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Assessment of technical efficiency of hospitals under Hamadan University of Medical Sciences on performance indicators and data envelopment analysis model in 2010
Reza Safi Arian,Reza Shahhoseini
Pajouhan Scientific Journal , 2013,
Abstract: Introduction: This study was aimed to evaluate the technical efficiency of Hamadan University of Medical Sciences and functional indexes based on using mathematical model analysis of inclusive data (DEA) in 2010.Material and Methods: This study is a cross – sectional, the data field of library and information through the use of doctoral dissertations and master and go directly to the hospital and the University's center for statistics. This method has limitations in dealing method using data envelopment analysis (DEA) to evaluate the technical efficiency of hospitals DEAP2 prescription coverage has been Hamadan University of medical sciences. The model used in this study analysis of multistage DEA model is used for the minimization of production factors and output variables.Results: Data inputs include the number of groups of physicians (general practitioners, specialists, doctors intern in teaching hospitals, physician residents in teaching hospitals), the number of nurses (nurses, nurse aid, nurse), the number of staff and beds and the output includes the number of surgeries, number of ambulatory patients, the percentage of occupied beds, average bed day stay patient is hospitalized. Then calculate the technical efficiency of hospitals and hospital efficiency (efficiency coefficient E=1) and the inefficient (the unit) is obtained.Discussion: The most important factors for technical efficiency in hospitals have been incorrect use of beds patient-day in sufficiency and bed-days occupied. Finally in Hamadan average surplus factor (input), respectively: 3 physician, 9 nurses, 8 other personnel and 3 active beds and there should be surplus production factors surplus to be removed to hospitals in the province average to reach the desired level of technical efficiency. The findings in this study shows the highest ratio of technical efficiency in Besat, Beheshti, Farshchian, Imam Hussein Malayer, ValiAsr Razan, Ali Moradian and Heydari Nahavand, Ghaem and Amiralmomenin Asadabad hospitals in comparison with other hospitals is.
Cryptanalysis of a Substitution-Permutation Network Using Gene Assembly in Ciliates  [PDF]
Arash Karimi, Hadi Shahriar Shahhoseini
Int'l J. of Communications, Network and System Sciences (IJCNS) , 2012, DOI: 10.4236/ijcns.2012.53020
Abstract: In this paper we provide a novel approach for breaking a significant class of block ciphers, the so-called SPN ciphers, using the process of gene assembly in ciliates. Our proposed scheme utilizes, for the first time, the Turing-powerful potential of gene assembly procedure of ciliated protozoa into the real world computations and has a fewer number of steps than the other proposed schemes to break a cipher. We elaborate notions of formal language theory based on AIR systems, which can be thought of as a modified version of intramolecular scheme to model the ciliate bio-operations, for construction of building blocks necessary for breaking the cipher, and based on these nature-inspired constructions which are as powerful as Turing machines, we propose a theoretical approach for breaking SPN ciphers. Then, we simulate our proposed plan for breaking these ciphers on a sample block cipher based on this structure. Our results show that the proposed scheme has 51.5 percent improvement over the best previously proposed nature-inspired scheme for breaking a cipher.
Epigenetic and Cellular Memory
Mahdyie Jadaliha,Maryam Shahhoseini
Cell Journal , 2010,
Abstract: It has been stated that cells sometimes have the ability to remember who and what theyare! They have this ability, even, though they contain although they have all the necessarygenes neededwith which to become all typeskinds of cells. In this regard, the pattern ofgene expression must be inherited from one cell generation to the next by mechanismsthat lie outside the DNA sequence itself, which is termed cellular memory or epigeneticinheritance.Developmental biology is under the control of both genetic and epigenetic mechanisms.Studies show that the regulation of chromatin structure by DNA methylation and histonemodification is crucial for genome reprogramming during early embryogenesis and gametogenesis,as well as for tissue-specific gene expression and differentiation. Understandingthe process of epigenetic reprogramming in development is important for studies of cloningand the clinical application of stem-cell therapy. In the current review we briefly discuss themolecular mechanism of cellular memory, under the control of epigenetic regulation.
BREAKING A FEISTEL-TYPE BLOCK CIPHER BY BACTERIA ENGINEERING
Arash Karimi,Hadi Shahriar Shahhoseini
Advanced Computing : an International Journal , 2012,
Abstract: In this paper we propose a theoretical method for breaking a block cipher based on a Feistel structurewhich is a variant of DES (S-DES) using one pair of (plaintext, ciphertext). Our scheme utilizes bacterialcomputing for the first time in cryptanalysis. For this reason, we design and simulate an engineered generegulatory network to break S-DES which possesses a superior performance than the other methodsbased on DNA computing because it utilizes the power of massive parallelism of DNA molecules as wellas capability of cellular division of bacterial cells which gives our proposed S-DES cracker system theflavour of massive parallel processing.
Load Balancing in Local Computational Grids within Resource Allocation Process
Rouhollah Golmohammadi,Hadi Shahriar Shahhoseini
Research Journal of Applied Sciences, Engineering and Technology , 2012,
Abstract: A suitable resource allocation method in computational grids should schedule resources in a way that provides the requirements of the users and the resource providers; i.e., the maximum number of tasks should be completed in their time and budget constraints and the received load be distributed equally between resources. This is a decision-making problem, while the scheduler should select a resource from all ones. This process is a multi criteria decision-making problem; because of affect of different properties of resources on this decision. The goal of this decision-making process is balancing the load and completing the tasks in their defined constraints. The proposed algorithm is an analytic hierarchy process based Resource Allocation (ARA) method. This method estimates a value for the preference of each resource and then selects the appropriate resource based on the allocated values. The simulations show the ARA method decreases the task failure rate at least 48% and increases the balance factor more than 3.4%.
Monitoring and determination of doses of Tehran research reactor staff during with various dosimetees and comparision of their responses
Navideh Aghaei Amirkhizi,Elham Shahhoseini,Ahmad Mohammadzadeh
Iranian Journal of Nuclear Medicine , 2010,
Abstract: It is a requirement according to ALARA to minimize radiation exposure of radiation workers and the public as low as reasonably achievable. To achieve this goal it is important to consider the following factors: an accurate recognition of radiation sources, measurement of environmental dose and workers' exposure, and reasons for radiation exposure. In this study, entitled "Evaluation of Personnel and Environmental Dose of Tehran Research Reactor's Radiation Workers with Various Dosimeters and Comparison of their Responses," personnel and environmental dose of the Tehran Research Reactor (TRR) was investigated. The personnel dose was evaluated with various dosimeters such as film badge, digital, Rados, pen and neutron dosimeters and the environmental dose was evaluated by using a Rados monitoring network which consisted of a number of dosimeters installed at various locations. The measured dose was then compared with the national and international dose level standards. In conjunction with the personnel dose assessment, a medical examination of the personnel including blood and urine analysis was performed. Final results of this study show that the environmental dose level of various locations of the reactor under monitoring is comparable to the international standards limits and the environmental dose level increase has a direct correlation with the TRR operating power and the release of irradiated samples from the reactor pool. Moreover, the personnel dose of TRR during operating hours did not exceed the standard limits and the results of the medical examinations confirm such findings.
Neuro-Fuzzy Modeling of Heat Recovery Steam Generator
A. Ghaffari,A. Chaibakhsh,S. Shahhoseini
International Journal of Machine Learning and Computing , 2013, DOI: 10.7763/ijmlc.2013.v3.271
Abstract: In this paper, an application of dynamic neuro-fuzzy systems is presented for modeling the subsystems of the heat recovery steam generator (HRSG). The dynamic neuro-fuzzy models were developed based on the formal NARX models topology. The clustering techniques were employed to define the structure of the fuzzy models by dividing the entire operating regions into smaller subspaces. The optimal cluster centers and corresponding membership functions are captured by FCM, where the parameters of consequent were adjusted by recursive LSE method. A comparison between the responses of the proposed models and the responses of the plants ware preformed, which validates the accuracy and performance of the modeling approach.
Enhancement of Glycosaminoglycan-Rich Matrix Production in Human Marrow-Derived Mesenchymal Stem Cell Chondrogenic Culture by Lithium Chloride and SB216763 Treatment
Mohamadreza Baghaban Eslaminejad,Negar Karimi,Maryam Shahhoseini
Cell Journal , 2011,
Abstract: Objective: Cartilage mass produced from mesenchymal stem cell (MSC) differentiationwould be a suitable candidate for use in regenerative medicine. Since the proper functionof cartilage tissue is largely dependent on matrix glycosaminoglycan (GAG) contents, theobjective of this study was to investigate the enhancing effect of two GSK3 inhibitors onthe GAG content of cartilage produced by human marrow MSCs in vitro chondrogenesis.Materials and Methods: MSCs that were used in this experimental study were derivedfrom human marrow aspirates and confirmed using standard assays. Optimal concentrationsof Lithium chloride and SB216763 were determined based on the yield of viable cellnumbers in MSC cultures treated with varying concentrations of either Lithium chloride orSB216763. Passaged-3 MSCs were then centrifuged into small aggregates and providedwith a chondrogenic medium supplemented with either lithium or SB216763 reagent atthe optimal concentration determined in the previous experiment. Three weeks after, GAGcontents of the culture were quantified and compared to each other and the control.Results: According to our data, the cultures treated with 5 mM Lithium and 1 μM SB216763tended to have comparatively more viable cells; therefore these concentrations were usedin the differentiation experiments. The addition of either SB216763 or lithium to chondrogeniccultures appeared to significantly enhance cartilage matrix production. In SB216763and Lithium-treated cultures average GAG concentrations were 6.17 ± 0.7 and 6.12 ± 1.1μg/ml compared to 2.00 ± 0.3 μg/ml in the control (p<0.05).Conclusion: Using SB216763 and Lithium as supplements in human marrow MSC chondrogenicculture can lead to the production of cartilage mass high in GAG content.
Epigenetic Regulation of Osteogenic and Chondrogenic Differentiation of Mesenchymal Stem Cells in Culture
Mohamadreza Baghaban Eslaminejad,Nesa Fani,Maryam Shahhoseini
Cell Journal , 2013,
Abstract: Management of mesenchymal stem cells (MSCs) capabilities to differentiate in to osteogenic and chondrogenic lineages would be of utmost importance for their future use in difficult to treat cases of destroyed bone and cartilage. Thus, an understanding of the epigenetic mechanisms as important modulators of stem cell differentiation might be useful. Epigenetic mechanism refers to a process that regulates heritable and long-lasting alterations in gene expression without changing the DNA sequence. Such stable changes would be mediated by several mechanisms including DNA methylation and histone modifications. The involvement of epigenetic mechanisms during MSC bone and cartilage differentiation has been investigated during the past decade. The purpose of this review is to cover outstanding research works that have attempted to ascertain the underlying epigenetic changes of the nuclear genome during in vitro differentiation of MSCs into bone and cartilage cell lineages. Understanding such genomic alterations may assist scientists to develop and recognize reagents that are able to efficiently promote this cellular differentiation. Before summarizing the progress on epigenetic regulation of MSC bone and cartilage differentiation, a brief description will be given regarding in vitro conditions that favor MSC osteocytic and chondrocytic differentiation and the main mechanisms responsible for epigenetic regulation of differentiation.
Dabigatran Etexilate, A Novel Oral Direct Thrombin Inhibitor, for Preventing Thromboembolic Events After Knee Replacement Arthroplasty
Moghtadaee M,Shahhoseini Gh,Farahini H,Yegane A
Tehran University Medical Journal , 2012,
Abstract: Background: Dabigatran etexilate is one of the few direct thrombin inhibitors with anti-coagulant activities and the following distinctive features: taken orally, no need to closely monitor for complications, and no need for regular dose adjustments. Relying on the above mentioned valuable advantages, dabigatran etexilate can be considered as a premier choice for the prevention of venous thromboembolism after knee replacement arthroplasty. Methods: Forty five patients undergoing 50 knee replacement surgeries were included in this case-series study undertaken in Hazrat Rasool Akram and Khatam-alanbia Hospitals during 2010. Dabigatran etexilate was administered for the prevention of venous thromboembolism after knee arthroplasty in doses of 110 mg in the first 1-4 h after surgery followed by daily doses of 220 mg for 10 days. Patients were examined 3 times and a color Doppler sonography was performed on the 11th day to check for venous thrombosis. Finally, the patients were re-examined at the end of the 1st and the 3rd months postoperatively. Results: Only one out of 45 patients was diagnosed to have venous thrombosis on sonography done on the 11th day but the patient did not have any symptoms and repeat sonographies at the end of the 1st and the 3rd months postoperatively showed no venous thrombosis either. No complications were witnessed in the patients in the 3-month follow-up period. Conclusion: Dabigatran etexilate (220 mg/d for 10 days) can be an effective drug against venous thrombosis after total knee replacement surgeries.
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