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Search Results: 1 - 10 of 19170 matches for " Richard Picking "
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A Gesture Controlled User Interface for Inclusive Design and Evaluative Study of Its Usability  [PDF]
Moniruzzaman Bhuiyan, Rich Picking
Journal of Software Engineering and Applications (JSEA) , 2011, DOI: 10.4236/jsea.2011.49059
Abstract: To meet the challenges of ubiquitous computing, ambient technologies and an increasingly older population, researchers have been trying to break away from traditional modes of interaction. A history of studies over the past 30 years reported in this paper suggests that Gesture Controlled User Interfaces (GCUI) now provide realistic and affordable opportunities, which may be appropriate for older and disabled people. We have developed a GCUI prototype application, called Open Gesture, to help users carry out everyday activities such as making phone calls, controlling their television and performing mathematical calculations. Open Gesture uses simple hand gestures to perform a diverse range of tasks via a television interface. This paper describes Open Gesture and reports its usability evaluation. We conclude that this inclusive technology offers some potential to improve the independence and quality of life of older and disabled users along with general users, although there remain significant challenges to be overcome.
Secure Military Social Networking and Rapid Sensemaking in Domain Specific Concept Systems: Research Issues and Future Solutions
Debbie Garside,Arjun Ponnusamy,Steve Chan,Richard Picking
Future Internet , 2012, DOI: 10.3390/fi4010253
Abstract: This paper identifies the need for a secure military social networking site and the underlying research issues linked to the successful development of such sites. The paper further proposes a solution to the most basic issues by identifying and tackling known potential security threats to military personnel and their families. The paper further defines the base platform for this development to facilitate rapid sensemaking to inform critical communications and rapid decision making processes during abrupt governance and eco-system change, and how the plethora of information (termed as Big Data) on social networking sites can be analysed and harnessed. Underlying architectural issues, efficiency and complexity are explored and their future development is considered.
A Smart Kitchen for Ambient Assisted Living
Rubén Blasco,álvaro Marco,Roberto Casas,Diego Cirujano,Richard Picking
Sensors , 2014, DOI: 10.3390/s140101629
Abstract: The kitchen environment is one of the scenarios in the home where users can benefit from Ambient Assisted Living (AAL) applications. Moreover, it is the place where old people suffer from most domestic injuries. This paper presents a novel design, implementation and assessment of a Smart Kitchen which provides Ambient Assisted Living services; a smart environment that increases elderly and disabled people’s autonomy in their kitchen-related activities through context and user awareness, appropriate user interaction and artificial intelligence. It is based on a modular architecture which integrates a wide variety of home technology (household appliances, sensors, user interfaces, etc.) and associated communication standards and media (power line, radio frequency, infrared and cabled). Its software architecture is based on the Open Services Gateway initiative (OSGi), which allows building a complex system composed of small modules, each one providing the specific functionalities required, and can be easily scaled to meet our needs. The system has been evaluated by a large number of real users (63) and carers (31) in two living labs in Spain and UK. Results show a large potential of system functionalities combined with good usability and physical, sensory and cognitive accessibility.
F?rster Resonance Energy Transfer (FRET) as a Tool for Dissecting the Molecular Mechanisms for Maturation of the Shigella Type III Secretion Needle Tip Complex
Nicholas E. Dickenson,William D. Picking
International Journal of Molecular Sciences , 2012, DOI: 10.3390/ijms131115137
Abstract: F?rster resonance energy transfer (FRET) provides a powerful tool for monitoring intermolecular interactions and a sensitive technique for studying ?-level protein conformational changes. One system that has particularly benefited from the sensitivity and diversity of FRET measurements is the maturation of the Shigella type III secretion apparatus (T3SA) needle tip complex. The Shigella T3SA delivers effector proteins into intestinal cells to promote bacterial invasion and spread. The T3SA is comprised of a basal body that spans the bacterial envelope and a needle with an exposed tip complex that matures in response to environmental stimuli. FRET measurements demonstrated bile salt binding by the nascent needle tip protein IpaD and also mapped resulting structural changes which led to the recruitment of the translocator IpaB. At the needle tip IpaB acts as a sensor for host cell contact but prior to secretion, it is stored as a heterodimeric complex with the chaperone IpgC. FRET analyses showed that chaperone binding to IpaB’s N-terminal domain causes a conformational change in the latter. These FRET analyses, with other biophysical methods, have been central to understanding T3SA maturation and will be highlighted, focusing on the details of the FRET measurements and the relevance to this particular system.
Evidence for alternative quaternary structure in a bacterial Type III secretion system chaperone
Michael L Barta, Lingling Zhang, Wendy L Picking, Brian V Geisbrecht
BMC Structural Biology , 2010, DOI: 10.1186/1472-6807-10-21
Abstract: In this study, we present the 3.3 ? crystal structure of an amino-terminally truncated form (residues 10-155, denoted IpgC10-155) of the class II chaperone IpgC from Shigella flexneri. Our structure demonstrates an alternative quaternary arrangement to that previously described for a carboxy-terminally truncated variant of IpgC (IpgC1-151). Specifically, we observe a rotationally-symmetric "head-to- head" dimerization interface that is far more similar to that previously described for SycD from Yersinia enterocolitica than to IpgC1-151. The IpgC structure presented here displays major differences in the amino terminal region, where extended coil-like structures are seen, as opposed to the short, ordered alpha helices and asymmetric dimerization interface seen within IpgC1-151. Despite these differences, however, both modes of dimerization support chaperone activity, as judged by a copurification assay with a recombinant form of the translocator protein, IpaB.From primary to quaternary structure, these results presented here suggest that a symmetric dimerization interface is conserved across bacterial class II chaperones. In light of previous data which have described the structure and function of asymmetric dimerization, our results raise the possibility that class II chaperones may transition between asymmetric and symmetric dimers in response to changes in either biochemical modifications (e.g. proteolytic cleavage) or other biological cues. Such transitions may contribute to the broad range of protein-protein interactions and functions attributed to class II chaperones.Type III secretion systems (TTSSs) use a conserved apparatus (TTSA) to provide an energy-driven conduit from a bacterium to the cell membrane and cytoplasm of targeted eukaryotic cells[1]. A hallmark of TTSSs is the presence of two secreted translocators that assume a position at the tip of the TTSA needle to form a pore in the host cell membrane[2]. Once the mature tip complex has formed, the cond
On the Prevention of Obesity and a Philosophy for Healthy Living  [PDF]
Richard Visser
Food and Nutrition Sciences (FNS) , 2012, DOI: 10.4236/fns.2012.37128
Abstract: Overweight and obesity have now reached historical, maximal peak values, with nearly one-third of world population suffering from these conditions. We are now witnessing the impact of this epidemic upon the global health status, with non-communicable diseases on the rise. We have also witnessed the shortcomings and failures of past actions taken when obesity is already present. In this essay the author reviews efforts made in the past regarding identification and treatment of obesity, and propose that actions should be taken before the onset of this disease, by motivating people to make intelligent, healthy choices when it comes to food and physical activity. A philosophy for healthy living should become central to the intervention actions, for them to be successful and sustained. Prevention of obesity should involve all those concerned irregardless of their position in society and curricular training, in order to create a multi-lateral, multi-national effort that will protect our families and our children from the consequences of this epidemic.
A Supportive Approach to Supervising Students Reading for a Phd in Systems and Software Engineering  [PDF]
Richard Lai
Creative Education (CE) , 2012, DOI: 10.4236/ce.2012.326138
Abstract: Supervising a PhD student is a complex teaching task as it involves a very unstructured environment and many intellectual challenges and stimuli, and it often requires a compatible student/supervisor relationship for successful outcomes. It is therefore not surprising that it has been reported that an aspect of teaching and learning that has been overlooked in higher education is research student supervision. Typical problems of poor supervision include: high rates of dissatisfaction with supervisors and high attrition rates and slow rates of completion for students. It has also been reported that there is no set prescription on appropriate and successful supervision; rather, the interactions between quality and style of supervision, and the field of study have all to be considered. It is not easy to know what a student and his/her supervisor should be doing in order to succeed. We are thus motivated to present in this paper our approach to supervising students reading for a PhD in systems and software engineering. This approach is centered on motivating students to learn and to do research by having supervisory activities that support their development throughout their candidature.
The Evolution of Curriculum Development in the Context of Increasing Social and Environmental Complexity  [PDF]
Richard Plate
Creative Education (CE) , 2012, DOI: 10.4236/ce.2012.38192
Abstract: The history of curriculum development has been characterized and a series of “crises” with the pendulum shifting between traditionalists’ call for getting back to the basics and the progressives’ focus on the learner. However, tracing this history, one can see a common theme in the criticisms expressed by both parties: the failure of the existing curriculum to meet the demands presented by an increasingly complex society. I follow this theme in order to provide historical context for contemporary calls by scientists and educators for wider use of systems-oriented curricula (i.e. curricula designed to improve systems thinking) at primary, secondary, and tertiary levels of education. With this context, one can view these current calls not as a radical shift of direction, but as a logical next stage in the evolution of curriculum. I conclude with a call for more research assessing the effectiveness of systems-oriented instruction and provide guidelines for enhancing the usefulness of such research in the current United States system.
Sino-French Engineering Curriculums: An Ongoing Process for Elitist Education?  [PDF]
Richard Mariom
Creative Education (CE) , 2012, DOI: 10.4236/ce.2012.37B048
Abstract: Here is a multisite case-study paper presenting Sino-French engineering education reform cooperation process. This questions the consequences for the introduction of a hybrid framework in a both dynamic and dichotomous innovation context such as Chinese one.
Kant’s Emergence and Sellarsian Cognitive Science  [PDF]
Richard McDonough
Open Journal of Philosophy (OJPP) , 2014, DOI: 10.4236/ojpp.2014.41007
Abstract:

The paper argues, against current views that see Kant as giving abstract descriptions of cognitive mechanisms (after the fashion of functionalism in cognitive science), that Kant sees mental phenomena as akin to emergent phenomena in a sense traditionally opposed to mechanism. After distinguishing several relevant notions of emergence, the paper distinguishes several of Kant’s basic emergentist theses, including his emergent materialism in chemistry and a species of mental emergence modelled on that chemical emergence. However, Kant’s doctrine of the epigenesis of pure Reason is argued to be Kant’s most fundamental emergentist thesis. The paper argues that Kant’s notion of mental emergence sheds light on some very puzzling aspects of his remarks about the unity of intuition and concept emphasized by Wilfrid Sellars. The paper sketches some of the problems in contemporary cognitive science and shows how a Sellarsian emergentism inspired by Kant addresses some of these problems and provides an interesting alternative to the kind of mechanistic positions that have tended to dominate the field. Finally, the paper locates the present emergentist reading with respect to the perspectivist reading of Kant.

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