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Search Results: 1 - 10 of 2668 matches for " Richter Torsten "
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Acute lung injury and acute respiratory distress syndrome
Ragaller Maximillian,Richter Torsten
Journal of Emergencies, Trauma and Shock , 2010,
Abstract: Every year, more information accumulates about the possibility of treating patients with acute lung injury or acute respiratory distress syndrome with specially designed mechanical ventilation strategies. Ventilator modes, positive end-expiratory pressure settings, and recruitment maneuvers play a major role in these strategies. However, what can we take from these experimental and clinical data to the clinical practice? In this article, we discuss substantial options of mechanical ventilation together with some adjunctive therapeutic measures, such as prone positioning and inhalation of nitric oxide.
Passenger Classification for an Airport Movement Forecast System
Stefan Richter,Christoph Ortmann,Torsten Reiners
Lecture Notes in Engineering and Computer Science , 2009,
Abstract:
Late Life-Threatening Hemorrhage after Percutaneous Tracheostomy
Torsten Richter,Birgit Gottschlich,Susanne Sutarski,Rainer Müller,Maximilian Ragaller
International Journal of Otolaryngology , 2011, DOI: 10.1155/2011/890380
Abstract: Purpose. Formation of a tracheoinnominate artery fistula (TIF) and consecutive hemorrhage is a rare and life-threatening complication with high mortality. Warning symptoms can be absent. The current literature contains only few considerations for misleading signs, especially in cases where the contact between the tissue and the cannula is tight. Method and Results. We report two cases of life-threatening hemorrhages that appeared six days and two months after percutaneous dilatational tracheostomy (PDT) in two patients, respectively. In these cases, diagnosis of tracheoinnominate artery fistula (TIF) was difficult. Tracheal ring fracture after PDT and pressure ulceration caused by cannula were implicated in TIF formation. The cannula was overblocked to buy time before surgical closure. Both patients survived without any additional neurological deficiency. Conclusion. Massive hemorrhage in patients after tracheostomy is likely due to TIF. Ultrasound scanning before PDT and careful periodical followup of the trachea are required.
Late Life-Threatening Hemorrhage after Percutaneous Tracheostomy
Torsten Richter,Birgit Gottschlich,Susanne Sutarski,Rainer Müller,Maximilian Ragaller
International Journal of Otolaryngology , 2011, DOI: 10.1155/2011/890380
Abstract: Purpose. Formation of a tracheoinnominate artery fistula (TIF) and consecutive hemorrhage is a rare and life-threatening complication with high mortality. Warning symptoms can be absent. The current literature contains only few considerations for misleading signs, especially in cases where the contact between the tissue and the cannula is tight. Method and Results. We report two cases of life-threatening hemorrhages that appeared six days and two months after percutaneous dilatational tracheostomy (PDT) in two patients, respectively. In these cases, diagnosis of tracheoinnominate artery fistula (TIF) was difficult. Tracheal ring fracture after PDT and pressure ulceration caused by cannula were implicated in TIF formation. The cannula was overblocked to buy time before surgical closure. Both patients survived without any additional neurological deficiency. Conclusion. Massive hemorrhage in patients after tracheostomy is likely due to TIF. Ultrasound scanning before PDT and careful periodical followup of the trachea are required. 1. Introduction Brachiocephalic artery hemorrhage is a life-threatening complication with high mortality [1, 2]. Fortunately, TIF is rare, with a reported incidence between 0.1–1% after surgical tracheostomy and 0.35% after PDT [3]. Delayed hemorrhage caused by TIF following PDT is assumed to be underreported [4]. 2. Case Reports Case 1. A 32-year-old female was admitted because of intracerebral bleeding due to a high-flow arteriovenous malformation of the posterior inferior cerebellar artery. It was treated by neuroradiological intervention and neurosurgical extirpation. Because of prolonged ventilation, translaryngeal tracheostomy using the Fantoni technique was performed. Excessive oropharyngeal hemorrhage occurred six days later, during a routine bedding procedure. The otorhinolaryngologist could not identify the source of bleeding and placed a nasopharyngeal, oropharyngeal and hypopharyngeal tamponade. Blood loss was reduced, and it stopped completely after about 15 minutes. Angiographic computer tomography could not show the source of bleeding. Two hours later, a second massive hemorrhage occurred from the oropharynx beside the tamponade and tracheal tube. The tube was overblocked extensively. A second attempt to identify the source of bleeding by angiography failed. The patient was transported to the operating room for revision of tracheostomy. An erosive lesion in the dorsal wall of the brachiocephalic artery was found (Figure 1) and closed. PDT was replaced by conventional tracheostomy. The following postoperative period
Genetic variation of the RASGRF1 regulatory region affects human hippocampus-dependent memory
Adriana Barman,Sylvia Richter,Joram Soch,Torsten Wüstenberg,Marieke Klein,Anni Richter,Gusalija Behnisch,Emrah Düzel,Constanze I. Seidenbecher,Bj?rn H. Schott
Frontiers in Human Neuroscience , 2014, DOI: 10.3389/fnhum.2014.00260
Abstract: The guanine nucleotide exchange factor RASGRF1 is an important regulator of intracellular signaling and neural plasticity in the brain. RASGRF1-deficient mice exhibit a complex phenotype with learning deficits and ocular abnormalities. Also in humans, a genome-wide association study has identified the single nucleotide polymorphism (SNP) rs8027411 in the putative transcription regulatory region of RASGRF1 as a risk variant of myopia. Here we aimed to assess whether, in line with the RASGRF1 knockout mouse phenotype, rs8027411 might also be associated with human memory function. We performed computer-based neuropsychological learning experiments in two independent cohorts of young, healthy participants. Tests included the Verbal Learning and Memory Test (VLMT) and the logical memory section of the Wechsler Memory Scale (WMS). Two sub-cohorts additionally participated in functional magnetic resonance imaging (fMRI) studies of hippocampus function. 119 participants performed a novelty encoding task that had previously been shown to engage the hippocampus, and 63 subjects participated in a reward-related memory encoding study. RASGRF1 rs8027411 genotype was indeed associated with memory performance in an allele dosage-dependent manner, with carriers of the T allele (i.e., the myopia risk allele) showing better memory performance in the early encoding phase of the VLMT and in the recall phase of the WMS logical memory section. In fMRI, T allele carriers exhibited increased hippocampal activation during presentation of novel images and during encoding of pictures associated with monetary reward. Taken together, our results provide evidence for a role of the RASGRF1 gene locus in hippocampus-dependent memory and, along with the previous association with myopia, point toward pleitropic effects of RASGRF1 genetic variations on complex neural function in humans.
Analysis of expression profiles of MAGE-A antigens in oral squamous cell carcinoma cell lines
Urs DA Müller-Richter, Albert Dowejko, Tobias Reuther, Johannes Kleinheinz, Torsten E Reichert, Oliver Driemel
Head & Face Medicine , 2009, DOI: 10.1186/1746-160x-5-10
Abstract: The expression profiles of MAGE-A2, -A3, -A4, -A6 and -A10 in five own oral squamous cell carcinoma cell lines were characterised by rt-PCR, qrt-PCR and immunocytochemistry with a global MAGE-A antibody (57B) and compared with those of an adult keratinocyte cell line (NHEK).All tumour cell lines expressed MAGE-A antigens. The antigens were expressed in groups with different preferences. The predominant antigens expressed were MAGE-A2, -A3 and -A6. MAGE-A10 was not expressed in the cell lines tested. The MAGE-A gene products detected in the adult keratinocyte cell line NHEK were used as a reference.MAGE-A antigens are expressed in oral squamous cell carcinomas. The expression profiles measured facilitate distinct examinations in forthcoming studies on responses to antineoplastic drugs or radiation therapy. MAGE-A antigens are still an interesting aim for immunotherapy.Tumour cells express specific antigens. Despite the fact that the protein products of these genes are absent or only partially found on healthy cells, the immunological response is insufficient[1,2]. The goal of several studies was to map these tumour antigens and use them to induce or boost the immunological response[3-5]. Of particular interest are tumour antigens that occur only on tumour cells and are not detectable on physiologically healthy cells. Such a group of tumour antigens are the MAGE-A antigens, a subgroup of cancer/testis antigens. These antigens are only expressed on germ cells and placenta cells[6,7]. The authors could also demonstrate an expression in fetal oral keratinocytes[25] but could not elucidate their role in development. In contrast, these antigens are commonly expressed on many different tumours[7-9]. They are found in dermal and oral squamous cell carcinomas, amongst others[7,10-12]. These studies suggest that MAGE-A antigens are simultaneously expressed in antigen groups. The MAGE-A subgroups differ in their protein structures[7,13]. This might influence an interaction with
A comparative study of four intensive care outcome prediction models in cardiac surgery patients
Fabian Doerr, Akmal MA Badreldin, Matthias B Heldwein, Torsten Bossert, Markus Richter, Thomas Lehmann, Ole Bayer, Khosro Hekmat
Journal of Cardiothoracic Surgery , 2011, DOI: 10.1186/1749-8090-6-21
Abstract: We prospectively included all consecutive adult patients who underwent open heart surgery and were admitted to the intensive care unit (ICU) between January 1st 2007 and December 31st 2008. Scores were calculated daily from ICU admission until discharge. The outcome measure was ICU mortality. The performance of the four scores was assessed by calibration and discrimination statistics. Derived variables (Mean- and Max- scores) were also evaluated.During the study period, 2801 patients (29.6% female) were included. Mean age was 66.9 ± 10.7 years and the ICU mortality rate was 5.2%. Calibration tests for SOFA and CASUS were reliable throughout (p-value not < 0.05), but there were significant differences between predicted and observed outcome for SAPS II (days 1, 2, 3 and 5) and APACHE II (days 2 and 3). CASUS, and its mean- and maximum-derivatives, discriminated better between survivors and non-survivors than the other scores throughout the study (area under curve ≥ 0.90). In order of best discrimination, CASUS was followed by SOFA, then SAPS II, and finally APACHE II. SAPS II and APACHE II derivatives had discrimination results that were superior to those of the SOFA derivatives.CASUS and SOFA are reliable ICU mortality risk stratification models for cardiac surgery patients. SAPS II and APACHE II did not perform well in terms of calibration and discrimination statistics.Scoring systems were introduced into intensive care medicine to provide the physician with an objective tool for judging a patient's condition and likely outcome. These scores can be used to estimate the severity of disease and to aid therapeutic decisions. The acute patho-physiological sequelae of cardiopulmonary bypass are transient and many physiologic changes may be masked by multiple system support devices, such as intra-aortic balloon pumps, ventricular assist devices, hemofiltration and mechanical ventilation. The subset of cardiac surgery patients was, therefore, excluded during the developmen
ANCA-Associated Vasculitides—An Update  [PDF]
Johanna Kegel, Torsten Kirsch
Health (Health) , 2014, DOI: 10.4236/health.2014.614209
Abstract: Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides are characterized by destruction of small vessels, granulomatous inflammation of the respiratory tract and necrotizing glomerulonephritis. This review describes the clinical diagnosis and therapy as well as the patho-physiology of ANCA-associated vasculitides with a specific focus on the interplay of ANCAs with activated neutrophils and the deleterious pathophysiological consequences of neutrophil-endothelium interaction.
Oral acantholytic squamous cell carcinoma shares clinical and histological features with angiosarcoma
Oliver Driemel, Urs DA Müller-Richter, Samer G Hakim, Richard Bauer, Alexander Berndt, Johannes Kleinheinz, Torsten E Reichert, Hartwig Kosmehl
Head & Face Medicine , 2008, DOI: 10.1186/1746-160x-4-17
Abstract: Four oral acantholytic squamous cell carcinomas and one intraoral angiosarcoma are used to compare the eruptive intraoral growth-pattern, age-peak, unfavourable prognosis and slit-like intratumorous spaces in common histological staining as identical clinical and histopathological features. Immunohistochemical staining for pancytokeratin, cytokeratin, collagen type IV, γ2-chain of laminin-5, endothelial differentiation marker CD31 and CD34, F VIII-associated antigen, Ki 67-antigen, β-catenin, E-cadherin, α-smooth-muscle-actin and Fli-1 were done.Cytokeratin-immunoreactive cells can be identified in both lesions. The large vascularization of ASCC complicates the interpretation of vascular differential markers being characteristic for angiosarcoma. Loss of cell-cell-adhesion, monitored by loss of E-cadherin and β-catenin membrane-staining, are indetified as reasons for massive expression of invasion-factor ln-5 in ASCC and considered responsible for unfavourable prognosis of ASCC. Expression of Fli-1 in angiosarcoma and cellular immunoreaction for ln-5 in ASCC are worked out as distinguishing features of both entities.Fli-1 in angiosarcoma and ln-5 in ASCC are distinguishing features.Both oral angiosarcoma and oral acantholytic squamous cell carcinoma (ASCC) are well-defined entities. The WHO classification of tumours describes angiosarcoma as a malignant tumour consisting of cells recapitulating variably the morphological and functional features of normal endothelium, ICD-O code 9120/3 [1-3]. ASCC (synonyms: acantholytic squamous cell carcinoma, adenoid squamous carcinoma, pseudoglandular squamous cell carcinoma, squamous cell carcinoma with glandlike (adenoid) features, angiosarcoma-like squamous cell carcinoma, adenoacanthoma, pseudovascular adenoid squamous cell carcinoma, pseudoangiosarcomatous carcinoma) is characterized as a squamous cell carcinoma containing pseudo-glandular spaces or lumina, ICD-O code 8075/3 [4,5].Although angiosarcoma (malignant soft tissue
Effects of AKAP5 Pro100Leu Genotype on Working Memory for Emotional Stimuli
Sylvia Richter, Xenia Gorny, Judith Machts, Gusalija Behnisch, Torsten Wüstenberg, Maike C. Herbort, Thomas F. Münte, Constanze I. Seidenbecher, Bj?rn H. Schott
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0055613
Abstract: Recent investigations addressing the role of the synaptic multiadaptor molecule AKAP5 in human emotion and behavior suggest that the AKAP5 Pro100Leu polymorphism (rs2230491) contributes to individual differences in affective control. Carriers of the less common Leu allele show a higher control of anger as indicated by behavioral measures and dACC brain response on emotional distracters when compared to Pro homozygotes. In the current fMRI study we used an emotional working memory task according to the n-back scheme with neutral and negative emotional faces as target stimuli. Pro homozygotes showed a performance advantage at the behavioral level and exhibited enhanced activation of the amygdala and fusiform face area during working memory for emotional faces. On the other hand, Leu carriers exhibited increased activation of the dACC during performance of the 2-back condition. Our results suggest that AKAP5 Pro100Leu effects on emotion processing might be task-dependent with Pro homozygotes showing lower control of emotional interference, but more efficient processing of task-relevant emotional stimuli.
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