions of citizenship and the parameters of a new cosmopolitanism beyond the limits of the Western tradition.
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