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Search Results: 1 - 10 of 1503 matches for " Richards JH "
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Deficiency of α-1-antitrypsin influences systemic iron homeostasis
Ghio AJ,Soukup JM,Richards JH,Fischer BM
International Journal of COPD , 2013,
Abstract: Andrew J Ghio,1 Joleen M Soukup,1 Judy H Richards,1 Bernard M Fischer,2 Judith A Voynow,2 Donald E Schmechel31US Environmental Protection Agency, Chapel Hill, NC, USA; 2Division of Pediatric Pulmonary Medicine, Department of Pediatrics,3Joseph and Kathleen Bryan Alzheimer Disease Research Center, Department of Medicine (Neurology), Duke University Medical Center, Durham, NC, USAAbstract: There is evidence that proteases and antiproteases participate in the iron homeostasis of cells and living systems. We tested the postulate that α-1 antitrypsin (A1AT) polymorphism and the consequent deficiency of this antiprotease in humans are associated with a systemic disruption in iron homeostasis. Archived plasma samples from Alpha-1 Foundation (30 MM, 30 MZ, and 30 ZZ individuals) were analyzed for A1AT, ferritin, transferrin, and C-reactive protein (CRP). Plasma samples were also assayed for metals using inductively coupled plasma atomic emission spectroscopy (ICPAES). Plasma levels of A1AT in MZ and ZZ individuals were approximately 60% and 20% of those for MM individuals respectively. Plasma ferritin concentrations in those with the ZZ genotype were greater relative to those individuals with either MM or MZ genotype. Plasma transferrin for MM, MZ, and ZZ genotypes showed no significant differences. Linear regression analysis revealed a significant (negative) relationship between plasma concentrations of A1AT and ferritin while that between A1AT and transferrin levels was not significant. Plasma CRP concentrations were not significantly different between MM, MZ, and ZZ individuals. ICPAES measurement of metals confirmed elevated plasma concentrations of nonheme iron among ZZ individuals. Nonheme iron concentrations correlated (negatively) with levels of A1AT. A1AT deficiency is associated with evidence of a disruption in iron homeostasis with plasma ferritin and nonheme iron concentrations being elevated among those with the ZZ genotype.Keywords: α-1-antitrypsin deficiency, serpins, proteinase inhibitor proteins, ferritin, transferrin
Deficiency of α-1-antitrypsin influences systemic iron homeostasis
Ghio AJ, Soukup JM, Richards JH, Fischer BM, Voynow JA, Schmechel DE
International Journal of Chronic Obstructive Pulmonary Disease , 2013, DOI: http://dx.doi.org/10.2147/COPD.S37897
Abstract: iency of α-1-antitrypsin influences systemic iron homeostasis Original Research (727) Total Article Views Authors: Ghio AJ, Soukup JM, Richards JH, Fischer BM, Voynow JA, Schmechel DE Published Date January 2013 Volume 2013:8 Pages 45 - 51 DOI: http://dx.doi.org/10.2147/COPD.S37897 Received: 08 September 2012 Accepted: 28 October 2012 Published: 22 January 2013 Andrew J Ghio,1 Joleen M Soukup,1 Judy H Richards,1 Bernard M Fischer,2 Judith A Voynow,2 Donald E Schmechel3 1US Environmental Protection Agency, Chapel Hill, NC, USA; 2Division of Pediatric Pulmonary Medicine, Department of Pediatrics,3Joseph and Kathleen Bryan Alzheimer Disease Research Center, Department of Medicine (Neurology), Duke University Medical Center, Durham, NC, USA Abstract: There is evidence that proteases and antiproteases participate in the iron homeostasis of cells and living systems. We tested the postulate that α-1 antitrypsin (A1AT) polymorphism and the consequent deficiency of this antiprotease in humans are associated with a systemic disruption in iron homeostasis. Archived plasma samples from Alpha-1 Foundation (30 MM, 30 MZ, and 30 ZZ individuals) were analyzed for A1AT, ferritin, transferrin, and C-reactive protein (CRP). Plasma samples were also assayed for metals using inductively coupled plasma atomic emission spectroscopy (ICPAES). Plasma levels of A1AT in MZ and ZZ individuals were approximately 60% and 20% of those for MM individuals respectively. Plasma ferritin concentrations in those with the ZZ genotype were greater relative to those individuals with either MM or MZ genotype. Plasma transferrin for MM, MZ, and ZZ genotypes showed no significant differences. Linear regression analysis revealed a significant (negative) relationship between plasma concentrations of A1AT and ferritin while that between A1AT and transferrin levels was not significant. Plasma CRP concentrations were not significantly different between MM, MZ, and ZZ individuals. ICPAES measurement of metals confirmed elevated plasma concentrations of nonheme iron among ZZ individuals. Nonheme iron concentrations correlated (negatively) with levels of A1AT. A1AT deficiency is associated with evidence of a disruption in iron homeostasis with plasma ferritin and nonheme iron concentrations being elevated among those with the ZZ genotype.
High density diets for dwarf layers
JH Quisenberry
Genetics Selection Evolution , 1972, DOI: 10.1186/1297-9686-4-2-271
Abstract:
Rations concentrées pour les pondeuses naines
JH Quisenberry
Genetics Selection Evolution , 1971, DOI: 10.1186/1297-9686-3-3-389
Abstract:
Breeding for beef production and dairy cattle ranching in Latin America
JH Weniger
Genetics Selection Evolution , 1982, DOI: 10.1186/1297-9686-14-1-102a
Abstract:
Disfunción Eréctil: Abordaje y Manejo del Paciente
Camacho,JH;
Revista de la Facultad de Medicina , 2002,
Abstract: considering the erectile dysfuntion as a condition that affect half the male population in the usa and other countries, including venezuela, and notably diminush the quality of life of the patient and his partner, a review of specilized literature about this subject was made, emphatizing on the most actual aspects about international and national epidemiology, associated risk factors, clinical approach and complementary tests, and therapeutic options (oral therapy: sildenafil, phentolamine; intracavernosal therapy: alprostadil; vaccum; psycotherapy, and alternative future therapy and others), seen from a primary physician point of view to primary physicians themselves, with the pourpose of divulgating the essencial knowledge about erectile dysfunction, to be applied in primary care and enhancing the quality of life of both the patient and his partner.
Jaja-Ibeno War of 1881: The Ibeno Account and the Refugee Settlements
JH Enemugwem
African Research Review , 2009,
Abstract: This essay deliberates on the Ibeno account and refugee settlements of the Jaja-Ibeno War of 1881 which was untouched by the previous researchers. Its contributions include the causes and course of the war, the mercenaries hired by King Jaja of Opobo, the casualties and entreaties such as the deaths of the Ibeno monarch: King Uko Utong and his son Prince Nso, Jaja’s rehabilitation of the Ibeno to prevent another war and the refugee camps. The need to give this history a balanced view made the paper to analyze the Ibeno relationship with Opobo and Jaja’s establishment of his kingdom in Obolo (Andoni) country which led to his intrusion in the Kwa Ibo palm produce trade.
Oil Pollution and Eastern Obolo Human Ecology, 1957-2007
JH Enemugwem
African Research Review , 2009,
Abstract: Human ecology concerns the relationship between man and his environment (Onosode 1998). In the environment are other organisms of flora and fauna whose importance to human beings need not be overstated. The occurrence of oil pollution in the Eastern Obolo ecosystem did not only degrade the human values but also deny the people of other organisms used by them to maintain and promote their living. As a result, this paper is a study of how oil pollution damaged Eastern Obolo (Andoni) human ecology. The paper started with the causes which are the exploration and exploitation of petroleum for half a century. It also analyzes the processes of extracting crude oil through which pollution emanates. The adverse effects on the flora and fauna, traditional economies and social practices of the people are parts of the text of this essay. So also are its engendered poverty, food contamination and lack of security of human life. Others are the desecration of religious, cultural and historical centres, loss of potential archaeological sites, decay in social values, increase of social vices and the health hazards experienced in the area within the period under review.
Epilepsy treatment in sub-Saharan Africa: closing the gap
JH Chin
African Health Sciences , 2012,
Abstract: According to World Health Organization (WHO), the prevalence of epilepsy is highest in low- and lower middle-income countries, which include over eighty percent of the countries of sub-Saharan Africa, where the majority of people with epilepsy are not receiving appropriate care. In sub-Saharan Africa, shortages of trained health workers, limited diagnostic equipment, inadequate anti-epileptic drug supplies, cultural beliefs, and social stigma contribute to the large treatment gap for epilepsy. The number of people with epilepsy, particularly children, will continue to rise as a result of projected epidemiologic and demographic changes. This paper examines the state of epilepsy care and treatment in sub-Saharan Africa and discusses priorities and approaches to scale up access to medications and services for people with epilepsy.
Social-scientific criticism: Perspective, process and payoff. Evil eye accusation at Galatia as illustration of the method
JH Elliott
HTS Theological Studies/Teologiese Studies , 2011,
Abstract: This article explores a presentation of the method, emergence and contribution of socialscientific criticism (SSC) as an inter-disciplinary operation of New Testament exegesis. A description of ancient evil eye belief and practice and its appearance in Paul’s letter to the Galatians illustrates how the method contributes to a more accurate translation of the biblical text, a clarification of its logic and a fuller understanding of the social dynamics involving Paul and his opponents.
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