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Search Results: 1 - 10 of 19261 matches for " Richard Pemberton "
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Self-Access Language Learning in Museums: A Materials Development Project.
Lucy Cooker,Richard Pemberton
Studies in Self-Access Learning Journal , 2010,
Abstract: This paper reports on a project carried out at The University of Nottingham to create and evaluate English for Speakers of Other Languages (ESOL) materials with the aim of exploiting the self-access language learning possibilities that museums offer. A series of thematic resources were produced and trialed with ESOL learners in the Lincolnshire area. Feedback from the learners indicated that museums could have an important role to play in providing flexible language learning opportunities for ESOL students. The authors conclude by suggesting that other public facilities such as libraries, art galleries, botanical gardens and even football stadia could be exploited for this purpose.
Flexible ureterorenoscopy and laser lithotripsy in children
Yeow Wen-Chan,Pemberton Richard,Barker Andrew
Journal of Indian Association of Pediatric Surgeons , 2009,
Abstract: Background: Flexible ureterorenoscopy (FUR) and laser lithotripsy (LL) are techniques used in the management of upper urinary tract disorders. These techniques, so far established in adults, are now being used in children as well. We report our experience with 26 cases of pediatric upper urinary tract disorders treated using these techniques. Methods: In the period from 1997 to 2006, FUR was performed in 26 children (14 males and 12 females) in the age group of three months to 15 years with a mean age of 8.2 years. Twenty five were stented prior to undergoing FUR and 24 presented with suspected upper tract stones (17 pelvicalyceal and seven midureteric). Two cases showed JJ stent migration post-pyeloplasty. Results: Eight cases involved diagnostic procedures. Six excluded the presence of renal calculi, one had focal medullary sponge kidney, and one had calcified papillae. There were 15 cases of therapeutic FUR. Of these, 12 had LL with only one had incomplete stone fragmentation which subsequently passed spontaneously. Other therapeutic procedures included removal of migrated JJ stents and FUR with the basket removal of a midureteric calculus. Three cases failed ureterorenoscopy due to technical difficulties. The overall success rate was 88.5% for FUR. Conclusion: FUR and LL are valuable minimally invasive techniques for the examination and treatment of pediatric upper urinary tract conditions. Preoperative stenting improves passage of the ureteroscope and with progressive miniaturization of instruments, the lower weight limit will decrease.
Dirt, disease and death: control, resistance and change in the post-emancipation Caribbean
Pemberton, Rita;
História, Ciências, Saúde-Manguinhos , 2012, DOI: 10.1590/S0104-59702012000500004
Abstract: this study examines how health facilities and services were used as an agency of worker control in the british caribbean between 1838 and 1860. it argues that planter health strategies were based on flawed assumptions. the resultant policy of deprivation of access to medical services by the labouring population backfired within 16 years of freedom when a cholera epidemic rocked the region. it exposed the poor living conditions of the free villages and generated fear and panic among the local elite who were forced to make policy changes regarding health and sanitation. as a result the first steps towards the establishment of public health services in the british caribbean were stimulated.
Deaths in Police Custody: The ‘acceptable’ consequences of a ‘law and order’ society?
Simon Pemberton
Outlines : Critical Practice Studies , 2005,
Abstract: This article seeks to explain the acceptance of the rising numbers of police custody deaths in England and Wales over the last 20 years. It argues that these deaths are a consequence of the transformation in the U.K., from a social democratic to an increasingly neo-liberal mode of social organisation. The article links the characteristics of the authoritarian state, which emerged at this point in time, to the current profile of police custody deaths. Then, by using interview material with those who have investigated these cases, the article seeks to understand the narratives which are mobilised to legitimate these deaths as the ‘acceptable’ consequences of a ‘law and order’ society.
Identification and comparative analysis of sixteen fungal peptidyl-prolyl cis/trans isomerase repertoires
Trevor J Pemberton
BMC Genomics , 2006, DOI: 10.1186/1471-2164-7-244
Abstract: PPIase numbers within these fungal repertoires appears associated with genome size and orthology between repertoires was found to be low. Phylogenetic analysis showed the single-domain FKBPs to evolve prior to the multi-domain FKBPs, whereas the multi-domain cyclophilins appear to evolve throughout cyclophilin evolution. A comparison of their known functions has identified, besides a common role within protein folding, multiple roles for the cyclophilins within pre-mRNA splicing and cellular signalling, and within transcription and cell cycle regulation for the parvulins. However, no such commonality was found with the FKBPs. Twelve of the 17 human cyclophilins and both human parvulins, but only one of the 13 human FKBPs, identified orthologues within these fungi. hPar14 orthologues were restricted to the Pezizomycotina fungi, and R. oryzae is unique in the known fungi in possessing an hCyp33 orthologue and a TPR-containing FKBP. The repertoires of Cryptococcus neoformans, Aspergillus fumigatus, and Aspergillus nidulans were found to exhibit the highest orthology to the human repertoire, and Saccharomyces cerevisiae one of the lowest.Given this data, we would hypothesize that: (i) the evolution of the fungal PPIases is driven, at least in part, by the size of the proteome, (ii) evolutionary pressures differ both between the different PPIase families and the different fungi, and (iii) whilst the cyclophilins and parvulins have evolved to perform conserved functions, the FKBPs have evolved to perform more variable roles. Also, the repertoire of Cryptococcus neoformans may represent a better model fungal system within which to study the functions of the PPIases as its genome size and genetic tractability are equal to those of Saccharomyces cerevisiae, whilst its repertoires exhibits greater orthology to that of humans. However, further experimental investigations are required to confirm this.The peptidyl-prolyl cis/trans isomerase (PPIase) class of proteins is traditio
A ‘Terror of Tyrannosaurs’: The First Trackways of Tyrannosaurids and Evidence of Gregariousness and Pathology in Tyrannosauridae
Richard T. McCrea, Lisa G. Buckley, James O. Farlow, Martin G. Lockley, Philip J. Currie, Neffra A. Matthews, S. George Pemberton
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0103613
Abstract: The skeletal record of tyrannosaurids is well-documented, whereas their footprint record is surprisingly sparse. There are only a few isolated footprints attributed to tyrannosaurids and, hitherto, no reported trackways. We report the world’s first trackways attributable to tyrannosaurids, and describe a new ichnotaxon attributable to tyrannosaurids. These trackways are from the Upper Cretaceous (Campanian - Maastrichtian) of northeastern British Columbia, Canada. One trackway consists of three tridactyl footprints, and two adjacent trackways consist of two footprints each. All three trackways show animals bearing southeast within an 8.5 meter-wide corridor. Similarities in depth and preservation of the tyrannosaurid tracks indicate that these three trackways were made by track-makers walking concurrently in the same direction. These trackways add significantly to previous osteology-based hypotheses of locomotion and behavior in Tyrannosauridae by providing ichnologic support for gregariousness in tyrannosaurids, and the first record of the walking gait of tyrannosaurids.
Novel gene expression responses in the ovine abomasal mucosa to infection with the gastric nematode Teladorsagia circumcincta
Pamela A Knight, Susan E Griffith, Alan D Pemberton, Judith M Pate, Lauren Guarneri, Katherine Anderson, Richard T Talbot, Sarah Smith, David Waddington, Mark Fell, Alan L Archibald, Stewart TG Burgess, David W Smith, Hugh RP Miller, Ivan W Morrison
Veterinary Research , 2011, DOI: 10.1186/1297-9716-42-78
Abstract: Parasitic gastroenteritis (PGE), caused by trichostrongylid nematodes, is the most commonly diagnosed systemic disease of sheep in the U.K. The principal causative nematode is the abomasal parasite Teladorsagia circumcincta. Control currently depends on the use of anthelmintics, but is failing due to the rapid emergence of drug resistance in the target nematodes [1]. Immunity builds up slowly on repeated exposure to the parasite, indicating vaccination could be a feasible alternative, but vaccine development is hampered by a lack of knowledge of the host-parasite interaction to infective larvae. This immunity can be replicated experimentally by giving animals a low level trickle infection over several weeks, which results in a significant level of protective immunity to T. circumcincta challenge, measurable by reduced worm burdens, stunting of the worms and increased levels of larval arrest [2-4]. Protective immunity includes both cellular and humoral components; previously exposed animals undergo a local blast cell response in the draining lymphatics which can convey protection to genetically identical na?ve recipients [2,5], while local IgA/IgE responses have been associated with certain protective responses such as stunted growth and reduced fecundity of the worms [4,6,7]. T. circumcincta challenge in previously immunised sheep elicits local predominantly Th2 cytokine expression, compared to a more Th1-bias in na?ve animals [8,9]. This response is accompanied by distinct Th2-type changes in the mucosa, such as mucous neck cell and mast cell hyperplasia, eosinophilia, recruitment of IgA/IgE producing cells and neutrophils, altered T-cell subsets and mucosal hypertrophy [10-14]. However, the molecular changes involved, and the relative contributions of these factors to both control of infection and the clinical symptoms of disease, are still poorly understood. The host immune responses may act concordantly to generate an unfavourable micro-environment [15], which c
Identification and Comparative Analysis of the Peptidyl-Prolyl cis/trans Isomerase Repertoires of H. sapiens, D. melanogaster, C. elegans, S. cerevisiae and Sz. pombe
Trevor J. Pemberton,John E. Kay
Comparative and Functional Genomics , 2005, DOI: 10.1002/cfg.482
Abstract: The peptidyl-prolyl cis/trans isomerase (PPIase) class of proteins comprises three member families that are found throughout nature and are present in all the major compartments of the cell. Their numbers appear to be linked to the number of genes in their respective genomes, although we have found the human repertoire to be smaller than expected due to a reduced cyclophilin repertoire. We show here that whilst the members of the cyclophilin family (which are predominantly found in the nucleus and cytoplasm) and the parvulin family (which are predominantly nuclear) are largely conserved between different repertoires, the FKBPs (which are predominantly found in the cytoplasm and endoplasmic reticulum) are not. It therefore appears that the cyclophilins and parvulins have evolved to perform conserved functions, while the FKBPs have evolved to fill ever-changing niches within the constantly evolving organisms. Many orthologous subgroups within the different PPIase families appear to have evolved from a distinct common ancestor, whereas others, such as the mitochondrial cyclophilins, appear to have evolved independently of one another. We have also identified a novel parvulin within Drosophila melanogaster that is unique to the fruit fly, indicating a recent evolutionary emergence. Interestingly, the fission yeast repertoire, which contains no unique cyclophilins and parvulins, shares no PPIases solely with the budding yeast but it does share a majority with the higher eukaryotes in this study, unlike the budding yeast. It therefore appears that, in comparison with Schizosaccharomyces pombe, Saccharomyces cerevisiae is a poor representation of the higher eukaryotes for the study of PPIases.
In Vitro Interactions of Extracellular Histones with LDL Suggest a Potential Pro-Atherogenic Role
Alan D. Pemberton,Jeremy K. Brown
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0009884
Abstract: Nuclear histones have previously been shown to aggregate LDL in vitro, suggestive of a possible pro-atherogenic role. Recent studies indicate that histones are released during acute inflammation, and therefore might interact with circulating lipoproteins in vivo. In view of the associative link between inflammation and cardiovascular disease, the behaviour of histones was investigated using in vitro models of LDL retention and foam cell formation.
An appraisal of ultrasound fetal biometry in the first trimester
Lily K Pemberton, Irina Burd, Eileen Wang
Reports in Medical Imaging , 2010, DOI: http://dx.doi.org/10.2147/RMI.S9119
Abstract: n appraisal of ultrasound fetal biometry in the first trimester Review (6593) Total Article Views Authors: Lily K Pemberton, Irina Burd, Eileen Wang Published Date August 2010 Volume 2010:3 Pages 11 - 15 DOI: http://dx.doi.org/10.2147/RMI.S9119 Lily K Pemberton, Irina Burd, Eileen Wang Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, PA, USA Abstract: We evaluate the current available literature on first trimester measurement references, how critically these data have been evaluated in subsequent studies, and the generalizability of the standards across different populations. We will then discuss the significance of first trimester dating for genetic screening tests and how growth in the first trimester may predict later pregnancy outcomes, which could lead to future research to modify these outcomes.
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