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Search Results: 1 - 10 of 19210 matches for " Richard Rothenberg "
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Empiricism and Theorizing in Epidemiology and Social Network Analysis
Richard Rothenberg,Elizabeth Costenbader
Interdisciplinary Perspectives on Infectious Diseases , 2011, DOI: 10.1155/2011/157194
Abstract: The connection between theory and data is an iterative one. In principle, each is informed by the other: data provide the basis for theory that in turn generates the need for new information. This circularity is reflected in the notion of abduction, a concept that focuses on the space between induction (generating theory from data) and deduction (testing theory with data). Einstein, in the 1920s, placed scientific creativity in that space. In the field of social network analysis, some remarkable theory has been developed, accompanied by sophisticated tools to develop, extend, and test the theory. At the same time, important empirical data have been generated that provide insight into transmission dynamics. Unfortunately, the connection between them is often tenuous and the iterative loop is frayed. This circumstance may arise both from data deficiencies and from the ease with which data can be created by simulation. But for whatever reason, theory and empirical data often occupy different orbits. Fortunately, the relationship, while frayed, is not broken, to which several recent analyses merging theory and extant data will attest. Their further rapprochement in the field of social network analysis could provide the field with a more creative approach to experimentation and inference. 1. Introduction Theory and empirical data are in principle intimately interwoven. Yet in the practice of social network analysis, there appears to be a disconnect: theorizing and empiricism often seem to occupy separate orbits, and these separate discussions may be difficult to relate to each other. The root of the problem may lie in the different skill sets required by each, or perhaps in the substantial obstacles to collection of human network data. The following exploration of the distance between theory and empiricism suggests that a rapprochement would be of considerable benefit to the field. The mid-19th Century American philosopher Charles Peirce coined the term “abduction” (which he also called “retroduction”) to fill a gap he perceived in the territory occupied by induction and deduction. As distilled by Professor Burch [1], Peirce used syllogisms to explain this term, substituting Rule, Case, and Result for the more familiar Major Premise, Minor Premise, and Conclusion. But perhaps more interesting to epidemiologists and social network analysts, he related this logical process to sampling. As Professor Burch explains it, a standard valid syllogism would progress as follows.Rule: All balls in this urn are red.Case: All balls in this particular random sample are
ALDH Activity Correlates with Metastatic Potential in Primary Sarcomas of Bone  [PDF]
Nicholas Greco, Trevor Schott, Xiaodong Mu, Adam Rothenberg, Clifford Voigt, Richard L. McGough III, Mark Goodman, Johnny Huard, Kurt R. Weiss
Journal of Cancer Therapy (JCT) , 2014, DOI: 10.4236/jct.2014.54040
Abstract:

Osteosarcoma (OS), chondrosarcoma (CSA), and Ewings sarcoma (ES) are the most common primary malignancies of bone, and are rare diseases. As with all sarcomas, the prognosis of these diseases ultimately depends on the presence of metastatic disease. Survival is therefore closely linked with the biology and metastatic potential of a particular bone tumor’s cells. Here we describe a significant correlation of aldehyde dehydrogenase (ALDH) activity and the presence/absence of distant metastases in ten consecutive cases of human bone sarcomas. Additionally, cultured human CSA cells, which are historically chemo- and radio-resistant, may be sensitive to the ALDH inhibitor, disulfiram. While it is premature to draw broad conclusions from such a small series, the importance of ALDH activity and inhibition in the metastatic potential of primary bone sarcomas should be investigated further.

Proof-Theoretic Soundness and Completeness
Robert Rothenberg
Mathematics , 2011,
Abstract: We give a calculus for reasoning about the first-order fragment of classical logic that is adequate for giving the truth conditions of intuitionistic Kripke frames, and outline a proof-theoretic soundness and completeness proof, which we believe is conducive to automation.
Translating Labels to Hypersequents for Intermediate Logics with Geometric Kripke Semantics
Robert Rothenberg
Mathematics , 2011,
Abstract: We give a procedure for translating geometric Kripke frame axioms into structural hypersequent rules for the corresponding intermediate logics in Int^*/Geo that admit weakening, contraction and in some cases, cut. We give a procedure for translating labelled sequents in the corresponding logic to hypersequents that share the same linear models (which correspond to G\"odel-Dummett logic). We prove that labelled proofs Int^*/Geo can be translated into hypersequent proofs that may use the linearity rule, which corresponds to the well-known communication rule for G\"odel-Dummett logic.
Modality for Free: Notes on Adding the Tarskian M?glichkeit to Substructural Logics
Robert Rothenberg
Mathematics , 2011,
Abstract: We briefly examine the modal formulae that can be derived in Multiplicative Additive Linear Logic (MALL) and some extensions by using Tarksi's extensional modal operators. We also breifly compare this with a substructural form of the modal logic K.
Clinical Use of the Intrauterine Morcellator: A Single Academic Center’s Experience  [PDF]
Stephanie Rothenberg, Shweta Nayak, Joseph S. Sanfilippo
Open Journal of Obstetrics and Gynecology (OJOG) , 2014, DOI: 10.4236/ojog.2014.46049
Abstract:

Objective: To reveal the breadth of experience for the intrauterine morcellator amongst gynecologists in a single US academic center. Design: Retrospective Descriptive. Setting: University Hospital. Patients: In total, 33 hysteroscopic procedures, with intrauterine morcellation, were performed for 28 patients for benign endometrial disease at Magee―Womens Hospital at the University of Pittsburgh Medical center between October 2006 and February 2012. Intervention: Operative Hysteroscopy with an intrauterine morcellator. Measurement and Main Results: The major indication for hysteroscopic surgery was endometrial polyp (54.5%), followed by intrauterine fibroids (18.2%), filling defect on sonohysterogram (15.2%), abnormal uterine bleeding (9.1%), and uterine synechiae (3%). The mean greatest diameter for all intrauterine pathology resected was 1.14 ± 0.46 cm (Range 0.6 - 1.9 cm), and, notably, the largest fibroid resected was 1.5 cm in greatest diameter. The average operative time was 39 ± 29 minutes (range 15 - 122 minutes), and average hysteroscopic fluid deficit was 286 ± 479.5 mL (range 30 - 2000 mL). There were only 2 patients for whom the deficit was greater than 1 L, one of whom underwent a myomectomy with total operative time of 26 minutes, while the other underwent a hysteroscopic adhesiolysis and had a total operative time of 122 minutes. The complication rate was 6.0%, and complications reported included uterine perforation (n = 1) and cervical injury (n = 1). Conclusion: The intrauterine morcellator is a useful tool for surgical treatment of intrauterine pathology that confers a low operative risk.

Dietary Patterns Associated with Alzheimer’s Disease: Population Based Study
Katarzyna Gustaw-Rothenberg
International Journal of Environmental Research and Public Health , 2009, DOI: 10.3390/ijerph6041335
Abstract: Recently dietary pattern analysis has emerged as a way for examining diet-disease relations in Alzheimer’s disease. In contrast with the conventional approach, which focuses on a single nutrient or a few nutrients or foods, this method considers overall eating patterns. We examined the dietary patterns defined by factor analysis using data collected with a food-frequency questionnaire in people with Alzheimer’s disease (AD) as compared to healthy controls. The diet data were obtained during population based study of the prevalence of Alzheimer’s disease in a population in Poland. Stratified sampling and random selection strategies were combined to obtain a representative population for screening (age group > 55). From the population screened three times, 71 people were diagnosed with Alzheimer’s according to DSM-IV, and were recruited for further diet risk factors assessment. A group of people with Alzheimer disease (n = 71; F/M 42/29) and the same number of healthy, age and gender matched control were recruited for the study. Patients and their caregivers as well as controls were presented with a food frequency questionnaire based on the 12 food groups. Factor analysis (principal component) was used to derive food patterns. The analysis was conducted using the factor procedure. The factors were rotated by an orthogonal transformation (Varimax rotation) to achieve simpler structure with greater interpretability. Using factor analysis, we identified major eating patterns, one for Alzheimer’s patients and a different one for control group. The AD dietary pattern, FACTOR AD was characterized by a high intake of meat, butter, high-fat dairy products, eggs, and refined sugar, whereas the other pattern, (FACTOR C) was characterized by a high intake of grains and vegetables. These data indicate the existence of dietary patterns defined by factor analysis with data from a food frequency questionnaire, characteristic for Alzheimer’s disease in a Polish population.
In Silico Design in Homogeneous Catalysis Using Descriptor Modelling
Enrico Burello,Gadi Rothenberg
International Journal of Molecular Sciences , 2006, DOI: 10.3390/i7090375
Abstract: This review summarises the state-of-the-art methodologies used for designing homogeneous catalysts and optimising reaction conditions (e.g. choosing the right solvent). We focus on computational techniques that can complement the current advances in high-throughput experimentation, covering the literature in the period 1996-2006. The review assesses the use of molecular modelling tools, from descriptor models based on semiempirical and molecular mechanics calculations, to 2D topological descriptors and graph theory methods. Different techniques are compared based on their computational and time cost, output level, problem relevance and viability. We also review the application of various data mining tools, including artificial neural networks, linear regression, and classification trees. The future of homogeneous catalysis discovery and optimisation is discussed in the light of these developments.
Interaction of Bacteriophage l with Its E. coli Receptor, LamB
Sujoy Chatterjee,Eli Rothenberg
Viruses , 2012, DOI: 10.3390/v4113162
Abstract: The initial step of viral infection is the binding of a virus onto the host cell surface. This first viral-host interaction would determine subsequent infection steps and the fate of the entire infection process. A basic understating of the underlining mechanism of initial virus-host binding is a prerequisite for establishing the nature of viral infection. Bacteriophage λ and its host Escherichia coli serve as an excellent paradigm for this purpose. λ phages bind to specific receptors, LamB, on the host cell surface during the infection process. The interaction of bacteriophage λ with the LamB receptor has been the topic of many studies, resulting in wealth of information on the structure, biochemical properties and molecular biology of this system. Recently, imaging studies using fluorescently labeled phages and its receptor unveil the role of spatiotemporal dynamics and divulge the importance of stochasticity from hidden variables in the infection outcomes. The scope of this article is to review the present state of research on the interaction of bacteriophage λ and its E. coli receptor, LamB.
On the homotopy invariance of L^2 torsion for covering spaces
Varghese Mathai,Mel Rothenberg
Mathematics , 1997,
Abstract: We prove the homotopy invariance of L^2 torsion for covering spaces, whenever the covering transformation group is either residually finite or amenable. In the case when the covering transformation group is residually finite and when the L^2 cohomology of the covering space vanishes, the homotopy invariance was established earlier by Lueck. We also give some applications of our results.
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