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The Metabolic Burden of Methyl Donor Deficiency with Focus on the Betaine Homocysteine Methyltransferase Pathway
Rima Obeid
Nutrients , 2013, DOI: 10.3390/nu5093481
Abstract: Methyl groups are important for numerous cellular functions such as DNA methylation, phosphatidylcholine synthesis, and protein synthesis. The methyl group can directly be delivered by dietary methyl donors, including methionine, folate, betaine, and choline. The liver and the muscles appear to be the major organs for methyl group metabolism. Choline can be synthesized from phosphatidylcholine via the cytidine-diphosphate (CDP) pathway. Low dietary choline loweres methionine formation and causes a marked increase in S-adenosylmethionine utilization in the liver. The link between choline, betaine, and energy metabolism in humans indicates novel functions for these nutrients. This function appears to goes beyond the role of the nutrients in gene methylation and epigenetic control. Studies that simulated methyl-deficient diets reported disturbances in energy metabolism and protein synthesis in the liver, fatty liver, or muscle disorders. Changes in plasma concentrations of total homocysteine (tHcy) reflect one aspect of the metabolic consequences of methyl group deficiency or nutrient supplementations. Folic acid supplementation spares betaine as a methyl donor. Betaine is a significant determinant of plasma tHcy, particularly in case of folate deficiency, methionine load, or alcohol consumption. Betaine supplementation has a lowering effect on post-methionine load tHcy. Hypomethylation and tHcy elevation can be attenuated when choline or betaine is available.
Cobalamin Analogues in Humans: A Study on Maternal and Cord Blood
Tore Forsingdal Hardlei, Rima Obeid, Wolfgang Herrmann, Ebba Nexo
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0061194
Abstract: Background Haptocorrin (HC) carries cobalamin analogues (CorA), but whether CorA are produced in the body is unknown. All cobalamins (Cbl) to the foetus are delivered by the Cbl-specific protein transcobalamin (TC), and therefore analysis of cord serum for CorA may help to clarify the origin of CorA. Methods HC-CorA were quantified in paired samples of cord serum from newborns and serum from mothers (n = 69). Results The CorA-concentration was higher in cord serum (median = 380, range: 41–780 pmol/L) than in serum from the mothers (median = 160, range: 64–330 pmol/L), (p<0.0001). HPLC-analysis showed CorA-peaks with retention times of 13.5, 14,5 and 16.5 min in samples from both the mother and cord serum. The peak with retention time 16.5 min constituted 24% (mother) and 45% (cord serum) of the total amount CorA, and eluted as does dicyanocobinamide. Conclusion Our results support that CorA in the human body are derived from Cbl.
Subjective Visual Vertical and Postural Performance in Healthy Children
Chrystal Gaertner, Maria Pia Bucci, Rima Obeid, Sylvette Wiener-Vacher
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0079623
Abstract: Introduction Verticality is essential in our life, especially for postural stability. Subjective vertical as well as postural stability depends on different sensorial information: visual, vestibular and somesthesic. They help to build the spatial referentials and create a central representation of verticality. Children are more visuo-dependant than adults; however, we did not find any study focusing on how children develop their sense of verticality. Methods We studied two groups of subjects: 10 children (from 6 to 8 years) and 12 young adults. We recorded postural stability with a Techno Concept plateform and perception of subjective visual vertical in the following conditions: while adjusting the vertical in the dark or with visual perturbation, while fixating the vertical bar, and with eyes closed. Results Children are more instable than adults in terms of postural parameters, and also while performing a double task, especially when no visual references are present. They also present a higher variability and lower accuracy than adults in reporting their perception of true vertical reference. Discussion Children might have limited attentional resources, and focus their attention on the more demanding task, corresponding to the U-shaped non-linear model.
Hepatic Methionine Homeostasis Is Conserved in C57BL/6N Mice on High-Fat Diet Despite Major Changes in Hepatic One-Carbon Metabolism
Christoph Dahlhoff, Charles Desmarchelier, Manuela Sailer, Rainer W. Fürst, Alexander Haag, Susanne E. Ulbrich, Bj?rn Hummel, Rima Obeid, Jürgen Geisel, Bernhard L. Bader, Hannelore Daniel
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0057387
Abstract: Obesity is an underlying risk factor in the development of cardiovascular disease, dyslipidemia and non-alcoholic fatty liver disease (NAFLD). Increased hepatic lipid accumulation is a hallmark in the progression of NAFLD and impairments in liver phosphatidylcholine (PC) metabolism may be central to the pathogenesis. Hepatic PC biosynthesis, which is linked to the one-carbon (C1) metabolism by phosphatidylethanolamine N-methyltransferase, is known to be important for hepatic lipid export by VLDL particles. Here, we assessed the influence of a high-fat (HF) diet and NAFLD status in mice on hepatic methyl-group expenditure and C1-metabolism by analyzing changes in gene expression, protein levels, metabolite concentrations, and nuclear epigenetic processes. In livers from HF diet induced obese mice a significant downregulation of cystathionine β-synthase (CBS) and an increased betaine-homocysteine methyltransferase (BHMT) expression were observed. Experiments in vitro, using hepatoma cells stimulated with peroxisome proliferator activated receptor alpha (PPARα) agonist WY14,643, revealed a significantly reduced Cbs mRNA expression. Moreover, metabolite measurements identified decreased hepatic cystathionine and L-α-amino-n-butyrate concentrations as part of the transsulfuration pathway and reduced hepatic betaine concentrations, but no metabolite changes in the methionine cycle in HF diet fed mice compared to controls. Furthermore, we detected diminished hepatic gene expression of de novo DNA methyltransferase 3b but no effects on hepatic global genomic DNA methylation or hepatic DNA methylation in the Cbs promoter region upon HF diet. Our data suggest that HF diet induces a PPARα-mediated downregulation of key enzymes in the hepatic transsulfuration pathway and upregulates BHMT expression in mice to accommodate to enhanced dietary fat processing while preserving the essential amino acid methionine.
Application of Cross-Plotting Techniques for Delineation of Coal and Non-Coal Litho-Units from Well Logs  [PDF]
Rima Chatterjee, Suman Paul
Geomaterials (GM) , 2012, DOI: 10.4236/gm.2012.24014
Abstract: Well log responses can be used to delineate coal and carbonaceous shale from other non-potential litho-units by cross-plotting technique. The cross-plotting between gamma ray and density had been carried out for 15 wells of Jharia coalfield, India. Through these different cross-plots across the study area, different litho-units like; coal, shaly coal, carbonaceous shale, shale, sand/sandstone, shaly sand, jhama and igneous intrusion (mica peridotite) have been identified. Clustering of points for different lithologies in the above cross-plots indicate that the different trends with marginal overlap between carbonaceous shale/shaly coal and shale as well as shaly sand and shale. The coal horizons are mostly overlain and underlain by shale or sandstone. Cross-plot analysis indicates the various coal lithologies which will play important role in CBM exploration and exploitation strategy.
Improvement of Spectrophotometric Method for the Determination of Atrazine in Contaminated Water by Inducing of Mannich Reaction
Karine Rima,Jamil Rima
Journal of Food Research (JFR) , 2012, DOI: 10.5539/jfr.v1n4p17
Abstract: The objective of this study is to develop a simple and economic spectrophotometric method for the quantitative determination of atrazine. This method is based on the complexation of atrazine derivatization (dechlorinated atrazine [DA]) with a mixture of formaldehyde and ketone compound, as described by Mannich reaction. The complex was determined by UV-Vis absorption measurement and the ketone compound used was the uranine due to its high coefficient absorption. The UV spectrum of the complex shows maxima of absorption at 207 nm and at 227 nm. An internal standard was used to quantify the atrazine. There is a good linearity between the absorbance and the concentration in the range of 0.1 - 10 ug.mL-1 of atrazine. The recovery value was 97 % and the limit of detection was 0.01 ug.mL-1. Real samples collected from irrigation local area were analyzed using this method and the estimated concentration of atrazine found in the mentioned river is 0.29 ± 0.011 ug.mL-1.
Determinants of Banks’ Profitability: Panel Data from Qatar  [PDF]
Rima Charbaji El-Kassem
Open Journal of Accounting (OJAcct) , 2017, DOI: 10.4236/ojacct.2017.64009
Purpose: The aim of this paper is to investigate the main determinants of banks’ profitability and answer the question “what is the effect of liquidity and risk variables on the explained variation of banks’ performance in Qatar?” Design/methodology/approach: A sample of six major lender banks for the period 2008-2015 is retrieved from the worldwide bankscope database. The dependent variable “Return on Average Assets (ROAA)” is taken as a function of independent variables that are basically liquidity and risk variables. Findings: Findings of this study show that variation in the independent variable “Total Capital Ratio %” positively and significantly affects the explained variation in performance of banks in Qatar measured by “ROAA”, while variation in “Cost to Income Ratio”, negatively and significantly impacts the variation in performance of banks in Qatar. At the same time, variation in “Reserves for impaired Loans/A nonperforming loan (NPL)” and variation in “Loan to Assets Ratio” significantly and negatively affect ROAA of banks in Qatar. Practical implications: It is recommended to replicate the findings of this study in each of the other GCC country before building an econometric model to cluster the GCC banks into homogeneous segments. Originality: The research problem is based on review of literature and investigation in a novel way using EViews 9 and Panel Data.
Prevalence of recurrent aphthous ulceration in Jordanian dental patients
Rima Safadi
BMC Oral Health , 2009, DOI: 10.1186/1472-6831-9-31
Abstract: A total of 684 dental patients who attended Jordan University of Science and Technology interviewed and administered to fill questionnaires related to history, size, shape, and duration of recurrent aphthous ulceration. Other related questions were also asked.About 78% of subjects experienced recurrent aphthous ulceration. Approximately 85% of ulcers were less than one cm in diameter, 66% were circular in shape, 92% were painful, 82% interfered with eating, and 55% located in lips and buccal mucosa. Only 50%of participants related ulcers to stress. Sixty eight percent reported no association with tiredness and 85% no association with types of food ingested. Of the 39% who had blood tests carried out, 7% had vitamin B12 and 4% hemoglobin deficiency.Recurrent aphthous ulceration is a common problem in Jordanian adults.Recurrent aphthous ulceration was reported as the most common inflammatory ulcerative condition of the oral mucosa. [1,2] Aphthous ulcers are classified on the basis of ulcer size into major, minor or herpetiform. [3] Minor aphthous ulcers are small (less than one cm in diameter), well defined, shallow, and heal within two weeks without scars. Major ulcers, however, are bigger, deeper, and take up to six weeks to heal leaving a scar behind. Herpetiform ulceration is also characterized by small (3-6 mm), shallow ulcers which takes weeks to heal, but with many numerous ulcers at once. [3]The etiology of recurrent aphthous ulceration is not understood. [4] No principal cause has been discovered, however attacks may be precipitated by, or associated with, local trauma, stress, food hypersensitivity, hormonal changes, microorganisms, and vitamin and trace element deficiencies. [5] Systemic conditions including genetic predisposition, immune dysregulation, and family history might play a role in recurrent aphthous ulceration in some patients. [6]A diagnosis of recurrent aphthous ulceration depends mainly on history and clinical examination. Patients with mild
Rima Nurasmi
Jurnal Informatika , 2012,
Abstract: Perkembangan teknologi informasi yang semakin cepat, semakin berat pula kemampuan komputer dalam membantu menyelesaikan permasalahan di berbagai bidang di antaranya adalah sistem pendukung keputusan berbasis komputer, seperti pada pengambilan keputusan dalam penanganan dini pada kecelakaan dalam lingkup rumah tangga. Perlu penanganan atau pertolongan segera agar terhindar dari kondisi yang lebih parah, dalam penanganan ini dapat dilakukan dengan menggunakan tanaman herbal. Kebanyakan masyarakat tidak tahu akan kegunaan dari tanaman herbal tersebut terutama untuk penanganan dini pada kecelakaan, untuk itu diperlukan suatu sistem pendukung keputusan untuk penanganan dini pada kecelakaan dengan metode herbal. Model yang digunakan dalam pengambilan keputusan adalah Case Base Reasoning, yang menitikberatkan pemecahan masalah dengan didasarkan pada knowledge dari kasus-kasus sebelumnya. Langkah pengembangan aplikasi diawali dengan analisis kebutuhan sistem yaitu analisis input, proses, dan output, kemudian dilakukan perancangan sistem yang berupa desain pemodelan data dan pemodelan proses. Perancangan sistem diimplementasikan ke dalam bahasa pemrograman Visual Basic 6.0 dan menggunakan Access. Hasil penelitian ini adalah aplikasi pendukung keputusan untuk penanganan dini pada kecelakaan dalam lingkup rumah tangga dengan metode herbal. Aplikasi ini telah diuji dengan menggunakan black box test dan alpha test, dan diperoleh kesimpulan bahwa aplikasi ini dinyatakan baik dan layak digunakan.
Engage Them, Don’t Enrage Them – Student Voices and What It Takes to Participate
Rima Aboudan
English Language Teaching , 2011, DOI: 10.5539/elt.v4n1p128
Abstract: Students who get involved reap several academic benefits (Furtwengler: 1991). This paper concerns features of pedagogy that involve students, get them to participate, and capture and sustain their interest. Analysis of data from feedback by 80 students and 40 faculty members in the United Arab Emirates University highlighted four core components in motivating student participation: the content connect-ability of subject-matter to students’ everyday lives; the use of student active-involvement opportunities in lessons; the students’ sharing of responsibility in the learning process; and the establishment of a rewarding system for effort and engagement.
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