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Search Results: 1 - 10 of 190329 matches for " Rhonda G. Pace "
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Histo-Blood Group Gene Polymorphisms as Potential Genetic Modifiers of Infection and Cystic Fibrosis Lung Disease Severity
Jennifer L. Taylor-Cousar, Maimoona A. Zariwala, Lauranell H. Burch, Rhonda G. Pace, Mitchell L. Drumm, Hollin Calloway, Haiying Fan, Brent W. Weston, Fred A. Wright, Michael R. Knowles, for the Gene Modifier Study Group
PLOS ONE , 2009, DOI: 10.1371/journal.pone.0004270
Abstract: Background The pulmonary phenotype in cystic fibrosis (CF) is variable; thus, environmental and genetic factors likely contribute to clinical heterogeneity. We hypothesized that genetically determined ABO histo-blood group antigen (ABH) differences in glycosylation may lead to differences in microbial binding by airway mucus, and thus predispose to early lung infection and more severe lung disease in a subset of patients with CF. Methods and Principal Findings Clinical information and DNA was collected on >800 patients with the ΔF508/ΔF508 genotype. Patients in the most severe and mildest quartiles for lung phenotype were enrolled. Blood samples underwent lymphocyte transformation and DNA extraction using standard methods. PCR and sequencing were performed using standard techniques to identify the 9 SNPs required to determine ABO blood type, and to identify the four SNPs that account for 90–95% of Lewis status in Caucasians. Allele identification of the one nonsynonymous SNP in FUT2 that accounts for >95% of the incidence of nonsecretor phenotype in Caucasians was completed using an ABI Taqman assay. The overall prevalence of ABO types, and of FUT2 (secretor) and FUT 3 (Lewis) alleles was consistent with that found in the Caucasian population. There was no difference in distribution of ABH type in the severe versus mild patients, or the age of onset of Pseudomonas aeruginosa infection in the severe or mild groups. Multivariate analyses of other clinical phenotypes, including gender, asthma, and meconium ileus demonstrated no differences between groups based on ABH type. Conclusions and Significance Polymorphisms in the genes encoding ABO blood type, secretor or Lewis genotypes were not shown to associate with severity of CF lung disease, or age of onset of P. aeruginosa infection, nor was there any association with other clinical phenotypes in a group of 808 patients homozygous for the ΔF508 mutation.
Variation in MSRA Modifies Risk of Neonatal Intestinal Obstruction in Cystic Fibrosis
Lindsay B. Henderson,Vishal K. Doshi,Scott M. Blackman,Kathleen M. Naughton,Rhonda G. Pace,Jackob Moskovitz,Michael R. Knowles,Peter R. Durie,Mitchell L. Drumm,Garry R. Cutting
PLOS Genetics , 2012, DOI: 10.1371/journal.pgen.1002580
Abstract: Meconium ileus (MI), a life-threatening intestinal obstruction due to meconium with abnormal protein content, occurs in approximately 15 percent of neonates with cystic fibrosis (CF). Analysis of twins with CF demonstrates that MI is a highly heritable trait, indicating that genetic modifiers are largely responsible for this complication. Here, we performed regional family-based association analysis of a locus that had previously been linked to MI and found that SNP haplotypes 5′ to and within the MSRA gene were associated with MI (P = 1.99×10?5 to 1.08×10?6; Bonferroni P = 0.057 to 3.1×10?3). The haplotype with the lowest P value showed association with MI in an independent sample of 1,335 unrelated CF patients (OR = 0.72, 95% CI [0.53–0.98], P = 0.04). Intestinal obstruction at the time of weaning was decreased in CF mice with Msra null alleles compared to those with wild-type Msra resulting in significant improvement in survival (P = 1.2×10?4). Similar levels of goblet cell hyperplasia were observed in the ilea of the Cftr?/? and Cftr?/?Msra?/? mice. Modulation of MSRA, an antioxidant shown to preserve the activity of enzymes, may influence proteolysis in the developing intestine of the CF fetus, thereby altering the incidence of obstruction in the newborn period. Identification of MSRA as a modifier of MI provides new insight into the biologic mechanism of neonatal intestinal obstruction caused by loss of CFTR function.
Mucin Variable Number Tandem Repeat Polymorphisms and Severity of Cystic Fibrosis Lung Disease: Significant Association with MUC5AC
XueLiang Guo, Rhonda G. Pace, Jaclyn R. Stonebraker, Clayton W. Commander, Anthony T. Dang, Mitchell L. Drumm, Ann Harris, Fei Zou, Dallas M. Swallow, Fred A. Wright, Wanda K. O'Neal, Michael R. Knowles
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0025452
Abstract: Variability in cystic fibrosis (CF) lung disease is partially due to non-CFTR genetic modifiers. Mucin genes are very polymorphic, and mucins play a key role in the pathogenesis of CF lung disease; therefore, mucin genes are strong candidates as genetic modifiers. DNA from CF patients recruited for extremes of lung phenotype was analyzed by Southern blot or PCR to define variable number tandem repeat (VNTR) length polymorphisms for MUC1, MUC2, MUC5AC, and MUC7. VNTR length polymorphisms were tested for association with lung disease severity and for linkage disequilibrium (LD) with flanking single nucleotide polymorphisms (SNPs). No strong associations were found for MUC1, MUC2, or MUC7. A significant association was found between the overall distribution of MUC5AC VNTR length and CF lung disease severity (p = 0.025; n = 468 patients); plus, there was robust association of the specific 6.4 kb HinfI VNTR fragment with severity of lung disease (p = 6.2×10?4 after Bonferroni correction). There was strong LD between MUC5AC VNTR length modes and flanking SNPs. The severity-associated 6.4 kb VNTR allele of MUC5AC was confirmed to be genetically distinct from the 6.3 kb allele, as it showed significantly stronger association with nearby SNPs. These data provide detailed respiratory mucin gene VNTR allele distributions in CF patients. Our data also show a novel link between the MUC5AC 6.4 kb VNTR allele and severity of CF lung disease. The LD pattern with surrounding SNPs suggests that the 6.4 kb allele contains, or is linked to, important functional genetic variation.
The discontinuous nature of chromospheric activity evolution
G. Pace
Physics , 2010, DOI: 10.1007/s10509-010-0310-5
Abstract: Chromospheric activity has been thought to decay smoothly with time and, hence, to be a viable age indicator. Measurements in solar type stars in open clusters seem to point to a different conclusion: chromospheric activity undergoes a fast transition from Hyades level to that of the Sun after about 1 Gyr of main--sequence lifetime and any decaying trend before or after this transition must be much less significant than the short term variations.
Deuteron Electromagnetic Properties with a Poincaré-Covariant Current Operator within Front-Form Hamiltonian Dynamics
E. Pace,G. Salme`
Physics , 2001,
Abstract: Deuteron elastic and deep inelastic electromagnetic properties have been studied within the front-form Hamiltonian dynamics, using a Poincar\'e-covariant current operator. The deuteron elastic form factors are strongly sensitive to different realistic $N-N$ interactions, while the relevance of different nucleon form factor models is huge for $A(Q^2)$, weak for $B(Q^2)$ and negligible for the tensor polarization. The possibility to gain information on the neutron charge form factor from an analysis of $A(Q^2)$ has been investigated. The extraction of the neutron structure functions from the deuteron deep inelastic structure functions at high $x$ is largely affected by the use of our Poincar\'e-covariant relativistic approach instead of the usual impulse approximation within an instant-form approach.
From Sméagol to Gollum: Mechanical Stress and Bone Remodelling  [PDF]
Nicole Pace
Open Journal of Orthopedics (OJO) , 2018, DOI: 10.4236/ojo.2018.84018
Abstract: This imaginary transformation from Sméagol to Gollum is a dramatization of the illusive repercussions of mechanical stress affecting bone. This paper presents the main ideas of mechanical stress and bone remodelling from a novel’s perspective. The object of this study is to provide evidence for new ways to explore bone’s functional adaptation to mechanical stress made through the copious interpretation and integration of new and existing literature. It tackles the underlying biology of bone cells and how they detect and react to strain stimuli. The different types of mechanical demands in daily activities are sifted through and any misconceptions found fallible in literature are refined. A personal experience of a stress fracture is reviewed to parallel the implications that lead to the incident with the findings on the link between mechanical stress and bone remodelling. Some factors regarding age, gender and ethnicity and the interplay with mechanical stress influencing bone remodelling are considered. Brief overviews of three new medical novelties in bone healing are outlined, hoping that these interventions of proper medical techniques can be a change for the better: one from Gollum to Sméagol rather than vice versa.
k-nets embedded in a projective plane over a field
G. Korchmaros,G. P. Nagy,N. Pace
Mathematics , 2013,
Abstract: We investigate $k$-nets with $k\geq 4$ embedded in the projective plane $PG(2,\mathbb{K})$ defined over a field $\mathbb{K}$; they are line configurations in $PG(2,\mathbb{K})$ consisting of $k$ pairwise disjoint line-sets, called components, such that any two lines from distinct families are concurrent with exactly one line from each component. The size of each component of a $k$-net is the same, the order of the $k$-net. If $\mathbb{K}$ has zero characteristic, no embedded $k$-net for $k\geq 5$ exists; see [1,2]. Here we prove that this holds true in positive characteristic $p$ as long as $p$ is sufficiently large compared with the order of the $k$-net. Our approach, different from that used in [1,2], also provides a new proof in characteristic zero. [1] J. Stipins, Old and new examples of k-nets in P2, math.AG/0701046. [2] S. Yuzvinsky, A new bound on the number of special fibers in a pencil of curves, Proc. Amer. Math. Soc. 137 (2009), 1641-1648.
Determining Factors Influencing the Outcome of College Basketball Games  [PDF]
Rhonda Magel, Samuel Unruh
Open Journal of Statistics (OJS) , 2013, DOI: 10.4236/ojs.2013.34026
Abstract: While a number of statistics are collected during an NCAA Division I men’s college basketball game, it is potentially of interest to universities, coaches, players, and fans to which these statistics are most significant in determining wins and losses. To this end, statistics were collected from two seasons of games and analyzed using logistic and least squares regression methods. The differences between the two competing teams in four common statistics were found to be significant to determining victory: assists, free throw attempts, defensive rebounds, and turnovers. The models were then used with data from the 2011-2012 Season to verify the accuracy of the models. The point spread model was also used with 2013 March Madness game statistics.
Does Work Environment Affect Faculty Health Scores?  [PDF]
Rhonda C. Magel
Sociology Mind (SM) , 2013, DOI: 10.4236/sm.2013.34043
Abstract:

This study investigates the relationship between self-reported health scores with work environment and various components of a women faculty score at a Research 1 University in the Midwest USA. The study examines the differences between male and female faculty responses in the various components making up the women faculty score and also gender differences in self-reported health scores and work environment scores. Differences between STEM and Non-STEM faculty are examined. A significant positive relationship is found between self-reported health scores and work environment controlling for gender. The study finds that the overall university work environment has a stronger relationship to faculty health than adequate gender ratio, women climate, and women leadership, even for women faculty. No significant differences in responses are found between STEM and Non-STEM faculty for women climate, women leadership, health scores, and work environment scores. Significant differences are found only in adequate gender ratio.

Big Fish in a Big Pond: a study of academic self concept in first year medical students
Kirsty Jackman, Ian G Wilson, Marjorie Seaton, Rhonda G Craven
BMC Medical Education , 2011, DOI: 10.1186/1472-6920-11-48
Abstract: Twenty first-year students in an Australian medical school completed a survey that included academic self-concept and social comparison measures, before and after their first written assessments. Focus groups were also conducted with a separate group of students to explore students' perceptions of competence, the medical school environment, and social comparison processes.The quantitative study did not reveal any changes in academic self-concept or self-evaluation. The qualitative study suggested that the attributions that students used when discussing performance were those that have been demonstrated to negatively affect self-concept. Students reported that the environment was slightly competitive and they used social comparison to evaluate their performance.Although the BFLPE was not evident in the quantitative study, results from the qualitative study suggest that the BFLPE might be operating In that students were using attributions that are associated with lower self-concepts, the environment was slightly competitive, and social comparisons were used for evaluation.Over the past 25 years, research has demonstrated that equally able students have lower academic self-concepts in schools where the average achievement level is higher than in schools where the average achievement level is lower [1-3]. Known as the Big-Fish-Little-Pond Effect (BFLPE), this finding has been replicated in primary schools [4], high schools [2], and across countries and cultures [5,6]. Although the BFLPE has also been shown to have an effect on admission to elite universities [7], to the knowledge of the authors it has not been explicitly tested at the university level. The purpose of the present investigation was to explore whether the BFLPE [1,2,8,9] could be extended to medical students.Self-concept can be defined as "a person's sense of self shaped through interaction with the environment and other people" [10]. A positive self-concept is regarded as important for good mental health,
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